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Aliases for CBY3 Gene

Aliases for CBY3 Gene

  • Chibby Family Member 3 2 3 5
  • Chibby Homolog 3 (Drosophila) 2

External Ids for CBY3 Gene

Previous GeneCards Identifiers for CBY3 Gene

  • GC05M179041
  • GC00U922289
  • GC05M179042
  • GC05M179106
  • GC05M173832

Summaries for CBY3 Gene

GeneCards Summary for CBY3 Gene

CBY3 (Chibby Family Member 3) is a Protein Coding gene. An important paralog of this gene is CBY1.

Additional gene information for CBY3 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CBY3 Gene

Genomics for CBY3 Gene

GeneHancer (GH) Regulatory Elements for CBY3 Gene

Promoters and enhancers for CBY3 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH05I179681 Promoter 0.8 EPDnew 550.8 -0.1 -80 0.1 ZKSCAN8 FOS THRB ZKSCAN1 CBY3 HMGB3P22 CANX GC05M179696
GH05I179761 Enhancer 1.3 Ensembl ENCODE dbSUPER 11.1 -82.1 -82061 2.9 HDGF PKNOX1 CLOCK ARID4B SIN3A ZNF2 GLIS2 GATA2 ZNF143 FOS MRNIP MAML1 ZNF879 LOC100996419 LTC4S MIR1229 SQSTM1 MGAT4B ZFP2 ZNF454
GH05I179758 Enhancer 1.2 Ensembl ENCODE dbSUPER 11.1 -78.8 -78826 2 HDGF PKNOX1 BATF ZNF121 ZNF366 FOS RCOR1 RUNX3 EGR2 ZNF280D MAML1 CANX LTC4S MIR1229 SQSTM1 MGAT4B HMGB3P22 CBY3 TBC1D9B MRNIP
GH05I179764 Enhancer 1.2 Ensembl ENCODE dbSUPER 11.1 -84.9 -84908 2.2 HDAC1 YY1 TCF12 FOS RXRA REST ZEB2 ZNF592 SMARCA4 IKZF1 MAML1 MGAT4B LTC4S MIR1229 SQSTM1 CBY3 MRNIP TBC1D9B CANX RNF130
GH05I179754 Enhancer 1.2 Ensembl ENCODE dbSUPER 11 -74.0 -73962 1.4 ELF3 ARID4B RAD21 RARA THAP11 MIXL1 PAF1 RXRA CEBPB ELF1 MAML1 LTC4S MIR1229 MGAT4B SQSTM1 CBY3 CANX HMGB3P22 TBC1D9B MRNIP
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around CBY3 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the CBY3 gene promoter:

Genomic Locations for CBY3 Gene

Genomic Locations for CBY3 Gene
chr5:179,678,558-179,680,974
(GRCh38/hg38)
Size:
2,417 bases
Orientation:
Minus strand
chr5:179,105,559-179,107,975
(GRCh37/hg19)

Genomic View for CBY3 Gene

Genes around CBY3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CBY3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CBY3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CBY3 Gene

Proteins for CBY3 Gene

  • Protein details for CBY3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    A6NI87-CBY3_HUMAN
    Recommended name:
    Protein chibby homolog 3
    Protein Accession:
    A6NI87

    Protein attributes for CBY3 Gene

    Size:
    242 amino acids
    Molecular mass:
    27343 Da
    Quaternary structure:
    No Data Available
    Miscellaneous:
    • Chibby is Japanese for small; the gene was so named for the RNAi phenotype seen in flies.

neXtProt entry for CBY3 Gene

Post-translational modifications for CBY3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CBY3 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for CBY3 Gene

Domains & Families for CBY3 Gene

Gene Families for CBY3 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for CBY3 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for CBY3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

A6NI87

UniProtKB/Swiss-Prot:

CBY3_HUMAN :
  • Belongs to the chibby family.
Family:
  • Belongs to the chibby family.
genes like me logo Genes that share domains with CBY3: view

