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Aliases for CBX8 Gene
Aliases for CBX8 Gene
External Ids for CBX8 Gene
- HGNC: 15962
- Entrez Gene: 57332
- Ensembl: ENSG00000141570
- OMIM: 617354
- UniProtKB: Q9HC52
Previous GeneCards Identifiers for CBX8 Gene
- GC17M077418
- GC17M081056
- GC17M078332
- GC17M078468
- GC17M078452
- GC17M075382
- GC17M077765
- GC17M073209
Summaries for CBX8 Gene
GeneCards Summary for CBX8 Gene
CBX8 (Chromobox 8) is a Protein Coding gene. Diseases associated with CBX8 include Hypochondriasis and Conversion Disorder. Among its related pathways are Cellular Senescence (REACTOME) and SUMOylation. Gene Ontology (GO) annotations related to this gene include ubiquitin-protein transferase activity and single-stranded RNA binding. An important paralog of this gene is CBX6.
UniProtKB/Swiss-Prot Summary for CBX8 Gene
-
Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility.
No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for CBX8 Gene
Genomics for CBX8 Gene
GeneHancer (GH) Regulatory Elements for CBX8 Gene
Promoters and enhancers for CBX8 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around CBX8 on UCSC Golden Path with GeneCards custom track
- Top Transcription factor binding sites by QIAGEN in the CBX8 gene promoter:
-
- c-Ets-1
- Gfi-1
- NF-kappaB
- NF-kappaB1
- NF-kappaB2
- Pax-4a
- Pax-6
- POU2F1
- POU2F1a
- SRY
Genomic Locations for CBX8 Gene
Genomic Locations for CBX8 Gene
- chr17:79,792,132-79,801,683
- (GRCh38/hg38)
- Size:
- 9,552 bases
- Orientation:
- Minus strand
- chr17:77,765,931-77,775,482
- (GRCh37/hg19)
- Size:
- 9,552 bases
- Orientation:
- Minus strand
Genomic View for CBX8 Gene
Genes around CBX8 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 17q25.3 by HGNC
- 17q25.3 by Entrez Gene
- 17q25.3 by Ensembl
CBX8 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for CBX8 Gene
Proteins for CBX8 Gene
-
Protein details for CBX8 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q9HC52-CBX8_HUMAN
- Recommended name:
- Chromobox protein homolog 8
- Protein Accession:
- Q9HC52
- Q96H39
- Q9NR07
Protein attributes for CBX8 Gene
- Size:
- 389 amino acids
- Molecular mass:
- 43396 Da
- Quaternary structure:
-
- Component of a PRC1-like complex. Interacts with RING1 RNF2, PCGF1, PCGF2, PCGF3, BMI1, PCGF5 AND PCGF6. Interacts with MLLT3 and histone H3. Interacts with PHC2 (By similarity).
- Miscellaneous:
-
- The human orthologuous proteins of Drosphila Polycomb group protein Pc, CBX2, CBX4, CBX6, CBX7 and CBX8, show distinct nuclear localizations, contribute differently to transcriptional repression, and appear to be part of distinct PRC1-like protein complexes. The hPRC-H complex purification reported by PubMed:12167701 probably presents a mixture of different complexes.
Protein Expression for CBX8 Gene
Post-translational modifications for CBX8 Gene
Other Protein References for CBX8 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- G Biosciences Immunotag™ CBX8 Antibody
- Atlas Antibodies Anti-CBX8 Antibody
-
Creative Biolabs
- Recombinant Human Anti-Human CBX8 Antibody, clone D302
- Mouse Anti-CBX8 (C-terminus) Recombinant Antibody (CBFYC-0903)
- Mouse Anti-CBX8 Recombinant Antibody (CBXC-2243)
- Mouse Anti-CBX8 Recombinant Antibody (1214CT171.154.107)
- Mouse Anti-CBX8 Recombinant Antibody (CBYY-C1045)
- Mouse Anti-CBX8 Recombinant Antibody (14i92)
- Mouse Anti-CBX8 Recombinant Antibody (4H3)
- Mouse Anti-CBX8 Recombinant Antibody (CBYY-C1046)
- Mouse Anti-CBX8 Recombinant Antibody (CBXC-2045)
- Mouse Anti-CBX8 Recombinant Antibody (2A5)
- Mouse Anti-CBX8 Recombinant Antibody (1C7)
- Mouse Anti-CBX8 (AA 17-222) Recombinant Antibody (CBFYC-0905)
- Mouse Anti-CBX8 Recombinant Antibody (3D1)
- Mouse Anti-CBX8 (AA 1-260) Recombinant Antibody (CBYY-C1043)
- Mouse Anti-CBX8 Recombinant Antibody (CBFYC-0904)
- Mouse Anti-CBX8 Recombinant Antibody (2C8)
- Mouse Anti-CBX8 Recombinant Antibody (CBYY-C1044)
- Mouse Anti-CBX8 Recombinant Antibody (CBXC-3018)
- Mouse Anti-CBX8 Recombinant Antibody (6D9)
- Mouse Anti-CBX8 Recombinant Antibody (6G4)
- Mouse Anti-CBX8 Recombinant Antibody (14i91)
- Mouse Anti-CBX8 Recombinant Antibody (5F3)
- Mouse Anti-CBX8 Recombinant Antibody (3A11)
- Mouse Anti-CBX8 Recombinant Antibody (CBXC-2171)
- Mouse Anti-CBX8 (AA 1-260) Recombinant Antibody (CBFYC-0906)
- Mouse Anti-CBX8 Recombinant Antibody (2B2)
- Mouse Anti-CBX8 Recombinant Antibody (CBYY-C1042)
-
Custom Antibody ServicesOriGene Antibodies for CBX8
- AP12236PU-N
- AP50746PU-N
- CF800491
- CF800492
- CF800493
- CF800494
- CF800499
- CF800500
- CF800569
- CF800600
- CF800601
- CF800617
- TA303368
- TA322245
- TA322246
- TA600302
- TA600303
- TA600304
- TA600305
- TA600306
- TA600307
- TA600308
- TA700302
- TA700303
- TA700304
- TA700305
- TA700306
- TA700307
- TA800491
- TA800492
- TA800493
- TA800494
- TA800499
- TA800500
- TA800569
- TA800600
- TA800601
- TA800617
- Novus Biologicals Antibodies for CBX8
-
Abcam antibodies for CBX8
- Invitrogen Antibodies for CBX8 (AFLGC-CBX8)
-
Santa Cruz Biotechnology (SCBT) Antibodies for CBX8
Protein Products
- Creative Biomart Recombinant Human CBX8 293 Cell Lysate
-
OriGene Purified Proteins for CBX8
- Search Origene for MassSpec and Protein Over-expression Lysates for CBX8
- Origene Custom Protein Services for CBX8
- antibodies-online: Show 3 available CBX8 Proteins ranked by validation data
- Compare Top CBX8 Proteins
-
Quality Products:
-
Abcam proteins for CBX8
No data available for DME Specific Peptides for CBX8 Gene
Domains & Families for CBX8 Gene
Gene Families for CBX8 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Predicted intracellular proteins
Protein Domains for CBX8 Gene
- Blocks:
- InterPro:
- ProtoNet:
Suggested Antigen Peptide Sequences for CBX8 Gene
- GenScript: Design optimal peptide antigens:
-
- Rectachrome 1 (CBX8_HUMAN)
- NADH dehydrogenase subunit 3 homolog/ND3 homolog (Q9P2Z1_HUMAN)
No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for CBX8 Gene
Function for CBX8 Gene
Molecular function for CBX8 Gene
- UniProtKB/Swiss-Prot Function:
- Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility.
