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Aliases for CCAT2 Gene

Subcategory (RNA class) for CCAT2 Gene

non-coding RNA

Quality Score for this RNA gene is

3

Aliases for CCAT2 Gene

  • Colon Cancer Associated Transcript 2 (Non-Protein Coding) 2 3 5
  • Non-Coding RNA Involved In Cancer Predisposition 1 2 3
  • Long Intergenic Non-Protein Coding RNA 873 2 3
  • LINC00873 3
  • NCCP1 3

External Ids for CCAT2 Gene

Previous GeneCards Identifiers for CCAT2 Gene

  • GC08U901766

Summaries for CCAT2 Gene

Entrez Gene Summary for CCAT2 Gene

  • This gene produces a long non-coding RNA that is upregulated in colon cancer and other cancers. This transcript promotes cell proliferation and suppresses apoptosis. It negatively regulates the biogenesis of microRNA 145. [provided by RefSeq, Dec 2017]

GeneCards Summary for CCAT2 Gene

CCAT2 (Colon Cancer Associated Transcript 2 (Non-Protein Coding)) is an RNA Gene, and is affiliated with the non-coding RNA class.

Additional gene information for CCAT2 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CCAT2 Gene

Genomics for CCAT2 Gene

GeneHancer (GH) Regulatory Elements for CCAT2 Gene

Promoters and enhancers for CCAT2 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH08I127396 Enhancer 1.3 FANTOM5 ENCODE dbSUPER 550.8 -0.1 -123 7.1 FOXA2 ARID4B RAD21 RARA ETS1 ZNF143 CREM HMG20B CEBPB MIER2 CCAT2 CASC8 MYC GC08M127382
GH08I127389 Enhancer 1.2 FANTOM5 Ensembl ENCODE dbSUPER 0.4 -8.7 -8739 3.3 JUND GATA3 POLR2A JUN MAX STAT3 CEBPB EP300 CASC8 MYC CCAT2 GC08M127382 CASC21
GH08I127393 Enhancer 0.7 FANTOM5 ENCODE dbSUPER 0.4 -5.6 -5569 2.4 ZNF512B CASC8 CCAT2 GC08M127382
GH08I127387 Enhancer 0.4 ENCODE 0.4 -13.2 -13248 0.2 IKZF1 RUNX3 SPI1 GC08M127382 CCAT2 CASC8 CASC21
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around CCAT2 on UCSC Golden Path with GeneCards custom track

Genomic Locations for CCAT2 Gene

Genomic Locations for CCAT2 Gene
chr8:127,400,399-127,402,150
(GRCh38/hg38)
Size:
1,752 bases
Orientation:
Plus strand

Genomic View for CCAT2 Gene

Genes around CCAT2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CCAT2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CCAT2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CCAT2 Gene

Proteins for CCAT2 Gene

Post-translational modifications for CCAT2 Gene

No Post-translational modifications

No data available for DME Specific Peptides for CCAT2 Gene

Domains & Families for CCAT2 Gene

Gene Families for CCAT2 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with CCAT2: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for CCAT2 Gene

Function for CCAT2 Gene

Phenotypes From GWAS Catalog for CCAT2 Gene

Animal Model Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for CCAT2 Gene

Localization for CCAT2 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for CCAT2 Gene

Pathways & Interactions for CCAT2 Gene

SuperPathways for CCAT2 Gene

No Data Available

Interacting Proteins for CCAT2 Gene

Gene Ontology (GO) - Biological Process for CCAT2 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for CCAT2 Gene

Drugs & Compounds for CCAT2 Gene

No Compound Related Data Available

Transcripts for CCAT2 Gene

mRNA/cDNA for CCAT2 Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for CCAT2 Gene

No ASD Table

Relevant External Links for CCAT2 Gene

GeneLoc Exon Structure for
CCAT2
ECgene alternative splicing isoforms for
CCAT2

Expression for CCAT2 Gene

NURSA nuclear receptor signaling pathways regulating expression of CCAT2 Gene:

CCAT2
No Expression Related Data Available

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for CCAT2 Gene

Orthologs for CCAT2 Gene

Evolution for CCAT2 Gene

ENSEMBL:
Gene Tree for CCAT2 (if available)
TreeFam:
Gene Tree for CCAT2 (if available)

No data available for Orthologs for CCAT2 Gene

Paralogs for CCAT2 Gene

No data available for Paralogs for CCAT2 Gene

Variants for CCAT2 Gene

Sequence variations from dbSNP and Humsavar for CCAT2 Gene

SNP ID Clin Chr 08 pos Variation AA Info Type
rs1001628743 -- 127,400,050(+) A/G upstream_transcript_variant
rs1001681100 -- 127,400,361(+) C/T upstream_transcript_variant
rs1002119926 -- 127,402,526(+) G/T downstream_transcript_variant
rs1003151845 -- 127,401,446(+) A/G non_coding_transcript_variant
rs1003296352 -- 127,401,674(+) A/C non_coding_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for CCAT2 Gene

Variant ID Type Subtype PubMed ID
nsv499795 OTHER inversion 21111241
nsv7419 OTHER inversion 18451855

Additional Variant Information for CCAT2 Gene

Human Gene Mutation Database (HGMD)
CCAT2
SNPedia medical, phenotypic, and genealogical associations of SNPs for
CCAT2

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for CCAT2 Gene

Disorders for CCAT2 Gene

Additional Disease Information for CCAT2

No disorders were found for CCAT2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CCAT2 Gene

Publications for CCAT2 Gene

  1. CCAT2 is a lung adenocarcinoma-specific long non-coding RNA and promotes invasion of non-small cell lung cancer. (PMID: 24504682) Qiu M … Yin R (Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine 2014) 2 3 58
  2. CCAT2, a novel noncoding RNA mapping to 8q24, underlies metastatic progression and chromosomal instability in colon cancer. (PMID: 23796952) Ling H … Calin GA (Genome research 2013) 2 3 58
  3. Long Noncoding RNA CCAT2 Knockdown Suppresses Tumorous Progression by Sponging miR-424 in Epithelial Ovarian Cancer. (PMID: 28550684) Hua F … Liu XP (Oncology research 2018) 3 58
  4. LncRNA CCAT2 promotes tumorigenesis by over-expressed Pokemon in non-small cell lung cancer. (PMID: 28088736) Zhao Z … Qu J (Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2017) 3 58
  5. The Expression of CCAT2, a Novel Long Noncoding RNA Transcript, and rs6983267 Single-Nucleotide Polymorphism Genotypes in Colorectal Cancers. (PMID: 27875818) Kasagi Y … Maehara Y (Oncology 2017) 3 58

Products for CCAT2 Gene

Sources for CCAT2 Gene

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