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Aliases for CCDC138 Gene

Aliases for CCDC138 Gene

  • Coiled-Coil Domain Containing 138 2 3 5

External Ids for CCDC138 Gene

Previous GeneCards Identifiers for CCDC138 Gene

  • GC02P109403
  • GC02P103001

Summaries for CCDC138 Gene

GeneCards Summary for CCDC138 Gene

CCDC138 (Coiled-Coil Domain Containing 138) is a Protein Coding gene.

Additional gene information for CCDC138 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CCDC138 Gene

Genomics for CCDC138 Gene

GeneHancer (GH) Regulatory Elements for CCDC138 Gene

Promoters and enhancers for CCDC138 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH02I108785 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 550.8 +0.0 43 2.3 HDGF PKNOX1 ZFP64 ARID4B SIN3A DMAP1 ZNF2 YY1 POLR2B ZNF143 CCDC138 GCC2 LIMS1 RANBP2 RPL39P16
GH02I108916 Enhancer 0.5 dbSUPER 5 +130.3 130278 2 SOX5 SOX13 POLR2A HLF GCC2 CCDC138 GC02M108928 PIR56059 EDAR
GH02I108923 Enhancer 0.5 ENCODE dbSUPER 4.2 +136.5 136480 0.1 JUND CCDC138 GC02M108928 PIR56059 EDAR
GH02I108890 Enhancer 0.4 FANTOM5 2.4 +103.4 103401 0.2 SETDB1 PIR52808 EDAR CCDC138 LIMS1 GC02M108869 RPL39P16
GH02I108718 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 0.2 -67.1 -67068 2.2 HDGF PKNOX1 CLOCK SMAD1 MLX ARNT ZFP64 ARID4B NEUROD1 SIN3A RANBP2 GCC2 GC02P108708 CCDC138
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around CCDC138 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the CCDC138 gene promoter:

Genomic Locations for CCDC138 Gene

Genomic Locations for CCDC138 Gene
chr2:108,786,750-108,885,477
(GRCh38/hg38)
Size:
98,728 bases
Orientation:
Plus strand
chr2:109,403,213-109,501,933
(GRCh37/hg19)

Genomic View for CCDC138 Gene

Genes around CCDC138 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CCDC138 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CCDC138 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CCDC138 Gene

Proteins for CCDC138 Gene

  • Protein details for CCDC138 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96M89-CC138_HUMAN
    Recommended name:
    Coiled-coil domain-containing protein 138
    Protein Accession:
    Q96M89
    Secondary Accessions:
    • Q05DF1
    • Q4ZG07
    • Q53TE1
    • Q6ZUY5
    • Q86VL7

    Protein attributes for CCDC138 Gene

    Size:
    665 amino acids
    Molecular mass:
    76219 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for CCDC138 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CCDC138 Gene

Post-translational modifications for CCDC138 Gene

  • Ubiquitination at Lys19, Lys41, Lys200, Lys230, posLast=295295, posLast=313313, posLast=399399, and Lys463
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for CCDC138 Gene

Domains & Families for CCDC138 Gene

Gene Families for CCDC138 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for CCDC138 Gene

ProtoNet:

Suggested Antigen Peptide Sequences for CCDC138 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with CCDC138: view

No data available for UniProtKB/Swiss-Prot for CCDC138 Gene

Function for CCDC138 Gene

Phenotypes for CCDC138 Gene

genes like me logo Genes that share phenotypes with CCDC138: view

Animal Model Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CCDC138 Gene

Localization for CCDC138 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CCDC138 gene
Compartment Confidence
cytosol 4
nucleus 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Nucleus (2)
See all subcellular structures

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for CCDC138 Gene

Pathways & Interactions for CCDC138 Gene

SuperPathways for CCDC138 Gene

No Data Available

Gene Ontology (GO) - Biological Process for CCDC138 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for CCDC138 Gene

