Aliases for CBY2 Gene

Aliases for CBY2 Gene

  • Chibby Family Member 2 2 3
  • Spermatid Associated 2 3 5
  • Spermatid Flower-Like Structure Protein 2 3
  • Spermatid-Associated Protein 3 4
  • Protein Chibby Homolog 2 3 4
  • SPERT 3 5
  • Testis-Specific Leucine Zipper Protein Nurit 3
  • Testis Specific Leucine Zipper Protein Nurit 2
  • Novel Leucine Zipper Testicular Protein 3
  • Testicular Tissue Protein Li 182 3
  • Chibby Homolog 2 (Drosophila) 2
  • NURIT 3

External Ids for CBY2 Gene

Previous HGNC Symbols for CBY2 Gene

  • SPERT

Summaries for CBY2 Gene

GeneCards Summary for CBY2 Gene

CBY2 (Chibby Family Member 2) is a Protein Coding gene. An important paralog of this gene is CCDC70.

Additional gene information for CBY2 Gene

No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for CBY2 Gene

Genomics for CBY2 Gene

GeneHancer (GH) Regulatory Elements for CBY2 Gene

Promoters and enhancers for CBY2 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH13J045701 Promoter/Enhancer 0.9 EPDnew dbSUPER 500.7 -0.5 -466 0.1 RELA NFYB POLR2A ARNT MEF2B ASH2L TBP NFATC3 ATF2 ATF7 CBY2 LINC01055
GH13J045702 Promoter/Enhancer 0.7 EPDnew dbSUPER 500.7 +0.0 9 0.1 POLR2A CREB1 RUNX3 CBY2 LINC01055 lnc-SPERT-1
GH13J045703 Promoter/Enhancer 0.5 EPDnew dbSUPER 500.7 +1.2 1216 0.1 CBY2 LINC01055 lnc-SPERT-1
GH13J046187 Promoter/Enhancer 0.6 FANTOM5 Ensembl 40.1 +485.3 485320 0.4 LOC105370192 CBY2 lnc-CPB2-3 LCP1
GH13J045768 Enhancer 0.8 Ensembl ENCODE CraniofacialAtlas 11 +67.2 67208 2.6 NANOG SPI1 POU5F1 RAD21 EZH2 CBY2 ENSG00000274357 SIAH3
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around CBY2 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for CBY2

Genomic Locations for CBY2 Gene

Genomic Locations for CBY2 Gene
chr13:45,702,292-45,714,559
(GRCh38/hg38)
Size:
12,268 bases
Orientation:
Plus strand
chr13:46,276,446-46,288,694
(GRCh37/hg19)
Size:
12,249 bases
Orientation:
Plus strand

Genomic View for CBY2 Gene

Genes around CBY2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CBY2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CBY2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CBY2 Gene

Proteins for CBY2 Gene

  • Protein details for CBY2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NA61-SPERT_HUMAN
    Recommended name:
    Spermatid-associated protein
    Protein Accession:
    Q8NA61
    Secondary Accessions:
    • A8K8I5
    • Q8NHV2

    Protein attributes for CBY2 Gene

    Size:
    448 amino acids
    Molecular mass:
    51570 Da
    Quaternary structure:
    • Homodimer. Binds to NEK1 (By similarity).

    Alternative splice isoforms for CBY2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CBY2 Gene

Post-translational modifications for CBY2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CBY2 Gene

No data available for DME Specific Peptides for CBY2 Gene

Domains & Families for CBY2 Gene

Gene Families for CBY2 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for CBY2 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for CBY2 Gene

GenScript: Design optimal peptide antigens:
  • Protein chibby homolog 2 (SPERT_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q8NA61

UniProtKB/Swiss-Prot:

SPERT_HUMAN :
  • Belongs to the chibby family. SPERT subfamily.
Family:
  • Belongs to the chibby family. SPERT subfamily.
genes like me logo Genes that share domains with CBY2: view

Function for CBY2 Gene

Phenotypes From GWAS Catalog for CBY2 Gene

Gene Ontology (GO) - Molecular Function for CBY2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 16189514
genes like me logo Genes that share ontologies with CBY2: view
genes like me logo Genes that share phenotypes with CBY2: view

Animal Model Products

CRISPR Products

miRNA for CBY2 Gene

miRTarBase miRNAs that target CBY2

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CBY2

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CBY2 Gene

Localization for CBY2 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CBY2 gene
Compartment Confidence
nucleus 4
cytosol 3
plasma membrane 2
extracellular 1
cytoskeleton 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cell Junctions (2)
  • Plasma membrane (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for CBY2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005814 NOT centriole IBA 21873635
GO:0031410 cytoplasmic vesicle ISS 12204287
GO:0036064 NOT ciliary basal body IBA 21873635
genes like me logo Genes that share ontologies with CBY2: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for CBY2 Gene

Pathways & Interactions for CBY2 Gene

PathCards logo

SuperPathways for CBY2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for CBY2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0030178 NOT negative regulation of Wnt signaling pathway IBA 21873635
GO:0060271 NOT cilium assembly IBA 21873635
GO:1905349 NOT ciliary transition zone assembly IBA 21873635
genes like me logo Genes that share ontologies with CBY2: view

No data available for Pathways by source and SIGNOR curated interactions for CBY2 Gene

Drugs & Compounds for CBY2 Gene

(1) Drugs for CBY2 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
genes like me logo Genes that share compounds with CBY2: view

Transcripts for CBY2 Gene

mRNA/cDNA for CBY2 Gene

3 REFSEQ mRNAs :
8 NCBI additional mRNA sequence :
4 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CBY2

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for CBY2 Gene

No ASD Table

Relevant External Links for CBY2 Gene

GeneLoc Exon Structure for
CBY2

Expression for CBY2 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for CBY2

SOURCE GeneReport for Unigene cluster for CBY2 Gene:

Hs.186363
No Expression Related Data Available

Primer Products

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for CBY2 Gene

Orthologs for CBY2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CBY2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SPERT 31
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia SPERT 31 30
  • 86.94 (n)
OneToOne
dog
(Canis familiaris)
Mammalia SPERT 31 30
  • 83.82 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia Spert 30
  • 82.21 (n)
mouse
(Mus musculus)
Mammalia Spert 31 30
  • 81.95 (n)
OneToOne
Cby2 17
oppossum
(Monodelphis domestica)
Mammalia SPERT 31
  • 56 (a)
OneToOne
chicken
(Gallus gallus)
Aves SPERT 31 30
  • 50.29 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SPERT 31
  • 36 (a)
OneToOne
Species where no ortholog for CBY2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for CBY2 Gene

ENSEMBL:
Gene Tree for CBY2 (if available)
TreeFam:
Gene Tree for CBY2 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for CBY2: view image

Paralogs for CBY2 Gene

Paralogs for CBY2 Gene

genes like me logo Genes that share paralogs with CBY2: view

Variants for CBY2 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for CBY2 Gene

SNP ID Clinical significance and condition Chr 13 pos Variation AA Info Type
rs7317245 - p.Lys329Glu

Additional dbSNP identifiers (rs#s) for CBY2 Gene

Structural Variations from Database of Genomic Variants (DGV) for CBY2 Gene

Variant ID Type Subtype PubMed ID
dgv223e201 CNV deletion 23290073

Variation tolerance for CBY2 Gene

Residual Variation Intolerance Score: 61.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 10.69; 91.48% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CBY2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CBY2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CBY2 Gene

Disorders for CBY2 Gene

No disorders were found for CBY2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot , Genatlas and External Links for CBY2 Gene

Publications for CBY2 Gene

  1. Nuclear roles for cilia-associated proteins. (PMID: 28560031) McClure-Begley TD … Klymkowsky MW (Cilia 2017) 2 3 54
  2. A genome-wide scan for signatures of recent selection in Holstein cattle. (PMID: 20096028) Qanbari S … Simianer H (Animal genetics 2010) 2 3 54
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 54
  4. Nurit, a novel leucine-zipper protein, expressed uniquely in the spermatid flower-like structure. (PMID: 12204287) Feige E … Motro B (Mechanisms of development 2002) 2 3 54
  5. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 54

Products for CBY2 Gene

Sources for CBY2 Gene