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Aliases for CCDC146 Gene

Aliases for CCDC146 Gene

  • Coiled-Coil Domain Containing 146 2 3 5
  • Coiled-Coil Domain-Containing Protein 146 3
  • KIAA1505 4

External Ids for CCDC146 Gene

Previous GeneCards Identifiers for CCDC146 Gene

  • GC07P076590
  • GC07P076673
  • GC07P071399
  • GC07P076751

Summaries for CCDC146 Gene

GeneCards Summary for CCDC146 Gene

CCDC146 (Coiled-Coil Domain Containing 146) is a Protein Coding gene. An important paralog of this gene is CFAP58.

Additional gene information for CCDC146 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CCDC146 Gene

Genomics for CCDC146 Gene

GeneHancer (GH) Regulatory Elements for CCDC146 Gene

Promoters and enhancers for CCDC146 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH07J077121 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 667.4 -0.2 -171 1.7 HDGF PKNOX1 CLOCK FOXA2 ARNT ARID4B SIN3A ZNF2 YY1 ZNF766 CCDC146 GC07M077214 FAM185BP RSBN1L SPDYE18 SPDYE17 ENSG00000213542 POMZP3 LOC100133091 UPK3B
GH07J077005 Promoter/Enhancer 0.8 EPDnew dbSUPER 650.1 -116.7 -116749 0.1 POLR2A UPK3BP1 CCDC146 PMS2P11 GC07M076952 GC07M076954 GC07M076953 GC07M076981 GC07M076987 GC07M076990 GC07M076994
GH07J077040 Promoter 0.5 EPDnew 650.2 -82.4 -82362 0.1 PMS2P9 ENSG00000201959 CCDC146 GC07M076989 GC07M076988 DTX2P1-UPK3BP1-PMS2P11
GH07J077796 Promoter/Enhancer 2.4 EPDnew FANTOM5 Ensembl ENCODE 11 +676.5 676492 4.5 CLOCK DMAP1 YY1 ZNF213 E2F8 ZNF143 SP3 NFYC MEF2D ZNF610 TMEM60 PHTF2 RSBN1L SPDYE18 FAM185BP SPDYE17 APTR PMS2P9 LOC100422695 CCDC146
GH07J077535 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 9.9 +416.1 416068 5.4 HDGF HNRNPUL1 PKNOX1 CLOCK FOXA2 SMAD1 MLX ARNT ZFP64 ARID4B PTPN12 GC07M077535 RSBN1L FAM185BP PMS2P9 APTR DTX2P1 POMZP3 CCDC146 LOC105375363
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around CCDC146 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the CCDC146 gene promoter:

Genomic Locations for CCDC146 Gene

Genomic Locations for CCDC146 Gene
chr7:77,122,434-77,329,533
(GRCh38/hg38)
Size:
207,100 bases
Orientation:
Plus strand
chr7:76,751,751-76,958,850
(GRCh37/hg19)

Genomic View for CCDC146 Gene

Genes around CCDC146 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CCDC146 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CCDC146 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CCDC146 Gene

Proteins for CCDC146 Gene

  • Protein details for CCDC146 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8IYE0-CC146_HUMAN
    Recommended name:
    Coiled-coil domain-containing protein 146
    Protein Accession:
    Q8IYE0
    Secondary Accessions:
    • A8K8X6
    • Q9P223

    Protein attributes for CCDC146 Gene

    Size:
    955 amino acids
    Molecular mass:
    112806 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAA96029.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for CCDC146 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CCDC146 Gene

Post-translational modifications for CCDC146 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CCDC146 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for CCDC146 Gene

Domains & Families for CCDC146 Gene

Gene Families for CCDC146 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for CCDC146 Gene

ProtoNet:

Suggested Antigen Peptide Sequences for CCDC146 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with CCDC146: view

No data available for UniProtKB/Swiss-Prot for CCDC146 Gene

Function for CCDC146 Gene

Phenotypes From GWAS Catalog for CCDC146 Gene

genes like me logo Genes that share phenotypes with CCDC146: view

Animal Model Products

miRNA for CCDC146 Gene

miRTarBase miRNAs that target CCDC146

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CCDC146 Gene

Localization for CCDC146 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CCDC146 Gene

Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole. Note=Localized to only one centriole identified as the mother centriole by co-staining with CEP164. {ECO:0000269 PubMed:25074808}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CCDC146 gene
Compartment Confidence
cytoskeleton 5
nucleus 3
cytosol 2
golgi apparatus 2
mitochondrion 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Golgi apparatus (2)
  • Vesicles (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for CCDC146 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005814 centriole IEA,IDA 25074808
GO:0005856 cytoskeleton IEA --
genes like me logo Genes that share ontologies with CCDC146: view

Pathways & Interactions for CCDC146 Gene

SuperPathways for CCDC146 Gene

No Data Available

Gene Ontology (GO) - Biological Process for CCDC146 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for CCDC146 Gene

Drugs & Compounds for CCDC146 Gene

No Compound Related Data Available

Transcripts for CCDC146 Gene

mRNA/cDNA for CCDC146 Gene

(8) Additional mRNA sequences :
(1) REFSEQ mRNAs :
(9) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for CCDC146 Gene

Coiled-coil domain containing 146:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for CCDC146 Gene

No ASD Table

Relevant External Links for CCDC146 Gene

GeneLoc Exon Structure for
CCDC146
ECgene alternative splicing isoforms for
CCDC146

Expression for CCDC146 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CCDC146 Gene

Protein differential expression in normal tissues from HIPED for CCDC146 Gene

This gene is overexpressed in Platelet (42.0) and Uterus (6.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for CCDC146 Gene



NURSA nuclear receptor signaling pathways regulating expression of CCDC146 Gene:

CCDC146

SOURCE GeneReport for Unigene cluster for CCDC146 Gene:

Hs.113940

Evidence on tissue expression from TISSUES for CCDC146 Gene

  • Lung(2.7)
genes like me logo Genes that share expression patterns with CCDC146: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for CCDC146 Gene

Orthologs for CCDC146 Gene

This gene was present in the common ancestor of animals.

