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Aliases for CCDC144NL Gene

Aliases for CCDC144NL Gene

  • Coiled-Coil Domain Containing 144 Family, N-Terminal Like 2 3 5
  • Putative Coiled-Coil Domain-Containing Protein 144 N-Terminal-Like 3

External Ids for CCDC144NL Gene

Previous GeneCards Identifiers for CCDC144NL Gene

  • GC17M020711
  • GC17M020766
  • GC17M019968
  • GC17M020740

Summaries for CCDC144NL Gene

GeneCards Summary for CCDC144NL Gene

CCDC144NL (Coiled-Coil Domain Containing 144 Family, N-Terminal Like) is a Protein Coding gene.

Additional gene information for CCDC144NL Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CCDC144NL Gene

Genomics for CCDC144NL Gene

GeneHancer (GH) Regulatory Elements for CCDC144NL Gene

Promoters and enhancers for CCDC144NL Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH17J020895 Promoter 1.3 EPDnew Ensembl 665.4 +0.5 546 1 CTCF POLR2A NRF1 ZBTB33 CCDC144NL PIR57151 RNU6-1178P PIR45393 ENSG00000266369 CCDC144CP CCDC144NL-AS1 GC17P025034
GH17J020851 Enhancer 1 Ensembl ENCODE 8.9 +44.4 44412 1.5 KLF17 ZNF335 GLIS2 ZNF366 ZSCAN5C SCRT2 EGR2 ZNF362 ZNF398 REST CCDC144NL ENSG00000266369 ABHD17AP6 GC17P025034
GH17J020919 Enhancer 1 Ensembl ENCODE 7.3 -24.8 -24751 3.4 PKNOX1 ZBTB40 FOSL1 ZNF664 CTBP1 ZNF316 ARID2 ZNF366 POLR2A VEZF1 LOC105369205 ENSG00000266369 CCDC144NL DHRS7B ENSG00000265099 CCDC144NL-AS1
GH17J020842 Enhancer 0.6 Ensembl 5.4 +53.1 53061 1.7 CTCF ZBTB6 L3MBTL2 NRF1 ZNF2 ZNF335 GLIS2 GLIS1 PATZ1 KLF9 CCDC144NL-AS1 CCDC144NL ENSG00000266369 ABHD17AP6 GC17P025034
GH17J021274 Enhancer 1.7 FANTOM5 Ensembl ENCODE dbSUPER 1.9 -379.2 -379224 1.9 FOXA2 ARID4B SIN3A DMAP1 FOS SP3 RXRA SP5 NFYC MXD4 ENSG00000235530 KCNJ12 NATD1 MAP2K3 CCDC144NL PIR52124
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around CCDC144NL on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the CCDC144NL gene promoter:

Genomic Locations for CCDC144NL Gene

Genomic Locations for CCDC144NL Gene
chr17:20,836,447-20,896,647
(GRCh38/hg38)
Size:
60,201 bases
Orientation:
Minus strand
chr17:20,739,760-20,799,453
(GRCh37/hg19)

Genomic View for CCDC144NL Gene

Genes around CCDC144NL on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CCDC144NL Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CCDC144NL Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CCDC144NL Gene

Proteins for CCDC144NL Gene

  • Protein details for CCDC144NL Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6NUI1-C144L_HUMAN
    Recommended name:
    Putative coiled-coil domain-containing protein 144 N-terminal-like
    Protein Accession:
    Q6NUI1

    Protein attributes for CCDC144NL Gene

    Size:
    221 amino acids
    Molecular mass:
    23810 Da
    Quaternary structure:
    No Data Available

neXtProt entry for CCDC144NL Gene

Post-translational modifications for CCDC144NL Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CCDC144NL Gene

No data available for DME Specific Peptides for CCDC144NL Gene

Domains & Families for CCDC144NL Gene

Gene Families for CCDC144NL Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for CCDC144NL Gene

ProtoNet:

Suggested Antigen Peptide Sequences for CCDC144NL Gene

Graphical View of Domain Structure for InterPro Entry

Q6NUI1

UniProtKB/Swiss-Prot:

C144L_HUMAN :
  • Belongs to the CCDC144 family.
Family:
  • Belongs to the CCDC144 family.
genes like me logo Genes that share domains with CCDC144NL: view

Function for CCDC144NL Gene

genes like me logo Genes that share phenotypes with CCDC144NL: view

Animal Model Products

miRNA for CCDC144NL Gene

miRTarBase miRNAs that target CCDC144NL

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CCDC144NL Gene

Localization for CCDC144NL Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CCDC144NL gene
Compartment Confidence
plasma membrane 2
nucleus 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleus (2)
  • Plasma membrane (2)
See all subcellular structures

