Aliases for CBX8 Gene
External Ids for CBX8 Gene
Previous GeneCards Identifiers for CBX8 Gene
GeneCards Summary for CBX8 Gene
CBX8 (Chromobox 8) is a Protein Coding gene. Diseases associated with CBX8 include Root Caries and Esophageal Varix. Among its related pathways are SUMOylation and Cellular Senescence (REACTOME). Gene Ontology (GO) annotations related to this gene include ubiquitin-protein transferase activity and single-stranded RNA binding. An important paralog of this gene is CBX6.
UniProtKB/Swiss-Prot Summary for CBX8 Gene
Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility.