Aliases for CCDC116 Gene

Aliases for CCDC116 Gene

  • Coiled-Coil Domain Containing 116 2 3 5
  • Coiled-Coil Domain-Containing Protein 116 3 4

External Ids for CCDC116 Gene

Previous GeneCards Identifiers for CCDC116 Gene

  • GC22P020317
  • GC22P021987
  • GC22P004944
  • GC22P021736
  • GC22P021815
  • GC22P022118
  • GC22P022165
  • GC22P021831
  • GC22P021860
  • GC22P021876
  • GC22P021914
  • GC22P021952
  • GC22P021984
  • GC22P022031
  • GC22P022073

Summaries for CCDC116 Gene

GeneCards Summary for CCDC116 Gene

CCDC116 (Coiled-Coil Domain Containing 116) is a Protein Coding gene.

Additional gene information for CCDC116 Gene

No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for CCDC116 Gene

Genomics for CCDC116 Gene

GeneHancer (GH) Regulatory Elements for CCDC116 Gene

Promoters and enhancers for CCDC116 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around CCDC116 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the CCDC116 gene promoter:
  • aMEF-2
  • AML1a
  • Brachyury
  • CREB
  • deltaCREB
  • E47
  • GATA-1
  • MEF-2A
  • Pax-5
  • YY1

Genomic Locations for CCDC116 Gene

Genomic Locations for CCDC116 Gene
chr22:21,632,147-21,637,329
(GRCh38/hg38)
Size:
5,183 bases
Orientation:
Plus strand
chr22:21,987,005-21,991,616
(GRCh37/hg19)
Size:
4,612 bases
Orientation:
Plus strand

Genomic View for CCDC116 Gene

Genes around CCDC116 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CCDC116 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CCDC116 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CCDC116 Gene

Proteins for CCDC116 Gene

  • Protein details for CCDC116 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8IYX3-CC116_HUMAN
    Recommended name:
    Coiled-coil domain-containing protein 116
    Protein Accession:
    Q8IYX3
    Secondary Accessions:
    • B7Z7H5
    • Q8N9Y9

    Protein attributes for CCDC116 Gene

    Size:
    613 amino acids
    Molecular mass:
    67946 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for CCDC116 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CCDC116 Gene

Post-translational modifications for CCDC116 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CCDC116 Gene

No data available for DME Specific Peptides for CCDC116 Gene

Domains & Families for CCDC116 Gene

Gene Families for CCDC116 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for CCDC116 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for CCDC116 Gene

GenScript: Design optimal peptide antigens:
  • Coiled-coil domain-containing protein 116 (CC116_HUMAN)
genes like me logo Genes that share domains with CCDC116: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for CCDC116 Gene

Function for CCDC116 Gene

Phenotypes From GWAS Catalog for CCDC116 Gene

Gene Ontology (GO) - Molecular Function for CCDC116 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 16189514
genes like me logo Genes that share ontologies with CCDC116: view
genes like me logo Genes that share phenotypes with CCDC116: view

Animal Models for CCDC116 Gene

MGI Knock Outs for CCDC116:

Animal Model Products

CRISPR Products

miRNA for CCDC116 Gene

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CCDC116 Gene

Localization for CCDC116 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CCDC116 Gene

Cytoplasm, cytoskeleton, microtubule organizing center, centrosome.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CCDC116 gene
Compartment Confidence
cytoskeleton 5
nucleus 3
cytosol 1

Gene Ontology (GO) - Cellular Components for CCDC116 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005813 centrosome IBA,IDA 25074808
GO:0005815 microtubule organizing center IEA --
GO:0005856 cytoskeleton IEA --
genes like me logo Genes that share ontologies with CCDC116: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for CCDC116 Gene

Pathways & Interactions for CCDC116 Gene

PathCards logo

SuperPathways for CCDC116 Gene

No Data Available

Gene Ontology (GO) - Biological Process for CCDC116 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for CCDC116 Gene

Drugs & Compounds for CCDC116 Gene

No Compound Related Data Available

Transcripts for CCDC116 Gene

mRNA/cDNA for CCDC116 Gene

(2) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(15) Selected AceView cDNA sequences:
(3) Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for CCDC116 Gene

ExUns: 1a · 1b ^ 2a · 2b · 2c ^ 3a · 3b ^ 4 ^ 5
SP1: - -
SP2: -
SP3:

Relevant External Links for CCDC116 Gene

GeneLoc Exon Structure for
CCDC116
ECgene alternative splicing isoforms for
CCDC116

Expression for CCDC116 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CCDC116 Gene

mRNA differential expression in normal tissues according to GTEx for CCDC116 Gene

This gene is overexpressed in Testis (x26.2).

