Aliases for CBR1 Gene
Aliases for CBR1 Gene
External Ids for CBR1 Gene
- HGNC: 1548
- Entrez Gene: 873
- Ensembl: ENSG00000159228
- OMIM: 114830
- UniProtKB: P16152
Previous HGNC Symbols for CBR1 Gene
- CBR
Previous GeneCards Identifiers for CBR1 Gene
- GC21P034019
- GC21P036362
- GC21P036364
- GC21P037442
- GC21P022920
Summaries for CBR1 Gene
-
The protein encoded by this gene belongs to the short-chain dehydrogenases/reductases (SDR) family, which function as NADPH-dependent oxidoreductases having wide specificity for carbonyl compounds, such as quinones, prostaglandins, and various xenobiotics. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Nov 2013]
GeneCards Summary for CBR1 Gene
CBR1 (Carbonyl Reductase 1) is a Protein Coding gene. Diseases associated with CBR1 include Retinitis Pigmentosa 58. Among its related pathways are Metabolism and Arachidonic acid metabolism. Gene Ontology (GO) annotations related to this gene include oxidoreductase activity and carbonyl reductase (NADPH) activity. An important paralog of this gene is CBR3.
UniProtKB/Swiss-Prot for CBR1 Gene
-
NADPH-dependent reductase with broad substrate specificity. Catalyzes the reduction of a wide variety of carbonyl compounds including quinones, prostaglandins, menadione, plus various xenobiotics. Catalyzes the reduction of the antitumor anthracyclines doxorubicin and daunorubicin to the cardiotoxic compounds doxorubicinol and daunorubicinol. Can convert prostaglandin E2 to prostaglandin F2-alpha. Can bind glutathione, which explains its higher affinity for glutathione-conjugated substrates. Catalyzes the reduction of S-nitrosoglutathione.
No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CBR1 Gene
Genomics for CBR1 Gene
GeneHancer (GH) Regulatory Elements for CBR1 Gene
Promoters and enhancers for CBR1 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data dump
GeneHancers around CBR1 on UCSC Golden Path with GeneCards custom track
Regulatory Element Products
Genomic Locations for CBR1 Gene
Genomic Locations for CBR1 Gene
- chr21:36,069,924-36,073,177
- (GRCh38/hg38)
- Size:
- 3,254 bases
- Orientation:
- Plus strand
- chr21:37,442,239-37,445,464
- (GRCh37/hg19)
Genomic View for CBR1 Gene
Genes around CBR1 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 21q22.12 by Ensembl
- 21q22.12 by Entrez Gene
- 21q22.12 by HGNC
CBR1 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for CBR1 Gene
Proteins for CBR1 Gene
-
Protein details for CBR1 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P16152-CBR1_HUMAN
- Recommended name:
- Carbonyl reductase [NADPH] 1
- Protein Accession:
- P16152
- B2RBZ7
- B4DFK7
- Q3LHW8
Protein attributes for CBR1 Gene
- Size:
- 277 amino acids
- Molecular mass:
- 30375 Da
- Quaternary structure:
-
- Monomer.
Three dimensional structures from OCA and Proteopedia for CBR1 Gene
Protein Expression for CBR1 Gene
Selected DME Specific Peptides for CBR1 Gene
- P16152:
-
- AEGPHGQFV
- NACCPGWVRTDM
- GTRDVCTELLPL
- AAVQQLQAEGLSP
- TPFHIQAEVTMKTNF
- KFVEDTK
- QSIRALRDFL
Post-translational modifications for CBR1 Gene
- Ubiquitination at Lys174 and Lys186
Other Protein References for CBR1 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
-
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- Novus Biologicals Antibodies for CBR1
-
Abcam antibodies for CBR1
-
Cloud-Clone Corp. Antibodies for CBR1
- Invitrogen Antibodies for CBR1
- antibodies-online: Search results for 81 available CBR1 Antibodies ranked by validation data
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-
Quality Products:
- ABIN289406
- ABIN116565
- ABIN267584
- ABIN5611547
- ABIN303355
- ABIN445367
- ABIN4299694
- ABIN267586
- ABIN452857
- ABIN452856
- ABIN289406
- ABIN116565
- ABIN267584
- ABIN5611547
- ABIN303355
- ABIN445367
- ABIN4299694
- ABIN267586
- ABIN452857
- ABIN452856
- ABIN289406
- ABIN116565
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- ABIN303355
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- ABIN4299694
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- ABIN452856
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-
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Assay Products
Domains & Families for CBR1 Gene
Gene Families for CBR1 Gene
- HGNC:
- IUPHAR :
- Human Protein Atlas (HPA):
-
- Enzymes
- Plasma proteins
- Predicted intracellular proteins
Protein Domains for CBR1 Gene
- InterPro:
- Blocks:
- ProtoNet:
Suggested Antigen Peptide Sequences for CBR1 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
P16152UniProtKB/Swiss-Prot:
CBR1_HUMAN :- Belongs to the short-chain dehydrogenases/reductases (SDR) family.
- Family:
-
- Belongs to the short-chain dehydrogenases/reductases (SDR) family.
Function for CBR1 Gene
Molecular function for CBR1 Gene
- GENATLAS Biochemistry:
- carbonyl reductase,NADPH-dependent oxidoreductase,cytosolic,involved in the metabolism of many carbonyl compounds,including antitumor anthracyne antibiotics
- UniProtKB/Swiss-Prot BiophysicochemicalProperties:
- Kinetic parameters: KM=30 uM for S-nitrosoglutathione {ECO:0000269 PubMed:17344335, ECO:0000269 PubMed:18826943}; KM=22 uM for menadione {ECO:0000269 PubMed:17344335, ECO:0000269 PubMed:18826943}; KM=309 uM for prostaglandin E2 {ECO:0000269 PubMed:17344335, ECO:0000269 PubMed:18826943}; KM=173 uM for daunorubicin {ECO:0000269 PubMed:17344335, ECO:0000269 PubMed:18826943}; KM=247 uM for NADPH {ECO:0000269 PubMed:17344335, ECO:0000269 PubMed:18826943};
- UniProtKB/Swiss-Prot CatalyticActivity:
- R-CHOH-R + NADP(+) = R-CO-R + NADPH.
- UniProtKB/Swiss-Prot CatalyticActivity:
- (5Z,13E)-(15S)-9-alpha,11-alpha,15-trihydroxyprosta-5,13-dienoate + NADP(+) = (5Z,13E)-(15S)-11-alpha,15-dihydroxy-9-oxoprosta-5,13-dienoate + NADPH.
- UniProtKB/Swiss-Prot CatalyticActivity:
- (13E)-(15S)-11-alpha,15-dihydroxy-9-oxoprost-13-enoate + NADP(+) = (13E)-11-alpha-hydroxy-9,15-dioxoprost-13-enoate + NADPH.
- UniProtKB/Swiss-Prot EnzymeRegulation:
- Inhibited by quercetin, rutenin and its derivatives.
- UniProtKB/Swiss-Prot Function:
- NADPH-dependent reductase with broad substrate specificity. Catalyzes the reduction of a wide variety of carbonyl compounds including quinones, prostaglandins, menadione, plus various xenobiotics. Catalyzes the reduction of the antitumor anthracyclines doxorubicin and daunorubicin to the cardiotoxic compounds doxorubicinol and daunorubicinol. Can convert prostaglandin E2 to prostaglandin F2-alpha. Can bind glutathione, which explains its higher affinity for glutathione-conjugated substrates. Catalyzes the reduction of S-nitrosoglutathione.
Enzyme Numbers (IUBMB) for CBR1 Gene
Phenotypes From GWAS Catalog for CBR1 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0004090 | carbonyl reductase (NADPH) activity | IDA | 18449627 |
| GO:0016491 | oxidoreductase activity | IEA | -- |
| GO:0016655 | oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor | IDA | 19442656 |
| GO:0047021 | 15-hydroxyprostaglandin dehydrogenase (NADP+) activity | IEA | -- |
| GO:0050221 | prostaglandin-E2 9-reductase activity | TAS | -- |
Phenotypes for CBR1 Gene
- GenomeRNAi human phenotypes for CBR1:
-
- Increased vaccinia virus (VACV) infection
- Decreased viability
- Decreased viability in esophageal squamous lineage
- Increased transferrin (TF) endocytosis
- Increased shRNA abundance (Z-score > 2)
- Negative genetic interaction between KRASG13D/+ and KRAS+/-
- Decreased viability after Maraba virus infection
- Decreased IL-8 secretion
- Decreased shRNA abundance (Z-score < -2)
- Synthetic lethal with paclitaxel
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-
-
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-
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CRISPR Products
-
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- Overview of 100 available CBR1 gene related products
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Recommended
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- pDONR223
