This gene produces a long non-coding RNA that is upregulated in colon cancer and other cancers. This transcript promotes cell proliferation and suppresses apoptosis. It negatively regulates the biogenesis of microRNA 145. [provided by RefSeq, Dec 2017] See more...

Aliases for CCAT2 Gene

Data sources for CCAT2 Gene:

RNA type for CCAT2 Gene

lncRNA

Aliases for CCAT2 Gene

External Ids for CCAT2 Gene

Previous GeneCards Identifiers for CCAT2 Gene

  • GC08U901766

Summaries for CCAT2 Gene

Entrez Gene Summary for CCAT2 Gene

  • This gene produces a long non-coding RNA that is upregulated in colon cancer and other cancers. This transcript promotes cell proliferation and suppresses apoptosis. It negatively regulates the biogenesis of microRNA 145. [provided by RefSeq, Dec 2017]

GeneCards Summary for CCAT2 Gene

CCAT2 (Colon Cancer Associated Transcript 2) is an RNA Gene, and is affiliated with the lncRNA class. Diseases associated with CCAT2 include Intrahepatic Cholangiocarcinoma and Small Cell Cancer Of The Lung.

Additional gene information for CCAT2 Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for CCAT2 Gene

Genomics for CCAT2 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for CCAT2 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH08J127396 Promoter/Enhancer 1.7 FANTOM5 Ensembl ENCODE dbSUPER 250.7 +0.5 504 8.3 CEBPA CHD4 CTCF CEBPB FOXA1 SIX4 HOMEZ FOXA2 CTBP1 SAP130 CCAT2 GQ911591 CASC8 MYC piR-41318-003 JX003864 POU5F1B lnc-FAM84B-14 HSALNG0068436 PCAT1
GH08J127389 Enhancer 1 FANTOM5 Ensembl ENCODE dbSUPER 0.4 -8.7 -8738 3.3 CEBPB MAX EP300 STAT3 TBP POLR2A CASC8 MYC CCAT2 lnc-FAM84B-83 JX003864 POU5F1B lnc-FAM84B-14 CASC21 HSALNG0068436 PCAT1
GH08J127393 Enhancer 0.9 FANTOM5 Ensembl ENCODE dbSUPER 0.4 -5.5 -5479 2.6 NCOA3 ZNF512B CASC8 CCAT2 lnc-FAM84B-83 JX003864 POU5F1B lnc-FAM84B-14 HSALNG0068436 MYC PCAT1
GH08J127387 Enhancer 0.6 Ensembl ENCODE 0.4 -13.4 -13397 2 IKZF1 SPI1 RUNX3 CASC8 lnc-FAM84B-83 CCAT2 JX003864 POU5F1B lnc-FAM84B-14 CASC21 HSALNG0068436 MYC PCAT1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around CCAT2 on the GeneHancer Hub at the UCSC Golden Path

Genomic Locations for CCAT2 Gene

Latest Assembly
chr8:127,400,398-127,402,150
(GRCh38/hg38)
Size:
1,753 bases
Orientation:
Plus strand

Previous Assembly
chr8:128,412,644-128,414,395
(GRCh37/hg19 by Entrez Gene)
Size:
1,752 bases
Orientation:
Plus strand

Genomic View for CCAT2 Gene

Genes around CCAT2 on UCSC Golden Path with GeneCards custom track
CCAT2 in the GeneCaRNA (GeneCards ncRNA compendium) hub on the UCSC Golden Path

Cytogenetic band:
CCAT2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CCAT2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CCAT2 Gene

Proteins for CCAT2 Gene

Post-translational modifications for CCAT2 Gene

No Post-translational modifications

No data available for DME Specific Peptides for CCAT2 Gene

Domains & Families for CCAT2 Gene

Gene Families for CCAT2 Gene

genes like me logo Genes that share domains with CCAT2: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for CCAT2 Gene

Function for CCAT2 Gene

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for CCAT2 Gene

Localization for CCAT2 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CCAT2 gene
Compartment Confidence
extracellular 2
nucleus 2
plasma membrane 1
cytoskeleton 1
mitochondrion 1
endosome 1
cytosol 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for CCAT2 Gene

Pathways & Interactions for CCAT2 Gene

PathCards logo

SuperPathways for CCAT2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for CCAT2 Gene