Orthologs for CCDC146 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CCDC146 34 33
  • 99.51 (n)
OneToOne
cow
(Bos Taurus)
Mammalia CCDC146 34 33
  • 89.91 (n)
OneToOne
dog
(Canis familiaris)
Mammalia CCDC146 34 33
  • 88.67 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Ccdc146 16 34 33
  • 80.04 (n)
rat
(Rattus norvegicus)
Mammalia Ccdc146 33
  • 79.89 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia CCDC146 34
  • 68 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia CCDC146 34
  • 65 (a)
OneToOne
chicken
(Gallus gallus)
Aves CCDC146 33
  • 60.96 (n)
-- 34
  • 54 (a)
OneToMany
-- 34
  • 43 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia CCDC146 34
  • 52 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ccdc146 33
  • 60.93 (n)
zebrafish
(Danio rerio)
Actinopterygii ccdc146 34 33
  • 51.99 (n)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta Ory 34
  • 17 (a)
ManyToMany
CG5882 34
  • 15 (a)
ManyToMany
CG6059 34
  • 14 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 45 (a)
OneToOne
Species where no ortholog for CCDC146 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CCDC146 Gene

ENSEMBL:
Gene Tree for CCDC146 (if available)
TreeFam:
Gene Tree for CCDC146 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for CCDC146: view image

Paralogs for CCDC146 Gene

Paralogs for CCDC146 Gene

Pseudogenes.org Pseudogenes for CCDC146 Gene

genes like me logo Genes that share paralogs with CCDC146: view

Variants for CCDC146 Gene

Sequence variations from dbSNP and Humsavar for CCDC146 Gene

SNP ID Clin Chr 07 pos Variation AA Info Type
rs1000019615 -- 77,292,625(+) A/T intron_variant
rs1000067358 -- 77,128,093(+) T/C intron_variant
rs1000085127 -- 77,286,508(+) A/C intron_variant
rs1000150506 -- 77,184,700(+) T/C intron_variant
rs1000188845 -- 77,230,309(+) G/T intron_variant

Structural Variations from Database of Genomic Variants (DGV) for CCDC146 Gene

Variant ID Type Subtype PubMed ID
dgv1928e212 CNV loss 25503493
dgv22n31 CNV gain 19718026
dgv233e55 CNV loss 17911159
dgv6475n100 CNV gain 25217958
esv2504283 CNV deletion 19546169
esv2664949 CNV deletion 23128226
esv2667964 CNV deletion 23128226
esv2675079 CNV deletion 23128226
esv26954 CNV loss 19812545
esv2734692 CNV deletion 23290073
esv2734693 CNV deletion 23290073
esv2734696 CNV deletion 23290073
esv2734697 CNV deletion 23290073
esv2734698 CNV deletion 23290073
esv34102 CNV loss 18971310
esv3541938 CNV deletion 23714750
esv3613789 CNV loss 21293372
esv3613790 CNV loss 21293372
esv3613792 CNV loss 21293372
esv3613794 CNV loss 21293372
esv3613796 CNV loss 21293372
nsv1032907 CNV gain 25217958
nsv1034874 CNV loss 25217958
nsv1119227 CNV duplication 24896259
nsv1140808 CNV deletion 24896259
nsv428174 CNV gain 18775914
nsv511380 CNV loss 21212237
nsv526097 CNV gain 19592680
nsv8166 CNV loss 18304495
nsv8167 CNV loss 18304495
nsv831038 CNV loss 17160897
nsv951363 CNV duplication 24416366
nsv956010 CNV deletion 24416366
nsv970900 CNV duplication 23825009

Variation tolerance for CCDC146 Gene

Residual Variation Intolerance Score: 53.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 8.78; 86.75% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CCDC146 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CCDC146

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CCDC146 Gene

Disorders for CCDC146 Gene

Additional Disease Information for CCDC146

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for CCDC146 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CCDC146 Gene

Publications for CCDC146 Gene

  1. Proteomic analysis of mammalian sperm cells identifies new components of the centrosome. (PMID: 25074808) Firat-Karalar EN … Stearns T (Journal of cell science 2014) 2 3 4 58
  2. Prediction of the coding sequences of unidentified human genes. XVII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10819331) Nagase T … Ohara O (DNA research : an international journal for rapid publication of reports on genes and genomes 2000) 2 3 4 58
  3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 44 58
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  5. A Global Analysis of the Receptor Tyrosine Kinase-Protein Phosphatase Interactome. (PMID: 28065597) Yao Z … Stagljar I (Molecular cell 2017) 3 58

Products for CCDC146 Gene

Sources for CCDC146 Gene

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