This gene encodes a protein that contains the CHROMO (CHRomatin Organization MOdifier) domain. The encoded protein is a component of the Polycomb repressive complex 1 (PRC1), and is thought to control the lifespan of several normal human cells. [provided by RefSeq, Oct 2016] See more...

Aliases for CBX7 Gene

Aliases for CBX7 Gene

  • Chromobox 7 2 3 5
  • Chromobox Protein Homolog 7 3 4
  • Chromobox Homolog 7 2
  • CBX7 5

External Ids for CBX7 Gene

Previous GeneCards Identifiers for CBX7 Gene

  • GC22U990068
  • GC22M036145
  • GC22M037769
  • GC22M037851
  • GC22M039518
  • GC22M039519
  • GC22M022493
  • GC22M039605
  • GC22M040104
  • GC22M039153
  • GC22M039830
  • GC22M042770
  • GC22M042885
  • GC22M042943
  • GC22M044552
  • GC22M039833
  • GC22M039940
  • GC22M040628
  • GC22M041076
  • GC22M041474
  • GC22M041882
  • GC22M042311
  • GC22M042662

Summaries for CBX7 Gene

Entrez Gene Summary for CBX7 Gene

  • This gene encodes a protein that contains the CHROMO (CHRomatin Organization MOdifier) domain. The encoded protein is a component of the Polycomb repressive complex 1 (PRC1), and is thought to control the lifespan of several normal human cells. [provided by RefSeq, Oct 2016]

GeneCards Summary for CBX7 Gene

CBX7 (Chromobox 7) is a Protein Coding gene. Diseases associated with CBX7 include Ovarian Clear Cell Adenocarcinoma and Melanoma, Cutaneous Malignant 1. Gene Ontology (GO) annotations related to this gene include chromatin binding and single-stranded RNA binding. An important paralog of this gene is CBX4.

UniProtKB/Swiss-Prot Summary for CBX7 Gene

  • Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. Promotes histone H3 trimethylation at 'Lys-9' (H3K9me3). Binds to trimethylated lysine residues in histones, and possibly also other proteins. Regulator of cellular lifespan by maintaining the repression of CDKN2A, but not by inducing telomerase activity.

No data available for CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for CBX7 Gene

Genomics for CBX7 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for CBX7 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around CBX7 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for CBX7

Top Transcription factor binding sites by QIAGEN in the CBX7 gene promoter:
  • ATF6
  • c-Myc
  • FOXO4
  • ITF-2
  • Max1
  • Msx-1
  • Tal-1beta
  • TGIF
  • YY1

Genomic Locations for CBX7 Gene

Genomic Locations for CBX7 Gene
chr22:39,120,167-39,152,680
(GRCh38/hg38)
Size:
32,514 bases
Orientation:
Minus strand
chr22:39,516,172-39,548,679
(GRCh37/hg19)
Size:
32,508 bases
Orientation:
Minus strand

Genomic View for CBX7 Gene

Genes around CBX7 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CBX7 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CBX7 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CBX7 Gene

Proteins for CBX7 Gene

  • Protein details for CBX7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O95931-CBX7_HUMAN
    Recommended name:
    Chromobox protein homolog 7
    Protein Accession:
    O95931
    Secondary Accessions:
    • Q86T17

    Protein attributes for CBX7 Gene

    Size:
    251 amino acids
    Molecular mass:
    28341 Da
    Quaternary structure:
    • Component of a PRC1-like complex. Interacts with RING1 and RNF2/RING1B, but not with BMI1, EED or EZH2. Interacts with PCGF1, PCGF2, PCGF3, PCGF5 and PCGF6.
    Miscellaneous:
    • The human orthologuous proteins of Drosphila Polycomb group protein Pc, CBX2, CBX4, CBX6, CBX7 and CBX8, show distinct nuclear localizations, contribute differently to transcriptional repression, and appear to be part of distinct PRC1-like protein complexes.