Phenotypes From GWAS Catalog for CBX8 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0003727 | single-stranded RNA binding | IEA | -- |
| GO:0005515 | protein binding | IPI | 16169070 |
| GO:0035064 | methylated histone binding | IDA | 21029866 |
| GO:0097027 | ubiquitin-protein transferase activator activity | IEA | -- |
Phenotypes for CBX8 Gene
- MGI mutant phenotypes for CBX8:
- inferred from 2 alleles
- GenomeRNAi human phenotypes for CBX8:
-
- Increased transcriptional activity
- Decreased viability in esophageal squamous lineage
- Increased Nanog expression
- Decreased viability
- no effect
- Increased vaccinia virus (VACV) infection
- Decreased interferon-beta reporter expression
- Decreased human papilloma virus 16 (HPV16) pseudovirus infection
- shRNA abundance <= 50%
- Increased viability
Animal Models for CBX8 Gene
- MGI Knock Outs for CBX8:
-
- Cbx8 Cbx8<tm1.1Hko>
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
CRISPR Products
-
OriGene CRISPR knockouts for CBX8
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for CBX8
- genomics-online: gRNA clones - Search for available CBX8 gRNA products
- Overview of 113 available CBX8 gene related products
-
Recommended
- Applied Biological Materials (abm): CRISPR Clones for CBX8 - Select products 50% OFF >
- * CBX8 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * CBX8 CRISPR applications: KO, Activation, Repression, and more - Browse All
-
Santa Cruz Biotechnology (SCBT) CRISPR for CBX8
miRNA for CBX8 Gene
- miRTarBase miRNAs that target CBX8
-
- hsa-mir-218-5p (MIRT440996)
- hsa-mir-140-3p (MIRT624417)
- hsa-mir-362-3p (MIRT624418)
- hsa-mir-329-3p (MIRT624419)
- hsa-mir-8485 (MIRT624420)
- hsa-mir-519c-3p (MIRT624421)
- hsa-mir-519b-3p (MIRT624422)
- hsa-mir-519a-3p (MIRT624423)
- hsa-mir-4796-3p (MIRT624424)
- hsa-mir-548ah-5p (MIRT624425)
- hsa-mir-3609 (MIRT624426)
- hsa-mir-106b-5p (MIRT624427)
- hsa-mir-20a-5p (MIRT624428)
- hsa-mir-20b-5p (MIRT624429)
- hsa-mir-519d-3p (MIRT624430)
- hsa-mir-17-5p (MIRT624431)
- hsa-mir-106a-5p (MIRT624432)
- hsa-mir-93-5p (MIRT624433)
- hsa-mir-526b-3p (MIRT624434)
- hsa-mir-6857-5p (MIRT669200)
- hsa-mir-450a-2-3p (MIRT669201)
- hsa-mir-6810-5p (MIRT669202)
- hsa-mir-2110 (MIRT669203)
- hsa-mir-6825-5p (MIRT669204)
- hsa-mir-939-5p (MIRT669205)
- hsa-mir-1343-5p (MIRT669206)
- hsa-mir-6827-5p (MIRT669207)
- hsa-mir-505-5p (MIRT669208)
- hsa-mir-5189-3p (MIRT669209)
- hsa-mir-509-3p (MIRT669210)
- hsa-mir-1203 (MIRT735960)
- hsa-mir-1207-5p (MIRT736011)
- hsa-mir-1286 (MIRT737042)
- hsa-mir-184 (MIRT738188)
- hsa-mir-211-3p (MIRT738925)
- hsa-mir-3064-5p (MIRT739693)
- hsa-mir-3180-3p (MIRT740769)
- hsa-mir-3180 (MIRT740809)
- hsa-mir-3184-5p (MIRT740853)
- hsa-mir-3196 (MIRT741066)
- hsa-mir-3648 (MIRT741861)
- hsa-mir-3652 (MIRT741884)
- hsa-mir-3978 (MIRT743223)
- hsa-mir-423-5p (MIRT743252)
- hsa-mir-4430 (MIRT744322)
- hsa-mir-4487 (MIRT745196)
- hsa-mir-4505 (MIRT745509)
- hsa-mir-4743-5p (MIRT748152)
- hsa-mir-4763-3p (MIRT748520)
- hsa-mir-4787-5p (MIRT748886)
- hsa-mir-493-3p (MIRT749246)
- hsa-mir-5580-5p (MIRT750927)
- hsa-mir-5787 (MIRT751459)
- hsa-mir-627-5p (MIRT752628)
- hsa-mir-6504-5p (MIRT752930)
- hsa-mir-6752-5p (MIRT754620)
- hsa-mir-6816-5p (MIRT756795)
- hsa-mir-6820-5p (MIRT756877)
- hsa-mir-6842-3p (MIRT757339)
- hsa-mir-6842-5p (MIRT757354)
- hsa-mir-6850-3p (MIRT757564)
- hsa-mir-7110-5p (MIRT758980)
- hsa-mir-7845-5p (MIRT759792)
- hsa-mir-875-3p (MIRT760349)
- hsa-mir-924 (MIRT760509)
miRNA Products
Inhibitory RNA Products
- Origene sirna, shrna, and RNAi products in human, mouse, rat for CBX8
- Browse OriGene Inhibitory RNA Products For CBX8
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CBX8
- genomics-online: shRNA clones - Search for available CBX8 shRNA products
- Overview of 113 available CBX8 gene related products
-
Recommended
Clone Products
- Sino Biological Human cDNA Clone for CBX8
- Addgene plasmids for CBX8
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for CBX8
- genomics-online: cdna clones - Search for available CBX8 CDNA products
- Overview of 113 available CBX8 gene related products
-
Recommended
- orf clones - Search for available CBX8 ORF products
- Overview of 113 available CBX8 gene related products
-
Recommended
- Applied Biological Materials (abm): Clones for CBX8 - Select products 50% OFF >
- * CBX8 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * CBX8 tags and reporters available: His, HA, Myc, Flag, GFP, RFP, Luciferase - Browse All
Cell Line Products
-
Horizon Cell Lines for CBX8
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CBX8 Gene
Localization for CBX8 Gene
Subcellular locations from UniProtKB/Swiss-Prot for CBX8 Gene
- Nucleus.
| Compartment | Confidence |
|---|---|
| nucleus | 5 |
| plasma membrane | 1 |
- Nucleoplasm (4)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000151 | ubiquitin ligase complex | IEA | -- |
| GO:0000790 | nuclear chromatin | IDA | 19636380 |
| GO:0000792 | heterochromatin | IEA | -- |
| GO:0005634 | nucleus | IEA,IDA | 21282530 |
| GO:0005654 | nucleoplasm | TAS | -- |
Pathways & Interactions for CBX8 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Cellular Senescence (REACTOME) | ||
| 2 | SUMOylation |
.95
|
|
| 3 | Metabolism of proteins | ||
| 4 | Chromatin Regulation / Acetylation | ||
| 5 | Transport of the SLBP independent Mature mRNA | ||
Pathways by source for CBX8 Gene
9 Reactome pathways for CBX8 Gene
1 Cell Signaling Technology pathway for CBX8 Gene
Interacting Proteins for CBX8 Gene
Selected Interacting proteins:
Q9HC52-CBX8_HUMAN
ENSP00000269385
for CBX8 Gene via
UniProtKB
MINT
STRING
IID
GPS-Prot Interaction Network for CBX8
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000122 | negative regulation of transcription by RNA polymerase II | IMP | 19636380 |
| GO:0006325 | chromatin organization | IEA | -- |
| GO:0008284 | positive regulation of cell proliferation | IEA | -- |
| GO:0016574 | histone ubiquitination | IEA | -- |
| GO:0032967 | positive regulation of collagen biosynthetic process | IEA | -- |
No data available for SIGNOR curated interactions for CBX8 Gene
Drugs & Compounds for CBX8 Gene
No Compound Related Data Available
Drug Products
- Creative Biomart Recombinant Human CBX8 293 Cell Lysate
Transcripts for CBX8 Gene
mRNA/cDNA for CBX8 Gene
- (1) REFSEQ mRNAs :
- (6) Additional mRNA sequences :
- (48) Selected AceView cDNA sequences:
- (4) Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000269385 3752 bps (ENST00000269385.8)
- ENST00000413392 777 bps (ENST00000413392.5)
- ENST00000427800 665 bps (ENST00000427800.2)
- ENST00000485449 581 bps (ENST00000485449.1)
CRISPR Products
-
OriGene CRISPR knockouts for CBX8
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for CBX8
- genomics-online: gRNA clones - Search for available CBX8 gRNA products
- Overview of 113 available CBX8 gene related products
-
Recommended
- Applied Biological Materials (abm): CRISPR Clones for CBX8 - Select products 50% OFF >
- * CBX8 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * CBX8 CRISPR applications: KO, Activation, Repression, and more - Browse All
-
Santa Cruz Biotechnology (SCBT) CRISPR for CBX8
miRNA Products
Inhibitory RNA Products
- Origene sirna, shrna, and RNAi products in human, mouse, rat for CBX8
- Browse OriGene Inhibitory RNA Products For CBX8
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CBX8
- genomics-online: shRNA clones - Search for available CBX8 shRNA products
- Overview of 113 available CBX8 gene related products
-
Recommended
Clone Products
- Sino Biological Human cDNA Clone for CBX8
- Addgene plasmids for CBX8
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for CBX8
- genomics-online: cdna clones - Search for available CBX8 CDNA products
- Overview of 113 available CBX8 gene related products
-
Recommended
- orf clones - Search for available CBX8 ORF products
- Overview of 113 available CBX8 gene related products
-
Recommended
- Applied Biological Materials (abm): Clones for CBX8 - Select products 50% OFF >
- * CBX8 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * CBX8 tags and reporters available: His, HA, Myc, Flag, GFP, RFP, Luciferase - Browse All
Expression for CBX8 Gene
This gene is overexpressed in Retina (28.7), Fetal Brain (8.2), and Pancreas (6.2).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for CBX8 Gene
- Elite partner
NURSA nuclear receptor signaling pathways regulating expression of CBX8 Gene:
CBX8SOURCE GeneReport for Unigene cluster for CBX8 Gene:
Hs.387258Evidence on tissue expression from TISSUES for CBX8 Gene
- Liver(4.2)
- Lung(4.2)
- Muscle(4.1)
Primer Products
-
OriGene qPCR primer pairs for CBX8
-
OriGene qPCR primer pairs and template standards for CBX8
- genomics-online: primer clones - Search for available CBX8 Primer products
- Overview of 113 available CBX8 gene related products
-
Recommended
Gene Expression Assay Products
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for CBX8 Gene
Orthologs for CBX8 Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | CBX8 33 32 |
|
OneToOne | |
| cow (Bos Taurus) |
Mammalia | CBX8 33 32 |
|
OneToOne | |
| dog (Canis familiaris) |
Mammalia | CBX8 33 32 |
|
OneToOne | |
| mouse (Mus musculus) |
Mammalia | Cbx8 17 33 32 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Cbx8 32 |
|
||
| platypus (Ornithorhynchus anatinus) |
Mammalia | CBX8 33 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | CBX8 33 32 |
|
OneToOne | |
| lizard (Anolis carolinensis) |
Reptilia | CBX8 33 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | cbx8 32 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | LOC100535436 32 |
|
||
| cbx8a 33 33 |
|
OneToMany | |||
| cbx8b 33 |
|
OneToMany | |||
| Dr.20034 32 |
|
||||
| fruit fly (Drosophila melanogaster) |
Insecta | Pc 33 |
|
OneToMany |
- Species where no ortholog for CBX8 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- oppossum (Monodelphis domestica)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
Evolution for CBX8 Gene
- ENSEMBL:
- Gene Tree for CBX8 (if available)
- TreeFam:
- Gene Tree for CBX8 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for CBX8: view image
Paralogs for CBX8 Gene
Variants for CBX8 Gene
| SNP ID | Clin | Chr 17 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs1000095911 | -- | 79,795,790(-) | A/T | intron_variant | |
| rs1000589411 | -- | 79,791,887(-) | G/A | downstream_transcript_variant | |
| rs1000645033 | -- | 79,797,600(-) | A/C | upstream_transcript_variant | |
| rs1001049861 | -- | 79,796,702(-) | C/T | intron_variant | |
| rs1001500874 | -- | 79,796,932(-) | T/C/G | coding_sequence_variant, missense_variant |
Residual Variation Intolerance Score:
60.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
1.50;
29.24% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for CBX8 Gene
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CBX8 Gene
Disorders for CBX8 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| hypochondriasis |
|
|
| conversion disorder |
|
|
Search CBX8 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for CBX8
- Genetic Association Database
- (GAD)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No data available for UniProtKB/Swiss-Prot and Genatlas for CBX8 Gene
Publications for CBX8 Gene
- HPC3 is a new human polycomb orthologue that interacts and associates with RING1 and Bmi1 and has transcriptional repression properties. (PMID: 10825164) Bárdos JI … Freemont PS (The Journal of biological chemistry 2000) 2 3 4 23 56
- Several distinct polycomb complexes regulate and co-localize on the INK4a tumor suppressor locus. (PMID: 19636380) Maertens GN … Peters G (PloS one 2009) 3 4 23 56
- Interaction proteomics analysis of polycomb proteins defines distinct PRC1 complexes in mammalian cells. (PMID: 21282530) Vandamme J … Angrand PO (Molecular & cellular proteomics : MCP 2011) 3 4 56
- Recognition and specificity determinants of the human cbx chromodomains. (PMID: 21047797) Kaustov L … Arrowsmith CH (The Journal of biological chemistry 2011) 3 4 56
- Bypass of senescence by the polycomb group protein CBX8 through direct binding to the INK4A-ARF locus. (PMID: 17332741) Dietrich N … Hansen KH (The EMBO journal 2007) 3 23 56
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Products for CBX8 Gene
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