Aliases for CBX8 Gene
Aliases for CBX8 Gene
External Ids for CBX8 Gene
- HGNC: 15962
- Entrez Gene: 57332
- Ensembl: ENSG00000141570
- OMIM: 617354
- UniProtKB: Q9HC52
Previous GeneCards Identifiers for CBX8 Gene
- GC17M077418
- GC17M081056
- GC17M078332
- GC17M078468
- GC17M078452
- GC17M075382
- GC17M077765
- GC17M073209
Summaries for CBX8 Gene
GeneCards Summary for CBX8 Gene
CBX8 (Chromobox 8) is a Protein Coding gene. Diseases associated with CBX8 include Conversion Disorder. Among its related pathways are Cellular Senescence (REACTOME) and SUMOylation. Gene Ontology (GO) annotations related to this gene include ubiquitin-protein transferase activity and single-stranded RNA binding. An important paralog of this gene is CBX6.
UniProtKB/Swiss-Prot for CBX8 Gene
-
Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A Lys-119, rendering chromatin heritably changed in its expressibility.
No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CBX8 Gene
Genomics for CBX8 Gene
GeneHancer (GH) Regulatory Elements for CBX8 Gene
Promoters and enhancers for CBX8 Gene
| GeneHancer (GH) Identifier | GH Type | GH Score |
GH Sources | Gene Association Score | Total Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites |
Gene Targets |
|---|---|---|---|---|---|---|---|---|---|---|
| GH17J079796 | Promoter/Enhancer | 2.2 | EPDnew Ensembl ENCODE dbSUPER | 657.2 | +4.6 | 4622 | 2.1 | HDGF PKNOX1 SMAD1 FOXA2 ARNT ARID4B SIN3A DMAP1 YY1 POLR2B | CBX8 USP36 CBX4 ENSG00000262768 GC17P079785 | |
| GH17J079802 | Enhancer | 1.3 | FANTOM5 ENCODE dbSUPER | 650.7 | -1.2 | -1222 | 0.4 | HDGF HDAC1 CHAMP1 ZNF766 ATF7 PHF21A SMAD5 ZBTB11 NCOA1 ELF1 | CBX8 CCDC40 PIR54271 | |
| GH17J079800 | Enhancer | 1.2 | ENCODE dbSUPER | 650.7 | +0.5 | 486 | 1.8 | ARID4B SIN3A FEZF1 DMAP1 ZNF2 ZBTB7B ZNF48 ZNF121 GLIS2 ZNF143 | CBX8 ENSG00000262768 EIF4A3 USP36 ENGASE SGSH CANT1 | |
| GH17J079801 | Enhancer | 0.8 | ENCODE dbSUPER | 650.7 | +1.7 | 1706 | 0.1 | ZIC2 PRDM2 HIC1 GLIS2 BCL6B GLIS1 ZBTB33 EZH2 | CBX8 ENSG00000262768 GC17P079785 | |
| GH17J079804 | Enhancer | 1.4 | FANTOM5 Ensembl ENCODE | 27.3 | -2.8 | -2816 | 0.8 | ZFP64 ARID4B IRF4 ZNF48 GLIS2 ZNF143 ATF7 RUNX3 SP3 JUNB | CBX8 CBX2 CBX4 PIR54271 |
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data dump
GeneHancers around CBX8 on UCSC Golden Path with GeneCards custom track
- Top Transcription factor binding sites by QIAGEN in the CBX8 gene promoter:
-
- Pax-4a
- Gfi-1
- SRY
- c-Ets-1
- NF-kappaB1
- NF-kappaB
- POU2F1a
- POU2F1
- Pax-6
- NF-kappaB2
Regulatory Element Products
Genomic Locations for CBX8 Gene
Genomic Locations for CBX8 Gene
- chr17:79,792,132-79,801,683
- (GRCh38/hg38)
- Size:
- 9,552 bases
- Orientation:
- Minus strand
- chr17:77,765,931-77,775,482
- (GRCh37/hg19)
- Size:
- 9,552 bases
- Orientation:
- Minus strand
Genomic View for CBX8 Gene
Genes around CBX8 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 17q25.3 by Entrez Gene
- 17q25.3 by HGNC
- 17q25.3 by Ensembl
CBX8 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for CBX8 Gene
Proteins for CBX8 Gene
-
Protein details for CBX8 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q9HC52-CBX8_HUMAN
- Recommended name:
- Chromobox protein homolog 8
- Protein Accession:
- Q9HC52
- Q96H39
- Q9NR07
Protein attributes for CBX8 Gene
- Size:
- 389 amino acids
- Molecular mass:
- 43396 Da
- Quaternary structure:
-
- Component of a PRC1-like complex. Interacts with RING1 RNF2, PCGF1, PCGF2, PCGF3, BMI1, PCGF5 AND PCGF6. Interacts with MLLT3 and histone H3. Interacts with PHC2 (By similarity).