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- pLenti-C-Myc-DDK
- pCMV6-Entry
- pCMV6-XL5
- Applied Biological Materials CRISPR for CBR1
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for CBR1
- GenScript: Design CRISPR guide RNA sequences for CBR1
miRNA for CBR1 Gene
- miRTarBase miRNAs that target CBR1
-
- hsa-mir-93-3p (MIRT038897)
- hsa-mir-484 (MIRT042005)
- hsa-mir-186-5p (MIRT045152)
- hsa-mir-92a-3p (MIRT049536)
- hsa-mir-599 (MIRT526052)
- hsa-mir-3161 (MIRT526053)
- hsa-mir-190a-3p (MIRT526054)
- hsa-mir-921 (MIRT526055)
- hsa-mir-3606-5p (MIRT526056)
- hsa-mir-1909-5p (MIRT526057)
- hsa-mir-153-5p (MIRT526058)
- hsa-mir-1250-3p (MIRT526059)
- hsa-mir-3174 (MIRT526060)
- hsa-mir-5694 (MIRT526061)
- hsa-mir-323a-3p (MIRT526062)
miRNA Products
- Search ViGene Biosciences for CBR1
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-
Recommended
- pGFP-V-RS
- pRFP-C-RS
- pPB-C-His
- pPB-N-His
- pLenti-U6-sgRNA-SFFV-Cas9-2A-Puro
- pLenti-U6-sgRNA-PGK-Neo
- pDONR223
- pLenti-C-mGFP
- pLenti-C-Myc-DDK
- pCMV6-Entry
- pCMV6-XL5
- pGFP-V-RS
- pRFP-C-RS
- pPB-C-His
- pPB-N-His
- pLenti-U6-sgRNA-SFFV-Cas9-2A-Puro
- pLenti-U6-sgRNA-PGK-Neo
- pDONR223
- pLenti-C-mGFP
- pLenti-C-Myc-DDK
- pCMV6-Entry
- pCMV6-XL5
- pGFP-V-RS
- pRFP-C-RS
- pPB-C-His
- pPB-N-His
- pLenti-U6-sgRNA-SFFV-Cas9-2A-Puro
- pLenti-U6-sgRNA-PGK-Neo
- pDONR223
- pLenti-C-mGFP
- pLenti-C-Myc-DDK
- pCMV6-Entry
- pCMV6-XL5
-
ViGene Biosciences ready-to-package AAV shRNAs for CBR1 gene
Clone Products
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-
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- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for CBR1
- genomics-online: cdna clones - Search results for 100 available CBR1 gene related products
- Overview of 100 available CBR1 gene related products
-
Recommended
- pGFP-V-RS
- pRFP-C-RS
- pPB-C-His
- pPB-N-His
- pLenti-U6-sgRNA-SFFV-Cas9-2A-Puro
- pLenti-U6-sgRNA-PGK-Neo
- pDONR223
- pLenti-C-mGFP
- pLenti-C-Myc-DDK
- pCMV6-Entry
- pCMV6-XL5
- pGFP-V-RS
- pRFP-C-RS
- pPB-C-His
- pPB-N-His
- pLenti-U6-sgRNA-SFFV-Cas9-2A-Puro
- pLenti-U6-sgRNA-PGK-Neo
- pDONR223
- pLenti-C-mGFP
- pLenti-C-Myc-DDK
- pCMV6-Entry
- pCMV6-XL5
- pGFP-V-RS
- pRFP-C-RS
- pPB-C-His
- pPB-N-His
- pLenti-U6-sgRNA-SFFV-Cas9-2A-Puro
- pLenti-U6-sgRNA-PGK-Neo
- pDONR223
- pLenti-C-mGFP
- pLenti-C-Myc-DDK
- pCMV6-Entry
- pCMV6-XL5
- orf clones - Search results for 100 available CBR1 gene related products
- Overview of 100 available CBR1 gene related products
-
Recommended
- pGFP-V-RS
- pRFP-C-RS
- pPB-C-His
- pPB-N-His
- pLenti-U6-sgRNA-SFFV-Cas9-2A-Puro
- pLenti-U6-sgRNA-PGK-Neo
- pDONR223
- pLenti-C-mGFP
- pLenti-C-Myc-DDK
- pCMV6-Entry
- pCMV6-XL5
- pGFP-V-RS
- pRFP-C-RS
- pPB-C-His
- pPB-N-His
- pLenti-U6-sgRNA-SFFV-Cas9-2A-Puro
- pLenti-U6-sgRNA-PGK-Neo
- pDONR223
- pLenti-C-mGFP
- pLenti-C-Myc-DDK
- pCMV6-Entry
- pCMV6-XL5
- pGFP-V-RS
- pRFP-C-RS
- pPB-C-His
- pPB-N-His
- pLenti-U6-sgRNA-SFFV-Cas9-2A-Puro
- pLenti-U6-sgRNA-PGK-Neo
- pDONR223
- pLenti-C-mGFP
- pLenti-C-Myc-DDK
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-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
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No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CBR1 Gene
Localization for CBR1 Gene
Subcellular locations from UniProtKB/Swiss-Prot for CBR1 Gene
- Cytoplasm.
| Compartment | Confidence |
|---|---|
| extracellular | 5 |
| cytosol | 5 |
| nucleus | 2 |
| mitochondrion | 1 |
| endoplasmic reticulum | 1 |
- Cytosol (3)
- Nucleus (2)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005737 | cytoplasm | IEA | -- |
| GO:0005829 | cytosol | TAS | -- |
| GO:0070062 | extracellular exosome | IDA,HDA | 19056867 |
| GO:1903561 | extracellular vesicle | HDA,IDA | 24769233 |
Pathways & Interactions for CBR1 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Drug metabolism - cytochrome P450 | ||
| 2 | Metabolism |
.37
|
|
| 3 | Arachidonic acid metabolism | ||
| 4 | Linoleic acid metabolism | ||
| 5 | Folate biosynthesis | ||
Pathways by source for CBR1 Gene
1 BioSystems pathway for CBR1 Gene
4 Reactome pathways for CBR1 Gene
5 KEGG pathways for CBR1 Gene
1 GeneGo (Thomson Reuters) pathway for CBR1 Gene
Interacting Proteins for CBR1 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0017144 | drug metabolic process | IDA | 18449627 |
| GO:0019371 | cyclooxygenase pathway | TAS | -- |
| GO:0030855 | epithelial cell differentiation | IEP | 21492153 |
| GO:0042373 | vitamin K metabolic process | IDA | 18449627 |
| GO:0055114 | oxidation-reduction process | IEA,IDA | 19442656 |
No data available for SIGNOR curated interactions for CBR1 Gene
Drugs & Compounds for CBR1 Gene
(24) Drugs for CBR1 Gene - From: DrugBank, PharmGKB, ApexBio, DGIdb, FDA Approved Drugs, HMDB, and Novoseek
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| Doxorubicin | Approved, Investigational | Pharma | Enzyme, substrate | Topo II inhibitor,immunosuppresive antineoplastic antibiotic | 1828 | |
| Acetohexamide | Approved, Investigational, Withdrawn | Pharma | Enzyme, substrate | 4 | ||
| Haloperidol | Approved | Pharma | Antagonist, Enzyme, substrate | Antipsychotic drug | 155 | |
| Lubiprostone | Approved, Investigational | Pharma | Activator, Enzyme, substrate | 46 | ||
| Curcumin | Approved, Investigational | Pharma | Target | Tyrosinase inhibitor | 155 |
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
|---|---|---|---|---|---|---|
| nadph |
|
53-57-6 | ||||
| (13E)-11a-Hydroxy-9,15-dioxoprost-13-enoic acid |
|
22973-19-9 |
|
|||
| 4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanol |
|
76014-81-8 |
|
|||
| 4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanone |
|
64091-91-4 |
|
|||
| Hydrogen Ion |
|
|
(1) ApexBio Compounds for CBR1 Gene
| Compound | Action | Cas Number |
|---|---|---|
| N6022 | GSNOR inhibitor | 1208315-24-5 |
Transcripts for CBR1 Gene
mRNA/cDNA for CBR1 Gene
- (2) REFSEQ mRNAs :
- (10) Additional mRNA sequences :
- (306) Selected AceView cDNA sequences:
- (5) Ensembl transcripts including schematic representations, and UCSC links where relevant :
CRISPR Products
-
OriGene CRISPR knockouts for CBR1
- genomics-online: gRNA clones - Search results for 100 available CBR1 gene related products
- Overview of 100 available CBR1 gene related products
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Recommended
- pGFP-V-RS
- pRFP-C-RS
- pPB-C-His
- pPB-N-His
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- pLenti-U6-sgRNA-PGK-Neo
- pDONR223
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- pLenti-C-Myc-DDK
- pCMV6-Entry
- pCMV6-XL5
- pGFP-V-RS
- pRFP-C-RS
- pPB-C-His
- pPB-N-His
- pLenti-U6-sgRNA-SFFV-Cas9-2A-Puro
- pLenti-U6-sgRNA-PGK-Neo
- pDONR223
- pLenti-C-mGFP
- pLenti-C-Myc-DDK
- pCMV6-Entry
- pCMV6-XL5
- pGFP-V-RS
- pRFP-C-RS
- pPB-C-His
- pPB-N-His
- pLenti-U6-sgRNA-SFFV-Cas9-2A-Puro
- pLenti-U6-sgRNA-PGK-Neo
- pDONR223
- pLenti-C-mGFP
- pLenti-C-Myc-DDK
- pCMV6-Entry
- pCMV6-XL5
- Applied Biological Materials CRISPR for CBR1
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for CBR1
- GenScript: Design CRISPR guide RNA sequences for CBR1
miRNA Products
- Search ViGene Biosciences for CBR1
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for CBR1
- Browse OriGene Inhibitory RNA Products For CBR1
