Aliases for CCDC138 Gene
Aliases for CCDC138 Gene
External Ids for CCDC138 Gene
- HGNC: 26531
- Entrez Gene: 165055
- Ensembl: ENSG00000163006
- UniProtKB: Q96M89
Previous GeneCards Identifiers for CCDC138 Gene
- GC02P109403
- GC02P103001
Summaries for CCDC138 Gene
GeneCards Summary for CCDC138 Gene
CCDC138 (Coiled-Coil Domain Containing 138) is a Protein Coding gene.
Additional gene information for CCDC138 Gene
No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CCDC138 Gene
Genomics for CCDC138 Gene
GeneHancer (GH) Regulatory Elements for CCDC138 Gene
Promoters and enhancers for CCDC138 Gene
| GeneHancer (GH) Identifier | GH Type | GH Score |
GH Sources | Gene Association Score | Total Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites |
Gene Targets |
|---|---|---|---|---|---|---|---|---|---|---|
| GH02J108785 | Promoter/Enhancer | 2 | EPDnew Ensembl ENCODE | 650.7 | +0.0 | 43 | 2.3 | HDGF PKNOX1 ZFP64 ARID4B SIN3A DMAP1 ZNF2 YY1 POLR2B ZNF143 | CCDC138 GCC2 LIMS1 RANBP2 RPL39P16 | |
| GH02J108916 | Enhancer | 0.5 | dbSUPER | 5 | +130.3 | 130278 | 2 | SOX5 SOX13 TFAP4 POLR2A HLF | GCC2 CCDC138 GC02M108928 PIR56059 EDAR | |
| GH02J108923 | Enhancer | 0.5 | ENCODE dbSUPER | 4.2 | +136.5 | 136480 | 0.1 | JUND | CCDC138 GC02M108928 PIR56059 EDAR | |
| GH02J108890 | Enhancer | 0.4 | FANTOM5 | 2.4 | +103.4 | 103401 | 0.2 | ZNF384 SETDB1 | PIR52808 EDAR CCDC138 LIMS1 GC02M108869 RPL39P16 | |
| GH02J108718 | Promoter/Enhancer | 2.1 | EPDnew Ensembl ENCODE | 0.2 | -67.1 | -67068 | 2.2 | CLOCK MLX ZFP64 FEZF1 DMAP1 YY1 ZNF213 E2F8 ZNF143 SP3 | RANBP2 GCC2 GC02P108708 CCDC138 |
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)
GeneHancers around CCDC138 on UCSC Golden Path with GeneCards custom track
- Top Transcription factor binding sites by QIAGEN in the CCDC138 gene promoter:
-
- AREB6
- FOXL1
- MRF-2
- POU2F1a
- Evi-1
- C/EBPalpha
- POU2F1
- POU2F1b
- POU2F1c
- TBP
Regulatory Element Products
Genomic Locations for CCDC138 Gene
Genomic Locations for CCDC138 Gene
- chr2:108,786,750-108,885,477
- (GRCh38/hg38)
- Size:
- 98,728 bases
- Orientation:
- Plus strand
- chr2:109,403,213-109,501,933
- (GRCh37/hg19)
- Size:
- 98,721 bases
- Orientation:
- Plus strand
Genomic View for CCDC138 Gene
Genes around CCDC138 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 2q13 by Entrez Gene
- 2q13 by HGNC
- 2q13 by Ensembl
CCDC138 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for CCDC138 Gene
Proteins for CCDC138 Gene
-
Protein details for CCDC138 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q96M89-CC138_HUMAN
- Recommended name:
- Coiled-coil domain-containing protein 138
- Protein Accession:
- Q96M89
- Q05DF1
- Q4ZG07
- Q53TE1
- Q6ZUY5
- Q86VL7
Protein attributes for CCDC138 Gene
- Size:
- 665 amino acids
- Molecular mass:
- 76219 Da
- Quaternary structure:
- No Data Available
Protein Expression for CCDC138 Gene
Post-translational modifications for CCDC138 Gene
Other Protein References for CCDC138 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
-
- NP_001338482.1
- NP_001338484.1
- NP_001338494.1
- NP_001338474.1
- XP_011509059.1
- XP_016858987.1
- XP_011509064.1
- XP_016858992.1
- XP_016858982.1
- NP_001338483.1
- NP_001338473.1
- XP_016858991.1
- XP_016858981.1
- NP_001338486.1
- XP_011509062.1
- NP_659415.1
- NP_001338488.1
- NP_001338478.1
- NP_001290034.1
- XP_016858993.1
- NP_001338480.1
- NP_001338490.1
- NP_001338477.1
- NP_001290035.1
- XP_024308505.1
- XP_011509063.1
Antibody Products
-
Custom Antibody ServicesOriGene Antibodies for CCDC138
- Novus Biologicals Antibodies for CCDC138
- Invitrogen Antibodies for CCDC138 (AFLGC-CCDC138)
- GeneTex CCDC138 Antibody for CCDC138
-
Boster Bio Antibodies for CCDC138
Protein Products
-
OriGene Purified Proteins for CCDC138
- Search Origene for MassSpec and Protein Over-expression Lysates for CCDC138
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- Search GeneTex for Proteins for CCDC138
-
Abcam proteins for CCDC138
Assay Products
No data available for DME Specific Peptides for CCDC138 Gene
Domains & Families for CCDC138 Gene
Gene Families for CCDC138 Gene
- Human Protein Atlas (HPA):
-
- Predicted intracellular proteins
Suggested Antigen Peptide Sequences for CCDC138 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
No data available for UniProtKB/Swiss-Prot for CCDC138 Gene
Function for CCDC138 Gene
Phenotypes for CCDC138 Gene
- GenomeRNAi human phenotypes for CCDC138:
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
- Cyagen custom Knockout/knockin (KOKI) mouse models for CCDC138
-
CRISPR Products
-
OriGene CRISPR knockouts for CCDC138
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- Overview of 64 available CCDC138 gene related products
- Applied Biological Materials CRISPR for CCDC138
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for CCDC138
- GenScript: Design CRISPR guide RNA sequences for CCDC138
miRNA for CCDC138 Gene
- miRTarBase miRNAs that target CCDC138
-
- mmu-mir-186-5p (MIRT579219)
- mmu-mir-669f-3p (MIRT579220)
- mmu-mir-466n-3p (MIRT579221)
- mmu-mir-669m-3p (MIRT579222)
- mmu-mir-1b-5p (MIRT579223)
- mmu-mir-466b-3p (MIRT579224)
- mmu-mir-466p-3p (MIRT579225)
- mmu-mir-466c-3p (MIRT579226)
- mmu-mir-466o-3p (MIRT579227)
- mmu-mir-466m-3p (MIRT579228)
- mmu-mir-466d-3p (MIRT579229)
- mmu-mir-466e-3p (MIRT579230)
- mmu-mir-467g (MIRT579231)
- mmu-mir-297b-3p (MIRT579232)
- mmu-mir-466a-3p (MIRT579233)
- mmu-mir-377-3p (MIRT579234)
miRNA Products
Inhibitory RNA Products
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- Overview of 64 available CCDC138 gene related products
Clone Products
-
GenScript: Next-day shipping of latest version cDNA ORF clones for CCDC138 in any vector
- XM_006712345.3
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- XM_011510758.2
- XM_011510760.2
- XM_011510761.2
- NM_001303105.1
- XM_017003497.1
- NM_001351559.1
- XM_017003503.1
- XM_017003504.1
- XM_017003495.1
- NM_001351565.1
- NM_001351555.1
- NM_001351551.1
- XM_017003502.1
- XM_017003498.1
- XM_017003494.1
- NM_001351561.1
- NM_001303106.1
- NM_001351544.1
- XM_017003501.1
- XM_017003496.1
- XM_017003499.1
- XM_017003500.1
- NM_001351545.1
- NM_001351549.1
- XM_017003492.1
- XM_017003493.1
- NM_001351553.1
- NM_001351554.1
- NM_001351548.1
- Sino Biological Human cDNA Clone for CCDC138
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for CCDC138
- Applied Biological Materials Clones for CCDC138
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Cell Line Products
-
Horizon Cell Lines for CCDC138