- Miscellaneous:
-
- The human orthologuous proteins of Drosphila Polycomb group protein Pc, CBX2, CBX4, CBX6, CBX7 and CBX8, show distinct nuclear localizations, contribute differently to transcriptional repression, and appear to be part of distinct PRC1-like protein complexes. The hPRC-H complex purification reported by PubMed:12167701 probably presents a mixture of different complexes.
Protein Expression for CBX8 Gene
Post-translational modifications for CBX8 Gene
Other Protein References for CBX8 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
-
Custom Antibody ServicesOriGene Antibodies for CBX8
- AP12236PU-N
- AP50746PU-N
- TA303368
- TA322245
- TA322246
- TA600302
- TA600303
- TA600304
- TA600305
- TA600306
- TA600307
- TA600308
- TA700302
- TA700303
- TA700304
- TA700305
- TA700306
- TA700307
- TA800491
- CF800491
- TA800492
- CF800492
- TA800493
- CF800493
- TA800494
- CF800494
- TA800499
- CF800499
- TA800500
- CF800500
- TA800569
- CF800569
- TA800600
- CF800600
- TA800601
- CF800601
- TA800617
- CF800617
- Novus Biologicals Antibodies for CBX8
-
Abcam antibodies for CBX8
- Invitrogen Antibodies for CBX8
- GeneTex CBX8 Antibody for CBX8
-
Santa Cruz Biotechnology (SCBT) Antibodies for CBX8
Protein Products
-
OriGene Purified Proteins for CBX8
- Search Origene for MassSpec and Protein Over-expression Lysates for CBX8
- Origene Custom Protein Services for CBX8
- antibodies-online: Search results for 3 available CBX8 Proteins ranked by validation data
- Compare Top CBX8 Proteins
-
Quality Products:
- Search GeneTex for Proteins for CBX8
-
Abcam proteins for CBX8
Assay Products
- antibodies-online: Search results for available CBX8 related products ranked by validation data
No data available for DME Specific Peptides for CBX8 Gene
Domains & Families for CBX8 Gene
Gene Families for CBX8 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Predicted intracellular proteins
Protein Domains for CBX8 Gene
- Blocks:
- InterPro:
- ProtoNet:
Suggested Antigen Peptide Sequences for CBX8 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
No data available for UniProtKB/Swiss-Prot for CBX8 Gene
Function for CBX8 Gene
Molecular function for CBX8 Gene
- UniProtKB/Swiss-Prot Function:
- Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A Lys-119, rendering chromatin heritably changed in its expressibility.
Phenotypes From GWAS Catalog for CBX8 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0003727 | single-stranded RNA binding | IEA | -- |
| GO:0005515 | protein binding | IPI | 16169070 |
| GO:0035064 | methylated histone binding | IDA | 21029866 |
| GO:0097027 | ubiquitin-protein transferase activator activity | IEA | -- |
Phenotypes for CBX8 Gene
- MGI mutant phenotypes for CBX8:
- inferred from 2 alleles
- GenomeRNAi human phenotypes for CBX8:
-
- Increased transcriptional activity
- Decreased viability in esophageal squamous lineage
- Increased Nanog expression
- Decreased viability
- no effect
- Increased vaccinia virus (VACV) infection
- Decreased interferon-beta reporter expression
- Decreased human papilloma virus 16 (HPV16) pseudovirus infection
- shRNA abundance <= 50%
- Increased viability
Animal Models for CBX8 Gene
- MGI Knock Outs for CBX8:
-
- Cbx8 Cbx8<tm1.1Hko>
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
- Cyagen custom Knockout/knockin (KOKI) mouse models for CBX8
-
CRISPR Products
-
OriGene CRISPR knockouts for CBX8
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for CBX8
- genomics-online: gRNA clones - Search results for 97 available CBX8 gene related products
- Overview of 97 available CBX8 gene related products
- Applied Biological Materials CRISPR for CBX8
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for CBX8
- GenScript: Design CRISPR guide RNA sequences for CBX8
miRNA for CBX8 Gene
- miRTarBase miRNAs that target CBX8
-
- hsa-mir-218-5p (MIRT440996)
- hsa-mir-140-3p (MIRT624417)
- hsa-mir-362-3p (MIRT624418)
- hsa-mir-329-3p (MIRT624419)
- hsa-mir-8485 (MIRT624420)
- hsa-mir-519c-3p (MIRT624421)
- hsa-mir-519b-3p (MIRT624422)
- hsa-mir-519a-3p (MIRT624423)
- hsa-mir-4796-3p (MIRT624424)
- hsa-mir-548ah-5p (MIRT624425)
- hsa-mir-3609 (MIRT624426)
- hsa-mir-106b-5p (MIRT624427)
- hsa-mir-20a-5p (MIRT624428)
- hsa-mir-20b-5p (MIRT624429)
- hsa-mir-519d-3p (MIRT624430)
- hsa-mir-17-5p (MIRT624431)
- hsa-mir-106a-5p (MIRT624432)
- hsa-mir-93-5p (MIRT624433)
- hsa-mir-526b-3p (MIRT624434)
- hsa-mir-6857-5p (MIRT669200)
- hsa-mir-450a-2-3p (MIRT669201)
- hsa-mir-6810-5p (MIRT669202)
- hsa-mir-2110 (MIRT669203)
- hsa-mir-6825-5p (MIRT669204)
- hsa-mir-939-5p (MIRT669205)
- hsa-mir-1343-5p (MIRT669206)
- hsa-mir-6827-5p (MIRT669207)
- hsa-mir-505-5p (MIRT669208)
- hsa-mir-5189-3p (MIRT669209)
- hsa-mir-509-3p (MIRT669210)
- hsa-mir-1203 (MIRT735960)
- hsa-mir-1207-5p (MIRT736011)
- hsa-mir-1286 (MIRT737042)
- hsa-mir-184 (MIRT738188)
- hsa-mir-211-3p (MIRT738925)
- hsa-mir-3064-5p (MIRT739693)
- hsa-mir-3180-3p (MIRT740769)
- hsa-mir-3180 (MIRT740809)
- hsa-mir-3184-5p (MIRT740853)
- hsa-mir-3196 (MIRT741066)
- hsa-mir-3648 (MIRT741861)
- hsa-mir-3652 (MIRT741884)
- hsa-mir-3978 (MIRT743223)
- hsa-mir-423-5p (MIRT743252)
- hsa-mir-4430 (MIRT744322)
- hsa-mir-4487 (MIRT745196)
- hsa-mir-4505 (MIRT745509)
- hsa-mir-4743-5p (MIRT748152)
- hsa-mir-4763-3p (MIRT748520)
- hsa-mir-4787-5p (MIRT748886)
- hsa-mir-493-3p (MIRT749246)
- hsa-mir-5580-5p (MIRT750927)
- hsa-mir-5787 (MIRT751459)
- hsa-mir-627-5p (MIRT752628)
- hsa-mir-6504-5p (MIRT752930)
- hsa-mir-6752-5p (MIRT754620)
- hsa-mir-6816-5p (MIRT756795)
- hsa-mir-6820-5p (MIRT756877)
- hsa-mir-6842-3p (MIRT757339)
- hsa-mir-6842-5p (MIRT757354)
- hsa-mir-6850-3p (MIRT757564)
- hsa-mir-7110-5p (MIRT758980)
- hsa-mir-7845-5p (MIRT759792)
- hsa-mir-875-3p (MIRT760349)
- hsa-mir-924 (MIRT760509)
miRNA Products
Inhibitory RNA Products
- Origene sirna, shrna, and RNAi products in human, mouse, rat for CBX8
- Browse OriGene Inhibitory RNA Products For CBX8
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CBX8
