Aliases for CBR4 Gene
- Carbonyl Reductase 4 2 3 5
- 3-Ketoacyl-[Acyl-Carrier-Protein] Reductase Beta Subunit 3 4
- Short Chain Dehydrogenase/Reductase Family 45C Member 1 3 4
- 3-Oxoacyl-[Acyl-Carrier-Protein] Reductase 3 4
- Quinone Reductase CBR4 3 4
- KAR Beta Subunit 3 4
- SDR45C1 3 4
- Short Chain Dehydrogenase/Reductase Family 45C, Member 1 2
External Ids for CBR4 Gene
Previous GeneCards Identifiers for CBR4 Gene
GeneCards Summary for CBR4 Gene
CBR4 (Carbonyl Reductase 4) is a Protein Coding gene. Diseases associated with CBR4 include Horner's Syndrome. Among its related pathways are Metabolism and Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha). Gene Ontology (GO) annotations related to this gene include oxidoreductase activity and NADPH binding. An important paralog of this gene is HSD17B8.
UniProtKB/Swiss-Prot for CBR4 Gene
The heterotetramer with HSD17B8 has NADH-dependent 3-ketoacyl-acyl carrier protein reductase activity, and thereby plays a role in mitochondrial fatty acid biosynthesis (PubMed:19571038, PubMed:25203508). Within the heterotetramer, HSD17B8 binds NADH; CBR4 binds NADPD (PubMed:25203508). The homotetramer has NADPH-dependent quinone reductase activity (PubMed:19000905). Both homotetramer and the heterotetramer have broad substrate specificity and can reduce 9,10-phenanthrenequinone, 1,4-benzoquinone and various other o-quinones and p-quinones (in vitro) (PubMed:19000905, PubMed:19571038, PubMed:25203508).