Aliases for CBR3 Gene
External Ids for CBR3 Gene
Previous GeneCards Identifiers for CBR3 Gene
Carbonyl reductase 3 catalyzes the reduction of a large number of biologically and pharmacologically active carbonyl compounds to their corresponding alcohols. The enzyme is classified as a monomeric NADPH-dependent oxidoreductase. CBR3 contains three exons spanning 11.2 kilobases and is closely linked to another carbonyl reductase gene - CBR1. [provided by RefSeq, Jul 2008]
GeneCards Summary for CBR3 Gene
CBR3 (Carbonyl Reductase 3) is a Protein Coding gene. Diseases associated with CBR3 include Renal Cell Carcinoma, Nonpapillary. Among its related pathways are Drug metabolism - cytochrome P450 and Prostaglandin 2 biosynthesis and metabolism FM. Gene Ontology (GO) annotations related to this gene include oxidoreductase activity and carbonyl reductase (NADPH) activity. An important paralog of this gene is CBR1.
UniProtKB/Swiss-Prot Summary for CBR3 Gene
Has low NADPH-dependent oxidoreductase activity towards 4-benzoylpyridine and menadione (in vitro).