No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CCDC138 Gene
Localization for CCDC138 Gene
| Compartment | Confidence |
|---|---|
| cytosol | 4 |
| nucleus | 2 |
- Cytosol (2)
- Nucleus (2)
No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for CCDC138 Gene
Pathways & Interactions for CCDC138 Gene
No Data Available
Interacting Proteins for CCDC138 Gene
GPS-Prot Interaction Network for CCDC138
No data available for Pathways by source and SIGNOR curated interactions for CCDC138 Gene
Transcripts for CCDC138 Gene
mRNA/cDNA for CCDC138 Gene
- (26) REFSEQ mRNAs :
- (5) Additional mRNA sequences :
- (74) Selected AceView cDNA sequences:
- (8) Ensembl transcripts including schematic representations, and UCSC links where relevant :
-
- ENST00000412964 2250 bps (uc002teo.2)
- ENST00000409529 2364 bps (uc010fjm.2)
- ENST00000295124 2383 bps (uc002ten.2)
- ENST00000470608 427 bps (uc061msu.1)
- ENST00000447782 539 bps (uc061msv.1)
Unigene Clusters for CCDC138 Gene
CRISPR Products
-
OriGene CRISPR knockouts for CCDC138
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for CCDC138
- genomics-online: gRNA clones - Search results for 64 available CCDC138 gene related products
- Overview of 64 available CCDC138 gene related products
- Applied Biological Materials CRISPR for CCDC138
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for CCDC138
- GenScript: Design CRISPR guide RNA sequences for CCDC138
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for CCDC138
- Browse OriGene Inhibitory RNA Products For CCDC138
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CCDC138
- genomics-online: shRNA clones - Search results for 64 available CCDC138 gene related products
- Overview of 64 available CCDC138 gene related products
Clone Products
-
GenScript: Next-day shipping of latest version cDNA ORF clones for CCDC138 in any vector
- XM_006712345.3
- XM_011510757.2
- NM_144978.2
- XM_011510762.2
- XM_006712344.2
- XM_011510758.2
- XM_011510760.2
- XM_011510761.2
- NM_001303105.1
- XM_017003497.1
- NM_001351559.1
- XM_017003503.1
- XM_017003504.1
- XM_017003495.1
- NM_001351565.1
- NM_001351555.1
- NM_001351551.1
- XM_017003502.1
- XM_017003498.1
- XM_017003494.1
- NM_001351561.1
- NM_001303106.1
- NM_001351544.1
- XM_017003501.1
- XM_017003496.1
- XM_017003499.1
- XM_017003500.1
- NM_001351545.1
- NM_001351549.1
- XM_017003492.1
- XM_017003493.1
- NM_001351553.1
- NM_001351554.1
- NM_001351548.1
- Sino Biological Human cDNA Clone for CCDC138
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for CCDC138
- Applied Biological Materials Clones for CCDC138
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
| ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3 | ^ | 4a | · | 4b | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11a | · | 11b | ^ | 12 | ^ | 13 | ^ | 14 | ^ | 15a | · | 15b | · | 15c | · | 15d |
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| SP1: | - | ||||||||||||||||||||||||||||||||||||||||
| SP2: | - | ||||||||||||||||||||||||||||||||||||||||
| SP3: | - | - | |||||||||||||||||||||||||||||||||||||||
| SP4: | - | ||||||||||||||||||||||||||||||||||||||||
| SP5: | - | - |
Expression for CCDC138 Gene
mRNA differential expression in normal tissues according to GTEx for CCDC138 Gene
This gene is overexpressed in Testis (x5.8).