None

No data available for Pathways by source , Interacting Proteins and SIGNOR curated interactions for CCAT2 Gene

Drugs & Compounds for CCAT2 Gene

No Compound Related Data Available

Transcripts for CCAT2 Gene

Non-coding RNA (ncRNA) Transcripts from RNAcentral for CCAT2 Gene

RNAcentral Transcript ID RNA Type Length (nts) # of Sources Source Identifiers and Annotations
URS000010576B_9606 lncRNA 1752 4

RefSeq: NR_109834,

Ensembl: ENST00000630920 (view in UCSC) ,

LNCipedia: CCAT2:3,

ENA: GQ911592.1:1..1752:ncRNA,

URS0000E99552_9606 lncRNA 1753 1

LncBook: HSALNT0143633,

URS0001BCC960_9606 lncRNA 1752 1

LncBook: HSALNT0143633,

CCAT2 in the GeneCaRNA (GeneCards ncRNA compendium) hub on the UCSC Golden Path

Additional transcripts not in RNAcentral for CCAT2 Gene

2 NCBI additional mRNA sequence :

Alternative Splicing Database (ASD) splice patterns (SP) for CCAT2 Gene

No ASD Table

Relevant External Links for CCAT2 Gene

GeneLoc Exon Structure for
CCAT2

Expression for CCAT2 Gene

No Expression Related Data Available

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for CCAT2 Gene

Orthologs for CCAT2 Gene

Evolution for CCAT2 Gene

ENSEMBL:
Gene Tree for CCAT2 (if available)
TreeFam:
Gene Tree for CCAT2 (if available)
Alliance of Genome Resources:
Additional Orthologs for CCAT2

No data available for Orthologs for CCAT2 Gene

Paralogs for CCAT2 Gene

No data available for Paralogs for CCAT2 Gene

Variants for CCAT2 Gene

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for CCAT2 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for CCAT2 Gene

Variant ID Type Subtype PubMed ID
nsv499795 OTHER inversion 21111241
nsv7419 OTHER inversion 18451855

Additional Variant Information for CCAT2 Gene

Human Gene Mutation Database (HGMD)
CCAT2
SNPedia medical, phenotypic, and genealogical associations of SNPs for
CCAT2
Leiden Open Variation Database (LOVD)
CCAT2

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP and Variation tolerance for CCAT2 Gene

Disorders for CCAT2 Gene

MalaCards: The human disease database

(20) MalaCards diseases for CCAT2 Gene - From: LNC, COP, and GCD

Disorder Aliases PubMed IDs
intrahepatic cholangiocarcinoma
  • intrahepatic bile duct carcinoma
small cell cancer of the lung
  • sclc1
pituitary adenoma
  • adenoma of the pituitary gland
clear cell renal cell carcinoma
  • clear cell carcinoma of kidney
lung squamous cell carcinoma
  • epidermoid cell carcinoma of the lung
- elite association - COSMIC cancer census association via MalaCards
Search CCAT2 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for CCAT2

genes like me logo Genes that share disorders with CCAT2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CCAT2 Gene

Publications for CCAT2 Gene

  1. CCAT2 is a lung adenocarcinoma-specific long non-coding RNA and promotes invasion of non-small cell lung cancer. (PMID: 24504682) Qiu M … Yin R (Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine 2014) 2 3 72
  2. CCAT2, a novel noncoding RNA mapping to 8q24, underlies metastatic progression and chromosomal instability in colon cancer. (PMID: 23796952) Ling H … Calin GA (Genome research 2013) 2 3 72
  3. LncRNA CCAT2 promoted osteosarcoma cell proliferation and invasion. (PMID: 29502343) Yan L … Ding X (Journal of cellular and molecular medicine 2018) 3 72
  4. Upregulation of long non‑coding RNA CCAT2 indicates a poor prognosis and promotes proliferation and metastasis in intrahepatic cholangiocarcinoma. (PMID: 29393466) Bai JG … Sun C (Molecular medicine reports 2018) 3 72
  5. Long Noncoding RNA CCAT2 Knockdown Suppresses Tumorous Progression by Sponging miR-424 in Epithelial Ovarian Cancer. (PMID: 28550684) Hua F … Liu XP (Oncology research 2018) 3 72

Products for CCAT2 Gene

Sources for CCAT2 Gene