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Aliases for CCDC136 Gene

Aliases for CCDC136 Gene

  • Coiled-Coil Domain Containing 136 2 3 5
  • Nasopharyngeal Carcinoma-Associated Gene 6 Protein 3 4
  • Coiled-Coil Domain-Containing Protein 136 3
  • KIAA1793 4
  • NAG6 3

External Ids for CCDC136 Gene

Previous GeneCards Identifiers for CCDC136 Gene

  • GC07P128219
  • GC07P128430
  • GC07P122792
  • GC07P128791
  • GC07P128793
  • GC07P128836
  • GC07P128874
  • GC07P128903

Summaries for CCDC136 Gene

GeneCards Summary for CCDC136 Gene

CCDC136 (Coiled-Coil Domain Containing 136) is a Protein Coding gene. Diseases associated with CCDC136 include Gastric Cancer. An important paralog of this gene is SLMAP.

UniProtKB/Swiss-Prot for CCDC136 Gene

  • May play a role in acrosome formation in spermatogenesis and in fertilization.

Additional gene information for CCDC136 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CCDC136 Gene

Genomics for CCDC136 Gene

GeneHancer (GH) Regulatory Elements for CCDC136 Gene

Promoters and enhancers for CCDC136 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH07I128790 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 559.5 +1.1 1082 2.4 HDGF ATF1 SIN3A ZNF2 ETS1 ZNF121 POLR2B ZNF766 GLIS2 KLF7 CCDC136 OPN1SW CALU GC07P128951 PIR31734
GH07I128791 Enhancer 0.5 ENCODE 550.8 -0.3 -253 0.1 ZNF335 ZNF766 POLR2A EZH2 CCDC136 TRP-AGG2-3
GH07I128737 Promoter/Enhancer 2.5 EPDnew Ensembl ENCODE dbSUPER 10.8 -50.1 -50054 6.6 HDGF HNRNPUL1 PKNOX1 SMAD1 ARNT ARID4B SIN3A DMAP1 ZNF2 YY1 CALU ENSG00000243302 ENSG00000230715 ENSG00000243679 ENSG00000242588 TNPO3 RPS10P15 ENSG00000229413 CDC26P1 OPN1SW
GH07I128858 Enhancer 1.4 Ensembl ENCODE dbSUPER 18.5 +69.3 69281 3 HDGF HNRNPUL1 PKNOX1 ARNT YBX1 POLR2B ZNF766 CBX5 E2F8 ZNF592 ENSG00000243302 ENSG00000242588 CCDC136 ENSG00000230715 ENSG00000243679 OPN1SW TNPO3 ENSG00000229413 RPS10P15 FLNC
GH07I128826 Promoter/Enhancer 2.6 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 8.9 +41.7 41678 11.9 HDGF PKNOX1 SMAD1 FOXA2 ARNT SIN3A POLR2B E2F8 FOS ZNF263 FLNC ENSG00000243679 ENSG00000230715 ENSG00000243302 ENSG00000229413 ENSG00000242588 TNPO3 CCDC136 LOC392787 ATP6V1F
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around CCDC136 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the CCDC136 gene promoter:

Genomic Locations for CCDC136 Gene

Genomic Locations for CCDC136 Gene
31,377 bases
Plus strand

Genomic View for CCDC136 Gene

Genes around CCDC136 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CCDC136 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CCDC136 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CCDC136 Gene

Proteins for CCDC136 Gene

  • Protein details for CCDC136 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Coiled-coil domain-containing protein 136
    Protein Accession:
    Secondary Accessions:
    • A4D1K1
    • A7MCY7
    • A8MYA7
    • Q6ZVK7
    • Q9H8M3
    • Q9UFE1

    Protein attributes for CCDC136 Gene

    1154 amino acids
    Molecular mass:
    134045 Da
    Quaternary structure:
    No Data Available
    • Restriction fragment length polymorphisms (RFLPs) in gastric cancer showed loss of 5 kb fragment in comparison with the corresponding normal tissue.
    • Sequence=AF156971; Type=Miscellaneous discrepancy; Note=Intron retention.; Evidence={ECO:0000305}; Sequence=BAB14590.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAB47422.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Alternative splice isoforms for CCDC136 Gene


neXtProt entry for CCDC136 Gene

Post-translational modifications for CCDC136 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for CCDC136 Gene

Domains & Families for CCDC136 Gene

Gene Families for CCDC136 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted membrane proteins

Protein Domains for CCDC136 Gene


Suggested Antigen Peptide Sequences for CCDC136 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with CCDC136: view

No data available for UniProtKB/Swiss-Prot for CCDC136 Gene

Function for CCDC136 Gene

Molecular function for CCDC136 Gene

UniProtKB/Swiss-Prot Function:
May play a role in acrosome formation in spermatogenesis and in fertilization.

Phenotypes From GWAS Catalog for CCDC136 Gene

genes like me logo Genes that share phenotypes with CCDC136: view

Animal Model Products

miRNA for CCDC136 Gene

miRTarBase miRNAs that target CCDC136

Clone Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CCDC136 Gene

Localization for CCDC136 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CCDC136 Gene

Cytoplasmic vesicle, secretory vesicle, acrosome membrane; Single-pass membrane protein. Note=Exclusively localized on a peripheral part of acrosome membrane (Golgi phase), localized on the equatorial segment of the acrosome (maturation phase). {ECO:0000250 UniProtKB:Q3TVA9}.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CCDC136 gene
Compartment Confidence
nucleus 4
mitochondrion 1
peroxisome 1
endoplasmic reticulum 1
cytosol 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for CCDC136 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002080 acrosomal membrane ISS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
GO:0031410 cytoplasmic vesicle IEA --
genes like me logo Genes that share ontologies with CCDC136: view

Pathways & Interactions for CCDC136 Gene

SuperPathways for CCDC136 Gene

No Data Available

Gene Ontology (GO) - Biological Process for CCDC136 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001675 acrosome assembly ISS --
GO:0007283 spermatogenesis ISS --
GO:0007338 single fertilization ISS --
GO:0030154 cell differentiation IEA --
genes like me logo Genes that share ontologies with CCDC136: view

No data available for Pathways by source and SIGNOR curated interactions for CCDC136 Gene

Drugs & Compounds for CCDC136 Gene

No Compound Related Data Available

Transcripts for CCDC136 Gene

Unigene Clusters for CCDC136 Gene

Coiled-coil domain containing 136:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for CCDC136 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9a · 9b ^ 10a · 10b ^ 11a · 11b ^ 12a · 12b · 12c · 12d ^ 13 ^ 14 ^ 15 ^ 16 ^ 17a ·
SP1: - -
SP2: - - - - - - - - - - - - - - - - -
SP3: - - - - -
SP6: - -
SP9: -

ExUns: 17b

Relevant External Links for CCDC136 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for CCDC136 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CCDC136 Gene

mRNA differential expression in normal tissues according to GTEx for CCDC136 Gene

This gene is overexpressed in Testis (x14.6) and Brain - Cerebellar Hemisphere (x4.1).

Protein differential expression in normal tissues from HIPED for CCDC136 Gene

This gene is overexpressed in Testis (14.1), Heart (12.8), Fetal ovary (12.7), Platelet (11.9), and Frontal cortex (8.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for CCDC136 Gene

Protein tissue co-expression partners for CCDC136 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of CCDC136 Gene:


SOURCE GeneReport for Unigene cluster for CCDC136 Gene:


mRNA Expression by UniProt/SwissProt for CCDC136 Gene:

Tissue specificity: Expressed in gastric tissues. Down-regulated in gastric cancer.

Evidence on tissue expression from TISSUES for CCDC136 Gene

  • Nervous system(4.7)
genes like me logo Genes that share expression patterns with CCDC136: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and Phenotype-based relationships between genes and organs from Gene ORGANizer for CCDC136 Gene

Orthologs for CCDC136 Gene

This gene was present in the common ancestor of animals.

