This gene produces a long non-coding RNA that is upregulated in colon cancer and other cancers. This transcript promotes cell proliferation and suppresses apoptosis. It negatively regulates the biogenesis of microRNA 145. [provided by RefSeq, Dec 2017] See more...

Aliases for CCAT2 Gene

Subcategory (RNA class) for CCAT2 Gene

lncRNA

Number of RNA Genes sources:

3 / 14

Aliases for CCAT2 Gene

  • Colon Cancer Associated Transcript 2 2 3 5
  • Colon Cancer Associated Transcript 2 (Non-Protein Coding) 2 3
  • Non-Coding RNA Involved In Cancer Predisposition 1 2 3
  • Long Intergenic Non-Protein Coding RNA 873 2 3
  • CCAT2 2 168
  • HSALNG0068443 167
  • LINC00873 3
  • NCCP1 3

External Ids for CCAT2 Gene

Previous GeneCards Identifiers for CCAT2 Gene

  • GC08U901766

Summaries for CCAT2 Gene

Entrez Gene Summary for CCAT2 Gene

  • This gene produces a long non-coding RNA that is upregulated in colon cancer and other cancers. This transcript promotes cell proliferation and suppresses apoptosis. It negatively regulates the biogenesis of microRNA 145. [provided by RefSeq, Dec 2017]

GeneCards Summary for CCAT2 Gene

CCAT2 (Colon Cancer Associated Transcript 2) is an RNA Gene, and is affiliated with the lncRNA class. Diseases associated with CCAT2 include Intrahepatic Cholangiocarcinoma and Ovarian Epithelial Cancer.

Additional gene information for CCAT2 Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for CCAT2 Gene

Genomics for CCAT2 Gene

GeneHancer (GH) Regulatory Elements for CCAT2 Gene

Promoters and enhancers for CCAT2 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH08J127396 Enhancer 1.4 FANTOM5 Ensembl ENCODE dbSUPER 500.7 +0.5 504 8.3 EP300 CTCF NCOR1 POLR2A TCF7 FOXA1 CUX1 SKI TEAD1 ZKSCAN8 CCAT2 GQ911591 CASC8 MYC piR-41318-003 JX003864 POU5F1B lnc-FAM84B-14 PCAT1
GH08J127389 Enhancer 1.1 FANTOM5 Ensembl ENCODE dbSUPER 0.4 -8.7 -8738 3.3 POLR2A EP300 CTCF FOS CEBPB JUN NR3C1 EZH2 GATA3 STAT3 CASC8 MYC CCAT2 lnc-FAM84B-83 JX003864 POU5F1B lnc-FAM84B-14 CASC21 PCAT1
GH08J127393 Enhancer 1 FANTOM5 Ensembl ENCODE dbSUPER 0.4 -5.5 -5479 2.6 POLR2A FOS NCOA3 ZNF512B MYC STAT3 CASC8 CCAT2 lnc-FAM84B-83 JX003864 POU5F1B lnc-FAM84B-14 PCAT1
GH08J127387 Enhancer 0.6 Ensembl ENCODE 0.4 -13.2 -13197 2 ZNF384 TBX21 SPI1 IKZF1 RUNX3 CASC8 lnc-FAM84B-83 CCAT2 JX003864 POU5F1B lnc-FAM84B-14 CASC21 PCAT1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around CCAT2 on UCSC Golden Path with GeneCards custom track

Genomic Locations for CCAT2 Gene

Genomic Locations for CCAT2 Gene
chr8:127,400,398-127,402,150
(GRCh38/hg38)
Size:
1,753 bases
Orientation:
Plus strand

Genomic View for CCAT2 Gene

Genes around CCAT2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CCAT2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CCAT2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CCAT2 Gene

Proteins for CCAT2 Gene

No data available for DME Specific Peptides for CCAT2 Gene

Domains & Families for CCAT2 Gene

Gene Families for CCAT2 Gene

genes like me logo Genes that share domains with CCAT2: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for CCAT2 Gene

