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Aliases for CCDC107 Gene

Aliases for CCDC107 Gene

  • Coiled-Coil Domain Containing 107 2 3 5
  • Coiled-Coil Domain-Containing Protein 107 3
  • PSEC0222 3

External Ids for CCDC107 Gene

Previous GeneCards Identifiers for CCDC107 Gene

  • GC09P035649
  • GC09P035613

Summaries for CCDC107 Gene

Entrez Gene Summary for CCDC107 Gene

  • This gene encodes a membrane protein which contains a coiled-coil domain in the central region. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2013]

GeneCards Summary for CCDC107 Gene

CCDC107 (Coiled-Coil Domain Containing 107) is a Protein Coding gene.

Additional gene information for CCDC107 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CCDC107 Gene

Genomics for CCDC107 Gene

GeneHancer (GH) Regulatory Elements for CCDC107 Gene

Promoters and enhancers for CCDC107 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH09I035656 Promoter/Enhancer 2.5 EPDnew Ensembl ENCODE dbSUPER 557.1 +2.7 2683 9.9 CLOCK MLX ZFP64 FEZF1 DMAP1 IRF4 YY1 SLC30A9 ZNF213 E2F8 ARHGEF39 CCDC107 NPR2 RGP1 PIGO RECK VCP ENSG00000230074 UNC13B CA9
GH09I035679 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 18.6 +27.8 27835 12.8 PKNOX1 ARID4B SIN3A POLR2B GLIS2 FOS SP3 REST SMARCB1 MIER3 TPM2 GBA2 TMEM8B TLN1 NPR2 CCDC107 SIT1 CREB3 RGP1 MSMP
GH09I035726 Promoter/Enhancer 2.5 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 11.6 +72.1 72133 8.6 YBX1 DMAP1 IRF4 YY1 SLC30A9 E2F8 ZNF143 SP3 NFYC MEF2D TLN1 CREB3 TMEM8B GBA2 ARHGEF39 TPM2 HMGB3P24 PIGO RN7SL22P ENSG00000228843
GH09I035602 Promoter/Enhancer 2.4 EPDnew FANTOM5 Ensembl ENCODE 11.2 -53.6 -53645 3.6 HDGF PKNOX1 MLX ARID4B SIN3A FEZF1 DMAP1 YY1 E2F8 ZNF143 GC09M035603 TESK1 CD72 ENSG00000231393 LOC101926948 CCDC107 RN7SL22P ARHGEF39 VCP RUSC2
GH09I035616 Promoter/Enhancer 2 EPDnew Ensembl ENCODE dbSUPER 12.2 -39.0 -39028 6.4 HDGF PKNOX1 ATF1 SMAD1 RB1 SIN3A BATF RFX5 ETS1 SCRT2 CD72 CCDC107 RN7SL22P ARHGEF39 SIT1 CA9 FAM166B TLN1 CREB3 GBA2
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around CCDC107 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the CCDC107 gene promoter:

Genomic Locations for CCDC107 Gene

Genomic Locations for CCDC107 Gene
chr9:35,658,282-35,661,511
(GRCh38/hg38)
Size:
3,230 bases
Orientation:
Plus strand
chr9:35,658,287-35,661,508
(GRCh37/hg19)

Genomic View for CCDC107 Gene

Genes around CCDC107 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CCDC107 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CCDC107 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CCDC107 Gene

Proteins for CCDC107 Gene

  • Protein details for CCDC107 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8WV48-CC107_HUMAN
    Recommended name:
    Coiled-coil domain-containing protein 107
    Protein Accession:
    Q8WV48
    Secondary Accessions:
    • A6XND6
    • Q5T4R5
    • Q5T4R8
    • Q5T4R9
    • Q86VB6
    • Q8N2E4

    Protein attributes for CCDC107 Gene

    Size:
    283 amino acids
    Molecular mass:
    30509 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=CAI13448.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Alternative splice isoforms for CCDC107 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CCDC107 Gene

Post-translational modifications for CCDC107 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for CCDC107 Gene

Domains & Families for CCDC107 Gene

Gene Families for CCDC107 Gene

Human Protein Atlas (HPA):
  • Predicted membrane proteins

Protein Domains for CCDC107 Gene

ProtoNet:

Suggested Antigen Peptide Sequences for CCDC107 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with CCDC107: view

No data available for UniProtKB/Swiss-Prot for CCDC107 Gene

Function for CCDC107 Gene

Phenotypes From GWAS Catalog for CCDC107 Gene

genes like me logo Genes that share phenotypes with CCDC107: view

Animal Model Products

miRNA for CCDC107 Gene

miRTarBase miRNAs that target CCDC107

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CCDC107 Gene

Localization for CCDC107 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CCDC107 Gene

Membrane; Single-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CCDC107 gene
Compartment Confidence
plasma membrane 2
nucleus 2
cytosol 2
extracellular 1
endoplasmic reticulum 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoplasm (4)
  • Plasma membrane (4)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for CCDC107 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with CCDC107: view

Pathways & Interactions for CCDC107 Gene

SuperPathways for CCDC107 Gene

No Data Available

Interacting Proteins for CCDC107 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://version10.5.string-db.org/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000414964%0d%0a9606.ENSP00000250416%0d%0a
Selected Interacting proteins: Q8WV48-CC107_HUMAN ENSP00000414964 for CCDC107 Gene via IID STRING MINT

Gene Ontology (GO) - Biological Process for CCDC107 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for CCDC107 Gene

Drugs & Compounds for CCDC107 Gene

No Compound Related Data Available

Transcripts for CCDC107 Gene

Unigene Clusters for CCDC107 Gene

Coiled-coil domain containing 107:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for CCDC107 Gene

No ASD Table

Relevant External Links for CCDC107 Gene

GeneLoc Exon Structure for
CCDC107
ECgene alternative splicing isoforms for
CCDC107

Expression for CCDC107 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CCDC107 Gene

Protein differential expression in normal tissues from HIPED for CCDC107 Gene

This gene is overexpressed in Heart (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for CCDC107 Gene



Protein tissue co-expression partners for CCDC107 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of CCDC107 Gene:

CCDC107

SOURCE GeneReport for Unigene cluster for CCDC107 Gene:

Hs.745107

Evidence on tissue expression from TISSUES for CCDC107 Gene

  • Pancreas(4.2)
genes like me logo Genes that share expression patterns with CCDC107: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for CCDC107 Gene

Orthologs for CCDC107 Gene

This gene was present in the common ancestor of mammals.

Orthologs for CCDC107 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CCDC107 33 34
  • 98.7 (n)
dog
(Canis familiaris)
Mammalia CCDC107 33 34
  • 85.19 (n)
cow
(Bos Taurus)
Mammalia CCDC107 33 34
  • 81.7 (n)
rat
(Rattus norvegicus)
Mammalia Ccdc107 33
  • 76.98 (n)
mouse
(Mus musculus)
Mammalia Ccdc107 33 16 34
  • 76.68 (n)
Species where no ortholog for CCDC107 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for CCDC107 Gene

ENSEMBL:
Gene Tree for CCDC107 (if available)
TreeFam:
Gene Tree for CCDC107 (if available)

Paralogs for CCDC107 Gene

Pseudogenes.org Pseudogenes for CCDC107 Gene

genes like me logo Genes that share paralogs with CCDC107: view

No data available for Paralogs for CCDC107 Gene

Variants for CCDC107 Gene

Sequence variations from dbSNP and Humsavar for CCDC107 Gene

SNP ID Clin Chr 09 pos Variation AA Info Type
rs1004469515 uncertain-significance, Anauxetic dysplasia 35,657,838(+) C/G/T upstream_transcript_variant
rs193117694 likely-benign, Anauxetic dysplasia 35,657,965(+) G/A upstream_transcript_variant
rs199476103 pathogenic, Metaphyseal chondrodysplasia, McKusick type, Metaphyseal dysplasia without hypotrichosis, not provided, Anauxetic dysplasia 35,657,948(+) T/C upstream_transcript_variant
rs387906533 pathogenic, Anauxetic dysplasia 1 35,657,927(+) CT/GC upstream_transcript_variant
rs530883024 uncertain-significance, Anauxetic dysplasia 35,657,953(+) T/C upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for CCDC107 Gene

Variant ID Type Subtype PubMed ID
nsv1125318 OTHER inversion 24896259

Variation tolerance for CCDC107 Gene

Residual Variation Intolerance Score: 84.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.44; 71.41% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CCDC107 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CCDC107

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CCDC107 Gene

Disorders for CCDC107 Gene

Additional Disease Information for CCDC107

No disorders were found for CCDC107 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CCDC107 Gene

Publications for CCDC107 Gene

  1. DNA sequence and analysis of human chromosome 9. (PMID: 15164053) Humphray SJ … Dunham I (Nature 2004) 3 4 58
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 2 3 58
  4. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
  5. Interactions of pathological hallmark proteins: tubulin polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PMID: 21832049) Oláh J … Ovádi J (The Journal of biological chemistry 2011) 3 58

Products for CCDC107 Gene

Sources for CCDC107 Gene

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