Aliases for CCDC105 Gene

Aliases for CCDC105 Gene

  • Coiled-Coil Domain Containing 105 2 3 5
  • Coiled-Coil Domain-Containing Protein 105 3 4

External Ids for CCDC105 Gene

Previous GeneCards Identifiers for CCDC105 Gene

  • GC19P014983
  • GC19P015121
  • GC19P014688

Summaries for CCDC105 Gene

GeneCards Summary for CCDC105 Gene

CCDC105 (Coiled-Coil Domain Containing 105) is a Protein Coding gene.

Additional gene information for CCDC105 Gene

No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for CCDC105 Gene

Genomics for CCDC105 Gene

GeneHancer (GH) Regulatory Elements for CCDC105 Gene

Promoters and enhancers for CCDC105 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH19J015011 Promoter/Enhancer 0.8 EPDnew ENCODE 500.7 0.0 -22 0.2 TEAD4 RFX1 PHF8 TAF1 EZH2 RBBP5 CCDC105 piR-43106-109 SLC1A6 lnc-OR7C2-1
GH19J015012 Enhancer 0.5 ENCODE 500.7 +0.3 318 0.2 PHF8 CTCF TAF1 POLR2A EZH2 RBBP5 CCDC105 SLC1A6 RF00017-2852 lnc-OR7C2-1
GH19J015010 Enhancer 0.3 ENCODE 500.7 -0.2 -247 0 EZH2 CCDC105 piR-43106-109 SLC1A6 lnc-OR7C2-1
GH19J015135 Enhancer 0.7 ENCODE 10.3 +125.4 125368 1.9 ZNF217 FOS RFX1 GATAD2B CTBP1 MBD2 NEUROD1 GATA3 IRF1 FOXA1 SYDE1 EPHX3 SLC1A6 CCDC105 OR7A10 OR7C1 ILVBL OR10B1P lnc-OR7C2-1
GH19J015137 Enhancer 0.5 Ensembl ENCODE 10.3 +127.7 127667 2.2 FOS CEBPB SYDE1 EPHX3 SLC1A6 CCDC105 OR7A10 OR7C1 ILVBL OR10B1P lnc-OR7C2-1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around CCDC105 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for CCDC105

Top Transcription factor binding sites by QIAGEN in the CCDC105 gene promoter:
  • c-Myc
  • Chx10
  • CUTL1
  • deltaCREB
  • E47
  • Ik-1
  • Max
  • NF-kappaB
  • NF-kappaB1
  • Tal-1

Genomic Locations for CCDC105 Gene

Genomic Locations for CCDC105 Gene
chr19:15,010,726-15,023,276
(GRCh38/hg38)
Size:
12,551 bases
Orientation:
Plus strand
chr19:15,121,539-15,134,083
(GRCh37/hg19)
Size:
12,545 bases
Orientation:
Plus strand

Genomic View for CCDC105 Gene

Genes around CCDC105 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CCDC105 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CCDC105 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CCDC105 Gene

Proteins for CCDC105 Gene

  • Protein details for CCDC105 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8IYK2-CC105_HUMAN
    Recommended name:
    Coiled-coil domain-containing protein 105
    Protein Accession:
    Q8IYK2
    Secondary Accessions:
    • Q8N7T5
    • Q8NDL5

    Protein attributes for CCDC105 Gene

    Size:
    499 amino acids
    Molecular mass:
    56909 Da
    Quaternary structure:
    No Data Available

neXtProt entry for CCDC105 Gene

Post-translational modifications for CCDC105 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CCDC105 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for CCDC105 Gene

Domains & Families for CCDC105 Gene

Gene Families for CCDC105 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for CCDC105 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for CCDC105 Gene

GenScript: Design optimal peptide antigens:
  • Coiled-coil domain-containing protein 105 (CC105_HUMAN)
genes like me logo Genes that share domains with CCDC105: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for CCDC105 Gene

Function for CCDC105 Gene

genes like me logo Genes that share phenotypes with CCDC105: view

Animal Model Products

CRISPR Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for CCDC105 Gene

Localization for CCDC105 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CCDC105 gene
Compartment Confidence
nucleus 2
cytosol 1

Gene Ontology (GO) - Cellular Components for CCDC105 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0070062 extracellular exosome HDA 19056867
genes like me logo Genes that share ontologies with CCDC105: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from the Human Protein Atlas (HPA) for CCDC105 Gene

