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This gene encodes a highly conserved nonhistone protein, which is a member of the heterochromatin protein family. The protein is enriched in the heterochromatin and associated with centromeres. The protein has a single N-terminal chromodomain which can bind to histone proteins via methylated lysine residues, and a C-terminal chromo shadow-domain (CSD) which is responsible for t... See more...
Aliases for CBX5 Gene
Aliases for CBX5 Gene
External Ids for CBX5 Gene
- HGNC: 1555
- NCBI Entrez Gene: 23468
- Ensembl: ENSG00000094916
- OMIM®: 604478
- UniProtKB/Swiss-Prot: P45973
Previous GeneCards Identifiers for CBX5 Gene
- GC12M054761
- GC12M054351
- GC12M052921
- GC12M054624
Summaries for CBX5 Gene
-
This gene encodes a highly conserved nonhistone protein, which is a member of the heterochromatin protein family. The protein is enriched in the heterochromatin and associated with centromeres. The protein has a single N-terminal chromodomain which can bind to histone proteins via methylated lysine residues, and a C-terminal chromo shadow-domain (CSD) which is responsible for the homodimerization and interaction with a number of chromatin-associated nonhistone proteins. The encoded product is involved in the formation of functional kinetochore through interaction with essential kinetochore proteins. The gene has a pseudogene located on chromosome 3. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Jul 2008]
GeneCards Summary for CBX5 Gene
CBX5 (Chromobox 5) is a Protein Coding gene. Diseases associated with CBX5 include Reynolds Syndrome and Immunodeficiency-Centromeric Instability-Facial Anomalies Syndrome. Among its related pathways are Response to elevated platelet cytosolic Ca2+ and E2F transcription factor network. Gene Ontology (GO) annotations related to this gene include protein homodimerization activity and histone deacetylase binding. An important paralog of this gene is CBX1.
UniProtKB/Swiss-Prot Summary for CBX5 Gene
-
Component of heterochromatin that recognizes and binds histone H3 tails methylated at 'Lys-9' (H3K9me), leading to epigenetic repression. In contrast, it is excluded from chromatin when 'Tyr-41' of histone H3 is phosphorylated (H3Y41ph). Can interact with lamin-B receptor (LBR). This interaction can contribute to the association of the heterochromatin with the inner nuclear membrane. Involved in the formation of functional kinetochore through interaction with MIS12 complex proteins.
Additional gene information for CBX5 Gene
- HGNC (1555)
- NCBI Entrez Gene (23468)
- Ensembl (ENSG00000094916)
- OMIM® (604478)
- UniProtKB/Swiss-Prot (P45973)
- Open Targets Platform(ENSG00000094916)
- Search for CBX5 at DataMed
- Search for CBX5 at HumanCyc
No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for CBX5 Gene
Genomics for CBX5 Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for CBX5 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around CBX5 on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for CBX5
- Top Transcription factor binding sites by QIAGEN in the CBX5 gene promoter:
-
- AML1a
- C/EBPalpha
- TBP
Genomic Locations for CBX5 Gene
Latest Assembly
- chr12:54,230,942-54,280,133
- (GRCh38/hg38)
- Size:
- 49,192 bases
- Orientation:
- Minus strand
Previous Assembly
- chr12:54,624,726-54,673,906
- (GRCh37/hg19 by Entrez Gene)
- Size:
- 49,181 bases
- Orientation:
- Minus strand
- chr12:54,624,724-54,673,886
- (GRCh37/hg19 by Ensembl)
- Size:
- 49,163 bases
- Orientation:
- Minus strand
Genomic View for CBX5 Gene
Genes around CBX5 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 12q13.13 by HGNC
- 12q13.13 by Entrez Gene
- 12q13.13 by Ensembl
CBX5 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for CBX5 Gene
Proteins for CBX5 Gene
-
Protein details for CBX5 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P45973-CBX5_HUMAN
- Recommended name:
- Chromobox protein homolog 5
- Protein Accession:
- P45973
- B2R8T9
Protein attributes for CBX5 Gene
- Size:
- 191 amino acids
- Molecular mass:
- 22225 Da
- Quaternary structure:
-
- Interacts with KMT5B and KMT5C (By similarity). Interacts with HP1BP3 (PubMed:20042602). Interacts directly with ATRX, CHAF1A, LBR, NIPBL, SP100, STAM2 and TRIM28 via the chromoshadow domain (PubMed:15882967, PubMed:9169472). Can interact directly with CBX3 via the chromoshadow domain (PubMed:9169472). Interacts with histone H3 methylated at 'Lys-9' (PubMed:11242053, PubMed:21047797). Interacts with BAHD1, MIS12 and DSN1 (PubMed:15502821, PubMed:19666599). Interacts with POGZ; POGZ and PXVXL motif-containing proteins such as INCENP and TRIM28 compete for interaction with CBX5 (PubMed:20562864, PubMed:20850016, PubMed:21346195). Interacts with INCENP and TRIM24 (PubMed:11313457). Interacts with CHAMP1 (PubMed:20850016). Interacts with PRR14 (via N-terminus) (PubMed:25906157). Interacts with RRP1B (PubMed:19710015). Interacts with HNRNPU (via C-terminus); this interaction is, at least in part, RNA-dependent (PubMed:19617346). Interacts with LRIF1 (via PxVxL motif) (PubMed:23542155).
- (Microbial infection) Interacts with JC virus agnoprotein; this interaction induces the dissociation of CBX5 from LBR, resulting in destabilization of the nuclear envelope.
Protein Expression for CBX5 Gene
Post-translational modifications for CBX5 Gene
- Phosphorylation of HP1 and LBR may be responsible for some of the alterations in chromatin organization and nuclear structure which occur at various times during the cell cycle (By similarity). Phosphorylated during interphase and possibly hyper-phosphorylated during mitosis.
- Ubiquitinated.
-
Ubiquitination at Lys32, Lys42, Lys91, Lys102, Lys125, Lys143, Lys154, and Lys159
- NX_P45973 (NX_P45973-1)
- Modification sites at PhosphoSitePlus
Other Protein References for CBX5 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibodies for research
- LifeSpan BioSciences CBX5 / HP1 Alpha Antibody
- G Biosciences Immunotag™ CBX5 Antibody
-
Custom Antibody ServicesOriGene Antibodies for CBX5
- Novus Biologicals Antibodies for CBX5
-
Abcam antibodies for CBX5
- Invitrogen Antibodies for CBX5 (AFLGC-Cbx5)
-
Custom Antibody ServicesProSci Antibodies for CBX5
- chromobox homolog 5 [13-998]
- chromobox homolog 5 [14-520]
- chromobox homolog 5 [14-529]
- chromobox homolog 5 [13-761]
- chromobox homolog 5 [13-877]
- chromobox homolog 5 [27-613]
- chromobox homolog 5 [45-372]
- Chromobox protein homolog 5 [57-266]
- Chromobox protein homolog 5 [60-399]
- chromobox homolog 5 [79-887]
-
Santa Cruz Biotechnology (SCBT) Antibodies for CBX5
- Sino Biological Antibodies for CBX5
Protein products for research
- Search Origene for MassSpec and Protein Over-expression Lysates for CBX5
- Origene Custom Protein Services for CBX5
- ProSpec Recombinant Proteins for CBX5
- antibodies-online: Show 8 available CBX5 Proteins ranked by validation data
- Compare Top CBX5 Proteins
-
Quality Products:
-
Abcam proteins for CBX5
Assay products for research
- antibodies-online: Show 2 available CBX5 Elisa Kits ranked by validation data
- Compare Top CBX5 Elisa Kits
-
Quality Products:
-
Boster Bio ELISA Kits for CBX5
No data available for DME Specific Peptides for CBX5 Gene
Domains & Families for CBX5 Gene
Gene Families for CBX5 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Predicted intracellular proteins
Protein Domains for CBX5 Gene
- InterPro:
- Blocks:
-
- Chromo domain
- Chromo shadow
- ProtoNet:
Suggested Antigen Peptide Sequences for CBX5 Gene
- GenScript: Design optimal peptide antigens:
-
- Heterochromatin protein 1 homolog alpha (CBX5_HUMAN)
- CBX5 protein (Q6I9T7_HUMAN)
No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for CBX5 Gene
Function for CBX5 Gene
Molecular function for CBX5 Gene
- UniProtKB/Swiss-Prot Function:
- Component of heterochromatin that recognizes and binds histone H3 tails methylated at 'Lys-9' (H3K9me), leading to epigenetic repression. In contrast, it is excluded from chromatin when 'Tyr-41' of histone H3 is phosphorylated (H3Y41ph). Can interact with lamin-B receptor (LBR). This interaction can contribute to the association of the heterochromatin with the inner nuclear membrane. Involved in the formation of functional kinetochore through interaction with MIS12 complex proteins.
Phenotypes From GWAS Catalog for CBX5 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0003682 | chromatin binding | IEA | -- |
| GO:0005515 | protein binding | IPI | 8663349 |
| GO:0030674 | protein binding, bridging | ISS | -- |
| GO:0035064 | methylated histone binding | IDA | 19783980 |
| GO:0042802 | identical protein binding | IPI | 18716626 |
Phenotypes for CBX5 Gene
- MGI mutant phenotypes for CBX5:
- inferred from 4 alleles
- GenomeRNAi human phenotypes for CBX5:
-
- Increased gamma-H2AX phosphorylation
- Increased vaccinia virus (VACV) infection
- no effect
- Decreased ionizing radiation sensitivity
- Increased epidermal growth factor (EGF) endocytosis, decreased transferrin (TF) endocytosis
- Decreased viability after Maraba virus infection
- Decreased viability in colon lineage
- Many micronuclei (grape)
Animal Models for CBX5 Gene
Animal Models for research
-
Taconic Biosciences Mouse Models for CBX5
CRISPR products for research
- Applied Biological Materials (abm): CRISPR Clones for CBX5 - Starting at $85 >
- * CBX5 CRISPR as ready-to-use vector or virus: Non-viral | Lenti- | Adeno- | AAV- | siRNA - Browse All
- * Cas9 Nucleases, Nickases, Null Mutants, and GFP tag also available.
-
OriGene CRISPR knockouts for CBX5
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for CBX5
-
Santa Cruz Biotechnology (SCBT) CRISPR for CBX5
miRNA for CBX5 Gene
- miRTarBase miRNAs that target CBX5
-
- hsa-miR-98-5p (MIRT004950)
- mmu-miR-758-3p (MIRT007583)
- mmu-miR-541-5p (MIRT008275)
- mmu-miR-362-5p (MIRT008983)
- mmu-miR-7b-5p (MIRT009251)
- mmu-miR-223-3p (MIRT009706)
- mmu-miR-324-3p (MIRT010856)
- mmu-miR-26a-5p (MIRT011237)
- mmu-let-7b-5p (MIRT012203)
- mmu-miR-34b-5p (MIRT012800)
- mmu-miR-149-5p (MIRT014642)
- mmu-miR-136-5p (MIRT014968)
- hsa-miR-1-3p (MIRT023531)
- hsa-miR-484 (MIRT041993)
- hsa-miR-339-5p (MIRT042774)
- hsa-miR-320a (MIRT044429)
- hsa-miR-197-3p (MIRT048055)
- hsa-miR-92a-3p (MIRT049796)
- hsa-let-7e-5p (MIRT051655)
- hsa-let-7b-5p (MIRT052318)
- hsa-miR-345-5p (MIRT065823)
- hsa-miR-4795-3p (MIRT187596)
- hsa-miR-1343-3p (MIRT248351)
- hsa-miR-6716-5p (MIRT248353)
- hsa-miR-6783-3p (MIRT248354)
- hsa-miR-6852-5p (MIRT248356)
- hsa-miR-6736-3p (MIRT248364)
- hsa-miR-548p (MIRT338259)
- hsa-miR-4438 (MIRT448968)
- hsa-miR-4635 (MIRT448969)
- hsa-miR-488-3p (MIRT448970)
- hsa-miR-583 (MIRT448971)
- hsa-miR-4650-5p (MIRT479924)
- hsa-miR-1304-5p (MIRT479925)
- hsa-miR-6878-3p (MIRT479926)
- hsa-miR-6734-5p (MIRT479927)
- hsa-miR-1226-5p (MIRT479928)
- hsa-miR-6834-5p (MIRT479929)
- hsa-miR-6721-5p (MIRT479930)
- hsa-miR-6744-3p (MIRT479931)
- hsa-miR-4757-5p (MIRT479932)
- hsa-miR-4763-3p (MIRT479933)
- hsa-miR-6781-3p (MIRT479934)
- hsa-miR-1207-5p (MIRT479935)
- hsa-miR-2682-3p (MIRT479936)
- hsa-miR-4721 (MIRT479937)
- hsa-miR-3616-3p (MIRT479938)
- hsa-miR-7843-5p (MIRT479939)
- hsa-miR-6879-5p (MIRT479940)
- hsa-miR-6735-5p (MIRT479941)
- hsa-miR-4632-5p (MIRT479942)
- hsa-miR-4436b-3p (MIRT479943)
- hsa-miR-548at-5p (MIRT479944)
- hsa-miR-376a-2-5p (MIRT549015)
- hsa-miR-202-3p (MIRT549016)
- hsa-miR-6831-5p (MIRT549017)
- hsa-miR-4668-3p (MIRT549018)
- hsa-miR-3927-3p (MIRT549019)
- hsa-let-7a-5p (MIRT549020)
- hsa-let-7c-5p (MIRT549021)
- hsa-let-7d-5p (MIRT549022)
- hsa-let-7g-5p (MIRT549023)
- hsa-miR-4458 (MIRT549024)
- hsa-let-7i-5p (MIRT549025)
- hsa-miR-4500 (MIRT549026)
- hsa-let-7f-5p (MIRT549027)
- hsa-miR-514b-3p (MIRT558905)
- hsa-miR-514a-3p (MIRT558906)
- hsa-miR-4477a (MIRT558907)
- hsa-miR-4316 (MIRT558908)
- hsa-miR-1294 (MIRT558909)
- hsa-miR-4677-3p (MIRT558910)
- hsa-miR-16-1-3p (MIRT558911)
- hsa-miR-126-5p (MIRT558912)
- hsa-miR-5683 (MIRT558913)
- hsa-miR-370-5p (MIRT558914)
- hsa-miR-383-3p (MIRT558915)
- hsa-miR-3065-3p (MIRT558916)
- mmu-miR-742-3p (MIRT595609)
- hsa-miR-5089-5p (MIRT633094)
- hsa-miR-7151-3p (MIRT633095)
- hsa-miR-5095 (MIRT633096)
- hsa-miR-5589-5p (MIRT633097)
- hsa-miR-4731-5p (MIRT633098)
- hsa-miR-6778-3p (MIRT633099)
- hsa-miR-4252 (MIRT633100)
- hsa-miR-6506-5p (MIRT633101)
- hsa-miR-619-5p (MIRT633102)
- hsa-miR-150-5p (MIRT633103)
- hsa-miR-3937 (MIRT633104)
- hsa-miR-520h (MIRT633105)
- hsa-miR-520g-3p (MIRT633106)
- hsa-miR-6504-3p (MIRT633107)
- hsa-miR-512-3p (MIRT633108)
- hsa-miR-449b-3p (MIRT633109)
- hsa-miR-520e (MIRT633110)
- hsa-miR-520d-3p (MIRT633111)
- hsa-miR-520c-3p (MIRT633112)
- hsa-miR-520b (MIRT633113)
- hsa-miR-520a-3p (MIRT633114)
- hsa-miR-373-3p (MIRT633115)
- hsa-miR-372-3p (MIRT633116)
- hsa-miR-302e (MIRT633117)
- hsa-miR-302d-3p (MIRT633118)
- hsa-miR-302c-3p (MIRT633119)
- hsa-miR-302b-3p (MIRT633120)
- hsa-miR-302a-3p (MIRT633121)
- hsa-miR-93-5p (MIRT633122)
- hsa-miR-526b-3p (MIRT633123)
- hsa-miR-519d-3p (MIRT633124)
- hsa-miR-20b-5p (MIRT633125)
- hsa-miR-20a-5p (MIRT633126)
- hsa-miR-17-5p (MIRT633127)
- hsa-miR-106b-5p (MIRT633128)
- hsa-miR-106a-5p (MIRT633129)
- hsa-miR-6771-5p (MIRT659777)
- hsa-miR-7977 (MIRT659778)
- hsa-miR-566 (MIRT659779)
- hsa-miR-4743-5p (MIRT659780)
- hsa-miR-4268 (MIRT659781)
- hsa-miR-6720-3p (MIRT659782)
- hsa-miR-20b-3p (MIRT659783)
- hsa-miR-6746-5p (MIRT659784)
- hsa-miR-4267 (MIRT659785)
- hsa-miR-2114-5p (MIRT659786)
- hsa-miR-5588-3p (MIRT659787)
- hsa-miR-4256 (MIRT720010)
- hsa-miR-6505-3p (MIRT720011)
- hsa-miR-617 (MIRT720012)
- hsa-miR-4646-5p (MIRT720013)
- hsa-miR-204-3p (MIRT720014)
- hsa-miR-4735-5p (MIRT720015)
- hsa-miR-6742-3p (MIRT720016)
- hsa-miR-939-3p (MIRT720017)
- hsa-miR-19b-3p (MIRT728041)
- hsa-miR-19a-3p (MIRT728043)
- hsa-miR-1180-5p (MIRT735872)
- hsa-miR-1343-5p (MIRT737454)
- hsa-miR-2110 (MIRT738892)
- hsa-miR-3150a-3p (MIRT740256)
- hsa-miR-3175 (MIRT740646)
- hsa-miR-3908 (MIRT742824)
- hsa-miR-450a-2-3p (MIRT745576)
- hsa-miR-509-3p (MIRT749691)
- hsa-miR-6763-5p (MIRT754998)
- hsa-miR-6810-5p (MIRT756647)
- hsa-miR-6825-5p (MIRT756963)
- hsa-miR-6857-5p (MIRT757753)
- hsa-miR-7114-3p (MIRT759130)
- hsa-miR-7973 (MIRT759969)
- hsa-miR-92a-1-5p (MIRT760515)
- hsa-miR-939-5p (MIRT760745)
miRNA products for research
Inhibitory RNAs for research
- Origene shrna, sirna, and RNAi products in human, mouse, rat for CBX5
- Browse OriGene Inhibitory RNA Products For CBX5
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CBX5
Clone products for research
- Applied Biological Materials (abm): Clones for CBX5 - Starting at $45 >
- * CBX5 as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Retro- | Protein Vector - Browse All
- * Viral Packaging Services and High Titer Production Services also available.