- genomics-online: shRNA clones - Search results for 97 available CBX8 gene related products
- Overview of 97 available CBX8 gene related products
Clone Products
- Sino Biological Human cDNA Clone for CBX8
- VectorBuilder custom plasmid, inducible vectors for CBX8
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for CBX8
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for CBX8
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for CBX8
- Applied Biological Materials Clones for CBX8
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Cell Line Products
-
Horizon Cell Lines for CBX8
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CBX8 Gene
Localization for CBX8 Gene
Subcellular locations from UniProtKB/Swiss-Prot for CBX8 Gene
- Nucleus.
| Compartment | Confidence |
|---|---|
| nucleus | 5 |
- Nucleoplasm (4)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000151 | ubiquitin ligase complex | IEA | -- |
| GO:0000790 | nuclear chromatin | IDA | 19636380 |
| GO:0000792 | heterochromatin | IEA | -- |
| GO:0005634 | nucleus | IEA,IDA | 21282530 |
| GO:0005654 | nucleoplasm | TAS | -- |
Pathways & Interactions for CBX8 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Cellular Senescence (REACTOME) | ||
| 2 | SUMOylation |
.95
|
|
| 3 | Metabolism of proteins | ||
| 4 | Chromatin Regulation / Acetylation | ||
| 5 | Transport of the SLBP independent Mature mRNA | ||
Pathways by source for CBX8 Gene
9 Reactome pathways for CBX8 Gene
1 Cell Signaling Technology pathway for CBX8 Gene
Interacting Proteins for CBX8 Gene
Selected Interacting proteins:
Q9HC52-CBX8_HUMAN
ENSP00000269385
for CBX8 Gene via
UniProtKB
MINT
STRING
IID
GPS-Prot Interaction Network for CBX8
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000122 | negative regulation of transcription by RNA polymerase II | IMP | 19636380 |
| GO:0006325 | chromatin organization | IEA | -- |
| GO:0006351 | transcription, DNA-templated | IEA | -- |
| GO:0006355 | regulation of transcription, DNA-templated | IEA | -- |
| GO:0008284 | positive regulation of cell proliferation | IEA | -- |
No data available for SIGNOR curated interactions for CBX8 Gene
Transcripts for CBX8 Gene
mRNA/cDNA for CBX8 Gene
- (1) REFSEQ mRNAs :
- (6) Additional mRNA sequences :
- (48) Selected AceView cDNA sequences:
- (4) Ensembl transcripts including schematic representations, and UCSC links where relevant :
-
- ENST00000269385 3791 bps (uc002jxd.3)
- ENST00000413392 777 bps (uc060kzo.1)
- ENST00000427800 665 bps (uc060kzp.1)
- ENST00000485449 581 bps (uc060kzq.1)
CRISPR Products
-
OriGene CRISPR knockouts for CBX8
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for CBX8
- genomics-online: gRNA clones - Search results for 97 available CBX8 gene related products
- Overview of 97 available CBX8 gene related products
- Applied Biological Materials CRISPR for CBX8
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for CBX8
- GenScript: Design CRISPR guide RNA sequences for CBX8
miRNA Products
Inhibitory RNA Products
- Origene sirna, shrna, and RNAi products in human, mouse, rat for CBX8
- Browse OriGene Inhibitory RNA Products For CBX8
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CBX8
- genomics-online: shRNA clones - Search results for 97 available CBX8 gene related products
- Overview of 97 available CBX8 gene related products
Clone Products
- Sino Biological Human cDNA Clone for CBX8
- VectorBuilder custom plasmid, inducible vectors for CBX8
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for CBX8
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for CBX8
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for CBX8