- genomics-online: shRNA clones - Search results for 100 available CBR1 gene related products
- Overview of 100 available CBR1 gene related products
-
Recommended
- pGFP-V-RS
- pRFP-C-RS
- pPB-C-His
- pPB-N-His
- pLenti-U6-sgRNA-SFFV-Cas9-2A-Puro
- pLenti-U6-sgRNA-PGK-Neo
- pDONR223
- pLenti-C-mGFP
- pLenti-C-Myc-DDK
- pCMV6-Entry
- pCMV6-XL5
- pGFP-V-RS
- pRFP-C-RS
- pPB-C-His
- pPB-N-His
- pLenti-U6-sgRNA-SFFV-Cas9-2A-Puro
- pLenti-U6-sgRNA-PGK-Neo
- pDONR223
- pLenti-C-mGFP
- pLenti-C-Myc-DDK
- pCMV6-Entry
- pCMV6-XL5
- pGFP-V-RS
- pRFP-C-RS
- pPB-C-His
- pPB-N-His
- pLenti-U6-sgRNA-SFFV-Cas9-2A-Puro
- pLenti-U6-sgRNA-PGK-Neo
- pDONR223
- pLenti-C-mGFP
- pLenti-C-Myc-DDK
- pCMV6-Entry
- pCMV6-XL5
-
ViGene Biosciences ready-to-package AAV shRNAs for CBR1 gene
Clone Products
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for CBR1
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for CBR1
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for CBR1
- genomics-online: cdna clones - Search results for 100 available CBR1 gene related products
- Overview of 100 available CBR1 gene related products
-
Recommended
- pGFP-V-RS
- pRFP-C-RS
- pPB-C-His
- pPB-N-His
- pLenti-U6-sgRNA-SFFV-Cas9-2A-Puro
- pLenti-U6-sgRNA-PGK-Neo
- pDONR223
- pLenti-C-mGFP
- pLenti-C-Myc-DDK
- pCMV6-Entry
- pCMV6-XL5
- pGFP-V-RS
- pRFP-C-RS
- pPB-C-His
- pPB-N-His
- pLenti-U6-sgRNA-SFFV-Cas9-2A-Puro
- pLenti-U6-sgRNA-PGK-Neo
- pDONR223
- pLenti-C-mGFP
- pLenti-C-Myc-DDK
- pCMV6-Entry
- pCMV6-XL5
- pGFP-V-RS
- pRFP-C-RS
- pPB-C-His
- pPB-N-His
- pLenti-U6-sgRNA-SFFV-Cas9-2A-Puro
- pLenti-U6-sgRNA-PGK-Neo
- pDONR223
- pLenti-C-mGFP
- pLenti-C-Myc-DDK
- pCMV6-Entry
- pCMV6-XL5
- orf clones - Search results for 100 available CBR1 gene related products
- Overview of 100 available CBR1 gene related products
-
Recommended
- pGFP-V-RS
- pRFP-C-RS
- pPB-C-His
- pPB-N-His
- pLenti-U6-sgRNA-SFFV-Cas9-2A-Puro
- pLenti-U6-sgRNA-PGK-Neo
- pDONR223
- pLenti-C-mGFP
- pLenti-C-Myc-DDK
- pCMV6-Entry
- pCMV6-XL5
- pGFP-V-RS
- pRFP-C-RS
- pPB-C-His
- pPB-N-His
- pLenti-U6-sgRNA-SFFV-Cas9-2A-Puro
- pLenti-U6-sgRNA-PGK-Neo
- pDONR223
- pLenti-C-mGFP
- pLenti-C-Myc-DDK
- pCMV6-Entry
- pCMV6-XL5
- pGFP-V-RS
- pRFP-C-RS
- pPB-C-His
- pPB-N-His
- pLenti-U6-sgRNA-SFFV-Cas9-2A-Puro
- pLenti-U6-sgRNA-PGK-Neo
- pDONR223
- pLenti-C-mGFP
- pLenti-C-Myc-DDK
- pCMV6-Entry
- pCMV6-XL5
- Applied Biological Materials Clones for CBR1
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
| ExUns: | 1a | · | 1b | · | 1c | · | 1d | ^ | 2a | · | 2b | ^ | 3 | ^ | 4a | · | 4b | · | 4c |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | ||||||||||||||||
| SP2: | - | ||||||||||||||||||
| SP3: | - | - | |||||||||||||||||
| SP4: |
Expression for CBR1 Gene
This gene is overexpressed in Liver, secretome (7.5).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for CBR1 Gene
NURSA nuclear receptor signaling pathways regulating expression of CBR1 Gene:
CBR1SOURCE GeneReport for Unigene cluster for CBR1 Gene:
Hs.88778Evidence on tissue expression from TISSUES for CBR1 Gene
- Nervous system(4.9)
- Skin(4.4)
- Liver(3.3)
- Lung(2.4)
- Kidney(2.3)
- Intestine(2.1)
Primer Products
-
OriGene qPCR primer pairs for CBR1
- genomics-online: primer clones - Search results for 100 available CBR1 gene related products
- Overview of 100 available CBR1 gene related products
-
Recommended
- pGFP-V-RS
- pRFP-C-RS
- pPB-C-His
- pPB-N-His
- pLenti-U6-sgRNA-SFFV-Cas9-2A-Puro
- pLenti-U6-sgRNA-PGK-Neo
- pDONR223
- pLenti-C-mGFP
- pLenti-C-Myc-DDK
- pCMV6-Entry
- pCMV6-XL5
- pGFP-V-RS
- pRFP-C-RS
- pPB-C-His
- pPB-N-His
- pLenti-U6-sgRNA-SFFV-Cas9-2A-Puro
- pLenti-U6-sgRNA-PGK-Neo
- pDONR223
- pLenti-C-mGFP
- pLenti-C-Myc-DDK
- pCMV6-Entry
- pCMV6-XL5
- pGFP-V-RS
- pRFP-C-RS
- pPB-C-His
- pPB-N-His
- pLenti-U6-sgRNA-SFFV-Cas9-2A-Puro
- pLenti-U6-sgRNA-PGK-Neo
- pDONR223
- pLenti-C-mGFP
- pLenti-C-Myc-DDK
- pCMV6-Entry
- pCMV6-XL5
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for CBR1 Gene
Orthologs for CBR1 Gene