Function for CBY3 Gene

Phenotypes From GWAS Catalog for CBY3 Gene

Phenotypes for CBY3 Gene

GenomeRNAi human phenotypes for CBY3:
genes like me logo Genes that share phenotypes with CBY3: view

miRNA for CBY3 Gene

miRTarBase miRNAs that target CBY3

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CBY3 Gene

Localization for CBY3 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CBY3 gene
Compartment Confidence
nucleus 3
cytosol 2
extracellular 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for CBY3 Gene

Pathways & Interactions for CBY3 Gene

No Data Available

Interacting Proteins for CBY3 Gene

Gene Ontology (GO) - Biological Process for CBY3 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for CBY3 Gene

Drugs & Compounds for CBY3 Gene

No Compound Related Data Available

Transcripts for CBY3 Gene

mRNA/cDNA for CBY3 Gene

(2) REFSEQ mRNAs :
(0) Additional mRNA sequences :
-
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for CBY3 Gene

Chibby homolog 3 (Drosophila):
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for CBY3 Gene

No ASD Table

Relevant External Links for CBY3 Gene

GeneLoc Exon Structure for
CBY3
ECgene alternative splicing isoforms for
CBY3

Expression for CBY3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CBY3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CBY3 Gene

This gene is overexpressed in Testis (x24.0).

NURSA nuclear receptor signaling pathways regulating expression of CBY3 Gene:

CBY3

SOURCE GeneReport for Unigene cluster for CBY3 Gene:

Hs.535767
genes like me logo Genes that share expression patterns with CBY3: view

No data available for Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for CBY3 Gene

Orthologs for CBY3 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CBY3 Gene

Organism Taxonomy Gene Similarity Type Details
dog
(Canis familiaris)
Mammalia CBY3 33 34
  • 82.95 (n)
cow
(Bos Taurus)
Mammalia CBY3 33 34
  • 76.81 (n)
mouse
(Mus musculus)
Mammalia Cby3 33 16 34
  • 74.47 (n)
rat
(Rattus norvegicus)
Mammalia Cby3 33
  • 72.12 (n)
oppossum
(Monodelphis domestica)
Mammalia CBY3 34
  • 52 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CBY3 34
  • 47 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CBY3 34
  • 48 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii cby1 34
  • 35 (a)
OneToMany
Species where no ortholog for CBY3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CBY3 Gene

ENSEMBL:
Gene Tree for CBY3 (if available)
TreeFam:
Gene Tree for CBY3 (if available)

Paralogs for CBY3 Gene

Paralogs for CBY3 Gene

(1) SIMAP similar genes for CBY3 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with CBY3: view

Variants for CBY3 Gene

Sequence variations from dbSNP and Humsavar for CBY3 Gene

SNP ID Clin Chr 05 pos Variation AA Info Type
rs1000132233 -- 179,680,792(-) G/A intron_variant
rs1000647566 -- 179,679,366(-) C/T intron_variant
rs1000754389 -- 179,683,823(-) C/T upstream_transcript_variant
rs1000933856 -- 179,681,301(-) A/C 5_prime_UTR_variant, genic_upstream_transcript_variant, upstream_transcript_variant
rs1001363741 -- 179,682,467(-) T/C upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for CBY3 Gene

Variant ID Type Subtype PubMed ID
dgv214n111 CNV duplication 26073780
esv3570595 CNV loss 25503493
nsv282 OTHER inversion 15895083
nsv5160 CNV insertion 18451855
nsv7375 OTHER inversion 18451855
nsv830560 CNV loss 17160897

Variation tolerance for CBY3 Gene

Gene Damage Index Score: 3.77; 57.98% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CBY3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CBY3

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CBY3 Gene

Disorders for CBY3 Gene

Additional Disease Information for CBY3

No disorders were found for CBY3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CBY3 Gene

Publications for CBY3 Gene

  1. The DNA sequence and comparative analysis of human chromosome 5. (PMID: 15372022) Schmutz J … Rubin EM (Nature 2004) 3 4 58

Products for CBY3 Gene

Sources for CBY3 Gene

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