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This gene encodes a protein that contains the CHROMO (CHRomatin Organization MOdifier) domain. The encoded protein is a component of the Polycomb repressive complex 1 (PRC1), and is thought to control the lifespan of several normal human cells. [provided by RefSeq, Oct 2016]
CBX7 (Chromobox 7) is a Protein Coding gene. Diseases associated with CBX7 include Ovarian Clear Cell Adenocarcinoma and Melanoma, Cutaneous Malignant 1. Gene Ontology (GO) annotations related to this gene include chromatin binding and single-stranded RNA binding. An important paralog of this gene is CBX4.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005515 | protein binding | IPI | 10369680 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000790 | nuclear chromatin | IDA | 19636380 |
GO:0005634 | nucleus | IEA,IDA | 21282530 |
GO:0005654 | nucleoplasm | IDA | -- |
GO:0005829 | cytosol | IDA | -- |
GO:0031519 | PcG protein complex | IBA,IDA | 21282530 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000122 | negative regulation of transcription by RNA polymerase II | IBA,IMP | 19636380 |
GO:0006325 | chromatin organization | IEA | -- |
Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
---|---|---|---|---|---|---|
UNC3866 | Pharma | a potent antagonist of CBX4 and CBX7 chromodomains | 0 |
Compound | Action | Cas Number |
---|---|---|
UNC3866 | a potent antagonist of CBX4 and CBX7 chromodomains |
ExUns: | 1 | ^ | 2a | · | 2b | ^ | 3 | ^ | 4 | ^ | 5a | · | 5b | ^ | 6a | · | 6b |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
SP1: | - | - | |||||||||||||||
SP2: | |||||||||||||||||
SP3: |
This gene was present in the common ancestor of animals.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | CBX7 30 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | CBX7 30 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | CBX7 30 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | Cbx7 30 |
|
||
Mouse (Mus musculus) |
Mammalia | Cbx7 30 17 31 |
|
OneToOne | |
Platypus (Ornithorhynchus anatinus) |
Mammalia | CBX7 31 |
|
OneToOne | |
Oppossum (Monodelphis domestica) |
Mammalia | CBX7 31 |
|
OneToOne | |
Chicken (Gallus gallus) |
Aves | CBX7 30 31 |
|
OneToOne | |
Lizard (Anolis carolinensis) |
Reptilia | CBX7 31 |
|
OneToOne | |
Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | cbx7 30 |
|
||
Zebrafish (Danio rerio) |
Actinopterygii | LOC101882803 30 |
|
||
cbx7b 31 |
|
OneToMany | |||
cbx7a 31 |
|
OneToMany | |||
Fruit Fly (Drosophila melanogaster) |
Insecta | Pc 31 |
|
OneToMany |
SNP ID | Clinical significance and condition | Chr 22 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
rs193920857 | Uncertain Significance: Malignant tumor of prostate | 39,138,655(-) | G/C | MISSENSE_VARIANT |
Disorder | Aliases | PubMed IDs |
---|---|---|
ovarian clear cell adenocarcinoma |
|
|
melanoma, cutaneous malignant 1 |
|
|