This gene was present in the common ancestor of eukaryotes.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | CBR1 33 34 |
|
||
| cow (Bos Taurus) |
Mammalia | -- 34 |
|
OneToMany | |
| CBR1 33 |
|
||||
| MGC127133 34 |
|
OneToMany | |||
| dog (Canis familiaris) |
Mammalia | -- 34 |
|
OneToMany | |
| LOC610164 33 |
|
||||
| -- 34 |
|
OneToMany | |||
| -- 34 |
|
OneToMany | |||
| mouse (Mus musculus) |
Mammalia | Cbr1 33 16 34 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Cbr1 33 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | -- 34 |
|
ManyToMany | |
| -- 34 |
|
ManyToMany | |||
| -- 34 |
|
ManyToMany | |||
| platypus (Ornithorhynchus anatinus) |
Mammalia | -- 34 |
|
OneToMany | |
| chicken (Gallus gallus) |
Aves | CBR1 33 34 |
|
||
| lizard (Anolis carolinensis) |
Reptilia | -- 34 |
|
ManyToMany | |
| -- 34 |
|
ManyToMany | |||
| tropical clawed frog (Silurana tropicalis) |
Amphibia | cbr3 33 |
|
||
| Str.11980 33 |
|
||||
| African clawed frog (Xenopus laevis) |
Amphibia | Xl.21423 33 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | cbr1 33 34 |
|
||
| rainbow trout (Oncorhynchus mykiss) |
Actinopterygii | Omy.9689 33 |
|
||
| thale cress (Arabidopsis thaliana) |
eudicotyledons | AT5G61830 33 |
|
||
| rice (Oryza sativa) |
Liliopsida | Os01g0929500 33 |
|
||
| sea squirt (Ciona intestinalis) |
Ascidiacea | Cin.1580 33 |
|
- Species where no ortholog for CBR1 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
Paralogs for CBR1 Gene
(1) SIMAP similar genes for CBR1 Gene using alignment to 4 proteins:
Pseudogenes.org Pseudogenes for CBR1 Gene
Variants for CBR1 Gene
| SNP ID | Clin | Chr 21 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs1000335693 | -- | 36,070,386(+) | G/A | coding_sequence_variant, missense_variant | |
| rs1000643873 | -- | 36,071,386(+) | T/G | intron_variant | |
| rs1000673305 | -- | 36,071,663(+) | A/G | intron_variant | |
| rs1000857332 | -- | 36,073,350(+) | T/A | downstream_transcript_variant | |
| rs1002191556 | -- | 36,071,189(+) | G/C | intron_variant |
Residual Variation Intolerance Score:
69.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
1.49;
29.10% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for CBR1 Gene
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CBR1 Gene
Disorders for CBR1 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| retinitis pigmentosa 58 |
|
|
Search CBR1 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for CBR1
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No data available for UniProtKB/Swiss-Prot and Genatlas for CBR1 Gene
Publications for CBR1 Gene
- Pharmacogenetics of human carbonyl reductase 1 (CBR1) in livers from black and white donors. (PMID: 19022938) Gonzalez-Covarrubias V … Blanco JG (Drug metabolism and disposition: the biological fate of chemicals 2009) 3 22 44 58
- CBR1 and CBR3 pharmacogenetics and their influence on doxorubicin disposition in Asian breast cancer patients. (PMID: 19016765) Lal S … Chowbay B (Cancer science 2008) 3 22 44 58
- Human carbonyl reductase 1 is an S-nitrosoglutathione reductase. (PMID: 18826943) Bateman RL … Shokat KM (The Journal of biological chemistry 2008) 3 4 22 58
- Inhibition of polymorphic human carbonyl reductase 1 (CBR1) by the cardioprotectant flavonoid 7-monohydroxyethyl rutoside (monoHER). (PMID: 18449627) Gonzalez-Covarrubias V … Blanco JG (Pharmaceutical research 2008) 3 4 22 58
- A functional genetic polymorphism on human carbonyl reductase 1 (CBR1 V88I) impacts on catalytic activity and NADPH binding affinity. (PMID: 17344335) Gonzalez-Covarrubias V … Blanco JG (Drug metabolism and disposition: the biological fate of chemicals 2007) 3 4 22 58
Products for CBR1 Gene
- Browse R&D Systems for Antibodies
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- CloneReady with Over 120,000 Genes
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- Browse Primary Antibodies
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- Browse Assay Kits at Cloud-Clone Corp.
