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Aliases for CCDC142 Gene

Aliases for CCDC142 Gene

  • Coiled-Coil Domain Containing 142 2 3 5
  • Coiled-Coil Domain-Containing Protein 142 3

External Ids for CCDC142 Gene

Previous GeneCards Identifiers for CCDC142 Gene

  • GC02M074555
  • GC02M074703
  • GC02M074436

Summaries for CCDC142 Gene

GeneCards Summary for CCDC142 Gene

CCDC142 (Coiled-Coil Domain Containing 142) is a Protein Coding gene.

Additional gene information for CCDC142 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CCDC142 Gene

Genomics for CCDC142 Gene

GeneHancer (GH) Regulatory Elements for CCDC142 Gene

Promoters and enhancers for CCDC142 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH02J074480 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 664.7 +1.0 988 3 PKNOX1 SMAD1 MLX ARNT ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 TTC31 CCDC142 LBX2 AUP1 MOGS ENSG00000273245 PCGF1 DUSP11 MTHFD2 MOB1A
GH02J074119 Promoter/Enhancer 1.6 Ensembl ENCODE 59.4 +363.0 363046 1.6 HDGF MLX ZFP64 ARID4B SIN3A DMAP1 ZNF2 ZBTB7B YY1 SLC30A9 FNBP1P1 PCGF1 CCDC142 ENSG00000273245 TTC31 DUSP11 ENSG00000217702 WBP1 INO80B MRPL53
GH02J074454 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 38.5 +26.3 26300 5.4 CLOCK MLX ZFP64 FEZF1 DMAP1 IRF4 YY1 SLC30A9 ZNF213 E2F8 WBP1 INO80B TTC31 PCGF1 DUSP11 ENSG00000273245 AUP1 CCDC142 MOGS LBX2
GH02J074196 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 31.5 +284.7 284661 3.9 CLOCK FEZF1 DMAP1 IRF4 YY1 SLC30A9 ZNF213 E2F8 ZNF143 SP3 ENSG00000279070 MTHFD2 PCGF1 ENSG00000273245 INO80B DUSP11 ALMS1 HTRA2 WBP1 AUP1
GH02J074528 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 22.4 -46.9 -46917 4.4 DMAP1 IRF4 YY1 SLC30A9 E2F8 ZNF143 SP3 NFYC GLIS1 NBN AUP1 HTRA2 LBX2 TTC31 CCDC142 PCGF1 DUSP11 MOB1A MOGS MTHFD2
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around CCDC142 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the CCDC142 gene promoter:

Genomic Locations for CCDC142 Gene

Genomic Locations for CCDC142 Gene
chr2:74,471,986-74,483,408
(GRCh38/hg38)
Size:
11,423 bases
Orientation:
Minus strand
chr2:74,699,113-74,710,535
(GRCh37/hg19)

Genomic View for CCDC142 Gene

Genes around CCDC142 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CCDC142 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CCDC142 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CCDC142 Gene

Proteins for CCDC142 Gene

  • Protein details for CCDC142 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q17RM4-CC142_HUMAN
    Recommended name:
    Coiled-coil domain-containing protein 142
    Protein Accession:
    Q17RM4
    Secondary Accessions:
    • B7ZKV5
    • Q8NBJ3
    • Q8NBV2
    • Q96KA7

    Protein attributes for CCDC142 Gene

    Size:
    750 amino acids
    Molecular mass:
    81643 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAC11474.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for CCDC142 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CCDC142 Gene

Post-translational modifications for CCDC142 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CCDC142 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for CCDC142 Gene

Domains & Families for CCDC142 Gene

Gene Families for CCDC142 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for CCDC142 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for CCDC142 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with CCDC142: view

No data available for UniProtKB/Swiss-Prot for CCDC142 Gene

Function for CCDC142 Gene

genes like me logo Genes that share phenotypes with CCDC142: view

Animal Model Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CCDC142 Gene

Localization for CCDC142 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CCDC142 gene
Compartment Confidence
extracellular 2
mitochondrion 1
peroxisome 1
nucleus 1
endoplasmic reticulum 1
cytosol 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for CCDC142 Gene