Function for CCAT2 Gene

Phenotypes From GWAS Catalog for CCAT2 Gene

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for CCAT2 Gene

Localization for CCAT2 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CCAT2 gene
Compartment Confidence
plasma membrane 2
nucleus 2
extracellular 1
cytoskeleton 1
mitochondrion 1
cytosol 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for CCAT2 Gene

Pathways & Interactions for CCAT2 Gene

PathCards logo

SuperPathways for CCAT2 Gene

No Data Available
;

Gene Ontology (GO) - Biological Process for CCAT2 Gene

None

No data available for Pathways by source , Interacting Proteins and SIGNOR curated interactions for CCAT2 Gene

Drugs & Compounds for CCAT2 Gene

No Compound Related Data Available

Transcripts for CCAT2 Gene

mRNA/cDNA for CCAT2 Gene

2 RNACentral transcripts :
1 REFSEQ mRNAs :
2 NCBI additional mRNA sequence :
1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
1 ENA transcripts :
1 LncBook transcripts :
1 LNCipedia transcripts :

Alternative Splicing Database (ASD) splice patterns (SP) for CCAT2 Gene

No ASD Table

Relevant External Links for CCAT2 Gene

GeneLoc Exon Structure for
CCAT2

Expression for CCAT2 Gene

No Expression Related Data Available

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for CCAT2 Gene

Orthologs for CCAT2 Gene

Evolution for CCAT2 Gene

ENSEMBL:
Gene Tree for CCAT2 (if available)
TreeFam:
Gene Tree for CCAT2 (if available)

No data available for Orthologs for CCAT2 Gene

Paralogs for CCAT2 Gene

No data available for Paralogs for CCAT2 Gene

Variants for CCAT2 Gene

Additional dbSNP identifiers (rs#s) for CCAT2 Gene

Structural Variations from Database of Genomic Variants (DGV) for CCAT2 Gene

Variant ID Type Subtype PubMed ID
nsv499795 OTHER inversion 21111241
nsv7419 OTHER inversion 18451855

Additional Variant Information for CCAT2 Gene

Human Gene Mutation Database (HGMD)
CCAT2
SNPedia medical, phenotypic, and genealogical associations of SNPs for
CCAT2

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP and Variation tolerance for CCAT2 Gene

Disorders for CCAT2 Gene

MalaCards: The human disease database

(20) MalaCards diseases for CCAT2 Gene - From: LncRNADisease, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
intrahepatic cholangiocarcinoma
  • cholangiocarcinoma
ovarian epithelial cancer
  • eoc
pituitary adenoma
  • adenoma of the pituitary gland
small cell cancer of the lung
  • sclc1
clear cell renal cell carcinoma
  • clear cell carcinoma of kidney
- elite association - COSMIC cancer census association via MalaCards
Search CCAT2 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for CCAT2

genes like me logo Genes that share disorders with CCAT2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CCAT2 Gene

Publications for CCAT2 Gene

  1. CCAT2 is a lung adenocarcinoma-specific long non-coding RNA and promotes invasion of non-small cell lung cancer. (PMID: 24504682) Qiu M … Yin R (Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine 2014) 2 3 54
  2. CCAT2, a novel noncoding RNA mapping to 8q24, underlies metastatic progression and chromosomal instability in colon cancer. (PMID: 23796952) Ling H … Calin GA (Genome research 2013) 2 3 54
  3. Circulating long non-coding RNA colon cancer-associated transcript 2 protected by exosome as a potential biomarker for colorectal cancer. (PMID: 30877883) Wang L … Wang C (Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2019) 3 54
  4. Increased expression of long non-coding RNA CCAT2 predicts poorer prognosis in patients with hepatocellular carcinoma. (PMID: 31626095) Fu C … Wu D (Medicine 2019) 3 54
  5. CCAT2 is an oncogenic long non-coding RNA in pancreatic ductal adenocarcinoma. (PMID: 29298720) Cai Y … Zhang D (Biological research 2018) 3 54

Products for CCAT2 Gene

Sources for CCAT2 Gene