Drugs & Compounds for CCDC138 Gene

No Compound Related Data Available

Transcripts for CCDC138 Gene

Unigene Clusters for CCDC138 Gene

Coiled-coil domain containing 138:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for CCDC138 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12 ^ 13 ^ 14 ^ 15a · 15b · 15c · 15d
SP1: -
SP2: -
SP3: - -
SP4: -
SP5: - -

Relevant External Links for CCDC138 Gene

GeneLoc Exon Structure for
CCDC138
ECgene alternative splicing isoforms for
CCDC138

Expression for CCDC138 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CCDC138 Gene

mRNA differential expression in normal tissues according to GTEx for CCDC138 Gene

This gene is overexpressed in Testis (x5.8).

Protein differential expression in normal tissues from HIPED for CCDC138 Gene

This gene is overexpressed in Lung (59.1) and Testis (9.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for CCDC138 Gene



Protein tissue co-expression partners for CCDC138 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of CCDC138 Gene:

CCDC138

SOURCE GeneReport for Unigene cluster for CCDC138 Gene:

Hs.731709
genes like me logo Genes that share expression patterns with CCDC138: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for CCDC138 Gene

Orthologs for CCDC138 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CCDC138 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CCDC138 33 34
  • 99.45 (n)
dog
(Canis familiaris)
Mammalia CCDC138 33 34
  • 88.35 (n)
rat
(Rattus norvegicus)
Mammalia Ccdc138 33
  • 82.9 (n)
mouse
(Mus musculus)
Mammalia Ccdc138 33 16 34
  • 81.67 (n)
cow
(Bos Taurus)
Mammalia CCDC138 34
  • 74 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CCDC138 34
  • 61 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia CCDC138 34
  • 59 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CCDC138 34
  • 55 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ccdc138 33
  • 64.07 (n)
Str.4317 33
zebrafish
(Danio rerio)
Actinopterygii CCDC138 34
  • 42 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea CSA.2655 34
  • 37 (a)
OneToOne
Species where no ortholog for CCDC138 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CCDC138 Gene

ENSEMBL:
Gene Tree for CCDC138 (if available)
TreeFam:
Gene Tree for CCDC138 (if available)

Paralogs for CCDC138 Gene

No data available for Paralogs for CCDC138 Gene

Variants for CCDC138 Gene

Sequence variations from dbSNP and Humsavar for CCDC138 Gene

SNP ID Clin Chr 02 pos Variation AA Info Type
rs1000014844 -- 108,840,757(+) T/C intron_variant
rs1000028371 -- 108,833,257(+) A/T intron_variant
rs1000029304 -- 108,815,569(+) G/A intron_variant
rs1000059657 -- 108,840,998(+) T/C intron_variant
rs1000083705 -- 108,805,789(+) T/C intron_variant

Structural Variations from Database of Genomic Variants (DGV) for CCDC138 Gene

Variant ID Type Subtype PubMed ID
nsv1149522 OTHER inversion 26484159
nsv1153528 CNV deletion 26484159
nsv2872 CNV insertion 18451855

Variation tolerance for CCDC138 Gene

Residual Variation Intolerance Score: 27.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 8.77; 86.72% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CCDC138 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CCDC138

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CCDC138 Gene

Disorders for CCDC138 Gene

Additional Disease Information for CCDC138

No disorders were found for CCDC138 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CCDC138 Gene

Publications for CCDC138 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 2 3 58
  3. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
  4. Phenotypic and Interaction Profiling of the Human Phosphatases Identifies Diverse Mitotic Regulators. (PMID: 27880917) St-Denis N … Gingras AC (Cell reports 2016) 3 58
  5. Proximity biotinylation and affinity purification are complementary approaches for the interactome mapping of chromatin-associated protein complexes. (PMID: 25281560) Lambert JP … Gingras AC (Journal of proteomics 2015) 3 58

Products for CCDC138 Gene

Sources for CCDC138 Gene

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