- Applied Biological Materials Clones for CBX8
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Expression for CBX8 Gene
This gene is overexpressed in Retina (28.7), Fetal Brain (8.2), and Pancreas (6.2).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for CBX8 Gene
- Elite partner
NURSA nuclear receptor signaling pathways regulating expression of CBX8 Gene:
CBX8SOURCE GeneReport for Unigene cluster for CBX8 Gene:
Hs.387258Evidence on tissue expression from TISSUES for CBX8 Gene
- Liver(4.2)
- Lung(4.2)
- Muscle(4.1)
Primer Products
-
OriGene qPCR primer pairs and template standards for CBX8
-
OriGene qPCR primer pairs for CBX8
- genomics-online: primer clones - Search results for 97 available CBX8 gene related products
- Overview of 97 available CBX8 gene related products
Gene Expression Assay Products
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for CBX8 Gene
Orthologs for CBX8 Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | CBX8 34 33 |
|
OneToOne | |
| cow (Bos Taurus) |
Mammalia | CBX8 34 33 |
|
OneToOne | |
| dog (Canis familiaris) |
Mammalia | CBX8 34 33 |
|
OneToOne | |
| mouse (Mus musculus) |
Mammalia | Cbx8 16 34 33 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Cbx8 33 |
|
||
| platypus (Ornithorhynchus anatinus) |
Mammalia | CBX8 34 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | CBX8 34 33 |
|
OneToOne | |
| lizard (Anolis carolinensis) |
Reptilia | CBX8 34 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | cbx8 33 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | LOC100535436 33 |
|
||
| cbx8a 34 34 |
|
OneToMany | |||
| cbx8b 34 |
|
OneToMany | |||
| Dr.20034 33 |
|
||||
| fruit fly (Drosophila melanogaster) |
Insecta | Pc 34 |
|
OneToMany |
- Species where no ortholog for CBX8 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- oppossum (Monodelphis domestica)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
Evolution for CBX8 Gene
- ENSEMBL:
- Gene Tree for CBX8 (if available)
- TreeFam:
- Gene Tree for CBX8 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for CBX8: view image
Paralogs for CBX8 Gene
Variants for CBX8 Gene
| SNP ID | Clin | Chr 17 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs1000095911 | -- | 79,795,790(-) | A/T | intron_variant | |
| rs1000645033 | -- | 79,797,600(-) | A/C | upstream_transcript_variant | |
| rs1001049861 | -- | 79,796,702(-) | C/T | intron_variant | |
| rs1001500874 | -- | 79,796,932(-) | T/C/G | coding_sequence_variant, missense_variant | |
| rs1002218411 | -- | 79,797,211(-) | G/C | upstream_transcript_variant |
Residual Variation Intolerance Score:
60.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
1.50;
29.24% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for CBX8 Gene
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CBX8 Gene
Disorders for CBX8 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| conversion disorder |
|
|
Search CBX8 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for CBX8
- Genetic Association Database
- (GAD)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No data available for UniProtKB/Swiss-Prot and Genatlas for CBX8 Gene
Publications for CBX8 Gene
- HPC3 is a new human polycomb orthologue that interacts and associates with RING1 and Bmi1 and has transcriptional repression properties. (PMID: 10825164) Bárdos JI … Freemont PS (The Journal of biological chemistry 2000) 2 3 4 22 58
- Several distinct polycomb complexes regulate and co-localize on the INK4a tumor suppressor locus. (PMID: 19636380) Maertens GN … Peters G (PloS one 2009) 3 4 22 58
- Recognition and specificity determinants of the human cbx chromodomains. (PMID: 21047797) Kaustov L … Arrowsmith CH (The Journal of biological chemistry 2011) 3 4 58
- Interaction proteomics analysis of polycomb proteins defines distinct PRC1 complexes in mammalian cells. (PMID: 21282530) Vandamme J … Angrand PO (Molecular & cellular proteomics : MCP 2011) 3 4 58
- Bypass of senescence by the polycomb group protein CBX8 through direct binding to the INK4A-ARF locus. (PMID: 17332741) Dietrich N … Hansen KH (The EMBO journal 2007) 3 22 58
Products for CBX8 Gene
- Browse R&D Systems for Antibodies
- Browse R&D Systems for Human Recombinant Proteins
- Browse R&D Systems for biochemical assays
- Browse Human Proteins and Enzymes
- Browse Primary Antibodies
- Browse Proteins and Enzymes
- Browse ELISAs
- Browse Activity Assays
- Browse cDNA Clones
- Browse Cell Culture Products
- Browse Cell Selection and Detection Kits
- Browse DNA Damage and Repair Kits
- Browse ELISpot/FluoroSpot Kits and Development Modules
- Browse Flow Cytometry Kits
- Browse Immunoprecipitation Assays
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- Custom Antibody ServicesOriGene Antibodies for CBX8
- AP12236PU-N
- AP50746PU-N
- TA303368
- TA322245
- TA322246
- TA600302
- TA600303
- TA600304
- TA600305
- TA600306
- TA600307
- TA600308
- TA700302
- TA700303
- TA700304
- TA700305
- TA700306
- TA700307
- TA800491
- CF800491
- TA800492
- CF800492
- TA800493
- CF800493
- TA800494
- CF800494
- TA800499
- CF800499
- TA800500
- CF800500
- TA800569
- CF800569
- TA800600
- CF800600
- TA800601
- CF800601
- TA800617
- CF800617
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- Custom Assay Services
- OriGene Purified Proteins for CBX8
- Search Origene for MassSpec and Protein Over-expression Lysates for CBX8
- Origene Custom Protein Services for CBX8
- Origene sirna, shrna, and RNAi products in human, mouse, rat for CBX8
- Browse OriGene Inhibitory RNA Products For CBX8
- OriGene qPCR primer pairs and template standards for CBX8
- OriGene qPCR primer pairs for CBX8
- OriGene CRISPR knockouts for CBX8
- OriGene ORF clones in human for CBX8
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For CBX8
- GenScript: Next-day shipping of latest version cDNA ORF clones for CBX8 in any vector
- GenScript Custom Purified and Recombinant Proteins Services for CBX8
- GenScript Custom Assay Services for CBX8
- GenScript Custom overexpressing Cell Line Services for CBX8
- GenScript: Design CRISPR guide RNA sequences for CBX8
- Design optimal peptide antigens
- CloneReady with Over 120,000 Genes
- Gene Synthesis: Any Gene in Any Vector
- Vector-based siRNA and miRNA, Ready for Transfection
- Gene Mutant Library, Variants up to 10^11
- Plasmid Preparation
- GenScript Custom Peptide Services for CBX8
- Sino Biological Human cDNA Clone for CBX8
- Browse Sino Biological Recombinant Proteins
- Browse Sino Biological Cell Lysates
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- Browse Sino Biological Assays
- Browse cDNA Clones
- Browse ELISA Kits
- Browse CRO Services
- High-throughput Antibody Production Service
- Protein Production Service
- Epitope Tag Antibodies & Reporter Protein Antibodies
- Lentiviral ORF Clones
- Novus Biologicals Antibodies for CBX8
- Novus Biologicals lysates and proteins for CBX8
- Novus Biologicals
- Novus Biologicals Tissue Microarrays
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- Abcam antibodies for CBX8
- Abcam proteins for CBX8
- Find your target
- Browse Primary Antibodies
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- Cyagen custom Knockout/knockin (KOKI) mouse models for CBX8
- VectorBuilder custom plasmid, inducible vectors for CBX8
