Aliases for CCDC110 Gene

Aliases for CCDC110 Gene

  • Coiled-Coil Domain Containing 110 2 3 5
  • Cancer/Testis Antigen 52 2 3 4
  • CT52 2 3 4
  • Coiled-Coil Domain-Containing Protein 110 3 4
  • Cancer/Testis Antigen KM-HN-1 3 4
  • KM-HN-1 2 3
  • KMHN1 3 4
  • MGC33607 2
  • CCDC110 5

External Ids for CCDC110 Gene

Previous GeneCards Identifiers for CCDC110 Gene

  • GC04M186604
  • GC04M186366
  • GC04M182120

Summaries for CCDC110 Gene

GeneCards Summary for CCDC110 Gene

CCDC110 (Coiled-Coil Domain Containing 110) is a Protein Coding gene. Diseases associated with CCDC110 include Leukorrhea.

Additional gene information for CCDC110 Gene

No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for CCDC110 Gene

Genomics for CCDC110 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for CCDC110 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH04J185470 Promoter/Enhancer 1.9 EPDnew Ensembl ENCODE CraniofacialAtlas 616.7 +0.5 451 2.2 RNF2 CTCF PRDM10 KDM1A BACH1 LARP7 PRDM1 ZNF143 ZIC2 RBFOX2 CCDC110 ENSG00000249679 LOC105377590 UFSP2 lnc-C4orf47-1
GH04J185469 Enhancer 0.2 Ensembl 600.7 +2.0 1951 0.4 CCDC110 ENSG00000249679 LOC105377590 lnc-C4orf47-1 UFSP2
GH04J185507 Enhancer 0.9 Ensembl dbSUPER 21.4 -36.6 -36649 0.8 GATAD2A PRDM10 ZNF629 SP1 CEBPA ZBTB44 TCF7L2 ESR1 CEBPB ZBTB17 ENSG00000249679 CCDC110 PDLIM3 piR-39904-017 lnc-SORBS2-3
GH04J185902 Enhancer 0.8 FANTOM5 Ensembl 14.4 -431.1 -431091 0.3 CREB1 ATF7 PRDM10 ZNF629 ZNF600 ZNF561 ZSCAN5C ATF2 ZNF335 RXRA ENSG00000235149 LOC101928929 CCDC110 SORBS2 lnc-PDLIM3-6 PDLIM3
GH04J185086 Enhancer 0.5 FANTOM5 21.6 +385.3 385343 0.3 REST MGA EHMT2 ZBTB33 L3MBTL2 ZNF143 LOC105377588 LRP2BP CCDC110 HELT CASP3 PRIMPOL KY994054-048 LINC02436 SLC25A4
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around CCDC110 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for CCDC110

Top Transcription factor binding sites by QIAGEN in the CCDC110 gene promoter:
  • aMEF-2
  • AML1a
  • FAC1
  • GATA-1
  • Gfi-1
  • MEF-2A
  • RSRFC4
  • Sox9

Genomic Locations for CCDC110 Gene

Genomic Locations for CCDC110 Gene
chr4:185,445,182-185,471,752
(GRCh38/hg38)
Size:
26,571 bases
Orientation:
Minus strand
chr4:186,366,336-186,392,913
(GRCh37/hg19)
Size:
26,578 bases
Orientation:
Minus strand

Genomic View for CCDC110 Gene

Genes around CCDC110 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CCDC110 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CCDC110 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CCDC110 Gene

Proteins for CCDC110 Gene

  • Protein details for CCDC110 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8TBZ0-CC110_HUMAN
    Recommended name:
    Coiled-coil domain-containing protein 110
    Protein Accession:
    Q8TBZ0
    Secondary Accessions:
    • Q86YI9
    • Q8N7W0

    Protein attributes for CCDC110 Gene

    Size:
    833 amino acids
    Molecular mass:
    96726 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for CCDC110 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CCDC110 Gene

Post-translational modifications for CCDC110 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for CCDC110 Gene

Domains & Families for CCDC110 Gene

Gene Families for CCDC110 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for CCDC110 Gene

ProtoNet:

Suggested Antigen Peptide Sequences for CCDC110 Gene

GenScript: Design optimal peptide antigens:
  • Cancer/testis antigen KM-HN-1 (CC110_HUMAN)
  • KM-HN-1 protein, isoform CRA_a (D3DP61_HUMAN)
genes like me logo Genes that share domains with CCDC110: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for CCDC110 Gene

Function for CCDC110 Gene

Phenotypes From GWAS Catalog for CCDC110 Gene

Gene Ontology (GO) - Molecular Function for CCDC110 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with CCDC110: view
genes like me logo Genes that share phenotypes with CCDC110: view

Animal Model Products

CRISPR Products

miRNA for CCDC110 Gene

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CCDC110

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CCDC110 Gene

Localization for CCDC110 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CCDC110 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CCDC110 gene
Compartment Confidence
nucleus 4
cytosol 2
golgi apparatus 2
plasma membrane 1
cytoskeleton 1

Gene Ontology (GO) - Cellular Components for CCDC110 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005856 cytoskeleton IBA 21873635
genes like me logo Genes that share ontologies with CCDC110: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for CCDC110 Gene

Pathways & Interactions for CCDC110 Gene

PathCards logo

SuperPathways for CCDC110 Gene

No Data Available

Interacting Proteins for CCDC110 Gene

Gene Ontology (GO) - Biological Process for CCDC110 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for CCDC110 Gene

Drugs & Compounds for CCDC110 Gene

No Compound Related Data Available

Transcripts for CCDC110 Gene

mRNA/cDNA for CCDC110 Gene

2 REFSEQ mRNAs :
10 NCBI additional mRNA sequence :
10 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CCDC110

Alternative Splicing Database (ASD) splice patterns (SP) for CCDC110 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8 ^ 9a · 9b
SP1: -
SP2: - -
SP3:
SP4: - -
SP5:
SP6: -
SP7: -

Relevant External Links for CCDC110 Gene

GeneLoc Exon Structure for
CCDC110

Expression for CCDC110 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for CCDC110 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

  • Lung (Respiratory System)
  • Testis (Reproductive System)

mRNA differential expression in normal tissues according to GTEx for CCDC110 Gene

This gene is overexpressed in Testis (x26.5) and Pancreas (x4.6).

Protein differential expression in normal tissues from HIPED for CCDC110 Gene

This gene is overexpressed in Bone marrow mesenchymal stem cell (40.4), Synovial fluid (16.4), and Pancreatic juice (7.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for CCDC110 Gene



Transcriptomic regulation report from SPP (The Signaling Pathways Project) for CCDC110

SOURCE GeneReport for Unigene cluster for CCDC110 Gene:

Hs.41101

mRNA Expression by UniProt/SwissProt for CCDC110 Gene:

Q8TBZ0-CC110_HUMAN
Tissue specificity: Expressed specifically in testis. Also expressed in tumors of different origins.
genes like me logo Genes that share expression patterns with CCDC110: view

No data available for Protein tissue co-expression partners , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for CCDC110 Gene

Orthologs for CCDC110 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CCDC110 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia CCDC110 30 31
  • 99.07 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia CCDC110 30 31
  • 88.63 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia CCDC110 30 31
  • 87.05 (n)
OneToOne
Mouse
(Mus musculus)
Mammalia Ccdc110 30 17 31
  • 75.04 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Ccdc110 30
  • 74.79 (n)
Oppossum
(Monodelphis domestica)
Mammalia CCDC110 31
  • 44 (a)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia CCDC110 31
  • 39 (a)
OneToOne
Chicken
(Gallus gallus)
Aves CCDC110 30
  • 56.15 (n)
Lizard
(Anolis carolinensis)
Reptilia CCDC110 31
  • 26 (a)
OneToOne
Species where no ortholog for CCDC110 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for CCDC110 Gene

ENSEMBL:
Gene Tree for CCDC110 (if available)
TreeFam:
Gene Tree for CCDC110 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for CCDC110: view image

Paralogs for CCDC110 Gene

(1) SIMAP similar genes for CCDC110 Gene using alignment to 6 proteins:

  • CC110_HUMAN
  • D6RB18_HUMAN
  • D6RCR3_HUMAN
  • D6RDN4_HUMAN
  • E7EUS2_HUMAN
  • H0Y9S3_HUMAN
genes like me logo Genes that share paralogs with CCDC110: view

No data available for Paralogs for CCDC110 Gene

Variants for CCDC110 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for CCDC110 Gene

SNP ID Clinical significance and condition Chr 04 pos Variation AA Info Type
rs11132306 - p.Ser409Phe
rs34800518 - p.Leu819Met
rs35596415 - p.Ile614Met
rs59319722 - p.Tyr500Asp
rs6827370 - p.Gln669Arg

Additional dbSNP identifiers (rs#s) for CCDC110 Gene

Structural Variations from Database of Genomic Variants (DGV) for CCDC110 Gene

Variant ID Type Subtype PubMed ID
dgv5493n100 CNV gain 25217958
esv2575908 CNV insertion 19546169
esv2759309 CNV loss 17122850
esv3303368 CNV mobile element insertion 20981092
esv3308387 CNV mobile element insertion 20981092
esv3373962 CNV insertion 20981092
esv3603492 CNV gain 21293372
esv3603496 CNV gain 21293372
esv3603497 CNV gain 21293372
esv3894088 CNV gain 25118596
nsv1029738 CNV gain 25217958
nsv1033523 CNV gain 25217958
nsv1139342 CNV deletion 24896259
nsv1141996 OTHER inversion 24896259
nsv428456 CNV gain+loss 18775914
nsv4638 CNV insertion 18451855
nsv517035 CNV gain+loss 19592680
nsv527026 CNV gain 19592680
nsv596373 CNV gain 21841781

Variation tolerance for CCDC110 Gene

Residual Variation Intolerance Score: 97.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 9.16; 87.88% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CCDC110 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CCDC110

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CCDC110 Gene

Disorders for CCDC110 Gene

MalaCards: The human disease database

(1) MalaCards diseases for CCDC110 Gene - From: DISEASES

Disorder Aliases PubMed IDs
leukorrhea
  • discharge - leukorrhea
- elite association - COSMIC cancer census association via MalaCards
genes like me logo Genes that share disorders with CCDC110: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CCDC110 Gene

Publications for CCDC110 Gene

  1. The centrosomal localization of KM-HN-1 (MGC33607) depends on the leucine zipper motif and the C-terminal coiled-coil domain. (PMID: 18160854) Park HJ … Seong YS (Experimental & molecular medicine 2007) 2 3
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4
  4. Identification of a novel human cancer/testis antigen, KM-HN-1, recognized by cellular and humoral immune responses. (PMID: 15447989) Monji M … Nishimura Y (Clinical cancer research : an official journal of the American Association for Cancer Research 2004) 3 4
  5. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3

Products for CCDC110 Gene

  • Biorbyt antibodies for CCDC110

Sources for CCDC110 Gene