Protein differential expression in normal tissues from HIPED for CCDC116 Gene

This gene is overexpressed in Cervix (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for CCDC116 Gene



Protein tissue co-expression partners for CCDC116 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of CCDC116 Gene:

CCDC116

SOURCE GeneReport for Unigene cluster for CCDC116 Gene:

Hs.131615

Evidence on tissue expression from TISSUES for CCDC116 Gene

  • Nervous system(4)
genes like me logo Genes that share expression patterns with CCDC116: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for CCDC116 Gene

Orthologs for CCDC116 Gene

This gene was present in the common ancestor of mammals.

Orthologs for CCDC116 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CCDC116 33 32
  • 98.87 (n)
OneToOne
dog
(Canis familiaris)
Mammalia CCDC116 33 32
  • 76.35 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Ccdc116 17 33 32
  • 74.9 (n)
rat
(Rattus norvegicus)
Mammalia Ccdc116 32
  • 74.49 (n)
cow
(Bos Taurus)
Mammalia CCDC116 33 32
  • 73.86 (n)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia CCDC116 33
  • 25 (a)
OneToOne
Species where no ortholog for CCDC116 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for CCDC116 Gene

ENSEMBL:
Gene Tree for CCDC116 (if available)
TreeFam:
Gene Tree for CCDC116 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for CCDC116: view image

Paralogs for CCDC116 Gene

(1) SIMAP similar genes for CCDC116 Gene using alignment to 2 proteins:

  • CC116_HUMAN
  • C9JW89_HUMAN
genes like me logo Genes that share paralogs with CCDC116: view

No data available for Paralogs for CCDC116 Gene

Variants for CCDC116 Gene

Sequence variations from dbSNP and Humsavar for CCDC116 Gene

SNP ID Clin Chr 22 pos Variation AA Info Type
rs1000521787 -- 21,637,225(+) C/T 3_prime_UTR_variant, genic_downstream_transcript_variant
rs1000611225 -- 21,631,204(+) G/A upstream_transcript_variant
rs1000993326 -- 21,632,244(+) C/T 5_prime_UTR_variant, genic_upstream_transcript_variant, upstream_transcript_variant
rs1001272449 -- 21,630,630(+) G/A upstream_transcript_variant
rs1001329710 -- 21,630,945(+) G/A upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for CCDC116 Gene

Variant ID Type Subtype PubMed ID
nsv1160730 CNV deletion 26073780
nsv516806 CNV loss 19592680
nsv7350 OTHER inversion 18451855

Variation tolerance for CCDC116 Gene

Residual Variation Intolerance Score: 98.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 10.25; 90.56% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CCDC116 Gene

Human Gene Mutation Database (HGMD)
CCDC116
SNPedia medical, phenotypic, and genealogical associations of SNPs for
CCDC116

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CCDC116 Gene

Disorders for CCDC116 Gene

Additional Disease Information for CCDC116

No disorders were found for CCDC116 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CCDC116 Gene

Publications for CCDC116 Gene

  1. Proteomic analysis of mammalian sperm cells identifies new components of the centrosome. (PMID: 25074808) Firat-Karalar EN … Stearns T (Journal of cell science 2014) 2 3 4 56
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 56
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 56
  4. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 56
  5. A cis-eQTL genetic variant of the cancer-testis gene CCDC116 is associated with risk of multiple cancers. (PMID: 28653172) Qin N … Hu Z (Human genetics 2017) 3 56

Products for CCDC116 Gene

Sources for CCDC116 Gene