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Aliases for CBWD6 Gene

Aliases for CBWD6 Gene

  • COBW Domain Containing 6 2 3 5
  • Cobalamin Synthase W Domain-Containing Protein 6 3 4
  • COBW Domain Containing 7 2 3
  • CBWD7 3 4
  • Putative Cobalamin Synthase W Domain-Containing Protein 7 3
  • Cobalamin Synthetase W Domain-Containing Protein 6 3
  • Putative COBW Domain-Containing Protein 7 3
  • COBW Domain-Containing Protein 6 3

External Ids for CBWD6 Gene

Previous HGNC Symbols for CBWD6 Gene

  • CBWD7

Previous GeneCards Identifiers for CBWD6 Gene

  • GC09P042659
  • GC09M068495
  • GC09M069204

Summaries for CBWD6 Gene

GeneCards Summary for CBWD6 Gene

CBWD6 (COBW Domain Containing 6) is a Protein Coding gene. An important paralog of this gene is CBWD3.

Additional gene information for CBWD6 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CBWD6 Gene

Genomics for CBWD6 Gene

GeneHancer (GH) Regulatory Elements for CBWD6 Gene

Promoters and enhancers for CBWD6 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH09J041188 Promoter 1 EPDnew Ensembl 650.4 +10.2 10160 1.4 CBWD6 FOXD4L6 FRG1HP
GH09J041272 Promoter 0.5 EPDnew 650.2 -73.7 -73746 0.1 LOC105376060 CBWD6 RNA5SP530
GH09J041194 Enhancer 0.2 Ensembl 0.7 +3.9 3860 2.4 CBWD6 FOXD4L6 FRG1HP
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around CBWD6 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the CBWD6 gene promoter:
  • GR-beta
  • GR-alpha
  • GR
  • ATF-2
  • GATA-1
  • Pax-6
  • Cdc5
  • POU3F2
  • HNF-4alpha2

Genomic Locations for CBWD6 Gene

Genomic Locations for CBWD6 Gene
67,956 bases
Minus strand
65,125 bases
Minus strand

Genomic View for CBWD6 Gene

Genes around CBWD6 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CBWD6 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CBWD6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CBWD6 Gene

Proteins for CBWD6 Gene

  • Protein details for CBWD6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    COBW domain-containing protein 6
    Protein Accession:

    Protein attributes for CBWD6 Gene

    395 amino acids
    Molecular mass:
    43964 Da
    Quaternary structure:
    No Data Available

neXtProt entry for CBWD6 Gene

Post-translational modifications for CBWD6 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for CBWD6 Gene

Domains & Families for CBWD6 Gene

Gene Families for CBWD6 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the SIMIBI class G3E GTPase family. CobW subfamily.
  • Belongs to the SIMIBI class G3E GTPase family. CobW subfamily.
genes like me logo Genes that share domains with CBWD6: view

Function for CBWD6 Gene

Gene Ontology (GO) - Molecular Function for CBWD6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005524 ATP binding IEA --
genes like me logo Genes that share ontologies with CBWD6: view

Phenotypes for CBWD6 Gene

genes like me logo Genes that share phenotypes with CBWD6: view

Animal Model Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for CBWD6 Gene

Localization for CBWD6 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CBWD6 gene
Compartment Confidence
cytosol 2
mitochondrion 1
nucleus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Plasma membrane (2)
See all subcellular structures

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for CBWD6 Gene

Pathways & Interactions for CBWD6 Gene

SuperPathways for CBWD6 Gene

No Data Available

Gene Ontology (GO) - Biological Process for CBWD6 Gene


No data available for Pathways by source and SIGNOR curated interactions for CBWD6 Gene

Drugs & Compounds for CBWD6 Gene

No Compound Related Data Available

Transcripts for CBWD6 Gene

mRNA/cDNA for CBWD6 Gene

(21) REFSEQ mRNAs :
(1) Additional mRNA sequences :
(18) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for CBWD6 Gene

COBW domain containing 6:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for CBWD6 Gene

No ASD Table

Relevant External Links for CBWD6 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for CBWD6 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CBWD6 Gene

NURSA nuclear receptor signaling pathways regulating expression of CBWD6 Gene:


SOURCE GeneReport for Unigene cluster for CBWD6 Gene:

genes like me logo Genes that share expression patterns with CBWD6: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for CBWD6 Gene

Orthologs for CBWD6 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for CBWD6 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia CBWD2 34
  • 63 (a)
(Bos Taurus)
Mammalia -- 34
  • 56 (a)
(Canis familiaris)
Mammalia -- 34
  • 56 (a)
(Mus musculus)
Mammalia Cbwd1 34
  • 51 (a)
(Monodelphis domestica)
Mammalia -- 34
  • 49 (a)
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 47 (a)
(Gallus gallus)
Aves CBWD1 34
  • 44 (a)
(Anolis carolinensis)
Reptilia -- 34
  • 43 (a)
(Danio rerio)
Actinopterygii cbwd 34
  • 42 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes -- 34
  • 18 (a)
Species where no ortholog for CBWD6 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CBWD6 Gene

Gene Tree for CBWD6 (if available)
Gene Tree for CBWD6 (if available)

Paralogs for CBWD6 Gene

Paralogs for CBWD6 Gene

(5) SIMAP similar genes for CBWD6 Gene using alignment to 6 proteins:

  • F5H3X4_HUMAN
  • H0Y6V8_HUMAN
  • Q4V338_HUMAN
  • Q4V340_HUMAN
  • Q4V342_HUMAN
genes like me logo Genes that share paralogs with CBWD6: view

Variants for CBWD6 Gene

Sequence variations from dbSNP and Humsavar for CBWD6 Gene

SNP ID Clin Chr 09 pos Variation AA Info Type
rs1000201935 -- 41,145,888(-) G/A genic_downstream_transcript_variant, intron_variant
rs1000453851 -- 41,184,651(-) C/T genic_upstream_transcript_variant, intron_variant
rs1000506989 -- 41,150,829(-) C/T genic_downstream_transcript_variant, intron_variant
rs1000535819 -- 41,150,449(-) C/A genic_downstream_transcript_variant, intron_variant
rs1000659552 -- 41,169,468(-) G/A intron_variant

Structural Variations from Database of Genomic Variants (DGV) for CBWD6 Gene

Variant ID Type Subtype PubMed ID
esv3346588 CNV duplication 20981092
esv3395969 CNV duplication 20981092
esv3416825 CNV duplication 20981092
nsv1110568 CNV duplication 24896259
nsv1125055 CNV duplication 24896259
nsv1151480 CNV duplication 26484159
nsv951495 CNV duplication 24416366
nsv972389 CNV duplication 23825009

Variation tolerance for CBWD6 Gene

Gene Damage Index Score: 6.31; 76.62% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CBWD6 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CBWD6 Gene

Disorders for CBWD6 Gene

Additional Disease Information for CBWD6

No disorders were found for CBWD6 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CBWD6 Gene

Publications for CBWD6 Gene

  1. DNA sequence and analysis of human chromosome 9. (PMID: 15164053) Humphray SJ … Dunham I (Nature 2004) 3 4 58
  2. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin EL … Gygi SP (Cell 2015) 3 58
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 58
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 3 58

Products for CBWD6 Gene

Sources for CBWD6 Gene

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