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Aliases for CCDC106 Gene

Aliases for CCDC106 Gene

  • Coiled-Coil Domain Containing 106 2 3 5
  • Coiled-Coil Domain-Containing Protein 106 3
  • Protein Predicted By Clone 23882 3
  • HSU79303 3
  • ZNF581 3

External Ids for CCDC106 Gene

Previous GeneCards Identifiers for CCDC106 Gene

  • GC19P060850
  • GC19P056158
  • GC19P052471

Summaries for CCDC106 Gene

GeneCards Summary for CCDC106 Gene

CCDC106 (Coiled-Coil Domain Containing 106) is a Protein Coding gene.

UniProtKB/Swiss-Prot for CCDC106 Gene

  • Promotes the degradation of p53/TP53 protein and inhibits its transactivity.

Additional gene information for CCDC106 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CCDC106 Gene

Genomics for CCDC106 Gene

GeneHancer (GH) Regulatory Elements for CCDC106 Gene

Promoters and enhancers for CCDC106 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH19I055639 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE 550.8 +1.3 1299 6.5 HDGF PKNOX1 SMAD1 ARNT ARID4B SIN3A DMAP1 ZNF2 IRF4 YY1 ZNF580 ZNF581 CCDC106 U2AF2 ENSG00000267523 ENSG00000267096 ZNF628 ZNF582 KMT5C FIZ1
GH19I055647 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 550.4 +7.4 7419 2.9 HDGF ARID4B SIN3A DMAP1 YY1 ZNF207 ZNF143 SP3 SP5 JUNB PIR41897 CCDC106 ZNF580
GH19I056594 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 13.5 +954.4 954378 1.4 HDGF PKNOX1 ZNF133 ARID4B SIN3A FEZF1 YBX1 GLI4 ZNF48 YY1 ZNF71 U2AF2 ZNF17 ZNF543 ZNF549 ZNF264 ZNF773 ENSG00000269696 ZNF550 ZFP28
GH19I055503 Enhancer 1.2 Ensembl ENCODE 13.6 -137.1 -137093 1.6 PKNOX1 CLOCK ARNT ARID4B SIN3A DMAP1 ZNF2 CBX5 ZNF213 E2F8 U2AF2 FIZ1 ZNF667 ZNF582 ZNF582-AS1 NAT14 ZNF667-AS1 ZNF542P ZNF580 ZNF583
GH19I055519 Enhancer 1.4 FANTOM5 Ensembl ENCODE 11.4 -120.9 -120853 1 HDGF ATF1 ZNF493 ZNF133 YBX1 GLI4 ZNF416 ZNF548 FOS ATF7 U2AF2 ZNF471 FIZ1 ZNF582 ZNF581 ZNF580 SSC5D ENSG00000267523 NAT14 ZNF667
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around CCDC106 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the CCDC106 gene promoter:

Genomic Locations for CCDC106 Gene

Genomic Locations for CCDC106 Gene
chr19:55,641,062-55,653,161
(GRCh38/hg38)
Size:
12,100 bases
Orientation:
Plus strand
chr19:56,152,428-56,164,527
(GRCh37/hg19)

Genomic View for CCDC106 Gene

Genes around CCDC106 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CCDC106 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CCDC106 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CCDC106 Gene

Proteins for CCDC106 Gene

  • Protein details for CCDC106 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BWC9-CC106_HUMAN
    Recommended name:
    Coiled-coil domain-containing protein 106
    Protein Accession:
    Q9BWC9
    Secondary Accessions:
    • B3KUF9
    • D3K183
    • Q99786

    Protein attributes for CCDC106 Gene

    Size:
    280 amino acids
    Molecular mass:
    32032 Da
    Quaternary structure:
    • Interacts with p53/TP53.
    SequenceCaution:
    • Sequence=AAB50227.1; Type=Erroneous termination; Positions=154; Note=Translated as Gln.; Evidence={ECO:0000305};

neXtProt entry for CCDC106 Gene

Post-translational modifications for CCDC106 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for CCDC106 Gene

Domains & Families for CCDC106 Gene

Gene Families for CCDC106 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for CCDC106 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for CCDC106 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with CCDC106: view

No data available for UniProtKB/Swiss-Prot for CCDC106 Gene

Function for CCDC106 Gene

Molecular function for CCDC106 Gene

UniProtKB/Swiss-Prot Function:
Promotes the degradation of p53/TP53 protein and inhibits its transactivity.

