Aliases for CCDC137 Gene

Aliases for CCDC137 Gene

  • Coiled-Coil Domain Containing 137 2 3 5
  • Coiled-Coil Domain-Containing Protein 137 3 4
  • Hepatocellular Carcinoma Related Protein 2 3
  • Retinoic Acid Resistance Factor 3
  • MGC16597 2
  • CCDC137 5
  • CPERP-B 4
  • RaRF 3

External Ids for CCDC137 Gene

Previous GeneCards Identifiers for CCDC137 Gene

  • GC17U900828
  • GC17P077245
  • GC17P079633
  • GC17P075079

Summaries for CCDC137 Gene

GeneCards Summary for CCDC137 Gene

CCDC137 (Coiled-Coil Domain Containing 137) is a Protein Coding gene.

Gene Wiki entry for CCDC137 Gene

No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for CCDC137 Gene

Genomics for CCDC137 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for CCDC137 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around CCDC137 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for CCDC137

Top Transcription factor binding sites by QIAGEN in the CCDC137 gene promoter:
  • ATF6
  • C/EBPalpha
  • FOXI1
  • HFH-3
  • HTF
  • RSRFC4
  • SREBP-1a
  • SREBP-1b
  • SREBP-1c

Genomic Locations for CCDC137 Gene

Latest Assembly
chr17:81,666,697-81,673,907
(GRCh38/hg38)
Size:
7,211 bases
Orientation:
Plus strand

Previous Assembly
chr17:79,633,767-79,640,929
(GRCh37/hg19 by Entrez Gene)
Size:
7,163 bases
Orientation:
Plus strand

chr17:79,633,394-79,640,934
(GRCh37/hg19 by Ensembl)
Size:
7,541 bases
Orientation:
Plus strand

Genomic View for CCDC137 Gene

Genes around CCDC137 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CCDC137 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CCDC137 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CCDC137 Gene

Proteins for CCDC137 Gene

  • Protein details for CCDC137 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6PK04-CC137_HUMAN
    Recommended name:
    Coiled-coil domain-containing protein 137
    Protein Accession:
    Q6PK04

    Protein attributes for CCDC137 Gene

    Size:
    289 amino acids
    Molecular mass:
    33231 Da
    Quaternary structure:
    No Data Available

neXtProt entry for CCDC137 Gene

Post-translational modifications for CCDC137 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CCDC137 Gene

No data available for DME Specific Peptides for CCDC137 Gene

Domains & Families for CCDC137 Gene

Gene Families for CCDC137 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for CCDC137 Gene

InterPro:

Suggested Antigen Peptide Sequences for CCDC137 Gene

GenScript: Design optimal peptide antigens:
  • Coiled-coil domain-containing protein 137 (CC137_HUMAN)
genes like me logo Genes that share domains with CCDC137: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for CCDC137 Gene

Function for CCDC137 Gene

Phenotypes From GWAS Catalog for CCDC137 Gene

Gene Ontology (GO) - Molecular Function for CCDC137 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding HDA 22658674
GO:0005515 protein binding IPI 21044950
genes like me logo Genes that share ontologies with CCDC137: view

Phenotypes for CCDC137 Gene

genes like me logo Genes that share phenotypes with CCDC137: view

Animal Models for CCDC137 Gene

MGI Knock Outs for CCDC137:

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CCDC137

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CCDC137 Gene

Localization for CCDC137 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CCDC137 Gene

Chromosome.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CCDC137 gene
Compartment Confidence
nucleus 5
mitochondrion 1
cytosol 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Mitotic chromosome (4)
  • Nucleoli (4)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for CCDC137 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001650 fibrillar center IDA --
GO:0005694 chromosome IDA 20813266
GO:0005730 nucleolus IDA --
genes like me logo Genes that share ontologies with CCDC137: view

Pathways & Interactions for CCDC137 Gene

PathCards logo

SuperPathways for CCDC137 Gene

No Data Available

Gene Ontology (GO) - Biological Process for CCDC137 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for CCDC137 Gene

Drugs & Compounds for CCDC137 Gene

No Compound Related Data Available

Transcripts for CCDC137 Gene

mRNA/cDNA for CCDC137 Gene

1 REFSEQ mRNAs :
4 NCBI additional mRNA sequence :
6 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CCDC137

Alternative Splicing Database (ASD) splice patterns (SP) for CCDC137 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4a · 4b · 4c ^ 5 ^ 6 ^ 7
SP1: -
SP2: - -
SP3: -

