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Aliases for CCDC13 Gene

Aliases for CCDC13 Gene

  • Coiled-Coil Domain Containing 13 2 3 5

External Ids for CCDC13 Gene

Previous GeneCards Identifiers for CCDC13 Gene

  • GC03M042725

Summaries for CCDC13 Gene

GeneCards Summary for CCDC13 Gene

CCDC13 (Coiled-Coil Domain Containing 13) is a Protein Coding gene.

UniProtKB/Swiss-Prot for CCDC13 Gene

  • Required for primary cilia formation and promotes the localization of the ciliopathy protein BBS4 to both centriolar satellites and cilia.

Additional gene information for CCDC13 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CCDC13 Gene

Genomics for CCDC13 Gene

GeneHancer (GH) Regulatory Elements for CCDC13 Gene

Promoters and enhancers for CCDC13 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH03I042772 Promoter/Enhancer 1.8 EPDnew Ensembl ENCODE 550.8 +0.1 103 1.4 PKNOX1 ATF1 SMAD1 SIN3A BMI1 IRF4 RFX5 YY1 ZNF207 ZNF143 CCDC13 CCDC13-AS1 HIGD1A LINC02158 ENSG00000280571
GH03I042802 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 11.5 -30.9 -30871 3.1 HDGF PKNOX1 FOXA2 MLX ARNT ZFP64 ARID4B SIN3A FEZF1 DMAP1 ACKR2 HIGD1A ENSG00000280571 NKTR ZNF662 SNRK-AS1 LINC02158 CCDC13 GC03M042803 ENSG00000235288
GH03I042589 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 10.4 +182.3 182287 2.5 HDGF PKNOX1 ATF1 IRF4 BRCA1 YY1 GTF3C2 POLR2B GLIS2 ZNF207 SS18L2 SEC22C NKTR CCDC13-AS1 CCDC13
GH03I042880 Enhancer 1.5 FANTOM5 Ensembl ENCODE 10.8 -107.8 -107787 1.3 PKNOX1 ATF1 ARID4B SIN3A DMAP1 ZNF2 ZNF48 YY1 ETS1 GLIS2 NKTR HIGD1A SNRK-AS1 ENSG00000235288 ACKR2 ZNF662 CCDC13 LINC02158 KRBOX1 CYP8B1
GH03I042744 Enhancer 1.1 Ensembl ENCODE dbSUPER 11.1 +28.8 28752 0.6 CTCF PKNOX1 RB1 SAP130 SIN3A CEBPG ZNF2 RAD21 CC2D1A MTA3 LINC02158 CCDC13 HHATL CCDC13-AS1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around CCDC13 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the CCDC13 gene promoter:

Genomic Locations for CCDC13 Gene

Genomic Locations for CCDC13 Gene
chr3:42,692,663-42,773,253
(GRCh38/hg38)
Size:
80,591 bases
Orientation:
Minus strand
chr3:42,734,155-42,814,745
(GRCh37/hg19)

Genomic View for CCDC13 Gene

Genes around CCDC13 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CCDC13 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CCDC13 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CCDC13 Gene

Proteins for CCDC13 Gene

  • Protein details for CCDC13 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8IYE1-CCD13_HUMAN
    Recommended name:
    Coiled-coil domain-containing protein 13
    Protein Accession:
    Q8IYE1

    Protein attributes for CCDC13 Gene

    Size:
    715 amino acids
    Molecular mass:
    80884 Da
    Quaternary structure:
    • Interacts with PCM1, CEP290 and PCNT.

neXtProt entry for CCDC13 Gene

Post-translational modifications for CCDC13 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CCDC13 Gene

No data available for DME Specific Peptides for CCDC13 Gene

Domains & Families for CCDC13 Gene

Gene Families for CCDC13 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for CCDC13 Gene

ProtoNet:

Suggested Antigen Peptide Sequences for CCDC13 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with CCDC13: view

No data available for UniProtKB/Swiss-Prot for CCDC13 Gene

Function for CCDC13 Gene

Molecular function for CCDC13 Gene

UniProtKB/Swiss-Prot Function:
Required for primary cilia formation and promotes the localization of the ciliopathy protein BBS4 to both centriolar satellites and cilia.

Phenotypes From GWAS Catalog for CCDC13 Gene

Gene Ontology (GO) - Molecular Function for CCDC13 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 24816561
genes like me logo Genes that share ontologies with CCDC13: view

Phenotypes for CCDC13 Gene

GenomeRNAi human phenotypes for CCDC13:
genes like me logo Genes that share phenotypes with CCDC13: view

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for CCDC13 Gene

Localization for CCDC13 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CCDC13 Gene

Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriolar satellite. Cytoplasm, cytoskeleton, cilium basal body.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CCDC13 gene
Compartment Confidence
nucleus 5
cytoskeleton 4
cytosol 4

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for CCDC13 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA --
GO:0005737 cytoplasm IEA --
GO:0005813 centrosome IDA 24816561
GO:0005815 microtubule organizing center IEA --
GO:0005829 cytosol IDA --
genes like me logo Genes that share ontologies with CCDC13: view

Pathways & Interactions for CCDC13 Gene

SuperPathways for CCDC13 Gene

No Data Available

Gene Ontology (GO) - Biological Process for CCDC13 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006974 cellular response to DNA damage stimulus IMP 24816561
GO:0030030 cell projection organization IEA --
GO:0031122 cytoplasmic microtubule organization IMP 24816561
GO:1905515 non-motile cilium assembly IDA 24816561
genes like me logo Genes that share ontologies with CCDC13: view

No data available for Pathways by source and SIGNOR curated interactions for CCDC13 Gene

Drugs & Compounds for CCDC13 Gene

No Compound Related Data Available

Transcripts for CCDC13 Gene

Unigene Clusters for CCDC13 Gene

Coiled-coil domain containing 13:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for CCDC13 Gene

No ASD Table

Relevant External Links for CCDC13 Gene

GeneLoc Exon Structure for
CCDC13
ECgene alternative splicing isoforms for
CCDC13

Expression for CCDC13 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CCDC13 Gene

mRNA differential expression in normal tissues according to GTEx for CCDC13 Gene

This gene is overexpressed in Testis (x7.0).

Protein differential expression in normal tissues from HIPED for CCDC13 Gene

This gene is overexpressed in Prostate (18.0), Islet of Langerhans (18.0), Testis (17.3), and Blymphocyte (14.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for CCDC13 Gene



Protein tissue co-expression partners for CCDC13 Gene

NURSA nuclear receptor signaling pathways regulating expression of CCDC13 Gene:

CCDC13

SOURCE GeneReport for Unigene cluster for CCDC13 Gene:

Hs.604182
genes like me logo Genes that share expression patterns with CCDC13: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for CCDC13 Gene

Orthologs for CCDC13 Gene

This gene was present in the common ancestor of animals.

Orthologs for CCDC13 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CCDC13 33 34
  • 99.25 (n)
cow
(Bos Taurus)
Mammalia CCDC13 33 34
  • 87.19 (n)
dog
(Canis familiaris)
Mammalia CCDC13 33 34
  • 86.97 (n)
rat
(Rattus norvegicus)
Mammalia Ccdc13 33
  • 81.85 (n)
mouse
(Mus musculus)
Mammalia Ccdc13 33 16 34
  • 80.84 (n)
oppossum
(Monodelphis domestica)
Mammalia CCDC13 34
  • 59 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CCDC13 34
  • 50 (a)
OneToOne
chicken
(Gallus gallus)
Aves CCDC13 33 34
  • 62.15 (n)
lizard
(Anolis carolinensis)
Reptilia CCDC13 34
  • 49 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ccdc13 33
  • 60.75 (n)
zebrafish
(Danio rerio)
Actinopterygii LOC555345 33
  • 54.29 (n)
CCDC13 34
  • 43 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG13032 34
  • 20 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 35 (a)
OneToOne
Species where no ortholog for CCDC13 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CCDC13 Gene

ENSEMBL:
Gene Tree for CCDC13 (if available)
TreeFam:
Gene Tree for CCDC13 (if available)

Paralogs for CCDC13 Gene

No data available for Paralogs for CCDC13 Gene

Variants for CCDC13 Gene

Sequence variations from dbSNP and Humsavar for CCDC13 Gene

SNP ID Clin Chr 03 pos Variation AA Info Type
rs1000022688 -- 42,713,388(-) C/T genic_downstream_transcript_variant, intron_variant
rs1000043507 -- 42,770,634(-) A/G/T genic_upstream_transcript_variant, intron_variant
rs1000117738 -- 42,716,757(-) C/T genic_downstream_transcript_variant, intron_variant
rs1000127617 -- 42,732,241(-) G/A genic_downstream_transcript_variant, intron_variant
rs1000191977 -- 42,716,278(-) A/G genic_downstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for CCDC13 Gene

Variant ID Type Subtype PubMed ID
dgv4728n100 CNV loss 25217958
esv3596003 CNV loss 21293372
nsv3782 CNV insertion 18451855
nsv954472 CNV deletion 24416366

Variation tolerance for CCDC13 Gene

Residual Variation Intolerance Score: 81.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 8.76; 86.68% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CCDC13 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CCDC13

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CCDC13 Gene

Disorders for CCDC13 Gene

Additional Disease Information for CCDC13

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for CCDC13 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CCDC13 Gene

Publications for CCDC13 Gene

  1. Ccdc13 is a novel human centriolar satellite protein required for ciliogenesis and genome stability. (PMID: 24816561) Staples CJ … Collis SJ (Journal of cell science 2014) 3 4 58
  2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 44 58
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 2 3 58
  5. Clozapine-induced agranulocytosis is associated with rare HLA-DQB1 and HLA-B alleles. (PMID: 25187353) Goldstein JI … Sullivan PF (Nature communications 2014) 3 58

Products for CCDC13 Gene

Sources for CCDC13 Gene

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