Phenotypes From GWAS Catalog for CCDC106 Gene

Gene Ontology (GO) - Molecular Function for CCDC106 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 16169070
genes like me logo Genes that share ontologies with CCDC106: view
genes like me logo Genes that share phenotypes with CCDC106: view

Animal Model Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CCDC106 Gene

Localization for CCDC106 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CCDC106 Gene

Nucleus. Note=Colocalizes with p53/TP53.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CCDC106 gene
Compartment Confidence
nucleus 5
cytosol 5

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleus (3)
  • Cytosol (1)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for CCDC106 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA --
GO:0005829 cytosol IDA --
genes like me logo Genes that share ontologies with CCDC106: view

Pathways & Interactions for CCDC106 Gene

SuperPathways for CCDC106 Gene

No Data Available

Gene Ontology (GO) - Biological Process for CCDC106 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for CCDC106 Gene

Drugs & Compounds for CCDC106 Gene

No Compound Related Data Available

Transcripts for CCDC106 Gene

Unigene Clusters for CCDC106 Gene

Coiled-coil domain containing 106:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for CCDC106 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b · 2c · 2d · 2e · 2f ^ 3a · 3b ^ 4a · 4b ^ 5a · 5b · 5c ^ 6
SP1: - - - - -
SP2: - - - -
SP3:
SP4: - - - - -
SP5: - -
SP6:
SP7: - -
SP8: -

Relevant External Links for CCDC106 Gene

GeneLoc Exon Structure for
CCDC106
ECgene alternative splicing isoforms for
CCDC106

Expression for CCDC106 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CCDC106 Gene

Protein differential expression in normal tissues from HIPED for CCDC106 Gene

This gene is overexpressed in Plasma (67.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for CCDC106 Gene



Protein tissue co-expression partners for CCDC106 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of CCDC106 Gene:

CCDC106

SOURCE GeneReport for Unigene cluster for CCDC106 Gene:

Hs.82482

Evidence on tissue expression from TISSUES for CCDC106 Gene

  • Nervous system(4.6)
  • Muscle(4.2)
  • Spleen(4.2)
genes like me logo Genes that share expression patterns with CCDC106: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for CCDC106 Gene

Orthologs for CCDC106 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CCDC106 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CCDC106 33 34
  • 99.52 (n)
dog
(Canis familiaris)
Mammalia CCDC106 33 34
  • 89.05 (n)
oppossum
(Monodelphis domestica)
Mammalia CCDC106 34
  • 89 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ccdc106 33 16 34
  • 87.57 (n)
cow
(Bos Taurus)
Mammalia CCDC106 33 34
  • 87.41 (n)
rat
(Rattus norvegicus)
Mammalia Ccdc106 33
  • 87.26 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia CCDC106 34
  • 62 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CCDC106 34
  • 59 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ccdc106 33
  • 63.67 (n)
zebrafish
(Danio rerio)
Actinopterygii ccdc106a 33 34
  • 63.73 (n)
ccdc106b 34
  • 38 (a)
OneToMany
CCDC106 (2 of 3) 34
  • 36 (a)
OneToMany
Species where no ortholog for CCDC106 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CCDC106 Gene

ENSEMBL:
Gene Tree for CCDC106 (if available)
TreeFam:
Gene Tree for CCDC106 (if available)

Paralogs for CCDC106 Gene

No data available for Paralogs for CCDC106 Gene

Variants for CCDC106 Gene

Sequence variations from dbSNP and Humsavar for CCDC106 Gene

SNP ID Clin Chr 19 pos Variation AA Info Type
rs1000012144 -- 55,653,544(+) A/G/T downstream_transcript_variant
rs1000130663 -- 55,652,138(+) GTCGGGGGGT/GT intron_variant
rs1001037145 -- 55,652,939(+) G/C 3_prime_UTR_variant
rs1001193099 -- 55,651,861(+) A/G intron_variant
rs1001434632 -- 55,647,129(+) T/C upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for CCDC106 Gene

Variant ID Type Subtype PubMed ID
nsv2553 CNV insertion 18451855
nsv833882 CNV loss 17160897
nsv953625 CNV deletion 24416366

Variation tolerance for CCDC106 Gene

Residual Variation Intolerance Score: 41.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 8.39; 85.50% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CCDC106 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CCDC106

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CCDC106 Gene

Disorders for CCDC106 Gene

Additional Disease Information for CCDC106

No disorders were found for CCDC106 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CCDC106 Gene

Publications for CCDC106 Gene

  1. Large-scale concatenation cDNA sequencing. (PMID: 9110174) Yu W … Gibbs RA (Genome research 1997) 2 3 4 58
  2. Identification and characterization of the novel protein CCDC106 that interacts with p53 and promotes its degradation. (PMID: 20159018) Zhou J … Zhang J (FEBS letters 2010) 3 4 58
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  5. A "double adaptor" method for improved shotgun library construction. (PMID: 8619474) Andersson B … Gibbs RA (Analytical biochemistry 1996) 2 3 58

Products for CCDC106 Gene

Sources for CCDC106 Gene

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