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- Cloud-Clone Corp. disease models service
- Browse cDNA clones at Cloud-Clone Corp.
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- Cloud-Clone Corp. primary cells service
- Invitrogen Antibodies for CBR1
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- ApexBio compounds for CBR1
- Cyagen custom Knockout/knockin (KOKI) mouse models for CBR1
- VectorBuilder custom plasmid, inducible vectors for CBR1
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for CBR1
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for CBR1
- antibodies-online: Search results for 81 available COL6 Antibodies ranked by validation data
- Compare Top COL6 Antibodies
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- ABIN452856
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- ABIN303355
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- ABIN116565
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- antibodies-online: Search results for 5 available COL6 Elisa Kits ranked by validation data
- Compare Top COL6 Elisa Kits
- antibodies-online: Search results for 10 available COL6 Proteins ranked by validation data
- Compare Top COL6 Proteins
- GeneTex CBR1 antibody for CBR1
- Search GeneTex for Proteins for CBR1
- ViGene Biosciences adenoviral particle packaged cDNA for CBR1 gene
- ViGene Biosciences lentiviral particle packaged cDNA for CBR1 gene
- ViGene Biosciences ready-to-package AAV shRNAs for CBR1 gene
- Search ViGene Biosciences for CBR1
- Santa Cruz Biotechnology (SCBT) Antibodies for CBR1
- Search Santa Cruz Biotechnology (SCBT) for CBR1 siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for CBR1
- Horizon Cell Lines for CBR1
- genomics-online: cdna clones - Search results for 100 available COL6 gene related products
- Overview of 100 available COL6 gene related products
- Recommended
- pCMV6-XL5
- pCMV6-Entry
- pLenti-C-Myc-DDK
- pLenti-C-mGFP
- pDONR223
- pLenti-U6-sgRNA-PGK-Neo
- pLenti-U6-sgRNA-SFFV-Cas9-2A-Puro
- pPB-N-His
- pPB-C-His
- pRFP-C-RS
- pGFP-V-RS
- pCMV6-XL5
- pCMV6-Entry
- pLenti-C-Myc-DDK
- pLenti-C-mGFP
- pDONR223
- pLenti-U6-sgRNA-PGK-Neo
- pLenti-U6-sgRNA-SFFV-Cas9-2A-Puro
- pPB-N-His
- pPB-C-His
- pRFP-C-RS
- pGFP-V-RS
- pCMV6-XL5
- pCMV6-Entry
- pLenti-C-Myc-DDK
- pLenti-C-mGFP
- pDONR223
- pLenti-U6-sgRNA-PGK-Neo
- pLenti-U6-sgRNA-SFFV-Cas9-2A-Puro
- pPB-N-His
- pPB-C-His
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- pGFP-V-RS
- orf clones - Search results for 100 available COL6 gene related products
- Overview of 100 available COL6 gene related products
- Recommended
- pCMV6-XL5
- pCMV6-Entry
- pLenti-C-Myc-DDK
- pLenti-C-mGFP
- pDONR223
- pLenti-U6-sgRNA-PGK-Neo
- pLenti-U6-sgRNA-SFFV-Cas9-2A-Puro
- pPB-N-His
- pPB-C-His
- pRFP-C-RS
- pGFP-V-RS
- pCMV6-XL5
- pCMV6-Entry
- pLenti-C-Myc-DDK
- pLenti-C-mGFP
- pDONR223
- pLenti-U6-sgRNA-PGK-Neo
- pLenti-U6-sgRNA-SFFV-Cas9-2A-Puro
- pPB-N-His
- pPB-C-His
- pRFP-C-RS
- pGFP-V-RS
- pCMV6-XL5
- pCMV6-Entry
- pLenti-C-Myc-DDK
- pLenti-C-mGFP
- pDONR223
- pLenti-U6-sgRNA-PGK-Neo
- pLenti-U6-sgRNA-SFFV-Cas9-2A-Puro
- pPB-N-His
- pPB-C-His
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- pGFP-V-RS
