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The protein encoded by this gene belongs to the short-chain dehydrogenases/reductases (SDR) family, which function as NADPH-dependent oxidoreductases having wide specificity for carbonyl compounds, such as quinones, prostaglandins, and various xenobiotics. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Nov 2013] See more...
Aliases for CBR1 Gene
Aliases for CBR1 Gene
- Carbonyl Reductase 1 2 3 5
- SDR21C1 2 3 4
- Short Chain Dehydrogenase/Reductase Family 21C Member 1 3 4
- 20-Beta-Hydroxysteroid Dehydrogenase 3 4
- NADPH-Dependent Carbonyl Reductase 1 3 4
- Prostaglandin-E(2) 9-Reductase 3 4
- Prostaglandin 9-Ketoreductase 3 4
- Carbonyl Reductase [NADPH] 1 3 4
- EC 1.1.1.184 4 51
- PG-9-KR 3 4
- CBR 3 4
External Ids for CBR1 Gene
- HGNC: 1548
- NCBI Entrez Gene: 873
- Ensembl: ENSG00000159228
- OMIM®: 114830
- UniProtKB/Swiss-Prot: P16152
Previous HGNC Symbols for CBR1 Gene
- CBR
Previous GeneCards Identifiers for CBR1 Gene
- GC21P034019
- GC21P036362
- GC21P036364
- GC21P037442
- GC21P022920
Summaries for CBR1 Gene
-
The protein encoded by this gene belongs to the short-chain dehydrogenases/reductases (SDR) family, which function as NADPH-dependent oxidoreductases having wide specificity for carbonyl compounds, such as quinones, prostaglandins, and various xenobiotics. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Nov 2013]
GeneCards Summary for CBR1 Gene
CBR1 (Carbonyl Reductase 1) is a Protein Coding gene. Diseases associated with CBR1 include Down Syndrome and Depersonalization Disorder. Among its related pathways are Arachidonic acid metabolism and Drug metabolism - cytochrome P450. Gene Ontology (GO) annotations related to this gene include oxidoreductase activity and carbonyl reductase (NADPH) activity. An important paralog of this gene is CBR3.
UniProtKB/Swiss-Prot Summary for CBR1 Gene
-
NADPH-dependent reductase with broad substrate specificity. Catalyzes the reduction of a wide variety of carbonyl compounds including quinones, prostaglandins, menadione, plus various xenobiotics. Catalyzes the reduction of the antitumor anthracyclines doxorubicin and daunorubicin to the cardiotoxic compounds doxorubicinol and daunorubicinol (PubMed:18449627, PubMed:15799708, PubMed:17912391, PubMed:7005231). Can convert prostaglandin E to prostaglandin F2-alpha (By similarity). Can bind glutathione, which explains its higher affinity for glutathione-conjugated substrates. Catalyzes the reduction of S-nitrosoglutathione (PubMed:18826943, PubMed:17344335).
Additional gene information for CBR1 Gene
- HGNC (1548)
- NCBI Entrez Gene (873)
- Ensembl (ENSG00000159228)
- OMIM® (114830)
- UniProtKB/Swiss-Prot (P16152)
- Open Targets Platform(ENSG00000159228)
- Search for CBR1 at DataMed
- Search for CBR1 at HumanCyc
No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for CBR1 Gene
Genomics for CBR1 Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for CBR1 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around CBR1 on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for CBR1
- Top Transcription factor binding sites by QIAGEN in the CBR1 gene promoter:
-
- AML1a
- ARP-1
- c-Myc
- FOXD3
- Ik-3
- Max
- NF-E2
- NF-E2 p45
- Olf-1
- RelA
Genomic Locations for CBR1 Gene
Latest Assembly
- chr21:36,069,941-36,073,166
- (GRCh38/hg38)
- Size:
- 3,226 bases
- Orientation:
- Plus strand
Previous Assembly
- chr21:37,442,322-37,445,462
- (GRCh37/hg19 by Entrez Gene)
- Size:
- 3,141 bases
- Orientation:
- Plus strand
- chr21:37,442,239-37,445,464
- (GRCh37/hg19 by Ensembl)
- Size:
- 3,226 bases
- Orientation:
- Plus strand
Genomic View for CBR1 Gene
Genes around CBR1 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 21q22.12 by HGNC
- 21q22.12 by Entrez Gene
- 21q22.12 by Ensembl
CBR1 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for CBR1 Gene
Proteins for CBR1 Gene
-
Protein details for CBR1 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P16152-CBR1_HUMAN
- Recommended name:
- Carbonyl reductase [NADPH] 1
- Protein Accession:
- P16152
- B2RBZ7
- B4DFK7
- Q3LHW8
Protein attributes for CBR1 Gene
- Size:
- 277 amino acids
- Molecular mass:
- 30375 Da
- Quaternary structure:
-
- Monomer.