-
- MG201823
- MG219678
- MR201823
- MR201823L3
- MR201823L4
- MR219678
- MR219678L3
- MR219678L4
- MR228392
- RC201515
- RC201515L1
- RC201515L2
- RC201515L3
- RC201515L4
- RC225208
- RC225208L1
- RC225208L2
- RC225208L3
- RC225208L4
- RC225209
- RC225209L1
- RC225209L2
- RC225209L3
- RC225209L4
- RG201515
- RG225208
- RG225209
- RR212070
- RR212070L3
- RR212070L4
- MR201823L3V
- MR201823L4V
- MR219678L3V
- MR219678L4V
- RC201515L1V
- RC201515L2V
- RC201515L3V
- RC201515L4V
- RC225208L1V
- RC225208L2V
- RC225208L3V
- RC225208L4V
- RC225209L1V
- RC225209L2V
- RC225209L3V
- RC225209L4V
- RR212070L3V
- RR212070L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for CBX5
- Addgene plasmids for CBX5
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for CBX5
Cell Lines for research
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CBX5 Gene
Localization for CBX5 Gene
Subcellular locations from UniProtKB/Swiss-Prot for CBX5 Gene
- Nucleus. Chromosome. Chromosome, centromere. Note=Colocalizes with HNRNPU in the nucleus (PubMed:19617346). Component of centromeric and pericentromeric heterochromatin. Associates with chromosomes during mitosis. Associates specifically with chromatin during metaphase and anaphase. {ECO:0000269 PubMed:19617346}.
| Compartment | Confidence |
|---|---|
| nucleus | 5 |
| cytoskeleton | 2 |
| plasma membrane | 1 |
| extracellular | 1 |
| mitochondrion | 1 |
| endoplasmic reticulum | 1 |
| endosome | 1 |
| cytosol | 1 |
| golgi apparatus | 1 |
- Nucleoplasm (4)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000118 | histone deacetylase complex | ISS | -- |
| GO:0000775 | chromosome, centromeric region | IEA | -- |
| GO:0000776 | kinetochore | IEA | -- |
| GO:0000781 | chromosome, telomeric region | HDA | 19135898 |
| GO:0000792 | heterochromatin | TAS | 8663349 |
Pathways & Interactions for CBX5 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Chromatin Regulation / Acetylation | ||
| 2 | Factors involved in megakaryocyte development and platelet production | ||
| 3 | Response to elevated platelet cytosolic Ca2+ |
.44
|
|
| 4 | E2F mediated regulation of DNA replication |
Cell cycle Start of DNA replication in early S phase
.53
|
|
| 5 | Aurora B signaling | ||
Pathways by source for CBX5 Gene
2 BioSystems pathways for CBX5 Gene
2 Reactome pathways for CBX5 Gene
1 GeneGo (Thomson Reuters) pathway for CBX5 Gene
- Cell cycle Start of DNA replication in early S phase
1 Cell Signaling Technology pathway for CBX5 Gene
Interacting Proteins for CBX5 Gene
Selected Interacting proteins:
P45973-CBX5_HUMAN
ENSP00000209875
for CBX5 Gene via
UniProtKB
MINT
STRING
IID
GPS-Prot Interaction Network for CBX5
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000122 | negative regulation of transcription by RNA polymerase II | IMP | 19617346 |
| GO:0006974 | cellular response to DNA damage stimulus | IMP | 27248496 |
| GO:0007596 | blood coagulation | TAS | -- |
| GO:0016032 | viral process | IEA | -- |
| GO:0045892 | negative regulation of transcription, DNA-templated | IMP | 9636146 |
Drugs & Compounds for CBX5 Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| Copper | Approved, Investigational | Pharma | Target | 271 |
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs |
|---|
Transcripts for CBX5 Gene
mRNA/cDNA for CBX5 Gene
- 3 REFSEQ mRNAs :
- 17 NCBI additional mRNA sequence :
- 6 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000209875 11546 nts (view in UCSC)
- ENST00000439541 1832 nts (view in UCSC)
- ENST00000547872 745 nts (view in UCSC)
- ENST00000550411 894 nts (view in UCSC)
- ENST00000552562 675 nts (view in UCSC)
CRISPR products for research
- Applied Biological Materials (abm): CRISPR Clones for CBX5 - Starting at $85 >
- * CBX5 CRISPR as ready-to-use vector or virus: Non-viral | Lenti- | Adeno- | AAV- | siRNA - Browse All
- * Cas9 Nucleases, Nickases, Null Mutants, and GFP tag also available.
-
OriGene CRISPR knockouts for CBX5
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for CBX5
-
Santa Cruz Biotechnology (SCBT) CRISPR for CBX5
miRNA products for research
Inhibitory RNAs for research
- Origene shrna, sirna, and RNAi products in human, mouse, rat for CBX5
- Browse OriGene Inhibitory RNA Products For CBX5
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CBX5
Clone products for research
- Applied Biological Materials (abm): Clones for CBX5 - Starting at $45 >
- * CBX5 as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Retro- | Protein Vector - Browse All
- * Viral Packaging Services and High Titer Production Services also available.
-
- MG201823
- MG219678
- MR201823
- MR201823L3
- MR201823L4
- MR219678
- MR219678L3
- MR219678L4
- MR228392
- RC201515
- RC201515L1
- RC201515L2
- RC201515L3
- RC201515L4
- RC225208
- RC225208L1
- RC225208L2
- RC225208L3
- RC225208L4
- RC225209
- RC225209L1
- RC225209L2
- RC225209L3
- RC225209L4
- RG201515
- RG225208
- RG225209
- RR212070
- RR212070L3
- RR212070L4
- MR201823L3V
- MR201823L4V
- MR219678L3V
- MR219678L4V
- RC201515L1V
- RC201515L2V
- RC201515L3V
- RC201515L4V
- RC225208L1V
- RC225208L2V
- RC225208L3V
- RC225208L4V
- RC225209L1V
- RC225209L2V
- RC225209L3V
- RC225209L4V
- RR212070L3V
- RR212070L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for CBX5
- Addgene plasmids for CBX5
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for CBX5
| ExUns: | 1a | · | 1b | ^ | 2a | · | 2b | · | 2c | ^ | 3 | ^ | 4 | ^ | 5a | · | 5b | · | 5c | · | 5d | ^ | 6 | ^ | 7 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | |||||||||||||||||||||||||
| SP2: | - | - | - | - | |||||||||||||||||||||
| SP3: | |||||||||||||||||||||||||
| SP4: | |||||||||||||||||||||||||
| SP5: | - |
Relevant External Links for CBX5 Gene
- GeneLoc Exon Structure for
- CBX5
Expression for CBX5 Gene
This gene is overexpressed in Peripheral blood mononuclear cells (9.6).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for CBX5 Gene
- Elite partner
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for CBX5
SOURCE GeneReport for Unigene cluster for CBX5 Gene:
Hs.349283Evidence on tissue expression from TISSUES for CBX5 Gene
- Nervous system(4.7)
- Liver(4.7)
- Kidney(4.6)
- Eye(3.5)
- Intestine(2.9)
- Skin(2.4)
- Blood(2.3)
- Heart(2.3)
- Lung(2.2)
- Spleen(2.1)
- Pancreas(2.1)
- Muscle(2.1)
- Thyroid gland(2.1)
- Bone marrow(2.1)
Primer products for research
-
OriGene qPCR primer pairs for CBX5
-
OriGene qPCR primer pairs and template standards for CBX5
Gene Expression Assays for research
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for CBX5 Gene
Orthologs for CBX5 Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | CBX5 30 31 |
|
OneToOne | |
| Cow (Bos Taurus) |
Mammalia | CBX5 30 31 |
|
OneToOne | |
| Dog (Canis familiaris) |
Mammalia | CBX5 30 31 |
|
OneToOne | |
| Mouse (Mus musculus) |
Mammalia | Cbx5 30 17 31 |
|
OneToOne | |
| Rat (Rattus norvegicus) |
Mammalia | Cbx5 30 |
|
||
| Oppossum (Monodelphis domestica) |
Mammalia | -- 31 |
|
ManyToMany | |
| Chicken (Gallus gallus) |
Aves | -- 31 |
|
ManyToMany | |
| Lizard (Anolis carolinensis) |
Reptilia | CBX5 31 |
|
OneToOne | |
| Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | cbx5 30 |
|
||
| African clawed frog (Xenopus laevis) |
Amphibia | cbx5-prov 30 |
|
||
| Zebrafish (Danio rerio) |
Actinopterygii | cbx5 30 31 |
|
OneToOne | |
| Fruit Fly (Drosophila melanogaster) |
Insecta | Su(var)205 31 |
|
ManyToMany | |
| HP6 31 |
|
ManyToMany | |||