- genomics-online: gRNA clones - Search results for 100 available COL6 gene related products
- Overview of 100 available COL6 gene related products
- Recommended
- pCMV6-XL5
- pCMV6-Entry
- pLenti-C-Myc-DDK
- pLenti-C-mGFP
- pDONR223
- pLenti-U6-sgRNA-PGK-Neo
- pLenti-U6-sgRNA-SFFV-Cas9-2A-Puro
- pPB-N-His
- pPB-C-His
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- pGFP-V-RS
- pCMV6-XL5
- pCMV6-Entry
- pLenti-C-Myc-DDK
- pLenti-C-mGFP
- pDONR223
- pLenti-U6-sgRNA-PGK-Neo
- pLenti-U6-sgRNA-SFFV-Cas9-2A-Puro
- pPB-N-His
- pPB-C-His
- pRFP-C-RS
- pGFP-V-RS
- pCMV6-XL5
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- pLenti-C-Myc-DDK
- pLenti-C-mGFP
- pDONR223
- pLenti-U6-sgRNA-PGK-Neo
- pLenti-U6-sgRNA-SFFV-Cas9-2A-Puro
- pPB-N-His
- pPB-C-His
- pRFP-C-RS
- pGFP-V-RS
- genomics-online: primer clones - Search results for 100 available COL6 gene related products
- Overview of 100 available COL6 gene related products
- Recommended
- pCMV6-XL5
- pCMV6-Entry
- pLenti-C-Myc-DDK
- pLenti-C-mGFP
- pDONR223
- pLenti-U6-sgRNA-PGK-Neo
- pLenti-U6-sgRNA-SFFV-Cas9-2A-Puro
- pPB-N-His
- pPB-C-His
- pRFP-C-RS
- pGFP-V-RS
- pCMV6-XL5
- pCMV6-Entry
- pLenti-C-Myc-DDK
- pLenti-C-mGFP
- pDONR223
- pLenti-U6-sgRNA-PGK-Neo
- pLenti-U6-sgRNA-SFFV-Cas9-2A-Puro
- pPB-N-His
- pPB-C-His
- pRFP-C-RS
- pGFP-V-RS
- pCMV6-XL5
- pCMV6-Entry
- pLenti-C-Myc-DDK
- pLenti-C-mGFP
- pDONR223
- pLenti-U6-sgRNA-PGK-Neo
- pLenti-U6-sgRNA-SFFV-Cas9-2A-Puro
- pPB-N-His
- pPB-C-His
- pRFP-C-RS
- pGFP-V-RS
- genomics-online: shRNA clones - Search results for 100 available COL6 gene related products
- Overview of 100 available COL6 gene related products
- Recommended
- pCMV6-XL5
- pCMV6-Entry
- pLenti-C-Myc-DDK
- pLenti-C-mGFP
- pDONR223
- pLenti-U6-sgRNA-PGK-Neo
- pLenti-U6-sgRNA-SFFV-Cas9-2A-Puro
- pPB-N-His
- pPB-C-His
- pRFP-C-RS
- pGFP-V-RS
- pCMV6-XL5
- pCMV6-Entry
- pLenti-C-Myc-DDK
- pLenti-C-mGFP
- pDONR223
- pLenti-U6-sgRNA-PGK-Neo
- pLenti-U6-sgRNA-SFFV-Cas9-2A-Puro
- pPB-N-His
- pPB-C-His
- pRFP-C-RS
- pGFP-V-RS
- pCMV6-XL5
- pCMV6-Entry
- pLenti-C-Myc-DDK
- pLenti-C-mGFP
- pDONR223
- pLenti-U6-sgRNA-PGK-Neo
- pLenti-U6-sgRNA-SFFV-Cas9-2A-Puro
- pPB-N-His
- pPB-C-His
- pRFP-C-RS
- pGFP-V-RS
Sources for CBR1 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
- (61) Tocris
- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
- (71) MOPED
- (72) neXtProt
- (73) Reactome
- (74) GeneGo (Thomson Reuters)
- (75) fRNAdb
- (76) DISEASES
- (77) SIMAP
- (78) GenomeRNAi
- (79) LifeMap
- (80) miRTarBase
- (81) MalaCards
- (82) Invitrogen
- (83) BitterDB
- (84) Vector BioLabs
- (85) ESI-BIO
- (86) RefSeq
- (87) BioSystems
- (88) MaxQB
- (89) IUPHAR
- (90) BioGPS
- (91) Illumina
- (92) COMPARTMENTS
- (93) HOMER
- (94) PaxDb
- (95) ApexBio
- (96) Addgene
- (97) antibodies-online
- (98) CYP
- (99) NONCODE
- (100) SwitchGear Genomics
- (101) TreeFam
- (102) PathCards
- (103) GeneReviews
- (104) GeneTex
- (105) Taconic Biosciences
- (106) GTEx
- (107) ProteomicsDB
- (108) SCBT
- (109) DGIdb
- (110) ClinicalTrials
- (111) FDA Approved Drugs
- (112) RVIS
- (113) SIGNOR
- (114) diseasecard
- (115) NIH Rare Diseases
- (116) Orphanet
- (117) UMLS
- (118) GTR
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