Free for academic non-profit institutions. Other users need a Commercial license

Aliases for CCDC134 Gene

Aliases for CCDC134 Gene

  • Coiled-Coil Domain Containing 134 2 3 5
  • Coiled-Coil Domain-Containing Protein 134 3

External Ids for CCDC134 Gene

Previous GeneCards Identifiers for CCDC134 Gene

  • GC22P040526
  • GC22P042196
  • GC22P025162

Summaries for CCDC134 Gene

GeneCards Summary for CCDC134 Gene

CCDC134 (Coiled-Coil Domain Containing 134) is a Protein Coding gene.

UniProtKB/Swiss-Prot for CCDC134 Gene

  • In extracellular secreted form, promotes proliferation and activation of CD8(+) T cells, suggesting a cytokine-like function (PubMed:25125657). Enhances cytotoxic anti-tumor activity of CD8(+) T cells (PubMed:25125657). May inhibit ERK and JNK signaling activity (PubMed:18087676, PubMed:23070808). May suppress cell migration and invasion activity, via its effects on ERK and JNK signaling (PubMed:23070808).

  • In the nucleus, enhances stability of the PCAF histone acetyltransferase (HAT) complex member TADA2A and thus promotes PCAF-mediated H3K14 and H4K8 HAT activity. May inhibit TADA2A-mediated TP53/p53 Lys-321 acetylation, leading to reduced TP53 stability and transcriptional activity. May also promote TADA2A-mediated XRCC6 acetylation thus facilitating cell apoptosis in response to DNA damage.

Additional gene information for CCDC134 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CCDC134 Gene

Genomics for CCDC134 Gene

GeneHancer (GH) Regulatory Elements for CCDC134 Gene

Promoters and enhancers for CCDC134 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH22J041799 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 650.7 +0.2 205 3.4 HDGF PKNOX1 SMAD1 MLX SIN3A DMAP1 YY1 POLR2B ZNF207 ZNF143 CCDC134 MEI1 DESI1 PHF5A L3MBTL2 POLDIP3 EP300 RRP7BP NAGA ZC3H7B
GH22J041379 Promoter/Enhancer 2.5 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 10 -418.7 -418659 4 HDGF PKNOX1 CLOCK FOXA2 MLX ARID4B SIN3A YY1 ZNF213 FOS LOC105373042 TEF EP300 MEI1 POLR3H EP300-AS1 ENSG00000272834 XRCC6 PHF5A LOC100313968
GH22J041687 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 10.1 -112.2 -112226 2.6 PKNOX1 SMAD1 ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 POLR2B E2F8 C22orf46 ST13 EP300 EP300-AS1 XRCC6 PHF5A LOC100313968 RN7SKP80 POLDIP3 ENSG00000232754
GH22J041681 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 7.9 -118.2 -118225 2.4 PKNOX1 ATF1 SMAD1 MLX ARID4B SIN3A DMAP1 BRCA1 ZNF48 POLR2B SNU13 C22orf46 MEI1 RN7SKP80 SLC25A17 POLDIP3 RRP7BP EP300 PHF5A L3MBTL2
GH22J041666 Enhancer 1.3 Ensembl ENCODE 10 -133.2 -133178 2.5 HDGF PKNOX1 FOXA2 ZFP64 ARID4B SIN3A DMAP1 ZNF2 YY1 POLR2B RN7SKP80 EP300 PHF5A POLDIP3 RRP7BP EP300-AS1 ENSG00000232754 XRCC6 SLC25A17 MEI1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around CCDC134 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the CCDC134 gene promoter:

Genomic Locations for CCDC134 Gene

Genomic Locations for CCDC134 Gene
chr22:41,800,622-41,832,164
(GRCh38/hg38)
Size:
31,543 bases
Orientation:
Plus strand
chr22:42,196,678-42,222,306
(GRCh37/hg19)

Genomic View for CCDC134 Gene

Genes around CCDC134 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CCDC134 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CCDC134 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CCDC134 Gene

Proteins for CCDC134 Gene

  • Protein details for CCDC134 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H6E4-CC134_HUMAN
    Recommended name:
    Coiled-coil domain-containing protein 134
    Protein Accession:
    Q9H6E4

    Protein attributes for CCDC134 Gene

    Size:
    229 amino acids
    Molecular mass:
    26561 Da
    Quaternary structure:
    • Interacts with TADA2A. Associates with the PCAF complex via TADA2A binding.

