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Aliases for CCDC121 Gene

Aliases for CCDC121 Gene

  • Coiled-Coil Domain Containing 121 2 3 5
  • Coiled-Coil Domain-Containing Protein 121 3

External Ids for CCDC121 Gene

Previous GeneCards Identifiers for CCDC121 Gene

  • GC02M027702
  • GC02M027849
  • GC02M027590

Summaries for CCDC121 Gene

GeneCards Summary for CCDC121 Gene

CCDC121 (Coiled-Coil Domain Containing 121) is a Protein Coding gene.

Additional gene information for CCDC121 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CCDC121 Gene

Genomics for CCDC121 Gene

GeneHancer (GH) Regulatory Elements for CCDC121 Gene

Promoters and enhancers for CCDC121 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH02J027626 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 650.7 +0.9 880 3.8 HDGF PKNOX1 SMAD1 MLX ARNT ZFP64 ARID4B SIN3A DMAP1 YY1 GPN1 CCDC121 CAD EIF2B4 SNX17 GTF3C2 NRBP1 ZNF513 GTF3C2-AS1 PPM1G
GH02J027662 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 21.4 -34.6 -34615 2.4 CLOCK MLX ZFP64 FEZF1 DMAP1 IRF4 YY1 SLC30A9 ZNF213 E2F8 SUPT7L SLC4A1AP GTF3C2 CAD GPN1 IFT172 ZNF512 SNX17 NRBP1 LOC105374363
GH02J027427 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 10 +199.2 199223 4.8 HDGF PKNOX1 ARNT ZFP64 ARID4B SIN3A DMAP1 ZBTB7B YY1 SLC30A9 NRBP1 GC02M027429 SNX17 GPN1 CAD LOC105374363 EIF2B4 GTF3C2-AS1 TMEM214 ZNF513
GH02J027703 Enhancer 1.4 Ensembl ENCODE dbSUPER 10 -76.3 -76326 4.1 SIN3A FEZF1 ZNF2 ZNF207 ZNF143 FOS DEK SP3 REST KAT8 CCDC121 GPN1 FNDC4 OST4 LOC105374378 LINC01460 SUPT7L GC02M027478
GH02J027680 Enhancer 1.3 Ensembl ENCODE dbSUPER 10.5 -53.5 -53546 3.5 HDGF PKNOX1 ATF1 FOXA2 ARID4B SIN3A ZNF48 ARID2 ZNF207 ZNF143 LINC01460 SLC4A1AP GPN1 CCDC121 ZNF512 C2orf16 SUPT7L LOC105374378 GC02M027478
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around CCDC121 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the CCDC121 gene promoter:
  • E47
  • Meis-1a
  • Tal-1
  • AhR
  • Arnt
  • HOXA9

Genomic Locations for CCDC121 Gene

Genomic Locations for CCDC121 Gene
chr2:27,625,638-27,629,031
(GRCh38/hg38)
Size:
3,394 bases
Orientation:
Minus strand
chr2:27,848,506-27,851,898
(GRCh37/hg19)
Size:
3,393 bases
Orientation:
Minus strand

Genomic View for CCDC121 Gene

Genes around CCDC121 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CCDC121 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CCDC121 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CCDC121 Gene

Proteins for CCDC121 Gene

  • Protein details for CCDC121 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6ZUS5-CC121_HUMAN
    Recommended name:
    Coiled-coil domain-containing protein 121
    Protein Accession:
    Q6ZUS5
    Secondary Accessions:
    • B3KW66
    • J3KQZ8
    • Q9H8G6

    Protein attributes for CCDC121 Gene

    Size:
    278 amino acids
    Molecular mass:
    33061 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAX93200.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAB14651.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for CCDC121 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CCDC121 Gene

Post-translational modifications for CCDC121 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CCDC121 Gene

No data available for DME Specific Peptides for CCDC121 Gene

Domains & Families for CCDC121 Gene

Gene Families for CCDC121 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for CCDC121 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for CCDC121 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with CCDC121: view

No data available for UniProtKB/Swiss-Prot for CCDC121 Gene

Function for CCDC121 Gene

Phenotypes From GWAS Catalog for CCDC121 Gene

Gene Ontology (GO) - Molecular Function for CCDC121 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 21516116
genes like me logo Genes that share ontologies with CCDC121: view
genes like me logo Genes that share phenotypes with CCDC121: view

Animal Model Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CCDC121 Gene

Localization for CCDC121 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CCDC121 gene
Compartment Confidence
cytoskeleton 2
mitochondrion 2
nucleus 2
cytosol 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Actin filaments (2)
  • Cytosol (2)
See all subcellular structures

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for CCDC121 Gene

Pathways & Interactions for CCDC121 Gene

SuperPathways for CCDC121 Gene

No Data Available

Gene Ontology (GO) - Biological Process for CCDC121 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for CCDC121 Gene

Drugs & Compounds for CCDC121 Gene

No Compound Related Data Available

Transcripts for CCDC121 Gene

mRNA/cDNA for CCDC121 Gene

Unigene Clusters for CCDC121 Gene

Coiled-coil domain containing 121:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for CCDC121 Gene

ExUns: 1 ^ 2a · 2b ^ 3a · 3b · 3c
SP1: - -
SP2:
SP3:

Relevant External Links for CCDC121 Gene

GeneLoc Exon Structure for
CCDC121
ECgene alternative splicing isoforms for
CCDC121

Expression for CCDC121 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CCDC121 Gene

mRNA differential expression in normal tissues according to GTEx for CCDC121 Gene

This gene is overexpressed in Testis (x5.3).

Protein differential expression in normal tissues from HIPED for CCDC121 Gene

This gene is overexpressed in Serum (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for CCDC121 Gene



Protein tissue co-expression partners for CCDC121 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of CCDC121 Gene:

CCDC121

SOURCE GeneReport for Unigene cluster for CCDC121 Gene:

Hs.21081
genes like me logo Genes that share expression patterns with CCDC121: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for CCDC121 Gene

Orthologs for CCDC121 Gene

This gene was present in the common ancestor of mammals.

Orthologs for CCDC121 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CCDC121 34 33
  • 99.55 (n)
OneToOne
dog
(Canis familiaris)
Mammalia -- 34
  • 63 (a)
OneToMany
-- 34
  • 59 (a)
OneToMany
-- 34
  • 58 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Ccdc121 16 34 33
  • 62.27 (n)
Gm6583 34
  • 27 (a)
OneToMany
Gm6588 34
  • 26 (a)
OneToMany
4930548H24Rik 34
  • 26 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Ccdc121 33
  • 61.66 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia CCDC121 34
  • 35 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia CCDC121 34
  • 32 (a)
OneToOne
Species where no ortholog for CCDC121 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for CCDC121 Gene

ENSEMBL:
Gene Tree for CCDC121 (if available)
TreeFam:
Gene Tree for CCDC121 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for CCDC121: view image

Paralogs for CCDC121 Gene

Pseudogenes.org Pseudogenes for CCDC121 Gene

genes like me logo Genes that share paralogs with CCDC121: view

No data available for Paralogs for CCDC121 Gene

Variants for CCDC121 Gene

Sequence variations from dbSNP and Humsavar for CCDC121 Gene

SNP ID Clin Chr 02 pos Variation AA Info Type
rs1000493511 -- 27,627,509(-) T/C coding_sequence_variant, synonymous_variant
rs1000844195 -- 27,627,985(-) C/T intron_variant
rs1002890420 -- 27,629,610(-) G/C upstream_transcript_variant
rs1002983607 -- 27,629,316(-) G/A upstream_transcript_variant
rs1003053872 -- 27,630,064(-) G/A upstream_transcript_variant

Variation tolerance for CCDC121 Gene

Residual Variation Intolerance Score: 58.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.67; 31.98% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CCDC121 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CCDC121

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for CCDC121 Gene

Disorders for CCDC121 Gene

Additional Disease Information for CCDC121

No disorders were found for CCDC121 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CCDC121 Gene

Publications for CCDC121 Gene

  1. A bivariate genome-wide approach to metabolic syndrome: STAMPEED consortium. (PMID: 21386085) Kraja AT … Borecki IB (Diabetes 2011) 3 44 58
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  3. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin EL … Gygi SP (Cell 2015) 3 58
  5. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T … Vidal M (Cell 2014) 3 58

Products for CCDC121 Gene

Sources for CCDC121 Gene

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