Aliases for CBX4 Gene
External Ids for CBX4 Gene
Previous GeneCards Identifiers for CBX4 Gene
GeneCards Summary for CBX4 Gene
CBX4 (Chromobox 4) is a Protein Coding gene. Diseases associated with CBX4 include Fanconi Anemia, Complementation Group A. Among its related pathways are SUMOylation and Cellular Senescence (REACTOME). Gene Ontology (GO) annotations related to this gene include chromatin binding and ligase activity. An important paralog of this gene is CBX6.
UniProtKB/Swiss-Prot Summary for CBX4 Gene
E3 SUMO-protein ligase which facilitates SUMO1 conjugation by UBE2I (PubMed:12679040). Involved in the sumoylation of HNRNPK, a p53/TP53 transcriptional coactivator, hence indirectly regulates p53/TP53 transcriptional activation resulting in p21/CDKN1A expression. Monosumoylates ZNF131 (PubMed:22825850).
Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development (PubMed:12167701, PubMed:19636380, PubMed:21282530). PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility (PubMed:12167701, PubMed:19636380, PubMed:21282530). Binds to histone H3 trimethylated at 'Lys-9' (H3K9me3) (By similarity). Plays a role in the lineage differentiation of the germ layers in embryonic development (By similarity).