Pathways & Interactions for CCDC105 Gene

PathCards logo

SuperPathways for CCDC105 Gene

No Data Available

Interacting Proteins for CCDC105 Gene

STRING Interaction Network Preview (showing top 2 STRING interactants - click image to see details)
STRING Interaction Network
Selected Interacting proteins: ENSP00000292574 Q8IYK2-CC105_HUMAN for CCDC105 Gene via STRING IID

;

Gene Ontology (GO) - Biological Process for CCDC105 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for CCDC105 Gene

Drugs & Compounds for CCDC105 Gene

No Compound Related Data Available

Transcripts for CCDC105 Gene

mRNA/cDNA for CCDC105 Gene

1 REFSEQ mRNAs :
3 NCBI additional mRNA sequence :
1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for CCDC105 Gene

No ASD Table

Relevant External Links for CCDC105 Gene

GeneLoc Exon Structure for
CCDC105

Expression for CCDC105 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for CCDC105 Gene

mRNA differential expression in normal tissues according to GTEx for CCDC105 Gene

This gene is overexpressed in Testis (x51.6).

Protein differential expression in normal tissues from HIPED for CCDC105 Gene

This gene is overexpressed in Stomach (36.0), Tlymphocyte (17.5), and Heart (10.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for CCDC105 Gene



Protein tissue co-expression partners for CCDC105 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for CCDC105

SOURCE GeneReport for Unigene cluster for CCDC105 Gene:

Hs.375985

Evidence on tissue expression from TISSUES for CCDC105 Gene

  • Nervous system(4.1)
genes like me logo Genes that share expression patterns with CCDC105: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for CCDC105 Gene

Orthologs for CCDC105 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CCDC105 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CCDC105 31 30
  • 96.25 (n)
OneToOne
dog
(Canis familiaris)
Mammalia CCDC105 31 30
  • 85.85 (n)
OneToOne
cow
(Bos Taurus)
Mammalia CCDC105 31 30
  • 85.72 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Ccdc105 17 31 30
  • 80.85 (n)
rat
(Rattus norvegicus)
Mammalia Ccdc105 30
  • 79.57 (n)
oppossum
(Monodelphis domestica)
Mammalia CCDC105 31
  • 52 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CCDC105 31
  • 40 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100487156 30
  • 42.63 (n)
zebrafish
(Danio rerio)
Actinopterygii LOC565570 30
  • 42.7 (n)
CCDC105 31
  • 26 (a)
OneToOne
Species where no ortholog for CCDC105 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CCDC105 Gene

ENSEMBL:
Gene Tree for CCDC105 (if available)
TreeFam:
Gene Tree for CCDC105 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for CCDC105: view image

Paralogs for CCDC105 Gene

No data available for Paralogs for CCDC105 Gene

Variants for CCDC105 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for CCDC105 Gene

SNP ID Clinical significance and condition Chr 19 pos Variation AA Info Type
rs17855585 - p.Asp434Glu
rs34375549 - p.Met248Thr
rs35352238 - p.Val245Met
rs8111625 - p.Ser444Thr
rs8112667 - p.Pro499Thr

Additional dbSNP identifiers (rs#s) for CCDC105 Gene

Structural Variations from Database of Genomic Variants (DGV) for CCDC105 Gene

Variant ID Type Subtype PubMed ID
esv2758746 CNV gain 17122850
nsv518179 CNV loss 19592680
nsv523277 CNV loss 19592680

Variation tolerance for CCDC105 Gene

Residual Variation Intolerance Score: 87.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 9.44; 88.62% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CCDC105 Gene

Human Gene Mutation Database (HGMD)
CCDC105
SNPedia medical, phenotypic, and genealogical associations of SNPs for
CCDC105

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CCDC105 Gene

Disorders for CCDC105 Gene

Additional Disease Information for CCDC105

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for CCDC105 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CCDC105 Gene

Publications for CCDC105 Gene

  1. Association between genetic variants in VEGF, ERCC3 and occupational benzene haematotoxicity. (PMID: 19773279) Hosgood HD … Lan Q (Occupational and environmental medicine 2009) 3 41 54
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 54
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 2 3 54
  4. E3 ubiquitin ligase RNF123 targets lamin B1 and lamin-binding proteins. (PMID: 29676528) Khanna R … Parnaik VK (The FEBS journal 2018) 3 54
  5. Interactome of the negative regulator of nuclear import BRCA1-binding protein 2. (PMID: 25820252) Fatima S … Jans DA (Scientific reports 2015) 3 54

Products for CCDC105 Gene

Sources for CCDC105 Gene