Three dimensional structures from OCA and Proteopedia for CBR1 Gene
Protein Expression for CBR1 Gene
Selected DME Specific Peptides for CBR1 Gene
- P16152:
-
- AEGPHGQFV
- NACCPGWVRTDM
- GTRDVCTELLPL
- AAVQQLQAEGLSP
- TPFHIQAEVTMKTNF
- KFVEDTK
- QSIRALRDFL
Post-translational modifications for CBR1 Gene
Other Protein References for CBR1 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibodies for research
- LifeSpan BioSciences CBR / CBR1 Monoclonal Antibody and CBR / CBR1 Antibody
-
Custom Antibody ServicesOriGene Antibodies for CBR1
- Novus Biologicals Antibodies for CBR1
-
Abcam antibodies for CBR1
- Invitrogen Antibodies for CBR1 (AFLGC-CBR1)
-
Santa Cruz Biotechnology (SCBT) Antibodies for CBR1
- Sino Biological Antibodies for CBR1
Protein products for research
-
OriGene Purified Proteins for CBR1
- Search Origene for MassSpec and Protein Over-expression Lysates for CBR1
- Origene Custom Protein Services for CBR1
- ProSpec Recombinant Proteins for CBR1
-
Abcam proteins for CBR1
Assay products for research
- antibodies-online: Show 8 available CBR1 Elisa Kits ranked by validation data
- Compare Top CBR1 Elisa Kits
-
Quality Products:
Domains & Families for CBR1 Gene
Gene Families for CBR1 Gene
- HGNC:
- IUPHAR :
- Human Protein Atlas (HPA):
-
- Enzymes
- Plasma proteins
- Predicted intracellular proteins
Protein Domains for CBR1 Gene
- InterPro:
- Blocks:
-
- Short-chain dehydrogenase/reductase SDR
- Glucose/ribitol dehydrogenase family signature
- ProtoNet:
Suggested Antigen Peptide Sequences for CBR1 Gene
- GenScript: Design optimal peptide antigens:
-
- cDNA FLJ60474, highly similar to Carbonyl reductase (B4DFK7_HUMAN)
- Prostaglandin-E(2) 9-reductase (CBR1_HUMAN)
Graphical View of Domain Structure for InterPro Entry
P16152UniProtKB/Swiss-Prot:
CBR1_HUMAN :- Belongs to the short-chain dehydrogenases/reductases (SDR) family.
- Family:
-
- Belongs to the short-chain dehydrogenases/reductases (SDR) family.
Function for CBR1 Gene
Molecular function for CBR1 Gene
- UniProtKB/Swiss-Prot Function:
- NADPH-dependent reductase with broad substrate specificity. Catalyzes the reduction of a wide variety of carbonyl compounds including quinones, prostaglandins, menadione, plus various xenobiotics. Catalyzes the reduction of the antitumor anthracyclines doxorubicin and daunorubicin to the cardiotoxic compounds doxorubicinol and daunorubicinol (PubMed:18449627, PubMed:15799708, PubMed:17912391, PubMed:7005231). Can convert prostaglandin E to prostaglandin F2-alpha (By similarity). Can bind glutathione, which explains its higher affinity for glutathione-conjugated substrates. Catalyzes the reduction of S-nitrosoglutathione (PubMed:18826943, PubMed:17344335).
- UniProtKB/Swiss-Prot CatalyticActivity:
- Reaction=a secondary alcohol + NADP(+) = a ketone + H(+) + NADPH; Xref=Rhea:RHEA:19257, ChEBI:CHEBI:15378, ChEBI:CHEBI:17087, ChEBI:CHEBI:35681, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349; EC=1.1.1.184;.