Orthologs for CCDC136 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia CCDC136 33 34
  • 98.66 (n)
(Canis familiaris)
Mammalia CCDC136 33 34
  • 85.58 (n)
(Bos Taurus)
Mammalia CCDC136 33 34
  • 83.2 (n)
(Mus musculus)
Mammalia Ccdc136 33 16 34
  • 80.79 (n)
(Rattus norvegicus)
Mammalia Ccdc136 33
  • 80.44 (n)
(Monodelphis domestica)
Mammalia CCDC136 34
  • 43 (a)
(Ornithorhynchus anatinus)
Mammalia CCDC136 34
  • 31 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia ccdc136 33
  • 57.9 (n)
(Danio rerio)
Actinopterygii LOC100330186 33
  • 56.68 (n)
ccdc136b 34 34
  • 36 (a)
slmapb 34
  • 22 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG17494 34
  • 7 (a)
(Caenorhabditis elegans)
Secernentea M4.1 34
  • 10 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.8207 34
  • 15 (a)
Species where no ortholog for CCDC136 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CCDC136 Gene

Gene Tree for CCDC136 (if available)
Gene Tree for CCDC136 (if available)

Paralogs for CCDC136 Gene

Paralogs for CCDC136 Gene

(1) SIMAP similar genes for CCDC136 Gene using alignment to 8 proteins:

genes like me logo Genes that share paralogs with CCDC136: view

Variants for CCDC136 Gene

Sequence variations from dbSNP and Humsavar for CCDC136 Gene

SNP ID Clin Chr 07 pos Variation AA Info Type
rs1000369486 -- 128,795,155(+) G/C intron_variant
rs1000440963 -- 128,821,812(+) T/A 3_prime_UTR_variant, coding_sequence_variant, genic_downstream_transcript_variant, missense_variant, stop_gained
rs1000443412 -- 128,814,426(+) G/A genic_downstream_transcript_variant, intron_variant
rs1000512189 -- 128,807,230(+) T/C intron_variant
rs1000586971 -- 128,793,610(+) T/C intron_variant

Structural Variations from Database of Genomic Variants (DGV) for CCDC136 Gene

Variant ID Type Subtype PubMed ID
dgv11611n54 CNV loss 21841781
dgv11612n54 CNV loss 21841781
esv1249692 CNV insertion 17803354
esv22837 CNV gain 19812545
esv2642516 CNV insertion 19546169
esv2670312 CNV deletion 23128226
esv2735137 CNV deletion 23290073
nsv1140844 CNV deletion 24896259
nsv464713 CNV loss 19166990
nsv464715 CNV loss 19166990
nsv512922 CNV insertion 21212237
nsv517923 CNV gain 19592680
nsv818553 CNV gain 17921354
nsv819324 CNV loss 19587683
nsv831125 CNV loss 17160897

Variation tolerance for CCDC136 Gene

Residual Variation Intolerance Score: 79.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.26; 70.18% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CCDC136 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CCDC136 Gene

Disorders for CCDC136 Gene

MalaCards: The human disease database

(1) MalaCards diseases for CCDC136 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
gastric cancer
  • gastric cancer, somatic
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for CCDC136

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with CCDC136: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CCDC136 Gene

Publications for CCDC136 Gene

  1. Expression of tumor related gene NAG6 in gastric cancer and restriction fragment length polymorphism analysis. (PMID: 15112360) Zhang XM … Li GY (World journal of gastroenterology 2004) 2 3 4 22 58
  2. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PMID: 20877624) Hendrickson SL … O'Brien SJ (PloS one 2010) 3 44 58
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  4. Human chromosome 7: DNA sequence and biology. (PMID: 12690205) Scherer SW … Tsui LC (Science (New York, N.Y.) 2003) 3 4 58
  5. Prediction of the coding sequences of unidentified human genes. XX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 11347906) Nagase T … Ohara O (DNA research : an international journal for rapid publication of reports on genes and genomes 2001) 3 4 58

Products for CCDC136 Gene

Sources for CCDC136 Gene

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