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CBX8 (Chromobox 8) is a Protein Coding gene. Diseases associated with CBX8 include Root Caries and Esophageal Varix. Among its related pathways are Metabolism of proteins and Chromatin Regulation / Acetylation. Gene Ontology (GO) annotations related to this gene include ubiquitin-protein transferase activity and single-stranded RNA binding. An important paralog of this gene is CBX6.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0003727 | single-stranded RNA binding | IEA | -- |
GO:0005515 | protein binding | IPI | 16169070 |
GO:0035064 | methylated histone binding | IDA | 21029866 |
GO:0097027 | ubiquitin-protein transferase activator activity | IEA | -- |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000151 | ubiquitin ligase complex | IEA | -- |
GO:0000785 | chromatin | IDA | 19636380 |
GO:0000792 | heterochromatin | IEA | -- |
GO:0005634 | nucleus | IEA,IDA | 21282530 |
GO:0005654 | nucleoplasm | TAS | -- |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Cellular Senescence (REACTOME) | ||
2 | SUMOylation |
.95
|
|
3 | Metabolism of proteins | ||
4 | Chromatin Regulation / Acetylation | ||
5 | Transport of the SLBP independent Mature mRNA |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000122 | negative regulation of transcription by RNA polymerase II | IMP | 19636380 |
GO:0006325 | chromatin organization | IEA | -- |
GO:0008284 | positive regulation of cell proliferation | IEA | -- |
GO:0016574 | histone ubiquitination | IEA | -- |
GO:0032967 | positive regulation of collagen biosynthetic process | IEA | -- |
This gene was present in the common ancestor of animals.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | CBX8 30 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | CBX8 30 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | CBX8 30 31 |
|
OneToOne | |
Mouse (Mus musculus) |
Mammalia | Cbx8 30 17 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | Cbx8 30 |
|
||
Platypus (Ornithorhynchus anatinus) |
Mammalia | CBX8 31 |
|
OneToOne | |
Chicken (Gallus gallus) |
Aves | CBX8 30 31 |
|
OneToOne | |
Lizard (Anolis carolinensis) |
Reptilia | CBX8 31 |
|
OneToOne | |
Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | cbx8 30 |
|
||
Zebrafish (Danio rerio) |
Actinopterygii | LOC100535436 30 |
|
||
cbx8a 31 31 |
|
OneToMany | |||
cbx8b 31 |
|
OneToMany | |||
Dr.20034 30 |
|
||||
Fruit Fly (Drosophila melanogaster) |
Insecta | Pc 31 |
|
OneToMany |
SNP ID | Clinical significance and condition | Chr 17 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
rs4889891 | - |
p.Gly317Val |
Disorder | Aliases | PubMed IDs |
---|---|---|
root caries |
|
|
esophageal varix |
|
|
congenital bile acid synthesis defect |
|
|
hypochondriasis |
|
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