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for CBX8
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for CBX8
- antibodies-online: Search results for 154 available CBX8 Antibodies ranked by validation data
- Compare Top CBX8 Antibodies
- Quality Products:
- antibodies-online: Search results for available CBX8 related products ranked by validation data
- antibodies-online: Search results for 3 available CBX8 Proteins ranked by validation data
- Compare Top CBX8 Proteins
- Quality Products:
- GeneTex CBX8 Antibody for CBX8
- Search GeneTex for Proteins for CBX8
- Santa Cruz Biotechnology (SCBT) Antibodies for CBX8
- Search Santa Cruz Biotechnology (SCBT) for CBX8 siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for CBX8
- Horizon Cell Lines for CBX8
- genomics-online: cdna clones - Search results for 97 available CBX8 gene related products
- Overview of 97 available CBX8 gene related products
- orf clones - Search results for 97 available CBX8 gene related products
- Overview of 97 available CBX8 gene related products
- genomics-online: gRNA clones - Search results for 97 available CBX8 gene related products
- Overview of 97 available CBX8 gene related products
- genomics-online: primer clones - Search results for 97 available CBX8 gene related products
- Overview of 97 available CBX8 gene related products
- genomics-online: shRNA clones - Search results for 97 available CBX8 gene related products
- Overview of 97 available CBX8 gene related products
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for CBX8
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for CBX8
- GeneCopoeia miRNA 3'UTR Target clone products for CBX8
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CBX8
Sources for CBX8 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
- (61) Tocris
- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
- (71) MOPED
- (72) neXtProt
- (73) Reactome
- (74) GeneGo (Thomson Reuters)
- (75) fRNAdb
- (76) DISEASES
- (77) SIMAP
- (78) GenomeRNAi
- (79) LifeMap
- (80) miRTarBase
- (81) MalaCards
- (82) Invitrogen
- (83) BitterDB
- (84) Vector BioLabs
- (85) ESI-BIO
- (86) RefSeq
- (87) BioSystems
- (88) MaxQB
- (89) IUPHAR
- (90) BioGPS
- (91) Illumina
- (92) COMPARTMENTS
- (93) HOMER
- (94) PaxDb
- (95) ApexBio
- (96) Addgene
- (97) antibodies-online
- (98) CYP
- (99) NONCODE
- (100) SwitchGear Genomics
- (101) TreeFam
- (102) PathCards
- (103) GeneReviews
- (104) GeneTex
- (105) Taconic Biosciences
- (106) GTEx
- (107) ProteomicsDB
- (108) SCBT
- (109) DGIdb
- (110) ClinicalTrials
- (111) FDA Approved Drugs
- (112) RVIS
- (113) SIGNOR
- (114) diseasecard
- (115) NIH Rare Diseases
- (116) Orphanet
- (117) UMLS
- (118) GTR
- (119) Disease Ontology
- (120) Genetics Home Reference
- (121) MeSH
- (122) MedlinePlus
- (123) CDC
- (124) NINDS
- (125) NCBI Bookshelf
- (126) ClinVar
- (127) Gene Damage Index
- (128) ViGene Biosciences
- (129) HPO
- (130) UDN
- (131) VISTA
- (132) FANTOM5
- (133) ENCODE
- (134) ProSci
- (135) Horizon
- (136) NURSA
- (137) IID
- (138) Cyagen
- (139) VectorBuilder
- (140) SNPedia
- (141) BRCA Exchange
- (142) St John's Lab
- (143) CIViC
- (144) ProteoGenix
- (145) dbSUPER
- (146) TISSUES
- (147) Gene ORGANizer
- (148) abm
- (149) CrownBio
- (150) Human Protein Atlas
- (151) GWAS Catalog
- (152) Monarch Initiative
- (153) DataMed
- (154) HumanCyc
- (155) genomics-online
- (156) UCNEbase
- (157) EPDnew
- (158) Applied Biosystems
- (159) GlyConnect
- (160) Aminode
- (161) GeneCopoeia
- (162) GPS-Prot
- (163) RNACentral
- (164) LncRNADisease
- (165) LOVD
- (166) miR2Disease
- (167) DiseaseEnhancer
- (168) Boster Bio
- (169) Biorbyt