neXtProt entry for CCDC134 Gene

Post-translational modifications for CCDC134 Gene

  • O-glycosylated, with additional sialic acid modifications.
  • Glycosylation at Thr193 and posLast=192192
  • Ubiquitination at Lys51
  • Modification sites at PhosphoSitePlus

Other Protein References for CCDC134 Gene

Antibody Products

  • Boster Bio Antibodies for CCDC134

No data available for DME Specific Peptides for CCDC134 Gene

Domains & Families for CCDC134 Gene

Gene Families for CCDC134 Gene

Human Protein Atlas (HPA):
  • Predicted secreted proteins

Protein Domains for CCDC134 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for CCDC134 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9H6E4

UniProtKB/Swiss-Prot:

CC134_HUMAN :
  • Belongs to the CCDC134 family.
Family:
  • Belongs to the CCDC134 family.
genes like me logo Genes that share domains with CCDC134: view

Function for CCDC134 Gene

Molecular function for CCDC134 Gene

UniProtKB/Swiss-Prot Function:
In extracellular secreted form, promotes proliferation and activation of CD8(+) T cells, suggesting a cytokine-like function (PubMed:25125657). Enhances cytotoxic anti-tumor activity of CD8(+) T cells (PubMed:25125657). May inhibit ERK and JNK signaling activity (PubMed:18087676, PubMed:23070808). May suppress cell migration and invasion activity, via its effects on ERK and JNK signaling (PubMed:23070808).
UniProtKB/Swiss-Prot Function:
In the nucleus, enhances stability of the PCAF histone acetyltransferase (HAT) complex member TADA2A and thus promotes PCAF-mediated H3K14 and H4K8 HAT activity. May inhibit TADA2A-mediated TP53/p53 Lys-321 acetylation, leading to reduced TP53 stability and transcriptional activity. May also promote TADA2A-mediated XRCC6 acetylation thus facilitating cell apoptosis in response to DNA damage.

Phenotypes From GWAS Catalog for CCDC134 Gene

Gene Ontology (GO) - Molecular Function for CCDC134 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 22644376
genes like me logo Genes that share ontologies with CCDC134: view
genes like me logo Genes that share phenotypes with CCDC134: view

Animal Models for CCDC134 Gene

MGI Knock Outs for CCDC134:

Animal Model Products

  • Taconic Biosciences Mouse Models for CCDC134

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CCDC134 Gene

Localization for CCDC134 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CCDC134 Gene

Nucleus. Cytoplasm. Secreted. Endoplasmic reticulum. Note=Accumulates in the nucleus in response to UV irradiation (PubMed:22644376). {ECO:0000269 PubMed:22644376}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CCDC134 gene
Compartment Confidence
extracellular 4
endoplasmic reticulum 4
nucleus 3
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for CCDC134 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0005634 nucleus IEA --
GO:0005737 cytoplasm IEA --
GO:0005783 endoplasmic reticulum IEA --
GO:0016020 membrane HDA 19946888
genes like me logo Genes that share ontologies with CCDC134: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for CCDC134 Gene

Pathways & Interactions for CCDC134 Gene

SuperPathways for CCDC134 Gene

No Data Available

Interacting Proteins for CCDC134 Gene

Gene Ontology (GO) - Biological Process for CCDC134 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for CCDC134 Gene

Drugs & Compounds for CCDC134 Gene

No Compound Related Data Available

Transcripts for CCDC134 Gene

mRNA/cDNA for CCDC134 Gene

Unigene Clusters for CCDC134 Gene

Coiled-coil domain containing 134:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for CCDC134 Gene

No ASD Table

Relevant External Links for CCDC134 Gene

GeneLoc Exon Structure for
CCDC134
ECgene alternative splicing isoforms for
CCDC134

Expression for CCDC134 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CCDC134 Gene

mRNA differential expression in normal tissues according to GTEx for CCDC134 Gene

This gene is overexpressed in Adrenal Gland (x4.7).

Protein differential expression in normal tissues from HIPED for CCDC134 Gene

This gene is overexpressed in Bone (23.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for CCDC134 Gene



NURSA nuclear receptor signaling pathways regulating expression of CCDC134 Gene:

CCDC134

SOURCE GeneReport for Unigene cluster for CCDC134 Gene:

Hs.474991

mRNA Expression by UniProt/SwissProt for CCDC134 Gene:

Q9H6E4-CC134_HUMAN
Tissue specificity: Expressed in cervical gland, cervical squamous epithelium, endometrium, stomach, kidney distal convoluted tubule, spermatogenic cells in testis, mammary gland, liver and striated muscle (at protein level) (PubMed:18087676, PubMed:23070808). Also detected in placenta (PubMed:18087676). Highest expression in testis relative to other tissues (PubMed:18087676). Detected in T cells and dendritic cells; highly expressed in activated CD8(+) T cells, and also expressed at lower levels in CD4(+) T cells (PubMed:25125657).

