External Ids for CBX7 Gene
Previous GeneCards Identifiers for CBX7 Gene
This gene encodes a protein that contains the CHROMO (CHRomatin Organization MOdifier) domain. The encoded protein is a component of the Polycomb repressive complex 1 (PRC1), and is thought to control the lifespan of several normal human cells. [provided by RefSeq, Oct 2016]
GeneCards Summary for CBX7 Gene
CBX7 (Chromobox 7) is a Protein Coding gene. Diseases associated with CBX7 include Ovarian Clear Cell Adenocarcinoma and Melanoma, Cutaneous Malignant 1. Gene Ontology (GO) annotations related to this gene include chromatin binding and single-stranded RNA binding. An important paralog of this gene is CBX4.
UniProtKB/Swiss-Prot Summary for CBX7 Gene
Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. Promotes histone H3 trimethylation at 'Lys-9' (H3K9me3). Binds to trimethylated lysine residues in histones, and possibly also other proteins. Regulator of cellular lifespan by maintaining the repression of CDKN2A, but not by inducing telomerase activity.