Pathways & Interactions for CCDC142 Gene

SuperPathways for CCDC142 Gene

No Data Available

Interacting Proteins for CCDC142 Gene

Gene Ontology (GO) - Biological Process for CCDC142 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for CCDC142 Gene

Drugs & Compounds for CCDC142 Gene

No Compound Related Data Available

Transcripts for CCDC142 Gene

mRNA/cDNA for CCDC142 Gene

Unigene Clusters for CCDC142 Gene

Coiled-coil domain containing 142:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for CCDC142 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8a · 8b · 8c ^ 9 ^ 10a · 10b ^ 11a · 11b · 11c ^ 12a · 12b ^ 13a · 13b
SP1: - - - -
SP2:
SP3:
SP4:
SP5: -
SP6:
SP7: - -
SP8:
SP9:

Relevant External Links for CCDC142 Gene

GeneLoc Exon Structure for
CCDC142
ECgene alternative splicing isoforms for
CCDC142

Expression for CCDC142 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CCDC142 Gene

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for CCDC142 Gene



Protein tissue co-expression partners for CCDC142 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of CCDC142 Gene:

CCDC142

SOURCE GeneReport for Unigene cluster for CCDC142 Gene:

Hs.430199

Evidence on tissue expression from TISSUES for CCDC142 Gene

  • Nervous system(3.2)
genes like me logo Genes that share expression patterns with CCDC142: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for CCDC142 Gene

Orthologs for CCDC142 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CCDC142 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CCDC142 34 33
  • 99.28 (n)
OneToOne
dog
(Canis familiaris)
Mammalia CCDC142 34 33
  • 84.75 (n)
OneToOne
cow
(Bos Taurus)
Mammalia CCDC142 34 33
  • 82.99 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ccdc142 33
  • 76.65 (n)
mouse
(Mus musculus)
Mammalia Ccdc142 16 34 33
  • 76.14 (n)
oppossum
(Monodelphis domestica)
Mammalia CCDC142 34
  • 54 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CCDC142 34
  • 35 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii CCDC142 34
  • 21 (a)
OneToOne
Species where no ortholog for CCDC142 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CCDC142 Gene

ENSEMBL:
Gene Tree for CCDC142 (if available)
TreeFam:
Gene Tree for CCDC142 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for CCDC142: view image

Paralogs for CCDC142 Gene

No data available for Paralogs for CCDC142 Gene

Variants for CCDC142 Gene

Sequence variations from dbSNP and Humsavar for CCDC142 Gene

SNP ID Clin Chr 02 pos Variation AA Info Type
rs1000023195 -- 74,479,770(-) T/G intron_variant
rs1000312320 -- 74,480,118(-) G/A intron_variant
rs1000398231 -- 74,477,480(-) A/G intron_variant
rs1000687841 -- 74,479,254(-) C/A intron_variant
rs1000739746 -- 74,478,880(-) G/A intron_variant

Structural Variations from Database of Genomic Variants (DGV) for CCDC142 Gene

Variant ID Type Subtype PubMed ID
esv2759061 CNV loss 17122850
nsv1127734 CNV deletion 24896259
nsv458185 CNV loss 19166990
nsv515851 CNV loss 19592680
nsv582214 CNV loss 21841781

Variation tolerance for CCDC142 Gene

Residual Variation Intolerance Score: 79.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.99; 60.08% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CCDC142 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CCDC142

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CCDC142 Gene

Disorders for CCDC142 Gene

Additional Disease Information for CCDC142

No disorders were found for CCDC142 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CCDC142 Gene

Publications for CCDC142 Gene

  1. Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries. (PMID: 16303743) Otsuki T … Isogai T (DNA research : an international journal for rapid publication of reports on genes and genomes 2005) 3 4 58
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  3. [Novel bidirectional promoter from human genome]. (PMID: 21790010) Orekhova AS … Rubtsov PM (Molekuliarnaia biologiia 2011) 3 58
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 4 58
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 3 58

Products for CCDC142 Gene

Sources for CCDC142 Gene

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