Evidence on tissue expression from TISSUES for CCDC134 Gene

  • Kidney(4.1)
genes like me logo Genes that share expression patterns with CCDC134: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for CCDC134 Gene

Orthologs for CCDC134 Gene

This gene was present in the common ancestor of animals.

Orthologs for CCDC134 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CCDC134 34 33
  • 99.56 (n)
OneToOne
cow
(Bos Taurus)
Mammalia CCDC134 34 33
  • 91.99 (n)
OneToOne
dog
(Canis familiaris)
Mammalia CCDC134 34 33
  • 91.12 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ccdc134 33
  • 88.58 (n)
mouse
(Mus musculus)
Mammalia Ccdc134 16 34 33
  • 88.26 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia CCDC134 34
  • 68 (a)
OneToOne
chicken
(Gallus gallus)
Aves CCDC134 34 33
  • 77.72 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CCDC134 34
  • 73 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ccdc134 33
  • 70.48 (n)
Str.6128 33
African clawed frog
(Xenopus laevis)
Amphibia LOC398726 33
zebrafish
(Danio rerio)
Actinopterygii LOC100536187 33
  • 69.76 (n)
CCDC134 (1 of 2) 34
  • 62 (a)
OneToMany
CCDC134 (2 of 2) 34
  • 61 (a)
OneToMany
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.7625 33
worm
(Caenorhabditis elegans)
Secernentea F56A8.9 34
  • 27 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea CSA.6343 34
  • 32 (a)
OneToOne
Species where no ortholog for CCDC134 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CCDC134 Gene

ENSEMBL:
Gene Tree for CCDC134 (if available)
TreeFam:
Gene Tree for CCDC134 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for CCDC134: view image

Paralogs for CCDC134 Gene

No data available for Paralogs for CCDC134 Gene

Variants for CCDC134 Gene

Sequence variations from dbSNP and Humsavar for CCDC134 Gene

SNP ID Clin Chr 22 pos Variation AA Info Type
rs1000095886 -- 41,820,059(+) G/A intron_variant
rs1000126741 -- 41,831,969(+) C/T 3_prime_UTR_variant, genic_downstream_transcript_variant
rs1000177249 -- 41,801,113(+) C/T intron_variant
rs1000243786 -- 41,813,124(+) G/A intron_variant
rs1000296970 -- 41,806,688(+) T/C intron_variant

Structural Variations from Database of Genomic Variants (DGV) for CCDC134 Gene

Variant ID Type Subtype PubMed ID
dgv8111n54 CNV gain 21841781
esv3647804 CNV loss 21293372
nsv3640 CNV insertion 18451855

Variation tolerance for CCDC134 Gene

Residual Variation Intolerance Score: 30.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.95; 36.17% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CCDC134 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CCDC134

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CCDC134 Gene

Disorders for CCDC134 Gene

Additional Disease Information for CCDC134

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for CCDC134 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CCDC134 Gene

Publications for CCDC134 Gene

  1. CCDC134, a novel secretory protein, inhibits activation of ERK and JNK, but not p38 MAPK. (PMID: 18087676) Huang J … Qiu X (Cellular and molecular life sciences : CMLS 2008) 2 3 4 58
  2. Cytokine-like molecule CCDC134 contributes to CD8⁺ T-cell effector functions in cancer immunotherapy. (PMID: 25125657) Huang J … Qiu X (Cancer research 2014) 3 4 58
  3. CCDC134 is down-regulated in gastric cancer and its silencing promotes cell migration and invasion of GES-1 and AGS cells via the MAPK pathway. (PMID: 23070808) Zhong J … Huang C (Molecular and cellular biochemistry 2013) 3 4 58
  4. CCDC134 interacts with hADA2a and functions as a regulator of hADA2a in acetyltransferase activity, DNA damage-induced apoptosis and cell cycle arrest. (PMID: 22644376) Huang J … Qiu X (Histochemistry and cell biology 2012) 3 4 58
  5. Genome-wide association study of CSF biomarkers Abeta1-42, t-tau, and p-tau181p in the ADNI cohort. (PMID: 21123754) Kim S … Alzheimer's Disease Neuroimaging Initiative (Neurology 2011) 3 44 58

Products for CCDC134 Gene

Sources for CCDC134 Gene

Content
Loading form....