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CBR4 (Carbonyl Reductase 4) is a Protein Coding gene. Diseases associated with CBR4 include Pancreatic Cancer 1 and Myopathy, Centronuclear, 6, With Fiber-Type Disproportion. Among its related pathways are Fatty acid biosynthesis (KEGG) and Metabolism. Gene Ontology (GO) annotations related to this gene include oxidoreductase activity and NADPH binding.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0003955 | NAD(P)H dehydrogenase (quinone) activity | IDA | 20837989 |
GO:0005515 | protein binding | IPI | 19571038 |
GO:0008753 | NADPH dehydrogenase (quinone) activity | IDA | 19000905 |
GO:0016491 | oxidoreductase activity | IEA | -- |
GO:0016616 | oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor | IBA | 21873635 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005739 | mitochondrion | IEA | -- |
GO:0005759 | mitochondrial matrix | TAS | -- |
GO:1990204 | oxidoreductase complex | IMP | 25203508 |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Metabolism |
.40
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2 | Fatty acid biosynthesis (KEGG) | ||
3 | Fatty Acyl-CoA Biosynthesis | ||
4 | Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0006629 | lipid metabolic process | IEA | -- |
GO:0006631 | fatty acid metabolic process | IEA | -- |
GO:0006633 | fatty acid biosynthetic process | IBA,IMP | 25203508 |
GO:0044597 | daunorubicin metabolic process | IMP | 20837989 |
GO:0044598 | doxorubicin metabolic process | IMP | 20837989 |
ExUns: | 1a | · | 1b | ^ | 2a | · | 2b | ^ | 3a | · | 3b | ^ | 4a | · | 4b | ^ | 5 | ^ | 6a | · | 6b | · | 6c | ^ | 7a | · | 7b | ^ | 8a | · | 8b |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
SP1: | - | - | - | - | |||||||||||||||||||||||||||
SP2: | - | - | - | - | - | - | |||||||||||||||||||||||||
SP3: | - | - | |||||||||||||||||||||||||||||
SP4: | - | ||||||||||||||||||||||||||||||
SP5: | - | - | - | ||||||||||||||||||||||||||||
SP6: | - | - | |||||||||||||||||||||||||||||
SP7: | |||||||||||||||||||||||||||||||
SP8: | - | - | - | - | - |
This gene was present in the common ancestor of eukaryotes.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | CBR4 30 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | CBR4 31 |
|
OneToOne | |
LOC477352 30 |
|
||||
Platypus (Ornithorhynchus anatinus) |
Mammalia | CBR4 31 |
|
OneToOne | |
Mouse (Mus musculus) |
Mammalia | Cbr4 30 17 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | CBR4 30 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | Cbr4 30 |
|
||
Oppossum (Monodelphis domestica) |
Mammalia | CBR4 31 |
|
OneToOne | |
Chicken (Gallus gallus) |
Aves | CBR4 30 31 |
|
OneToOne | |
Lizard (Anolis carolinensis) |
Reptilia | CBR4 31 |
|
OneToOne | |
Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | cbr4 30 |
|
||
Str.15559 30 |
|
||||
African clawed frog (Xenopus laevis) |
Amphibia | Xl.11545 30 |
|
||
Zebrafish (Danio rerio) |
Actinopterygii | cbr4 30 31 |
|
OneToOne | |
Thale Cress (Arabidopsis thaliana) |
eudicotyledons | AT1G24360 30 |
|
||
Rice (Oryza sativa) |
Liliopsida | Os12g0242700 30 |
|
||
Bread mold (Neurospora crassa) |
Ascomycetes | NCU03525 30 |
|
||
Fission Yeast (Schizosaccharomyces pombe) |
Schizosaccharomycetes | oar2 30 |
|
SNP ID | Clinical significance and condition | Chr 04 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
641520 | Uncertain Significance: Pancreatic adenocarcinoma | 168,924,286(-) | T/G | MISSENSE_VARIANT | |
648376 | Uncertain Significance: Pancreatic adenocarcinoma | 168,921,627(-) | G/A | MISSENSE_VARIANT | |
650493 | Uncertain Significance: Pancreatic adenocarcinoma | 168,913,931(-) | G/A | MISSENSE_VARIANT | |
654773 | Uncertain Significance: Pancreatic adenocarcinoma | 168,898,493(-) | G/A | MISSENSE_VARIANT | |
658471 | Uncertain Significance: Pancreatic adenocarcinoma | 168,924,949(-) | C/T | MISSENSE_VARIANT |
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
esv34043 | CNV | loss | 18971310 |
nsv1026854 | CNV | gain | 25217958 |
Disorder | Aliases | PubMed IDs |
---|---|---|
pancreatic cancer 1 |
|
|
myopathy, centronuclear, 6, with fiber-type disproportion |
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myopathy, centronuclear, 1 |
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