Aliases for CBX5 Gene
Aliases for CBX5 Gene
External Ids for CBX5 Gene
- HGNC: 1555
- Entrez Gene: 23468
- Ensembl: ENSG00000094916
- OMIM: 604478
- UniProtKB: P45973
Previous GeneCards Identifiers for CBX5 Gene
- GC12M054761
- GC12M054351
- GC12M052921
- GC12M054624
Summaries for CBX5 Gene
-
This gene encodes a highly conserved nonhistone protein, which is a member of the heterochromatin protein family. The protein is enriched in the heterochromatin and associated with centromeres. The protein has a single N-terminal chromodomain which can bind to histone proteins via methylated lysine residues, and a C-terminal chromo shadow-domain (CSD) which is responsible for the homodimerization and interaction with a number of chromatin-associated nonhistone proteins. The encoded product is involved in the formation of functional kinetochore through interaction with essential kinetochore proteins. The gene has a pseudogene located on chromosome 3. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Jul 2008]
GeneCards Summary for CBX5 Gene
CBX5 (Chromobox 5) is a Protein Coding gene. Diseases associated with CBX5 include Reynolds Syndrome and Immunodeficiency-Centromeric Instability-Facial Anomalies Syndrome. Among its related pathways are E2F mediated regulation of DNA replication and Response to elevated platelet cytosolic Ca2+. Gene Ontology (GO) annotations related to this gene include protein homodimerization activity and histone deacetylase binding. An important paralog of this gene is CBX1.
UniProtKB/Swiss-Prot for CBX5 Gene
-
Component of heterochromatin that recognizes and binds histone H3 tails methylated at Lys-9 (H3K9me), leading to epigenetic repression. In contrast, it is excluded from chromatin when Tyr-41 of histone H3 is phosphorylated (H3Y41ph). Can interact with lamin-B receptor (LBR). This interaction can contribute to the association of the heterochromatin with the inner nuclear membrane. Involved in the formation of functional kinetochore through interaction with MIS12 complex proteins.
No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CBX5 Gene
Genomics for CBX5 Gene
GeneHancer (GH) Regulatory Elements for CBX5 Gene
Promoters and enhancers for CBX5 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data dump
GeneHancers around CBX5 on UCSC Golden Path with GeneCards custom track
- Top Transcription factor binding sites by QIAGEN in the CBX5 gene promoter:
-
- AML1a
- C/EBPalpha
- TBP
Regulatory Element Products
Genomic Locations for CBX5 Gene
Genomic Locations for CBX5 Gene
- chr12:54,230,940-54,280,133
- (GRCh38/hg38)
- Size:
- 49,194 bases
- Orientation:
- Minus strand
- chr12:54,624,724-54,673,915
- (GRCh37/hg19)
- Size:
- 49,192 bases
- Orientation:
- Minus strand
Genomic View for CBX5 Gene
Genes around CBX5 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 12q13.13 by Entrez Gene
- 12q13.13 by HGNC
- 12q13.13 by Ensembl
CBX5 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for CBX5 Gene
Proteins for CBX5 Gene
-
Protein details for CBX5 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P45973-CBX5_HUMAN
- Recommended name:
- Chromobox protein homolog 5
- Protein Accession:
- P45973
- B2R8T9
Protein attributes for CBX5 Gene
- Size:
- 191 amino acids
- Molecular mass:
- 22225 Da
- Quaternary structure:
-
- Interacts with KMT5B and KMT5C (By similarity). Interacts with HP1BP3 (PubMed:20042602). Interacts directly with ATRX, CHAF1A, LBR, NIPBL, SP100, STAM2 and TRIM28 via the chromoshadow domain (PubMed:15882967, PubMed:9169472). Can interact directly with CBX3 via the chromoshadow domain (PubMed:9169472). Interacts with histone H3 methylated at Lys-9 (PubMed:11242053, PubMed:21047797). Interacts with BAHD1, MIS12 and DSN1 (PubMed:15502821, PubMed:19666599). Interacts with POGZ; POGZ and PXVXL motif-containing proteins such as INCENP and TRIM28 compete for interaction with CBX5 (PubMed:20562864, PubMed:20850016, PubMed:21346195). Interacts with INCENP and TRIM24 (PubMed:11313457). Interacts with JC virus agnoprotein; this interaction induces the dissociation of CBX5 from LBR, resulting in destabilization of the nuclear envelope (PubMed:15864296). Interacts with CHAMP1 (PubMed:20850016). Interacts with ASXL1 (PubMed:19880879). Interacts with PRR14 (via N-terminus) (PubMed:25906157). Interacts with RRP1B (PubMed:19710015). Interacts with HNRNPU (via C-terminus); this interaction is, at least in part, RNA-dependent (PubMed:19617346).
Protein Expression for CBX5 Gene
Post-translational modifications for CBX5 Gene
- Phosphorylation of HP1 and LBR may be responsible for some of the alterations in chromatin organization and nuclear structure which occur at various times during the cell cycle (By similarity). Phosphorylated during interphase and possibly hyper-phosphorylated during mitosis.
- Ubiquitinated.
- Ubiquitination at Lys159, posLast=154154, Lys143, Lys125, posLast=102102, Lys91, posLast=4242, and posLast=3232
- Modification sites at PhosphoSitePlus
Other Protein References for CBX5 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
-
Custom Antibody ServicesOriGene Antibodies for CBX5
- Novus Biologicals Antibodies for CBX5
- Invitrogen Antibodies for CBX5
- GeneTex CBX5 Antibody for CBX5
-
Santa Cruz Biotechnology (SCBT) Antibodies for CBX5
- Sino Biological Antibodies for CBX5
Protein Products
- Search Origene for MassSpec and Protein Over-expression Lysates for CBX5
- Origene Custom Protein Services for CBX5
- ProSpec Recombinant Proteins for CBX5
- antibodies-online: Search results for 8 available CBX5 Proteins ranked by validation data
- Compare Top CBX5 Proteins
-
Quality Products:
- Search GeneTex for Proteins for CBX5
Assay Products
- antibodies-online: Search results for available CBX5 related products ranked by validation data
No data available for DME Specific Peptides for CBX5 Gene
Domains & Families for CBX5 Gene
Gene Families for CBX5 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Predicted intracellular proteins
Protein Domains for CBX5 Gene
- Blocks:
- InterPro:
- ProtoNet:
Suggested Antigen Peptide Sequences for CBX5 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
No data available for UniProtKB/Swiss-Prot for CBX5 Gene
Function for CBX5 Gene
Molecular function for CBX5 Gene
- UniProtKB/Swiss-Prot Function:
- Component of heterochromatin that recognizes and binds histone H3 tails methylated at Lys-9 (H3K9me), leading to epigenetic repression. In contrast, it is excluded from chromatin when Tyr-41 of histone H3 is phosphorylated (H3Y41ph). Can interact with lamin-B receptor (LBR). This interaction can contribute to the association of the heterochromatin with the inner nuclear membrane. Involved in the formation of functional kinetochore through interaction with MIS12 complex proteins.
Phenotypes From GWAS Catalog for CBX5 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0003682 | chromatin binding | IEA | -- |
| GO:0005515 | protein binding | IPI | 8663349 |
| GO:0030674 | protein binding, bridging | ISS | -- |
| GO:0035064 | methylated histone binding | IDA | 19783980 |
| GO:0042802 | identical protein binding | IPI | 18716626 |
Phenotypes for CBX5 Gene
- MGI mutant phenotypes for CBX5:
- inferred from 4 alleles
- GenomeRNAi human phenotypes for CBX5:
-
- Dynamic nuclei (hole, folded or small irregular)
- Decreased ionizing radiation sensitivity
- Decreased viability in esophageal squamous lineage
- Decreased viability
- no effect
- Increased vaccinia virus (VACV) infection
- Increased gamma-H2AX phosphorylation
- Decreased viability after Maraba virus infection
- Increased transferrin (TF) endocytosis
Animal Models for CBX5 Gene
Animal Model Products
-
Taconic Biosciences Mouse Models for CBX5
- Cyagen custom Knockout/knockin (KOKI) mouse models for CBX5
-
CRISPR Products
-
OriGene CRISPR knockouts for CBX5
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for CBX5
- genomics-online: gRNA clones - Search results for 144 available CBX5 gene related products
- Overview of 144 available CBX5 gene related products
-
Recommended
- Applied Biological Materials CRISPR for CBX5
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for CBX5
- GenScript: Design CRISPR guide RNA sequences for CBX5
miRNA for CBX5 Gene
- miRTarBase miRNAs that target CBX5
-
- hsa-mir-98-5p (MIRT004950)
- hsa-mir-1-3p (MIRT023531)
- hsa-mir-484 (MIRT041993)
- hsa-mir-339-5p (MIRT042774)
- hsa-mir-320a (MIRT044429)
- hsa-mir-197-3p (MIRT048055)
- hsa-mir-92a-3p (MIRT049796)
- hsa-let-7e-5p (MIRT051655)
- hsa-let-7b-5p (MIRT052318)
- hsa-mir-345-5p (MIRT065823)
- hsa-mir-4795-3p (MIRT187596)
- hsa-mir-1343-3p (MIRT248351)
- hsa-mir-6716-5p (MIRT248353)
- hsa-mir-6783-3p (MIRT248354)
- hsa-mir-6852-5p (MIRT248356)
- hsa-mir-6736-3p (MIRT248364)
- hsa-mir-548p (MIRT338259)
- hsa-mir-4438 (MIRT448968)
- hsa-mir-4635 (MIRT448969)
- hsa-mir-488-3p (MIRT448970)
- hsa-mir-583 (MIRT448971)
- hsa-mir-4650-5p (MIRT479924)
- hsa-mir-1304-5p (MIRT479925)
- hsa-mir-6878-3p (MIRT479926)
- hsa-mir-6734-5p (MIRT479927)
- hsa-mir-1226-5p (MIRT479928)
- hsa-mir-6834-5p (MIRT479929)
- hsa-mir-6721-5p (MIRT479930)
- hsa-mir-6744-3p (MIRT479931)
- hsa-mir-4757-5p (MIRT479932)
- hsa-mir-4763-3p (MIRT479933)
- hsa-mir-6781-3p (MIRT479934)
- hsa-mir-1207-5p (MIRT479935)
- hsa-mir-2682-3p (MIRT479936)
- hsa-mir-4721 (MIRT479937)
- hsa-mir-3616-3p (MIRT479938)
- hsa-mir-7843-5p (MIRT479939)
- hsa-mir-6879-5p (MIRT479940)
- hsa-mir-6735-5p (MIRT479941)
- hsa-mir-4632-5p (MIRT479942)
- hsa-mir-4436b-3p (MIRT479943)
- hsa-mir-548at-5p (MIRT479944)
- hsa-mir-376a-2-5p (MIRT549015)
- hsa-mir-202-3p (MIRT549016)
- hsa-mir-6831-5p (MIRT549017)
- hsa-mir-4668-3p (MIRT549018)
- hsa-mir-3927-3p (MIRT549019)
- hsa-let-7a-5p (MIRT549020)
- hsa-let-7c-5p (MIRT549021)
- hsa-let-7d-5p (MIRT549022)
- hsa-let-7g-5p (MIRT549023)
- hsa-mir-4458 (MIRT549024)
- hsa-let-7i-5p (MIRT549025)
- hsa-mir-4500 (MIRT549026)
- hsa-let-7f-5p (MIRT549027)
- hsa-mir-514b-3p (MIRT558905)
- hsa-mir-514a-3p (MIRT558906)
- hsa-mir-4477a (MIRT558907)
- hsa-mir-4316 (MIRT558908)
- hsa-mir-1294 (MIRT558909)
- hsa-mir-4677-3p (MIRT558910)
- hsa-mir-16-1-3p (MIRT558911)
- hsa-mir-126-5p (MIRT558912)
- hsa-mir-5683 (MIRT558913)
- hsa-mir-370-5p (MIRT558914)
- hsa-mir-383-3p (MIRT558915)
- hsa-mir-3065-3p (MIRT558916)
- hsa-mir-5089-5p (MIRT633094)
- hsa-mir-7151-3p (MIRT633095)
- hsa-mir-5095 (MIRT633096)
- hsa-mir-5589-5p (MIRT633097)
- hsa-mir-4731-5p (MIRT633098)
- hsa-mir-6778-3p (MIRT633099)
- hsa-mir-4252 (MIRT633100)
- hsa-mir-6506-5p (MIRT633101)
- hsa-mir-619-5p (MIRT633102)
- hsa-mir-150-5p (MIRT633103)
- hsa-mir-3937 (MIRT633104)
- hsa-mir-520h (MIRT633105)
- hsa-mir-520g-3p (MIRT633106)
- hsa-mir-6504-3p (MIRT633107)
- hsa-mir-512-3p (MIRT633108)
- hsa-mir-449b-3p (MIRT633109)
- hsa-mir-520e (MIRT633110)
- hsa-mir-520d-3p (MIRT633111)
- hsa-mir-520c-3p (MIRT633112)
- hsa-mir-520b (MIRT633113)
- hsa-mir-520a-3p (MIRT633114)
- hsa-mir-373-3p (MIRT633115)
- hsa-mir-372-3p (MIRT633116)
- hsa-mir-302e (MIRT633117)
- hsa-mir-302d-3p (MIRT633118)
- hsa-mir-302c-3p (MIRT633119)
- hsa-mir-302b-3p (MIRT633120)
- hsa-mir-302a-3p (MIRT633121)
- hsa-mir-93-5p (MIRT633122)
- hsa-mir-526b-3p (MIRT633123)
- hsa-mir-519d-3p (MIRT633124)
- hsa-mir-20b-5p (MIRT633125)
- hsa-mir-20a-5p (MIRT633126)
- hsa-mir-17-5p (MIRT633127)
- hsa-mir-106b-5p (MIRT633128)
- hsa-mir-106a-5p (MIRT633129)
- hsa-mir-6771-5p (MIRT659777)
- hsa-mir-7977 (MIRT659778)
- hsa-mir-566 (MIRT659779)
- hsa-mir-4743-5p (MIRT659780)
- hsa-mir-4268 (MIRT659781)
- hsa-mir-6720-3p (MIRT659782)
- hsa-mir-20b-3p (MIRT659783)
- hsa-mir-6746-5p (MIRT659784)
- hsa-mir-4267 (MIRT659785)
- hsa-mir-2114-5p (MIRT659786)
- hsa-mir-5588-3p (MIRT659787)
- hsa-mir-4256 (MIRT720010)
- hsa-mir-6505-3p (MIRT720011)
- hsa-mir-617 (MIRT720012)
- hsa-mir-4646-5p (MIRT720013)
- hsa-mir-204-3p (MIRT720014)
- hsa-mir-4735-5p (MIRT720015)
- hsa-mir-6742-3p (MIRT720016)
- hsa-mir-939-3p (MIRT720017)
- hsa-mir-19b-3p (MIRT728041)
- hsa-mir-19a-3p (MIRT728043)
- hsa-mir-1180-5p (MIRT735872)
- hsa-mir-1343-5p (MIRT737454)
- hsa-mir-2110 (MIRT738892)
- hsa-mir-3150a-3p (MIRT740256)
- hsa-mir-3175 (MIRT740646)
- hsa-mir-3908 (MIRT742824)
- hsa-mir-450a-2-3p (MIRT745576)
- hsa-mir-509-3p (MIRT749691)
- hsa-mir-6763-5p (MIRT754998)
- hsa-mir-6810-5p (MIRT756647)
- hsa-mir-6825-5p (MIRT756963)
- hsa-mir-6857-5p (MIRT757753)
- hsa-mir-7114-3p (MIRT759130)
- hsa-mir-7973 (MIRT759969)
- hsa-mir-92a-1-5p (MIRT760515)
- hsa-mir-939-5p (MIRT760745)
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for CBX5
- Browse OriGene Inhibitory RNA Products For CBX5
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CBX5
- genomics-online: shRNA clones - Search results for 144 available CBX5 gene related products
- Overview of 144 available CBX5 gene related products
-
Recommended
Clone Products
-
OriGene ORF clones in human for CBX5
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for CBX5
- VectorBuilder custom plasmid, inducible vectors for CBX5
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for CBX5
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for CBX5
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for CBX5
- genomics-online: cdna clones - Search results for 144 available CBX5 gene related products
- Overview of 144 available CBX5 gene related products
-
Recommended
- orf clones - Search results for 144 available CBX5 gene related products
- Overview of 144 available CBX5 gene related products
-
Recommended
- Applied Biological Materials Clones for CBX5
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Cell Line Products
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CBX5 Gene
Localization for CBX5 Gene
Subcellular locations from UniProtKB/Swiss-Prot for CBX5 Gene
- Nucleus. Chromosome. Chromosome, centromere. Note=Colocalizes with HNRNPU in the nucleus (PubMed:19617346). Component of centromeric and pericentromeric heterochromatin. Associates with chromosomes during mitosis. Associates specifically with chromatin during metaphase and anaphase. {ECO:0000269 PubMed:19617346}.
| Compartment | Confidence |
|---|---|
| nucleus | 5 |
- Nucleus (4)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000118 | histone deacetylase complex | ISS | -- |
| GO:0000775 | chromosome, centromeric region | IEA | -- |
| GO:0000776 | kinetochore | IEA | -- |
| GO:0000784 | nuclear chromosome, telomeric region | HDA | 19135898 |
| GO:0000792 | heterochromatin | IEA | -- |
Pathways & Interactions for CBX5 Gene
Pathways by source for CBX5 Gene
2 BioSystems pathways for CBX5 Gene
2 Reactome pathways for CBX5 Gene
1 GeneGo (Thomson Reuters) pathway for CBX5 Gene
1 Cell Signaling Technology pathway for CBX5 Gene
Interacting Proteins for CBX5 Gene
Selected Interacting proteins:
P45973-CBX5_HUMAN
ENSP00000209875
for CBX5 Gene via
IID
UniProtKB
MINT
STRING
GPS-Prot Interaction Network for CBX5
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000122 | negative regulation of transcription by RNA polymerase II | IMP | 19617346 |
| GO:0007596 | blood coagulation | TAS | -- |
| GO:0016032 | viral process | IEA | -- |
| GO:0045892 | negative regulation of transcription, DNA-templated | IMP | 9636146 |
| GO:0070317 | negative regulation of G0 to G1 transition | TAS | -- |
Drugs & Compounds for CBX5 Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| Copper | Approved, Investigational | Pharma | Target | 202 |
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs |
|---|
Transcripts for CBX5 Gene
mRNA/cDNA for CBX5 Gene
- (3) REFSEQ mRNAs :
- (13) Additional mRNA sequences :
- (643) Selected AceView cDNA sequences:
- (6) Ensembl transcripts including schematic representations, and UCSC links where relevant :
-
- ENST00000209875 11528 bps (uc001sfk.6)
- ENST00000439541 1832 bps (uc001sfj.6)
- ENST00000547872 745 bps (uc058ovh.1)
- ENST00000550411 894 bps (uc001sfh.6)
- ENST00000552562 675 bps (uc058ovi.1)
Unigene Clusters for CBX5 Gene
- Chromobox homolog 5:
- Representative Sequences:
CRISPR Products
-
OriGene CRISPR knockouts for CBX5
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for CBX5
- genomics-online: gRNA clones - Search results for 144 available CBX5 gene related products
- Overview of 144 available CBX5 gene related products
-
Recommended
- Applied Biological Materials CRISPR for CBX5
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for CBX5
- GenScript: Design CRISPR guide RNA sequences for CBX5
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for CBX5
- Browse OriGene Inhibitory RNA Products For CBX5
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CBX5
- genomics-online: shRNA clones - Search results for 144 available CBX5 gene related products
- Overview of 144 available CBX5 gene related products
-
Recommended
Clone Products
-
OriGene ORF clones in human for CBX5
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for CBX5
- VectorBuilder custom plasmid, inducible vectors for CBX5
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for CBX5
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for CBX5
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for CBX5
- genomics-online: cdna clones - Search results for 144 available CBX5 gene related products
- Overview of 144 available CBX5 gene related products
-
Recommended
- orf clones - Search results for 144 available CBX5 gene related products
- Overview of 144 available CBX5 gene related products
-
Recommended
- Applied Biological Materials Clones for CBX5
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
| ExUns: | 1a | · | 1b | ^ | 2a | · | 2b | · | 2c | ^ | 3 | ^ | 4 | ^ | 5a | · | 5b | · | 5c | · | 5d | ^ | 6 | ^ | 7 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | |||||||||||||||||||||||||
| SP2: | - | - | - | - | |||||||||||||||||||||
| SP3: | |||||||||||||||||||||||||
| SP4: | |||||||||||||||||||||||||
| SP5: | - |
Expression for CBX5 Gene
This gene is overexpressed in Peripheral blood mononuclear cells (9.6).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for CBX5 Gene
- Elite partner
NURSA nuclear receptor signaling pathways regulating expression of CBX5 Gene:
CBX5SOURCE GeneReport for Unigene cluster for CBX5 Gene:
Hs.349283Evidence on tissue expression from TISSUES for CBX5 Gene
- Liver(4.6)
- Nervous system(4.6)
- Kidney(4.4)