This gene is overexpressed in Lung (59.1) and Testis (9.9).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for CCDC138 Gene
- Elite partner
NURSA nuclear receptor signaling pathways regulating expression of CCDC138 Gene:
CCDC138SOURCE GeneReport for Unigene cluster for CCDC138 Gene:
Hs.731709Primer Products
-
OriGene qPCR primer pairs for CCDC138
- genomics-online: primer clones - Search results for 64 available CCDC138 gene related products
- Overview of 64 available CCDC138 gene related products
Gene Expression Assay Products
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for CCDC138 Gene
Orthologs for CCDC138 Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | CCDC138 34 33 |
|
OneToOne | |
| dog (Canis familiaris) |
Mammalia | CCDC138 34 33 |
|
OneToOne | |
| rat (Rattus norvegicus) |
Mammalia | Ccdc138 33 |
|
||
| mouse (Mus musculus) |
Mammalia | Ccdc138 16 34 33 |
|
||
| cow (Bos Taurus) |
Mammalia | CCDC138 34 |
|
OneToOne | |
| platypus (Ornithorhynchus anatinus) |
Mammalia | CCDC138 34 |
|
OneToOne | |
| oppossum (Monodelphis domestica) |
Mammalia | CCDC138 34 |
|
OneToOne | |
| lizard (Anolis carolinensis) |
Reptilia | CCDC138 34 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | ccdc138 33 |
|
||
| Str.4317 33 |
|
||||
| zebrafish (Danio rerio) |
Actinopterygii | CCDC138 34 |
|
OneToOne | |
| sea squirt (Ciona savignyi) |
Ascidiacea | CSA.2655 34 |
|
OneToOne |
- Species where no ortholog for CCDC138 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- chicken (Gallus gallus)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
Evolution for CCDC138 Gene
- ENSEMBL:
- Gene Tree for CCDC138 (if available)
- TreeFam:
- Gene Tree for CCDC138 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for CCDC138: view image
Paralogs for CCDC138 Gene
No data available for Paralogs for CCDC138 Gene
Variants for CCDC138 Gene
| SNP ID | Clin | Chr 02 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs1000014844 | -- | 108,840,757(+) | T/C | intron_variant | |
| rs1000028371 | -- | 108,833,257(+) | A/T | intron_variant | |
| rs1000029304 | -- | 108,815,569(+) | G/A | intron_variant | |
| rs1000059657 | -- | 108,840,998(+) | T/C | intron_variant | |
| rs1000083705 | -- | 108,805,789(+) | T/C | intron_variant |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| nsv1149522 | OTHER | inversion | 26484159 |
| nsv1153528 | CNV | deletion | 26484159 |
| nsv2872 | CNV | insertion | 18451855 |
Residual Variation Intolerance Score:
27.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
8.77;
86.72% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for CCDC138 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- CCDC138
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CCDC138 Gene
Disorders for CCDC138 Gene
Additional Disease Information for CCDC138
No disorders were found for CCDC138 Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CCDC138 Gene
Publications for CCDC138 Gene
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 2 3 58
- Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
- Phenotypic and Interaction Profiling of the Human Phosphatases Identifies Diverse Mitotic Regulators. (PMID: 27880917) St-Denis N … Gingras AC (Cell reports 2016) 3 58
- Proximity biotinylation and affinity purification are complementary approaches for the interactome mapping of chromatin-associated protein complexes. (PMID: 25281560) Lambert JP … Gingras AC (Journal of proteomics 2015) 3 58
Products for CCDC138 Gene
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- XM_006712345.3
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- XM_011510758.2
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- NM_001351549.1
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- NM_001351554.1
- NM_001351548.1
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- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for CCDC138
- GeneCopoeia miRNA 3'UTR Target clone products for CCDC138
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CCDC138
- Boster Bio Antibodies for CCDC138
- Browse Boster Bio ELISA Kits
Sources for CCDC138 Gene
- (1) GeneCards
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- (4) Swiss-Prot
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- (39) Pseudogene
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- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
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- (55) miRBase
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- (68) Cloud-Clone Corp.
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- (74) GeneGo (Thomson Reuters)
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