Relevant External Links for CCDC137 Gene

GeneLoc Exon Structure for
CCDC137

Expression for CCDC137 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for CCDC137 Gene

Protein differential expression in normal tissues from HIPED for CCDC137 Gene

This gene is overexpressed in Lung (56.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for CCDC137 Gene



Protein tissue co-expression partners for CCDC137 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for CCDC137

SOURCE GeneReport for Unigene cluster for CCDC137 Gene:

Hs.744125

Evidence on tissue expression from TISSUES for CCDC137 Gene

  • Muscle(4.1)
  • Nervous system(2.9)
genes like me logo Genes that share expression patterns with CCDC137: view

Primer products for research

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for CCDC137 Gene

Orthologs for CCDC137 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CCDC137 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia CCDC137 30
  • 96 (a)
OneToOne
Dog
(Canis familiaris)
Mammalia CCDC137 29 30
  • 83.77 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia CCDC137 29 30
  • 83.71 (n)
OneToOne
Mouse
(Mus musculus)
Mammalia Ccdc137 29 16 30
  • 76.87 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Ccdc137 29
  • 75.17 (n)
Oppossum
(Monodelphis domestica)
Mammalia CCDC137 30
  • 57 (a)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia CCDC137 30
  • 47 (a)
OneToOne
Chicken
(Gallus gallus)
Aves CCDC137 29 30
  • 60.52 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia CCDC137 30
  • 44 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia LOC100485278 29
  • 59.03 (n)
Zebrafish
(Danio rerio)
Actinopterygii ccdc137 29 30
  • 54.29 (n)
OneToOne
Species where no ortholog for CCDC137 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for CCDC137 Gene

ENSEMBL:
Gene Tree for CCDC137 (if available)
TreeFam:
Gene Tree for CCDC137 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for CCDC137: view image
Alliance of Genome Resources:
Additional Orthologs for CCDC137

Paralogs for CCDC137 Gene

Pseudogenes.org Pseudogenes for CCDC137 Gene

genes like me logo Genes that share paralogs with CCDC137: view

No data available for Paralogs for CCDC137 Gene

Variants for CCDC137 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for CCDC137 Gene

SNP ID Clinical significance and condition Chr 17 pos Variation AA Info Type
rs11150805 -- p.Arg177Trp
rs11546630 -- p.Arg229Gln
rs11546631 -- p.Arg282Trp
rs7226091 -- p.His127Gln

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for CCDC137 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for CCDC137 Gene

Variant ID Type Subtype PubMed ID
esv26223 CNV gain+loss 19812545
nsv428351 CNV gain 18775914
nsv470620 CNV loss 18288195
nsv828128 CNV loss 20364138
nsv952390 CNV deletion 24416366

Variation tolerance for CCDC137 Gene

Residual Variation Intolerance Score: 92.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 10.30; 90.66% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CCDC137 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CCDC137
Leiden Open Variation Database (LOVD)
CCDC137

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CCDC137 Gene

Disorders for CCDC137 Gene

Additional Disease Information for CCDC137

No disorders were found for CCDC137 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CCDC137 Gene

Publications for CCDC137 Gene

  1. The protein composition of mitotic chromosomes determined using multiclassifier combinatorial proteomics. (PMID: 20813266) Ohta S … Rappsilber J (Cell 2010) 3 4
  2. Systems analysis of RhoGEF and RhoGAP regulatory proteins reveals spatially organized RAC1 signalling from integrin adhesions. (PMID: 32203420) Müller PM … Rocks O (Nature cell biology 2020) 3
  3. Wnt regulation: exploring Axin-Disheveled interactions and defining mechanisms by which the SCF E3 ubiquitin ligase is recruited to the destruction complex. (PMID: 32129710) Schaefer KN … Peifer M (Molecular biology of the cell 2020) 3
  4. The midbody interactome reveals unexpected roles for PP1 phosphatases in cytokinesis. (PMID: 31586073) Capalbo L … D'Avino PP (Nature communications 2019) 3
  5. A protein-interaction network of interferon-stimulated genes extends the innate immune system landscape. (PMID: 30833792) Hubel P … Pichlmair A (Nature immunology 2019) 3

Products for CCDC137 Gene

Sources for CCDC137 Gene