| HP1b 31 32 |
|
ManyToMany | |||
| HP1e 31 |
|
ManyToMany | |||
| HP1c 31 |
|
ManyToMany | |||
| Worm (Caenorhabditis elegans) |
Secernentea | hpl-1 31 |
|
OneToMany | |
| Sea Squirt (Ciona savignyi) |
Ascidiacea | CSA.3133 31 |
|
OneToMany |
- Species where no ortholog for CBX5 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Baker's yeast (Saccharomyces cerevisiae)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Platypus (Ornithorhynchus anatinus)
- Rainbow Trout (Oncorhynchus mykiss)
- Rice (Oryza sativa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Vase (Ciona intestinalis)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Thale Cress (Arabidopsis thaliana)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Wheat (Triticum aestivum)
Evolution for CBX5 Gene
- ENSEMBL:
- Gene Tree for CBX5 (if available)
- TreeFam:
- Gene Tree for CBX5 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for CBX5: view image
Paralogs for CBX5 Gene
(16) SIMAP similar genes for CBX5 Gene using alignment to 3 proteins:
- CBX5_HUMAN
- F8VNY3_HUMAN
- Q6I9T7_HUMAN
Pseudogenes.org Pseudogenes for CBX5 Gene
Variants for CBX5 Gene
All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).
Residual Variation Intolerance Score:
49.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
0.06;
1.35% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for CBX5 Gene
SNP Genotyping and Copy Number Assays for research
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for CBX5 Gene
Disorders for CBX5 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| reynolds syndrome |
|
|
| immunodeficiency-centromeric instability-facial anomalies syndrome |
|
|
| hyperoxaluria, primary, type i |
|
|
| carbohydrate metabolic disorder |
|
|
| primary hyperoxaluria |
|
|
Search CBX5 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for CBX5
- Atlas
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
- Open Targets Platform
- Open Targets Platform
No data available for UniProtKB/Swiss-Prot and Genatlas for CBX5 Gene
Publications for CBX5 Gene
- Interaction between an integral protein of the nuclear envelope inner membrane and human chromodomain proteins homologous to Drosophila HP1. (PMID: 8663349) Ye Q … Worman HJ (The Journal of biological chemistry 1996) 2 3 4 23
- Human BAHD1 promotes heterochromatic gene silencing. (PMID: 19666599) Bierne H … Cossart P (Proceedings of the National Academy of Sciences of the United States of America 2009) 3 4 23
- In vivo HP1 targeting causes large-scale chromatin condensation and enhanced histone lysine methylation. (PMID: 15899859) Verschure PJ … van Driel R (Molecular and cellular biology 2005) 3 4 23
- Common properties of nuclear body protein SP100 and TIF1alpha chromatin factor: role of SUMO modification. (PMID: 11313457) Seeler JS … Dejean A (Molecular and cellular biology 2001) 3 4 23
- Localization and phosphorylation of HP1 proteins during the cell cycle in mammalian cells. (PMID: 10460410) Minc E … Buendia B (Chromosoma 1999) 3 4 23
ExternalLinks
Products for CBX5 Gene
- Custom Antibody ServicesOriGene Antibodies for CBX5
- Browse OriGene ELISA Kits
- Custom Assay Services
- Search Origene for MassSpec and Protein Over-expression Lysates for CBX5
- Origene Custom Protein Services for CBX5
- Origene shrna, sirna, and RNAi products in human, mouse, rat for CBX5
- Browse OriGene Inhibitory RNA Products For CBX5
- OriGene qPCR primer pairs for CBX5
- OriGene qPCR primer pairs and template standards for CBX5
- OriGene CRISPR knockouts for CBX5