Aliases for CBX8 Gene
External Ids for CBX8 Gene
Previous GeneCards Identifiers for CBX8 Gene
GeneCards Summary for CBX8 Gene
CBX8 (Chromobox 8) is a Protein Coding gene. Diseases associated with CBX8 include Root Caries and Esophageal Varix. Among its related pathways are Metabolism of proteins and Chromatin Regulation / Acetylation. Gene Ontology (GO) annotations related to this gene include ubiquitin-protein transferase activity and single-stranded RNA binding. An important paralog of this gene is CBX6.
UniProtKB/Swiss-Prot Summary for CBX8 Gene
Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility.