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Aliases for CBX8 Gene
Aliases for CBX8 Gene
External Ids for CBX8 Gene
- HGNC: 15962
- Entrez Gene: 57332
- Ensembl: ENSG00000141570
- OMIM: 617354
- UniProtKB: Q9HC52
Previous GeneCards Identifiers for CBX8 Gene
- GC17M077418
- GC17M081056
- GC17M078332
- GC17M078468
- GC17M078452
- GC17M075382
- GC17M077765
- GC17M073209
Summaries for CBX8 Gene
GeneCards Summary for CBX8 Gene
CBX8 (Chromobox 8) is a Protein Coding gene. Among its related pathways are Metabolism of proteins and Chromatin Regulation / Acetylation. Gene Ontology (GO) annotations related to this gene include ubiquitin-protein transferase activity and single-stranded RNA binding. An important paralog of this gene is CBX6.
UniProtKB/Swiss-Prot Summary for CBX8 Gene
-
Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility.
Additional gene information for CBX8 Gene
- HGNC(15962)
- Entrez Gene(57332)
- Ensembl(ENSG00000141570)
- OMIM(617354)
- UniProtKB(Q9HC52)
- Open Targets Platform(ENSG00000141570)
- Search for CBX8 at DataMed
- Search for CBX8 at HumanCyc
No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for CBX8 Gene
Genomics for CBX8 Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for CBX8 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around CBX8 on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for CBX8
- Top Transcription factor binding sites by QIAGEN in the CBX8 gene promoter:
-
- c-Ets-1
- Gfi-1
- NF-kappaB
- NF-kappaB1
- NF-kappaB2
- Pax-4a
- Pax-6
- POU2F1
- POU2F1a
- SRY
Genomic Locations for CBX8 Gene
Genomic Locations for CBX8 Gene
- chr17:79,792,132-79,801,683
- (GRCh38/hg38)
- Size:
- 9,552 bases
- Orientation:
- Minus strand
- chr17:77,765,931-77,775,482
- (GRCh37/hg19)
- Size:
- 9,552 bases
- Orientation:
- Minus strand
Genomic View for CBX8 Gene
Genes around CBX8 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 17q25.3 by HGNC
- 17q25.3 by Entrez Gene
- 17q25.3 by Ensembl
CBX8 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for CBX8 Gene
Proteins for CBX8 Gene
-
Protein details for CBX8 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q9HC52-CBX8_HUMAN
- Recommended name:
- Chromobox protein homolog 8
- Protein Accession:
- Q9HC52
- Q96H39
- Q9NR07
Protein attributes for CBX8 Gene
- Size:
- 389 amino acids
- Molecular mass:
- 43396 Da
- Quaternary structure:
-
- Component of a PRC1-like complex. Interacts with RING1 RNF2, PCGF1, PCGF2, PCGF3, BMI1, PCGF5 AND PCGF6. Interacts with MLLT3 and histone H3. Interacts with PHC2 (By similarity).
- Miscellaneous:
-
- The human orthologuous proteins of Drosphila Polycomb group protein Pc, CBX2, CBX4, CBX6, CBX7 and CBX8, show distinct nuclear localizations, contribute differently to transcriptional repression, and appear to be part of distinct PRC1-like protein complexes. The hPRC-H complex purification reported by PubMed:12167701 probably presents a mixture of different complexes.
Protein Expression for CBX8 Gene
Post-translational modifications for CBX8 Gene
Other Protein References for CBX8 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- G Biosciences Immunotag™ CBX8 Antibody
- HUABIO Anti-CBX8 Antibody
-
Custom Antibody ServicesOriGene Antibodies for CBX8
- AP12236PU-N
- AP50746PU-N
- CF800491
- CF800492
- CF800493
- CF800494
- CF800499
- CF800500
- CF800569
- CF800600
- CF800601
- CF800617
- TA303368
- TA322245
- TA322246
- TA600302
- TA600303
- TA600304
- TA600305
- TA600306
- TA600307
- TA600308
- TA700302
- TA700303
- TA700304
- TA700305
- TA700306
- TA700307
- TA800491
- TA800491S
- TA800492
- TA800492S
- TA800493
- TA800493S
- TA800494
- TA800494S
- TA800499
- TA800499S
- TA800500
- TA800500S
- TA800569
- TA800569S
- TA800600
- TA800600S
- TA800601
- TA800601S
- TA800617
- TA800617S
- Novus Biologicals Antibodies for CBX8
-
Abcam antibodies for CBX8
- Invitrogen Antibodies for CBX8 (AFLGC-CBX8)
-
Santa Cruz Biotechnology (SCBT) Antibodies for CBX8
- Sino Biological Antibodies for CBX8
Protein Products
-
OriGene Purified Proteins for CBX8
- Search Origene for MassSpec and Protein Over-expression Lysates for CBX8
- Origene Custom Protein Services for CBX8
- antibodies-online: Show 3 available CBX8 Proteins ranked by validation data
- Compare Top CBX8 Proteins
-
Quality Products:
-
Signalway Proteins for CBX8
-
Abcam proteins for CBX8
No data available for DME Specific Peptides for CBX8 Gene
Domains & Families for CBX8 Gene
Gene Families for CBX8 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Predicted intracellular proteins
Protein Domains for CBX8 Gene
- InterPro:
- Blocks:
-
- Chromo domain
- ProtoNet:
Suggested Antigen Peptide Sequences for CBX8 Gene
- GenScript: Design optimal peptide antigens:
-
- Rectachrome 1 (CBX8_HUMAN)
- NADH dehydrogenase subunit 3 homolog/ND3 homolog (Q9P2Z1_HUMAN)
No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for CBX8 Gene
Function for CBX8 Gene
Molecular function for CBX8 Gene
- UniProtKB/Swiss-Prot Function:
- Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility.
Phenotypes From GWAS Catalog for CBX8 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0003727 | single-stranded RNA binding | IEA | -- |
| GO:0005515 | protein binding | IPI | 16169070 |
| GO:0035064 | methylated histone binding | IDA | 21029866 |
| GO:0097027 | ubiquitin-protein transferase activator activity | IEA | -- |
Phenotypes for CBX8 Gene
- MGI mutant phenotypes for CBX8:
- inferred from 2 alleles
- GenomeRNAi human phenotypes for CBX8:
-
- Increased vaccinia virus (VACV) infection
- no effect
- Decreased viability
- Decreased vaccinia virus (VACV) infection
- shRNA abundance <= 50%
- Decreased viability in glioblastoma multiforme (GBM) lineage
- Increased Nanog expression
- Decreased human papilloma virus 16 (HPV16) pseudovirus infection
- Increased transcriptional activity
- Decreased interferon-beta reporter expression
Animal Models for CBX8 Gene
- MGI Knock Outs for CBX8:
-
- Cbx8 Cbx8<tm1.1Hko>
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for CBX8 - Select products 50% OFF >
- * CBX8 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for CBX8
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for CBX8
-
Santa Cruz Biotechnology (SCBT) CRISPR for CBX8
miRNA for CBX8 Gene
- miRTarBase miRNAs that target CBX8
-
- hsa-miR-218-5p (MIRT440996)
- hsa-miR-140-3p (MIRT624417)
- hsa-miR-362-3p (MIRT624418)
- hsa-miR-329-3p (MIRT624419)
- hsa-miR-8485 (MIRT624420)
- hsa-miR-519c-3p (MIRT624421)
- hsa-miR-519b-3p (MIRT624422)
- hsa-miR-519a-3p (MIRT624423)
- hsa-miR-4796-3p (MIRT624424)
- hsa-miR-548ah-5p (MIRT624425)
- hsa-miR-3609 (MIRT624426)
- hsa-miR-106b-5p (MIRT624427)
- hsa-miR-20a-5p (MIRT624428)
- hsa-miR-20b-5p (MIRT624429)
- hsa-miR-519d-3p (MIRT624430)
- hsa-miR-17-5p (MIRT624431)
- hsa-miR-106a-5p (MIRT624432)
- hsa-miR-93-5p (MIRT624433)
- hsa-miR-526b-3p (MIRT624434)
- hsa-miR-6857-5p (MIRT669200)
- hsa-miR-450a-2-3p (MIRT669201)
- hsa-miR-6810-5p (MIRT669202)
- hsa-miR-2110 (MIRT669203)
- hsa-miR-6825-5p (MIRT669204)
- hsa-miR-939-5p (MIRT669205)
- hsa-miR-1343-5p (MIRT669206)
- hsa-miR-6827-5p (MIRT669207)
- hsa-miR-505-5p (MIRT669208)
- hsa-miR-5189-3p (MIRT669209)
- hsa-miR-509-3p (MIRT669210)
- hsa-miR-1203 (MIRT735960)
- hsa-miR-1207-5p (MIRT736011)
- hsa-miR-1286 (MIRT737042)
- hsa-miR-184 (MIRT738188)
- hsa-miR-211-3p (MIRT738925)
- hsa-miR-3064-5p (MIRT739693)
- hsa-miR-3180-3p (MIRT740769)
- hsa-miR-3180 (MIRT740809)
- hsa-miR-3184-5p (MIRT740853)
- hsa-miR-3196 (MIRT741066)
- hsa-miR-3648 (MIRT741861)
- hsa-miR-3652 (MIRT741884)
- hsa-miR-3978 (MIRT743223)
- hsa-miR-423-5p (MIRT743252)
- hsa-miR-4430 (MIRT744322)
- hsa-miR-4487 (MIRT745196)
- hsa-miR-4505 (MIRT745509)
- hsa-miR-4743-5p (MIRT748152)
- hsa-miR-4763-3p (MIRT748520)
- hsa-miR-4787-5p (MIRT748886)
- hsa-miR-493-3p (MIRT749246)
- hsa-miR-5580-5p (MIRT750927)
- hsa-miR-5787 (MIRT751459)
- hsa-miR-627-5p (MIRT752628)
- hsa-miR-6504-5p (MIRT752930)
- hsa-miR-6752-5p (MIRT754620)
- hsa-miR-6816-5p (MIRT756795)
- hsa-miR-6820-5p (MIRT756877)
- hsa-miR-6842-3p (MIRT757339)
- hsa-miR-6842-5p (MIRT757354)
- hsa-miR-6850-3p (MIRT757564)
- hsa-miR-7110-5p (MIRT758980)
- hsa-miR-7845-5p (MIRT759792)
- hsa-miR-875-3p (MIRT760349)
- hsa-miR-924 (MIRT760509)
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for CBX8
- Browse OriGene Inhibitory RNA Products For CBX8
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CBX8
Clone Products
- Applied Biological Materials (abm): Clones for CBX8 - Select products 50% OFF >
- * CBX8 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Sino Biological Human cDNA Clone for CBX8
- Addgene plasmids for CBX8
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for CBX8
Cell Line Products
-
Horizon Cell Lines for CBX8
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CBX8 Gene
Localization for CBX8 Gene
Subcellular locations from UniProtKB/Swiss-Prot for CBX8 Gene
- Nucleus.
| Compartment | Confidence |
|---|---|
| nucleus | 5 |
| plasma membrane | 2 |
| extracellular | 2 |
| cytoskeleton | 2 |
| mitochondrion | 1 |
| endoplasmic reticulum | 1 |
| endosome | 1 |
| cytosol | 1 |
| golgi apparatus | 1 |
- Nucleoplasm (4)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000151 | ubiquitin ligase complex | IEA | -- |
| GO:0000790 | nuclear chromatin | IDA | 19636380 |
| GO:0000792 | heterochromatin | IEA | -- |
| GO:0005634 | nucleus | IEA,IDA | 21282530 |
| GO:0005654 | nucleoplasm | TAS | -- |
Pathways & Interactions for CBX8 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Cellular Senescence (REACTOME) | ||
| 2 | SUMOylation |
.95
|
|
| 3 | Metabolism of proteins | ||
| 4 | Chromatin Regulation / Acetylation | ||
| 5 | Transport of the SLBP independent Mature mRNA | ||
Pathways by source for CBX8 Gene
9 Reactome pathways for CBX8 Gene
1 Cell Signaling Technology pathway for CBX8 Gene
Interacting Proteins for CBX8 Gene
Selected Interacting proteins:
Q9HC52-CBX8_HUMAN
ENSP00000269385
for CBX8 Gene via
UniProtKB
MINT
STRING
IID
GPS-Prot Interaction Network for CBX8
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000122 | negative regulation of transcription by RNA polymerase II | IMP | 19636380 |
| GO:0006325 | chromatin organization | IEA | -- |
| GO:0008284 | positive regulation of cell proliferation | IEA | -- |
| GO:0016574 | histone ubiquitination | IEA | -- |
| GO:0032967 | positive regulation of collagen biosynthetic process | IEA | -- |
No data available for SIGNOR curated interactions for CBX8 Gene
Transcripts for CBX8 Gene
mRNA/cDNA for CBX8 Gene
- 1 REFSEQ mRNAs :
- 6 NCBI additional mRNA sequence :
- 4 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000269385 3752 nts (view in UCSC)
- ENST00000413392 777 nts (view in UCSC)
- ENST00000427800 665 nts (view in UCSC)
- ENST00000485449 581 nts (view in UCSC)
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for CBX8 - Select products 50% OFF >
- * CBX8 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for CBX8
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for CBX8
-
Santa Cruz Biotechnology (SCBT) CRISPR for CBX8
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for CBX8
- Browse OriGene Inhibitory RNA Products For CBX8
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CBX8
Clone Products
- Applied Biological Materials (abm): Clones for CBX8 - Select products 50% OFF >
- * CBX8 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Sino Biological Human cDNA Clone for CBX8
- Addgene plasmids for CBX8
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for CBX8
Relevant External Links for CBX8 Gene
- GeneLoc Exon Structure for
- CBX8
Expression for CBX8 Gene
This gene is overexpressed in Retina (28.7), Fetal Brain (8.2), and Pancreas (6.2).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for CBX8 Gene
- Elite partner
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for CBX8
SOURCE GeneReport for Unigene cluster for CBX8 Gene:
Hs.387258Evidence on tissue expression from TISSUES for CBX8 Gene
- Liver(4.4)
- Muscle(4.4)
- Lung(4.3)
- Skin(2.5)
- Blood(2.4)
- Nervous system(2.3)
- Eye(2.2)
Primer Products
-
OriGene qPCR primer pairs for CBX8
-
OriGene qPCR primer pairs and template standards for CBX8
Gene Expression Assay Products
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for CBX8 Gene
Orthologs for CBX8 Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | CBX8 30 31 |
|
OneToOne | |
| Cow (Bos Taurus) |
Mammalia | CBX8 30 31 |
|
OneToOne | |
| Dog (Canis familiaris) |
Mammalia | CBX8 30 31 |
|
OneToOne | |
| Mouse (Mus musculus) |
Mammalia | Cbx8 30 17 31 |
|
OneToOne | |
| Rat (Rattus norvegicus) |
Mammalia | Cbx8 30 |
|
||
| Platypus (Ornithorhynchus anatinus) |
Mammalia | CBX8 31 |
|
OneToOne | |
| Chicken (Gallus gallus) |
Aves | CBX8 30 31 |
|
OneToOne | |
| Lizard (Anolis carolinensis) |
Reptilia | CBX8 31 |
|
OneToOne | |
| Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | cbx8 30 |
|
||
| Zebrafish (Danio rerio) |
Actinopterygii | LOC100535436 30 |
|
||
| cbx8a 31 31 |
|
OneToMany | |||
| cbx8b 31 |
|
OneToMany | |||
| Dr.20034 30 |
|
||||
| Fruit Fly (Drosophila melanogaster) |
Insecta | Pc 31 |
|
OneToMany |
- Species where no ortholog for CBX8 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Baker's yeast (Saccharomyces cerevisiae)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Oppossum (Monodelphis domestica)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Rainbow Trout (Oncorhynchus mykiss)
- Rice (Oryza sativa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Vase (Ciona intestinalis)
- Sea Squirt (Ciona savignyi)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Thale Cress (Arabidopsis thaliana)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Wheat (Triticum aestivum)
- Worm (Caenorhabditis elegans)
Evolution for CBX8 Gene
- ENSEMBL:
- Gene Tree for CBX8 (if available)
- TreeFam:
- Gene Tree for CBX8 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for CBX8: view image
Paralogs for CBX8 Gene
Variants for CBX8 Gene
Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for CBX8 Gene
| SNP ID | Clinical significance and condition | Chr 17 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs4889891 | - | p.Gly317Val |
Residual Variation Intolerance Score:
60.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
1.50;
29.24% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for CBX8 Gene
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CBX8 Gene
Disorders for CBX8 Gene
Additional Disease Information for CBX8
- Genetic Association Database
- (GAD)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
- Open Targets Platform
No disorders were found for CBX8 Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CBX8 Gene
Publications for CBX8 Gene
- HPC3 is a new human polycomb orthologue that interacts and associates with RING1 and Bmi1 and has transcriptional repression properties. (PMID: 10825164) Bárdos JI … Freemont PS (The Journal of biological chemistry 2000) 2 3 4 23
- Several distinct polycomb complexes regulate and co-localize on the INK4a tumor suppressor locus. (PMID: 19636380) Maertens GN … Peters G (PloS one 2009) 3 4 23
- Recognition and specificity determinants of the human cbx chromodomains. (PMID: 21047797) Kaustov L … Arrowsmith CH (The Journal of biological chemistry 2011) 3 4
- Interaction proteomics analysis of polycomb proteins defines distinct PRC1 complexes in mammalian cells. (PMID: 21282530) Vandamme J … Angrand PO (Molecular & cellular proteomics : MCP 2011) 3 4
- Bypass of senescence by the polycomb group protein CBX8 through direct binding to the INK4A-ARF locus. (PMID: 17332741) Dietrich N … Hansen KH (The EMBO journal 2007) 3 23
ExternalLinks
Products for CBX8 Gene
- Custom Antibody ServicesOriGene Antibodies for CBX8
- AP12236PU-N
- AP50746PU-N
- CF800491
- CF800492
- CF800493
- CF800494
- CF800499
- CF800500
- CF800569
- CF800600
- CF800601
- CF800617
- TA303368
- TA322245
- TA322246
- TA600302
- TA600303
- TA600304
- TA600305
- TA600306
- TA600307
- TA600308
- TA700302
- TA700303
- TA700304
- TA700305
- TA700306
- TA700307
- TA800491
- TA800491S
- TA800492
- TA800492S
- TA800493
- TA800493S
- TA800494
- TA800494S
- TA800499
- TA800499S
- TA800500
- TA800500S
- TA800569
- TA800569S
- TA800600
- TA800600S
- TA800601
- TA800601S
- TA800617
- TA800617S
- Browse OriGene ELISA Kits
- Custom Assay Services
- OriGene Purified Proteins for CBX8
- Search Origene for MassSpec and Protein Over-expression Lysates for CBX8
- Origene Custom Protein Services for CBX8
- Origene shrna, sirna, and RNAi products in human, mouse, rat for CBX8
- Browse OriGene Inhibitory RNA Products For CBX8
- OriGene qPCR primer pairs for CBX8
- OriGene qPCR primer pairs and template standards for CBX8
- OriGene CRISPR knockouts for CBX8
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For CBX8
- Sino Biological Human cDNA Clone for CBX8
- Browse Sino Biological Recombinant Proteins
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- Sino Biological Antibodies for CBX8
- Browse Sino Biological Assays
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- Browse CRO Services
- High-throughput Antibody Production Service
- Protein Production Service
- Epitope Tag Antibodies & Reporter Protein Antibodies
- Lentiviral ORF Clones
- Novus Biologicals Antibodies for CBX8
- Novus Biologicals proteins and lysates for CBX8
- Browse Antibodies
- Browse Peptides and Proteins
- Browse Lysates
- Browse ELISA Kits
- Abcam antibodies for CBX8
- Abcam proteins for CBX8
- Find your target
- Browse Primary Antibodies
- Browse Conjugated Primary Antibodies
- Browse Secondary Antibodies
- Browse ELISA Kits
- Browse Matched Antibody Pairs
- Browse Proteins and Peptides
- Search Knockout (KO) Validated Antibodies
- Browse Monoclonal Antibodies
- Browse Recombinant Antibodies
- Invitrogen Antibodies for CBX8 (AFLGC-CBX8)
- VectorBuilder Custom and pre-made DNA vectors for CBX8 (ie. gene expression, shRNA knockdown, CRISPR)
- VectorBuilder Viral vectors for CBX8 (ie. lentivirus, AAV, adenovirus)
- VectorBuilder CRISPR vectors for CBX8 (ie. knockout, knockin, CRISPRa, CRISPRi)
- VectorBuilder Virus packaging for CBX8 CRISPR vectors (ie. lentivirus, AAV, adenovirus)
- VectorBuilder Stable cell line generation for CBX8
- Addgene plasmids for CBX8
- antibodies-online: Show 48 available CBX8 Antibodies ranked by validation data
- Compare Top CBX8 Antibodies
- antibodies-online: Search results for available CBX8 related products ranked by validation data
- antibodies-online: Show 3 available CBX8 Proteins ranked by validation data
- Compare Top CBX8 Proteins
- Quality Products:
- Santa Cruz Biotechnology (SCBT) Antibodies for CBX8
- Search Santa Cruz Biotechnology (SCBT) for CBX8 siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for CBX8
- Horizon Cell Lines for CBX8
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for CBX8
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for CBX8
- Search GeneCopoeia for miRNA 3'UTR Target clone products for CBX8
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CBX8
- Signalway Proteins for CBX8
Sources for CBX8 Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) UniProtKB/TrEMBL
- (14) InterPro
- (15) ProtoNet
- (16) Blocks
- (17) MGI
- (18) IUBMB
- (19) KEGG
- (20) MINT
- (21) STRING
- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) ASD
- (28) SAGE
- (29) SOURCE
- (30) HomoloGene
- (31) PanEnsembl
- (32) euGenes
- (33) SGD
- (34) FlyBase
- (35) WormBase
- (36) Pseudogene
- (37) DGV
- (38) dbSNP
- (39) GenAtlas
- (40) HGMD
- (41) GAD
- (42) BGMUT
- (43) HuGE
- (44) Atlas
- (45) GenBank
- (46) HORDE
- (47) HUGE
- (48) IMGT
- (49) Leiden
- (50) miRBase
- (51) DME
- (52) OriGene
- (53) PubMed
- (54) R&D Systems
- (55) TGDB
- (56) Tocris
- (57) Abcam
- (58) Novus Biologicals
- (59) ProSpec
- (60) Sino Biological
- (61) GenScript
- (62) Qiagen
- (63) OCA
- (64) Proteopedia
- (65) MOPED
- (66) neXtProt
- (67) Reactome
- (68) GeneGo (Thomson Reuters)
- (69) DISEASES
- (70) SIMAP
- (71) GenomeRNAi
- (72) LifeMap
- (73) miRTarBase
- (74) MalaCards
- (75) Invitrogen
- (76) BitterDB
- (77) ESI-BIO
- (78) RefSeq
- (79) BioSystems
- (80) MaxQB
- (81) IUPHAR
- (82) BioGPS
- (83) Illumina
- (84) COMPARTMENTS
- (85) HOMER
- (86) PaxDb
- (87) ApexBio
- (88) Addgene
- (89) antibodies-online
- (90) CYP
- (91) NONCODE
- (92) TreeFam
- (93) PathCards
- (94) GeneReviews
- (95) GeneTex
- (96) Taconic Biosciences
- (97) GTEx
- (98) ProteomicsDB
- (99) SCBT
- (100) DGIdb
- (101) ClinicalTrials
- (102) RVIS
- (103) SIGNOR
- (104) diseasecard
- (105) NIH Rare Diseases
- (106) Orphanet
- (107) UMLS
- (108) GTR
- (109) Disease Ontology
- (110) Genetics Home Reference
- (111) MeSH
- (112) MedlinePlus
- (113) CDC
- (114) NINDS
- (115) NCBI Bookshelf
- (116) ClinVar
- (117) Gene Damage Index
- (118) HPO
- (119) UDN
- (120) VISTA
- (121) FANTOM5
- (122) ENCODE
- (123) ProSci
- (124) Horizon
- (125) The Signaling Pathways Project (SPP)
- (126) IID
- (127) VectorBuilder
- (128) SNPedia
- (129) BRCA Exchange
- (130) CIViC
- (131) ProteoGenix
- (132) dbSUPER
- (133) TISSUES
- (134) Gene ORGANizer
- (135) abm
- (136) Human Protein Atlas
- (137) GWAS Catalog
- (138) Monarch Initiative
- (139) DataMed
- (140) HumanCyc
- (141) UCNEbase
- (142) EPDnew
- (143) Applied Biosystems
- (144) GlyConnect
- (145) Aminode
- (146) GeneCopoeia
- (147) GPS-Prot
- (148) RNACentral
- (149) LncRNADisease
- (150) LOVD
- (151) miR2Disease
- (152) DiseaseEnhancer
- (153) Boster Bio
- (154) Biorbyt
- (155) Biocompare
- (156) Mastermind
- (157) CTD^2 Dashboard
- (158) CraniofacialAtlas
- (159) GeneImprint
- (160) Synthego
- (161) ENA
- (162) GtRNAdb
- (163) LncBase
- (164) LncBook
- (165) LNCipedia
- (166) Modomics
- (167) PDBe
- (168) Rfam
- (169) SILVA
- (170) snOPY
- (171) SRPDB
- (172) GENCODE
- (173) TarBase
- (174) Signalway Antibody
- (175) Open Targets Platform
- (176) 5SRRNADB
- (177) snoDB
- (178) MirGeneDB