- Eye(3.2)
- Intestine(2.2)
Primer Products
-
OriGene qPCR primer pairs and template standards for CBX5
-
OriGene qPCR primer pairs for CBX5
- genomics-online: primer clones - Search results for 144 available CBX5 gene related products
- Overview of 144 available CBX5 gene related products
-
Recommended
Gene Expression Assay Products
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for CBX5 Gene
Orthologs for CBX5 Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | CBX5 34 33 |
|
OneToOne | |
| cow (Bos Taurus) |
Mammalia | CBX5 34 33 |
|
OneToOne | |
| dog (Canis familiaris) |
Mammalia | CBX5 34 33 |
|
OneToOne | |
| mouse (Mus musculus) |
Mammalia | Cbx5 16 34 33 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Cbx5 33 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | -- 34 |
|
ManyToMany | |
| chicken (Gallus gallus) |
Aves | -- 34 |
|
ManyToMany | |
| lizard (Anolis carolinensis) |
Reptilia | CBX5 34 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | cbx5 33 |
|
||
| African clawed frog (Xenopus laevis) |
Amphibia | cbx5-prov 33 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | cbx5 34 33 |
|
OneToOne | |
| fruit fly (Drosophila melanogaster) |
Insecta | Su(var)205 34 |
|
ManyToMany | |
| HP6 34 |
|
ManyToMany | |||
| HP1b 34 35 |
|
ManyToMany | |||
| HP1e 34 |
|
ManyToMany | |||
| HP1c 34 |
|
ManyToMany | |||
| worm (Caenorhabditis elegans) |
Secernentea | hpl-1 34 |
|
OneToMany | |
| sea squirt (Ciona savignyi) |
Ascidiacea | CSA.3133 34 |
|
OneToMany |
- Species where no ortholog for CBX5 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- platypus (Ornithorhynchus anatinus)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
Evolution for CBX5 Gene
- ENSEMBL:
- Gene Tree for CBX5 (if available)
- TreeFam:
- Gene Tree for CBX5 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for CBX5: view image
Paralogs for CBX5 Gene
(16) SIMAP similar genes for CBX5 Gene using alignment to 3 proteins:
- CBX5_HUMAN
- F8VNY3_HUMAN
- Q6I9T7_HUMAN
Pseudogenes.org Pseudogenes for CBX5 Gene
Variants for CBX5 Gene
| SNP ID | Clin | Chr 12 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs74625894 | benign, not specified | 54,281,778(-) | A/G | upstream_transcript_variant | |
| rs1000095385 | -- | 54,246,496(-) | G/A | intron_variant | |
| rs1000150733 | -- | 54,233,759(-) | T/C | 3_prime_UTR_variant | |
| rs1000264281 | -- | 54,241,046(-) | G/T | 3_prime_UTR_variant | |
| rs1000353290 | -- | 54,253,531(-) | A/G | intron_variant |
Residual Variation Intolerance Score:
49.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
0.06;
1.35% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for CBX5 Gene
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CBX5 Gene
Disorders for CBX5 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| reynolds syndrome |
|
|
| immunodeficiency-centromeric instability-facial anomalies syndrome |
|
Search CBX5 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for CBX5
No data available for UniProtKB/Swiss-Prot and Genatlas for CBX5 Gene
Publications for CBX5 Gene
- Interaction between an integral protein of the nuclear envelope inner membrane and human chromodomain proteins homologous to Drosophila HP1. (PMID: 8663349) Ye Q … Worman HJ (The Journal of biological chemistry 1996) 2 3 4 22 58
- In vivo HP1 targeting causes large-scale chromatin condensation and enhanced histone lysine methylation. (PMID: 15899859) Verschure PJ … van Driel R (Molecular and cellular biology 2005) 3 4 22 58
- Localization and phosphorylation of HP1 proteins during the cell cycle in mammalian cells. (PMID: 10460410) Minc E … Buendia B (Chromosoma 1999) 3 4 22 58
- Recognition and specificity determinants of the human cbx chromodomains. (PMID: 21047797) Kaustov L … Arrowsmith CH (The Journal of biological chemistry 2011) 3 4 58
- Mitotic centromeric targeting of HP1 and its binding to Sgo1 are dispensable for sister-chromatid cohesion in human cells. (PMID: 21346195) Kang J … Yu H (Molecular biology of the cell 2011) 3 4 58
Products for CBX5 Gene
- Browse R&D Systems for Antibodies
- Browse R&D Systems for Human Recombinant Proteins
- Browse R&D Systems for biochemical assays
- Browse Human Proteins and Enzymes
- Browse Primary Antibodies
- Browse Proteins and Enzymes
- Browse ELISAs
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- Browse cDNA Clones
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- Browse Peptides
- Browse Proteome Profiler Antibody Arrays
- Browse Small Molecules
- Custom Antibody ServicesOriGene Antibodies for CBX5
- Browse OriGene ELISA Kits
- Custom Assay Services
- Search Origene for MassSpec and Protein Over-expression Lysates for CBX5
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- OriGene qPCR primer pairs and template standards for CBX5
- OriGene qPCR primer pairs for CBX5
- OriGene CRISPR knockouts for CBX5
- OriGene ORF clones in human for CBX5
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For CBX5
- GenScript: Next-day shipping of latest version cDNA ORF clones for CBX5 in any vector
- GenScript Custom Purified and Recombinant Proteins Services for CBX5
- GenScript Custom Assay Services for CBX5
- GenScript Custom overexpressing Cell Line Services for CBX5
- GenScript: Design CRISPR guide RNA sequences for CBX5
- Design optimal peptide antigens
- CloneReady with Over 120,000 Genes
- Gene Synthesis: Any Gene in Any Vector
- Vector-based siRNA and miRNA, Ready for Transfection
- Gene Mutant Library, Variants up to 10^11
- Plasmid Preparation
- GenScript Custom Peptide Services for CBX5
- Sino Biological Human cDNA Clone for CBX5
- Browse Sino Biological Recombinant Proteins
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- Sino Biological Antibodies for CBX5
- Browse Sino Biological Assays
- Browse Antibodies
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- Browse ELISA Kits
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- High-throughput Antibody Production Service
- Protein Production Service
- Epitope Tag Antibodies & Reporter Protein Antibodies
- Lentiviral ORF Clones
- Novus Biologicals Antibodies for CBX5
- Novus Biologicals lysates and proteins for CBX5
- Novus Biologicals
- Novus Biologicals Tissue Microarrays
- Browse Antibodies
- Browse Peptides and Proteins
- Browse Lysates
- Browse ELISA Kits
- ProSpec Recombinant Proteins for CBX5
- Taconic Biosciences Mouse Models for CBX5
- Find your next knockout model in the Taconic Knockout Repository
- Genetically Engineered Models Available Immediately
- Humanized Mice
- VectorBuilder custom plasmid, inducible vectors for CBX5
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for CBX5
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for CBX5
- antibodies-online: Search results for 272 available CBX5 Antibodies ranked by validation data
- Compare Top CBX5 Antibodies
- antibodies-online: Search results for available CBX5 related products ranked by validation data
- antibodies-online: Search results for 8 available CBX5 Proteins ranked by validation data
- Compare Top CBX5 Proteins
- Quality Products:
- GeneTex CBX5 Antibody for CBX5
- Search GeneTex for Proteins for CBX5
- Santa Cruz Biotechnology (SCBT) Antibodies for CBX5
- Search Santa Cruz Biotechnology (SCBT) for CBX5 siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for CBX5
- genomics-online: cdna clones - Search results for 144 available CBX5 gene related products
- Overview of 144 available CBX5 gene related products
- Recommended
- orf clones - Search results for 144 available CBX5 gene related products
- Overview of 144 available CBX5 gene related products
- Recommended
- genomics-online: gRNA clones - Search results for 144 available CBX5 gene related products
- Overview of 144 available CBX5 gene related products
- Recommended
- genomics-online: primer clones - Search results for 144 available CBX5 gene related products
- Overview of 144 available CBX5 gene related products
- Recommended
- genomics-online: shRNA clones - Search results for 144 available CBX5 gene related products
- Overview of 144 available CBX5 gene related products
- Recommended
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for CBX5
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for CBX5
- GeneCopoeia miRNA 3'UTR Target clone products for CBX5
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CBX5
Sources for CBX5 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP</