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Aliases for CCDC137 Gene

Aliases for CCDC137 Gene

  • Coiled-Coil Domain Containing 137 2 3 5
  • Hepatocellular Carcinoma Related Protein 2 3
  • Coiled-Coil Domain-Containing Protein 137 3
  • Retinoic Acid Resistance Factor 3
  • CPERP-B 4
  • RaRF 3

External Ids for CCDC137 Gene

Previous GeneCards Identifiers for CCDC137 Gene

  • GC17U900828
  • GC17P077245
  • GC17P079633
  • GC17P075079

Summaries for CCDC137 Gene

GeneCards Summary for CCDC137 Gene

CCDC137 (Coiled-Coil Domain Containing 137) is a Protein Coding gene.

Gene Wiki entry for CCDC137 Gene

Additional gene information for CCDC137 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CCDC137 Gene

Genomics for CCDC137 Gene

GeneHancer (GH) Regulatory Elements for CCDC137 Gene

Promoters and enhancers for CCDC137 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH17I081664 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 569.6 +0.5 474 3.7 HDGF PKNOX1 SMAD1 ARNT ARID4B SIN3A DMAP1 YY1 POLR2B ZNF766 CCDC137 OXLD1 ARL16 OGFOD3 HGS FAAP100 ALYREF ENSG00000262877 FOXK2 CEP131
GH17I081709 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 20.3 +46.0 45951 4.7 HNRNPUL1 PKNOX1 CLOCK FOXA2 MLX ZFP64 ARID4B SIN3A FEZF1 DMAP1 GC17M081707 SLC25A10 ARL16 HGS ALYREF ENSG00000260563 NARF-IT1 ENSG00000262652 TEPSIN CSNK1D
GH17I081700 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 19.5 +36.4 36426 4.2 HDGF CLOCK MLX ARID4B SIN3A DMAP1 ZBTB7B IRF4 YY1 POLR2B MRPL12 ENSG00000262660 ENSG00000262049 ARL16 ENSG00000260563 FAAP100 NARF-IT1 ENSG00000262652 ARL2BPP9 RFNG
GH17I081682 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 15.4 +17.8 17790 3.5 PKNOX1 SMAD1 ARNT ARID4B SIN3A DMAP1 ZNF2 SLC30A9 POLR2B ZNF213 ARL16 HGS ALYREF FOXK2 LOC105371942 CCDC137 PDE6G NPLOC4 TSPAN10 P4HB
GH17I082271 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 11.6 +606.7 606708 3.5 HDGF PKNOX1 SMAD1 FOXA2 ZFP64 ARID4B SIN3A FEZF1 DMAP1 ZNF2 CSNK1D OGFOD3 OXLD1 ENSG00000263321 ALYREF HGS ENSG00000260011 ENSG00000262877 CCDC137 ENSG00000262663
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around CCDC137 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the CCDC137 gene promoter:

Genomic Locations for CCDC137 Gene

Genomic Locations for CCDC137 Gene
chr17:81,666,364-81,673,907
(GRCh38/hg38)
Size:
7,544 bases
Orientation:
Plus strand
chr17:79,633,394-79,640,937
(GRCh37/hg19)

Genomic View for CCDC137 Gene

Genes around CCDC137 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CCDC137 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CCDC137 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CCDC137 Gene

Proteins for CCDC137 Gene

  • Protein details for CCDC137 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6PK04-CC137_HUMAN
    Recommended name:
    Coiled-coil domain-containing protein 137
    Protein Accession:
    Q6PK04

    Protein attributes for CCDC137 Gene

    Size:
    289 amino acids
    Molecular mass:
    33231 Da
    Quaternary structure:
    No Data Available

neXtProt entry for CCDC137 Gene

Post-translational modifications for CCDC137 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CCDC137 Gene

No data available for DME Specific Peptides for CCDC137 Gene

Domains & Families for CCDC137 Gene

Gene Families for CCDC137 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for CCDC137 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for CCDC137 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with CCDC137: view

No data available for UniProtKB/Swiss-Prot for CCDC137 Gene

Function for CCDC137 Gene

Phenotypes From GWAS Catalog for CCDC137 Gene

Gene Ontology (GO) - Molecular Function for CCDC137 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding HDA,IDA 22658674
GO:0005515 protein binding IPI 21044950
genes like me logo Genes that share ontologies with CCDC137: view

Phenotypes for CCDC137 Gene

GenomeRNAi human phenotypes for CCDC137:
genes like me logo Genes that share phenotypes with CCDC137: view

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CCDC137 Gene

Localization for CCDC137 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CCDC137 Gene

Chromosome.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CCDC137 gene
Compartment Confidence
nucleus 5
mitochondrion 2
cytosol 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for CCDC137 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001650 fibrillar center IDA --
GO:0005694 chromosome IDA,IEA 20813266
GO:0005730 nucleolus IDA --
genes like me logo Genes that share ontologies with CCDC137: view

Pathways & Interactions for CCDC137 Gene

SuperPathways for CCDC137 Gene

No Data Available

Gene Ontology (GO) - Biological Process for CCDC137 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for CCDC137 Gene

Drugs & Compounds for CCDC137 Gene

No Compound Related Data Available

Transcripts for CCDC137 Gene

Unigene Clusters for CCDC137 Gene

Coiled-coil domain containing 137:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for CCDC137 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4a · 4b · 4c ^ 5 ^ 6 ^ 7
SP1: -
SP2: - -
SP3: -

Relevant External Links for CCDC137 Gene

GeneLoc Exon Structure for
CCDC137
ECgene alternative splicing isoforms for
CCDC137

Expression for CCDC137 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CCDC137 Gene

Protein differential expression in normal tissues from HIPED for CCDC137 Gene

This gene is overexpressed in Lung (56.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for CCDC137 Gene



Protein tissue co-expression partners for CCDC137 Gene

NURSA nuclear receptor signaling pathways regulating expression of CCDC137 Gene:

CCDC137

SOURCE GeneReport for Unigene cluster for CCDC137 Gene:

Hs.744125

Evidence on tissue expression from TISSUES for CCDC137 Gene

  • Muscle(4.1)
  • Nervous system(2.9)
genes like me logo Genes that share expression patterns with CCDC137: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for CCDC137 Gene

Orthologs for CCDC137 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CCDC137 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CCDC137 34
  • 96 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CCDC137 33 34
  • 83.77 (n)
cow
(Bos Taurus)
Mammalia CCDC137 33 34
  • 83.71 (n)
mouse
(Mus musculus)
Mammalia Ccdc137 33 16 34
  • 76.87 (n)
rat
(Rattus norvegicus)
Mammalia Ccdc137 33
  • 75.17 (n)
oppossum
(Monodelphis domestica)
Mammalia CCDC137 34
  • 57 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CCDC137 34
  • 47 (a)
OneToOne
chicken
(Gallus gallus)
Aves CCDC137 33 34
  • 60.52 (n)
lizard
(Anolis carolinensis)
Reptilia CCDC137 34
  • 44 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100485278 33
  • 59.03 (n)
zebrafish
(Danio rerio)
Actinopterygii ccdc137 33 34
  • 54.29 (n)
Species where no ortholog for CCDC137 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CCDC137 Gene

ENSEMBL:
Gene Tree for CCDC137 (if available)
TreeFam:
Gene Tree for CCDC137 (if available)

Paralogs for CCDC137 Gene

Pseudogenes.org Pseudogenes for CCDC137 Gene

genes like me logo Genes that share paralogs with CCDC137: view

No data available for Paralogs for CCDC137 Gene

Variants for CCDC137 Gene

Sequence variations from dbSNP and Humsavar for CCDC137 Gene

SNP ID Clin Chr 17 pos Variation AA Info Type
rs1000030742 -- 81,667,578(+) C/A intron_variant
rs1000064904 -- 81,672,896(+) T/A 3_prime_UTR_variant, genic_downstream_transcript_variant
rs1000267608 -- 81,670,057(+) C/T intron_variant
rs1000448346 -- 81,673,783(+) C/T 3_prime_UTR_variant, genic_downstream_transcript_variant
rs1000631619 -- 81,668,653(+) G/A intron_variant

Structural Variations from Database of Genomic Variants (DGV) for CCDC137 Gene

Variant ID Type Subtype PubMed ID
esv26223 CNV gain+loss 19812545
nsv428351 CNV gain 18775914
nsv470620 CNV loss 18288195
nsv828128 CNV loss 20364138
nsv952390 CNV deletion 24416366

Variation tolerance for CCDC137 Gene

Residual Variation Intolerance Score: 92.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 10.30; 90.66% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CCDC137 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CCDC137

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CCDC137 Gene

Disorders for CCDC137 Gene

Additional Disease Information for CCDC137

No disorders were found for CCDC137 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CCDC137 Gene

Publications for CCDC137 Gene

  1. The protein composition of mitotic chromosomes determined using multiclassifier combinatorial proteomics. (PMID: 20813266) Ohta S … Rappsilber J (Cell 2010) 3 4 58
  2. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
  3. Interactions of the Antiviral Factor Interferon Gamma-Inducible Protein 16 (IFI16) Mediate Immune Signaling and Herpes Simplex Virus-1 Immunosuppression. (PMID: 25693804) Diner BA … Cristea IM (Molecular & cellular proteomics : MCP 2015) 3 58
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin EL … Gygi SP (Cell 2015) 3 58
  5. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein MY … Mann M (Cell 2015) 3 58

Products for CCDC137 Gene

Sources for CCDC137 Gene

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