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for CCDC144NL Gene

Pathways & Interactions for CCDC144NL Gene

SuperPathways for CCDC144NL Gene

No Data Available

Interacting Proteins for CCDC144NL Gene

Selected Interacting proteins: Q6NUI1-C144L_HUMAN for CCDC144NL Gene via IID

Symbol External ID(s) Details
APP

Gene Ontology (GO) - Biological Process for CCDC144NL Gene

None

No data available for Pathways by source and SIGNOR curated interactions for CCDC144NL Gene

Drugs & Compounds for CCDC144NL Gene

No Compound Related Data Available

Transcripts for CCDC144NL Gene

mRNA/cDNA for CCDC144NL Gene

(5) Selected AceView cDNA sequences:
(1) Additional mRNA sequences :
(4) REFSEQ mRNAs :
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for CCDC144NL Gene

Coiled-coil domain containing 144 family, N-terminal like:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for CCDC144NL Gene

No ASD Table

Relevant External Links for CCDC144NL Gene

GeneLoc Exon Structure for
CCDC144NL
ECgene alternative splicing isoforms for
CCDC144NL

Expression for CCDC144NL Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CCDC144NL Gene

mRNA differential expression in normal tissues according to GTEx for CCDC144NL Gene

This gene is overexpressed in Testis (x7.8) and Brain - Spinal cord (cervical c-1) (x6.3).

Protein differential expression in normal tissues from HIPED for CCDC144NL Gene

This gene is overexpressed in Adipocyte (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for CCDC144NL Gene



Protein tissue co-expression partners for CCDC144NL Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of CCDC144NL Gene:

CCDC144NL

SOURCE GeneReport for Unigene cluster for CCDC144NL Gene:

Hs.674830
genes like me logo Genes that share expression patterns with CCDC144NL: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for CCDC144NL Gene

Orthologs for CCDC144NL Gene

This gene was present in the common ancestor of human and chimp.

Orthologs for CCDC144NL Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CCDC144NL 34 33
  • 97.44 (n)
OneToOne
Species where no ortholog for CCDC144NL was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for CCDC144NL Gene

ENSEMBL:
Gene Tree for CCDC144NL (if available)
TreeFam:
Gene Tree for CCDC144NL (if available)
Aminode:
Evolutionary constrained regions (ECRs) for CCDC144NL: view image

Paralogs for CCDC144NL Gene

(2) SIMAP similar genes for CCDC144NL Gene using alignment to 1 proteins:

  • C144L_HUMAN

Pseudogenes.org Pseudogenes for CCDC144NL Gene

genes like me logo Genes that share paralogs with CCDC144NL: view

No data available for Paralogs for CCDC144NL Gene

Variants for CCDC144NL Gene

Sequence variations from dbSNP and Humsavar for CCDC144NL Gene

SNP ID Clin Chr 17 pos Variation AA Info Type
rs1000061149 -- 20,892,386(-) G/A intron_variant
rs1000093213 -- 20,892,204(-) T/C intron_variant
rs1000113790 -- 20,868,369(-) G/A intron_variant
rs1000138585 -- 20,859,622(-) A/C genic_downstream_transcript_variant, intron_variant
rs1000180210 -- 20,897,406(-) C/G upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for CCDC144NL Gene

Variant ID Type Subtype PubMed ID
dgv1432n106 CNV duplication 24896259
dgv3122n100 CNV loss 25217958
esv24431 CNV loss 19812545
esv2673401 CNV deletion 23128226
esv2751619 CNV gain 17911159
esv3640216 CNV loss 21293372
esv3640219 CNV loss 21293372
nsv1059146 CNV gain 25217958
nsv1075928 CNV duplication 25765185
nsv1075929 CNV duplication 25765185
nsv1078306 OTHER inversion 25765185
nsv1109053 CNV deletion 24896259
nsv1109054 CNV deletion 24896259
nsv1116195 CNV deletion 24896259
nsv1116196 CNV deletion 24896259
nsv1123100 CNV deletion 24896259
nsv1129590 CNV tandem duplication 24896259
nsv1134611 CNV deletion 24896259
nsv1138508 CNV deletion 24896259
nsv1150352 CNV duplication 26484159
nsv953850 CNV duplication 24416366
nsv953851 CNV duplication 24416366
nsv960439 CNV duplication 23825009

Variation tolerance for CCDC144NL Gene

Residual Variation Intolerance Score: 97.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.53; 55.64% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CCDC144NL Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CCDC144NL

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CCDC144NL Gene

Disorders for CCDC144NL Gene

Additional Disease Information for CCDC144NL

No disorders were found for CCDC144NL Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CCDC144NL Gene

Publications for CCDC144NL Gene

  1. Genome-wide association study identifies loci affecting blood copper, selenium and zinc. (PMID: 23720494) Evans DM … Whitfield JB (Human molecular genetics 2013) 3 58
  2. Interactions of pathological hallmark proteins: tubulin polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PMID: 21832049) Oláh J … Ovádi J (The Journal of biological chemistry 2011) 3 58
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 4 58
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 3 58

Products for CCDC144NL Gene

Sources for CCDC144NL Gene

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