    Three dimensional structures from OCA and Proteopedia for CBX7 Gene

neXtProt entry for CBX7 Gene

Post-translational modifications for CBX7 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CBX7 Gene

No data available for DME Specific Peptides for CBX7 Gene

Domains & Families for CBX7 Gene

Gene Families for CBX7 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for CBX7 Gene

Suggested Antigen Peptide Sequences for CBX7 Gene

GenScript: Design optimal peptide antigens:
  • Chromobox protein homolog 7 (CBX7_HUMAN)
genes like me logo Genes that share domains with CBX7: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for CBX7 Gene

Function for CBX7 Gene

Molecular function for CBX7 Gene

UniProtKB/Swiss-Prot Function:
Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. Promotes histone H3 trimethylation at 'Lys-9' (H3K9me3). Binds to trimethylated lysine residues in histones, and possibly also other proteins. Regulator of cellular lifespan by maintaining the repression of CDKN2A, but not by inducing telomerase activity.
GENATLAS Biochemistry:
Drosophila polycomb-like (PcG) chromobox homolog 7,mouse ortholog,involved in the compaction of chromatin

Phenotypes From GWAS Catalog for CBX7 Gene

Gene Ontology (GO) - Molecular Function for CBX7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 10369680
genes like me logo Genes that share ontologies with CBX7: view
genes like me logo Genes that share phenotypes with CBX7: view

Animal Models for CBX7 Gene

MGI Knock Outs for CBX7:
  • Cbx7 Cbx7<tm1Afus>
  • Cbx7 Cbx7<tm1a(KOMP)Wtsi>

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CBX7

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CBX7 Gene

Localization for CBX7 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CBX7 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CBX7 gene
Compartment Confidence
nucleus 5
cytosol 4
plasma membrane 1
extracellular 1
cytoskeleton 1
mitochondrion 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (3)
  • Nucleoplasm (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for CBX7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000790 nuclear chromatin IDA 19636380
GO:0005634 nucleus IEA,IDA 21282530
GO:0005654 nucleoplasm IDA --
GO:0005829 cytosol IDA --
GO:0031519 PcG protein complex IBA,IDA 21282530
genes like me logo Genes that share ontologies with CBX7: view

Pathways & Interactions for CBX7 Gene

PathCards logo

SuperPathways for CBX7 Gene

No Data Available

SIGNOR curated interactions for CBX7 Gene

Activates:

Gene Ontology (GO) - Biological Process for CBX7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription by RNA polymerase II IBA,IMP 19636380
GO:0006325 chromatin organization IEA --
genes like me logo Genes that share ontologies with CBX7: view

No data available for Pathways by source for CBX7 Gene

Drugs & Compounds for CBX7 Gene

(1) Drugs for CBX7 Gene - From: ApexBio

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
UNC3866 Pharma a potent antagonist of CBX4 and CBX7 chromodomains 0

(1) ApexBio Compounds for CBX7 Gene

Compound Action Cas Number
UNC3866 a potent antagonist of CBX4 and CBX7 chromodomains
genes like me logo Genes that share compounds with CBX7: view

Drug Products

Transcripts for CBX7 Gene

mRNA/cDNA for CBX7 Gene

3 REFSEQ mRNAs :
6 NCBI additional mRNA sequence :
7 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CBX7

Alternative Splicing Database (ASD) splice patterns (SP) for CBX7 Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b
SP1: - -
SP2:
SP3:

Relevant External Links for CBX7 Gene

GeneLoc Exon Structure for
CBX7

Expression for CBX7 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for CBX7 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for CBX7 Gene

This gene is overexpressed in Retina (25.5) and Blymphocyte (21.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for CBX7 Gene



Transcriptomic regulation report from SPP (The Signaling Pathways Project) for CBX7

SOURCE GeneReport for Unigene cluster for CBX7 Gene:

Hs.356416

Evidence on tissue expression from TISSUES for CBX7 Gene

  • Nervous system(4.8)
  • Eye(2.7)
  • Intestine(2.6)
  • Muscle(2.5)
  • Heart(2.4)
  • Kidney(2.4)
  • Skin(2.4)
  • Thyroid gland(2.3)
  • Lung(2.3)
  • Pancreas(2.2)
  • Lymph node(2.2)
  • Blood(2.1)
  • Spleen(2)
genes like me logo Genes that share expression patterns with CBX7: view

No data available for mRNA differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for CBX7 Gene

Orthologs for CBX7 Gene

This gene was present in the common ancestor of animals.

Orthologs for CBX7 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia CBX7 30 31
  • 99.73 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia CBX7 30 31
  • 94.42 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia CBX7 30 31
  • 91.7 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Cbx7 30
  • 85.19 (n)
Mouse
(Mus musculus)
Mammalia Cbx7 30 17 31
  • 84.99 (n)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia CBX7 31
  • 77 (a)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia CBX7 31
  • 55 (a)
OneToOne
Chicken
(Gallus gallus)
Aves CBX7 30 31
  • 73.33 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia CBX7 31
  • 72 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia cbx7 30
  • 62.96 (n)
Zebrafish
(Danio rerio)
Actinopterygii LOC101882803 30
  • 57.69 (n)
cbx7b 31
  • 46 (a)
OneToMany
cbx7a 31
  • 26 (a)
OneToMany
Fruit Fly
(Drosophila melanogaster)
Insecta Pc 31
  • 19 (a)
OneToMany
Species where no ortholog for CBX7 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for CBX7 Gene

ENSEMBL:
Gene Tree for CBX7 (if available)
TreeFam:
Gene Tree for CBX7 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for CBX7: view image

Paralogs for CBX7 Gene

Paralogs for CBX7 Gene

(6) SIMAP similar genes for CBX7 Gene using alignment to 3 proteins:

  • CBX7_HUMAN
  • B0QYP2_HUMAN
  • B0QYP3_HUMAN
genes like me logo Genes that share paralogs with CBX7: view

Variants for CBX7 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for CBX7 Gene

SNP ID Clinical significance and condition Chr 22 pos Variation AA Info Type
rs193920857 Uncertain Significance: Malignant tumor of prostate 39,138,655(-) G/C MISSENSE_VARIANT

Additional dbSNP identifiers (rs#s) for CBX7 Gene

Structural Variations from Database of Genomic Variants (DGV) for CBX7 Gene

Variant ID Type Subtype PubMed ID
nsv510807 CNV deletion 20534489
nsv834196 CNV loss 17160897
nsv834197 CNV gain 17160897

Variation tolerance for CBX7 Gene

Residual Variation Intolerance Score: 43% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.41; 8.97% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CBX7 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CBX7

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CBX7 Gene

Disorders for CBX7 Gene

MalaCards: The human disease database

(2) MalaCards diseases for CBX7 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
ovarian clear cell adenocarcinoma
melanoma, cutaneous malignant 1
  • melanoma, cutaneous malignant, susceptibility to, 1
- elite association - COSMIC cancer census association via MalaCards
Search CBX7 in MalaCards View complete list of genes associated with diseases
genes like me logo Genes that share disorders with CBX7: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CBX7 Gene

Publications for CBX7 Gene

  1. Several distinct polycomb complexes regulate and co-localize on the INK4a tumor suppressor locus. (PMID: 19636380) Maertens GN … Peters G (PloS one 2009) 3 4 23
  2. Recognition and specificity determinants of the human cbx chromodomains. (PMID: 21047797) Kaustov L … Arrowsmith CH (The Journal of biological chemistry 2011) 3 4
  3. Interaction proteomics analysis of polycomb proteins defines distinct PRC1 complexes in mammalian cells. (PMID: 21282530) Vandamme J … Angrand PO (Molecular & cellular proteomics : MCP 2011) 3 4
  4. Polycomb group targeting through different binding partners of RING1B C-terminal domain. (PMID: 20696397) Wang R … Kim CA (Structure (London, England : 1993) 2010) 3 4
  5. Polycomb CBX7 directly controls trimethylation of histone H3 at lysine 9 at the p16 locus. (PMID: 21060834) Li Q … Deng D (PloS one 2010) 3 4

Products for CBX7 Gene

Sources for CBX7 Gene