- UniProtKB/Swiss-Prot CatalyticActivity:
- Reaction=NADP(+) + prostaglandin F2alpha = H(+) + NADPH + prostaglandin E2; Xref=Rhea:RHEA:24508, ChEBI:CHEBI:15378, ChEBI:CHEBI:57404, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349, ChEBI:CHEBI:606564; EC=1.1.1.189; Evidence={ECO:0000250|UniProtKB:Q28960};.
- UniProtKB/Swiss-Prot CatalyticActivity:
- Reaction=NADP(+) + prostaglandin E1 = 15-oxoprostaglandin E1 + H(+) + NADPH; Xref=Rhea:RHEA:11636, ChEBI:CHEBI:15378, ChEBI:CHEBI:57397, ChEBI:CHEBI:57401, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349; EC=1.1.1.197; Evidence={ECO:0000269|PubMed:7005231};.
- UniProtKB/Swiss-Prot CatalyticActivity:
- Reaction=H(+) + menadione + NADPH = menadiol + NADP(+); Xref=Rhea:RHEA:63492, ChEBI:CHEBI:6746, ChEBI:CHEBI:15378, ChEBI:CHEBI:28869, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349; Evidence={ECO:0000269|PubMed:17344335};.
- UniProtKB/Swiss-Prot CatalyticActivity:
- Reaction=NADP(+) + prostaglandin D2 = 15-oxoprostaglandin D2 + H(+) + NADPH; Xref=Rhea:RHEA:20744, ChEBI:CHEBI:15378, ChEBI:CHEBI:57406, ChEBI:CHEBI:57408, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349; EC=1.1.1.196; Evidence={ECO:0000250|UniProtKB:Q28960};.
- UniProtKB/Swiss-Prot CatalyticActivity:
- Reaction=NADP(+) + prostaglandin E2 = 15-oxoprostaglandin E2 + H(+) + NADPH; Xref=Rhea:RHEA:63476, ChEBI:CHEBI:15378, ChEBI:CHEBI:57400, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349, ChEBI:CHEBI:606564; Evidence={ECO:0000250|UniProtKB:Q28960};.
- UniProtKB/Swiss-Prot CatalyticActivity:
- Reaction=NADP(+) + prostaglandin F2alpha = 15-oxoprostaglandin F2alpha + H(+) + NADPH; Xref=Rhea:RHEA:63480, ChEBI:CHEBI:15378, ChEBI:CHEBI:57404, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349, ChEBI:CHEBI:133409; Evidence={ECO:0000250|UniProtKB:Q28960};.
- UniProtKB/Swiss-Prot CatalyticActivity:
- Reaction=daunorubicin + H(+) + NADPH = 13-dihydrodaunorubicin + NADP(+); Xref=Rhea:RHEA:63504, ChEBI:CHEBI:15378, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349, ChEBI:CHEBI:64677, ChEBI:CHEBI:75296; Evidence={ECO:0000250|UniProtKB:Q28960};.
- UniProtKB/Swiss-Prot CatalyticActivity:
- Reaction=H(+) + NADPH + S-nitrosoglutathione = NADP(+) + sulfinamide glutathione; Xref=Rhea:RHEA:63500, ChEBI:CHEBI:15378, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349, ChEBI:CHEBI:145544, ChEBI:CHEBI:145547; Evidence={ECO:0000250|UniProtKB:Q28960};.
- UniProtKB/Swiss-Prot BiophysicochemicalProperties:
- Kinetic parameters: KM=30 uM for S-nitrosoglutathione {ECO:0000269|PubMed:17344335, ECO:0000269|PubMed:18826943}; KM=22 uM for menadione {ECO:0000269|PubMed:17344335, ECO:0000269|PubMed:18826943}; KM=309 uM for prostaglandin E2 {ECO:0000269|PubMed:17344335, ECO:0000269|PubMed:18826943}; KM=450 uM for prostaglandin E1 {ECO:0000269|PubMed:7005231}; KM=4 mM for phenylglyoxal {ECO:0000269|PubMed:7005231}; KM=1.6 mM for 4-nitrobenzaldehyde {ECO:0000269|PubMed:7005231}; KM=17 uM for ubiquinone-1 {ECO:0000269|PubMed:7005231}; KM=173 uM for daunorubicin {ECO:0000269|PubMed:17344335, ECO:0000269|PubMed:18826943}; KM=247 uM for NADPH {ECO:0000269|PubMed:17344335, ECO:0000269|PubMed:18826943};
- UniProtKB/Swiss-Prot EnzymeRegulation:
- Inhibited by quercetin, rutenin and its derivatives.
- GENATLAS Biochemistry:
- carbonyl reductase,NADPH-dependent oxidoreductase,cytosolic,involved in the metabolism of many carbonyl compounds,including antitumor anthracyne antibiotics
Enzyme Numbers (IUBMB) for CBR1 Gene
Phenotypes From GWAS Catalog for CBR1 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0004090 | carbonyl reductase (NADPH) activity | TAS,IDA | 18449627 |
| GO:0016491 | oxidoreductase activity | IEA | -- |
| GO:0016655 | oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor | IDA | 19442656 |
| GO:0047020 | 15-hydroxyprostaglandin-D dehydrogenase (NADP+) activity | IEA | -- |
| GO:0047021 | 15-hydroxyprostaglandin dehydrogenase (NADP+) activity | ISS | -- |
Phenotypes for CBR1 Gene
- GenomeRNAi human phenotypes for CBR1:
-
- Increased vaccinia virus (VACV) infection
- Decreased viability
- no effect
- Increased transferrin (TF) endocytosis
- Increased shRNA abundance (Z-score > 2)
- Decreased viability after Maraba virus infection
- Negative genetic interaction between KRASG13D/+ and KRAS+/-
- Decreased viability in non-small-cell lung cancer (NSCLC) lineage
- Increased IL-8 secretion
- Decreased shRNA abundance (Z-score < -2)
- Synthetic lethal with paclitaxel
Animal Models for research
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
CRISPR products for research
- Applied Biological Materials (abm): CRISPR Clones for CBR1 - Starting at $85 >
- * CBR1 CRISPR as ready-to-use vector or virus: Non-viral | Lenti- | Adeno- | AAV- | siRNA - Browse All
- * Cas9 Nucleases, Nickases, Null Mutants, and GFP tag also available.
-
OriGene CRISPR knockouts for CBR1
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for CBR1
-
Santa Cruz Biotechnology (SCBT) CRISPR for CBR1
miRNA for CBR1 Gene
- miRTarBase miRNAs that target CBR1
-
- hsa-miR-93-3p (MIRT038897)
- hsa-miR-484 (MIRT042005)
- hsa-miR-186-5p (MIRT045152)
- hsa-miR-92a-3p (MIRT049536)
- hsa-miR-599 (MIRT526052)
- hsa-miR-3161 (MIRT526053)
- hsa-miR-190a-3p (MIRT526054)
- hsa-miR-921 (MIRT526055)
- hsa-miR-3606-5p (MIRT526056)
- hsa-miR-1909-5p (MIRT526057)
- hsa-miR-153-5p (MIRT526058)
- hsa-miR-1250-3p (MIRT526059)
- hsa-miR-3174 (MIRT526060)
- hsa-miR-5694 (MIRT526061)
- hsa-miR-323a-3p (MIRT526062)
miRNA products for research
Inhibitory RNAs for research
- Origene shrna, sirna, and RNAi products in human, mouse, rat for CBR1
- Browse OriGene Inhibitory RNA Products For CBR1
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CBR1
Clone products for research
- Applied Biological Materials (abm): Clones for CBR1 - Starting at $45 >
- * CBR1 as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Retro- | Protein Vector - Browse All
- * Viral Packaging Services and High Titer Production Services also available.
- Sino Biological Human cDNA Clone for CBR1
- Addgene plasmids for CBR1
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for CBR1
Cell Lines for research
-
Horizon Cell Lines for CBR1
No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CBR1 Gene
Localization for CBR1 Gene
Subcellular locations from UniProtKB/Swiss-Prot for CBR1 Gene
- Cytoplasm.
| Compartment | Confidence |
|---|---|
| cytosol | 5 |
| extracellular | 4 |
| nucleus | 3 |
| plasma membrane | 2 |
| cytoskeleton | 2 |
| mitochondrion | 2 |
| endoplasmic reticulum | 2 |
| peroxisome | 1 |
| endosome | 1 |
| lysosome | 1 |
| golgi apparatus | 1 |
- Cytosol (3)
- Nucleoplasm (2)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005737 | cytoplasm | IEA | -- |
| GO:0005829 | cytosol | TAS | -- |
| GO:0070062 | extracellular exosome | HDA | 19056867 |
| GO:1903561 | extracellular vesicle | HDA | 24769233 |
Pathways & Interactions for CBR1 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Drug metabolism - cytochrome P450 | ||
| 2 | Metabolism |
.40
|
|
| 3 | Arachidonic acid metabolism | ||
| 4 | Linoleic acid metabolism | ||
| 5 | Folate biosynthesis | ||
Pathways by source for CBR1 Gene
1 BioSystems pathway for CBR1 Gene
4 Reactome pathways for CBR1 Gene
5 KEGG pathways for CBR1 Gene
1 GeneGo (Thomson Reuters) pathway for CBR1 Gene
- Prostaglandin 2 biosynthesis and metabolism FM
Interacting Proteins for CBR1 Gene
GPS-Prot Interaction Network for CBR1
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0017144 | drug metabolic process | IDA | 18449627 |
| GO:0019371 | cyclooxygenase pathway | TAS | -- |
| GO:0030855 | epithelial cell differentiation | IEP | 21492153 |
| GO:0042373 | vitamin K metabolic process | IDA | 18449627 |
| GO:0055114 | oxidation-reduction process | IEA | -- |
No data available for SIGNOR curated interactions for CBR1 Gene
Drugs & Compounds for CBR1 Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| Doxorubicin | Approved, Investigational | Pharma | Enzyme, substrate | Topo II inhibitor,immunosuppresive antineoplastic antibiotic | 2086 | |
| Acetohexamide | Approved, Investigational, Withdrawn | Pharma | Enzyme, substrate | 5 | ||
| Haloperidol | Approved | Pharma | Enzyme, substrate | Antipsychotic drug | 173 | |
| Lubiprostone | Approved, Investigational | Pharma | Enzyme, substrate | 49 | ||
| Curcumin | Approved, Experimental, Investigational | Pharma | Target | Tyrosinase inhibitor | 240 |
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
|---|---|---|---|---|---|---|
| (13E)-11a-Hydroxy-9,15-dioxoprost-13-enoic acid |
|
22973-19-9 |
|
|||
| 1-Oxo-1H-2-benzopyran-3-carboxaldehyde |
|
34328-51-3 |
|
|||
| 2-(dimethylamino)acetaldehyde |
|
|
||||
| 2-(methylamino)acetaldehyde |
|
|
||||
| 2-benzylheptanal |
|
|
(1) ApexBio Compounds for CBR1 Gene
| Compound | Action | Cas Number |
|---|---|---|
| N6022 | GSNOR inhibitor | 1208315-24-5 |
Transcripts for CBR1 Gene
mRNA/cDNA for CBR1 Gene
- 2 REFSEQ mRNAs :
- 13 NCBI additional mRNA sequence :
- 5 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000290349 1208 nts (view in UCSC)
- ENST00000399191 838 nts (view in UCSC)
- ENST00000439427 1024 nts (view in UCSC)
- ENST00000466328 595 nts (view in UCSC)
- ENST00000530908 1924 nts (view in UCSC)
CRISPR products for research
- Applied Biological Materials (abm): CRISPR Clones for CBR1 - Starting at $85 >
- * CBR1 CRISPR as ready-to-use vector or virus: Non-viral | Lenti- | Adeno- | AAV- | siRNA - Browse All
- * Cas9 Nucleases, Nickases, Null Mutants, and GFP tag also available.
-
OriGene CRISPR knockouts for CBR1
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for CBR1
-
Santa Cruz Biotechnology (SCBT) CRISPR for CBR1
miRNA products for research
Inhibitory RNAs for research
- Origene shrna, sirna, and RNAi products in human, mouse, rat for CBR1
- Browse OriGene Inhibitory RNA Products For CBR1
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CBR1
Clone products for research
- Applied Biological Materials (abm): Clones for CBR1 - Starting at $45 >
- * CBR1 as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Retro- | Protein Vector - Browse All
- * Viral Packaging Services and High Titer Production Services also available.
- Sino Biological Human cDNA Clone for CBR1
- Addgene plasmids for CBR1
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for CBR1
| ExUns: | 1a | · | 1b | · | 1c | · | 1d | ^ | 2a | · | 2b | ^ | 3 | ^ | 4a | · | 4b | · | 4c |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | ||||||||||||||||
| SP2: | - | ||||||||||||||||||
| SP3: | - | - | |||||||||||||||||
| SP4: |
Relevant External Links for CBR1 Gene
- GeneLoc Exon Structure for
- CBR1
Expression for CBR1 Gene
This gene is overexpressed in Liver, secretome (7.5).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for CBR1 Gene
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for CBR1
SOURCE GeneReport for Unigene cluster for CBR1 Gene:
Hs.88778mRNA Expression by UniProt/SwissProt for CBR1 Gene:
P16152-CBR1_HUMAN
Tissue specificity:
Expressed in kidney (at protein level).
Evidence on tissue expression from TISSUES for CBR1 Gene
- Nervous system(5)
- Skin(4.5)
- Liver(3.4)
- Kidney(3)
- Intestine(2.5)
- Stomach(2.5)
- Lung(2.5)
- Heart(2.4)
- Muscle(2.4)
- Adrenal gland(2.1)
- Blood(2.1)
Primer products for research
-
OriGene qPCR primer pairs for CBR1
-
OriGene qPCR primer pairs and template standards for CBR1
Gene Expression Assays for research
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for CBR1 Gene
Orthologs for CBR1 Gene
This gene was present in the common ancestor of eukaryotes.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | CBR1 30 31 |
|
OneToOne | |
| Cow (Bos Taurus) |
Mammalia | -- 31 |
|
OneToMany | |
| CBR1 30 |
|
||||
| MGC127133 31 |
|
OneToMany | |||
| Dog (Canis familiaris) |
Mammalia | -- 31 |
|
OneToMany | |
| LOC610164 30 |
|
||||
| -- 31 |
|
OneToMany | |||
| -- 31 |
|
OneToMany | |||
| Mouse (Mus musculus) |
Mammalia | Cbr1 30 17 31 |
|
OneToOne | |
| Rat (Rattus norvegicus) |
Mammalia | Cbr1 30 |
|
||
| Oppossum (Monodelphis domestica) |
Mammalia | -- 31 |
|
ManyToMany | |
| -- 31 |
|
ManyToMany | |||
| -- 31 |
|
ManyToMany | |||
| Platypus (Ornithorhynchus anatinus) |
Mammalia | -- 31 |
|
OneToMany | |
| Chicken (Gallus gallus) |
Aves | CBR1 30 31 |
|
OneToMany | |
| Lizard (Anolis carolinensis) |
Reptilia | -- 31 |
|
ManyToMany | |
| -- 31 |
|
ManyToMany | |||
| Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | cbr3 30 |
|
||
| Str.11980 30 |
|
||||
| African clawed frog (Xenopus laevis) |
Amphibia | Xl.21423 30 |
|
||
| Zebrafish (Danio rerio) |
Actinopterygii | cbr1 30 31 |
|
OneToMany | |
| Rainbow Trout (Oncorhynchus mykiss) |
Actinopterygii | Omy.9689 30 |
|
||
| Thale Cress (Arabidopsis thaliana) |
eudicotyledons | AT5G61830 30 |
|
||
| Rice (Oryza sativa) |
Liliopsida | Os01g0929500 30 |
|
||
| Sea Vase (Ciona intestinalis) |
Ascidiacea | Cin.1580 30 |
|
- Species where no ortholog for CBR1 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Baker's yeast (Saccharomyces cerevisiae)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Fruit Fly (Drosophila melanogaster)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Squirt (Ciona savignyi)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Wheat (Triticum aestivum)
- Worm (Caenorhabditis elegans)
Evolution for CBR1 Gene
- ENSEMBL:
- Gene Tree for CBR1 (if available)
- TreeFam:
- Gene Tree for CBR1 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for CBR1: view image
Paralogs for CBR1 Gene
Paralogs for CBR1 Gene
(1) SIMAP similar genes for CBR1 Gene using alignment to 4 proteins:
- CBR1_HUMAN
- A8MTM1_HUMAN
- B4DFK7_HUMAN
- E9PQ63_HUMAN
Pseudogenes.org Pseudogenes for CBR1 Gene
Variants for CBR1 Gene
Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for CBR1 Gene
| SNP ID | Clinical significance and condition | Chr 21 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs146758729 | Likely Benign: not provided | 36,072,631(+) |
G/A NM_001757.4(CBR1):c.583G>A (p.Gly195Arg) |
MISSENSE_VARIANT,THREE_PRIME_UTR | |
| rs2230191 | Benign: not provided | 36,072,639(+) |
G/A NM_001757.4(CBR1):c.591G>A (p.Thr197=) |
SYNONYMOUS_VARIANT,THREE_PRIME_UTR | |
| rs1143663 | - |
p.Val88Ile |
|||
| rs41557318 | - |
p.Pro131Ser |
All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).
Residual Variation Intolerance Score:
69.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
1.49;
29.10% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for CBR1 Gene
SNP Genotyping and Copy Number Assays for research
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CBR1 Gene
Disorders for CBR1 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| down syndrome |
|
|
| depersonalization disorder |
|
|
| constipation |
|
|
Search CBR1 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for CBR1
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- Atlas
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
- Open Targets Platform
- Open Targets Platform
No data available for UniProtKB/Swiss-Prot and Genatlas for CBR1 Gene
Publications for CBR1 Gene
- Pharmacogenetics of human carbonyl reductase 1 (CBR1) in livers from black and white donors. (PMID: 19022938) Gonzalez-Covarrubias V … Blanco JG (Drug metabolism and disposition: the biological fate of chemicals 2009) 3 23 41
- Human carbonyl reductase 1 is an S-nitrosoglutathione reductase. (PMID: 18826943) Bateman RL … Shokat KM (The Journal of biological chemistry 2008) 3 4 23
- Inhibition of polymorphic human carbonyl reductase 1 (CBR1) by the cardioprotectant flavonoid 7-monohydroxyethyl rutoside (monoHER). (PMID: 18449627) Gonzalez-Covarrubias V … Blanco JG (Pharmaceutical research 2008) 3 4 23
- CBR1 and CBR3 pharmacogenetics and their influence on doxorubicin disposition in Asian breast cancer patients. (PMID: 19016765) Lal S … Chowbay B (Cancer science 2008) 3 23 41
- A functional genetic polymorphism on human carbonyl reductase 1 (CBR1 V88I) impacts on catalytic activity and NADPH binding affinity. (PMID: 17344335) Gonzalez-Covarrubias V … Blanco JG (Drug metabolism and disposition: the biological fate of chemicals 2007) 3 4 23
ExternalLinks
Products for CBR1 Gene
- Custom Antibody ServicesOriGene Antibodies for CBR1
- Browse OriGene ELISA Kits
- Custom Assay Services
- OriGene Purified Proteins for CBR1
- Search Origene for MassSpec and Protein Over-expression Lysates for CBR1
- Origene Custom Protein Services for CBR1
- Origene shrna, sirna, and RNAi products in human, mouse, rat for CBR1
- Browse OriGene Inhibitory RNA Products For CBR1
- OriGene qPCR primer pairs for CBR1
- OriGene qPCR primer pairs and template standards for CBR1
- OriGene CRISPR knockouts for CBR1
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For CBR1
- Sino Biological Human cDNA Clone for CBR1
- Browse Sino Biological Recombinant Proteins
- Browse Sino Biological Cell Lysates
- Sino Biological Antibodies for CBR1
- Browse Sino Biological Assays
- Browse Antibodies
- Browse cDNA Clones
- Browse ELISA Kits
- Browse CRO Services
- High-throughput Antibody Production Service
- Protein Production Service
- Epitope Tag Antibodies & Reporter Protein Antibodies
- Lentiviral ORF Clones
- Novus Biologicals Antibodies for CBR1
- Novus Biologicals proteins and lysates for CBR1
- Browse Antibodies
- Browse Peptides and Proteins
- Browse Lysates
- Browse ELISA Kits
- Abcam antibodies for CBR1
- Abcam proteins for CBR1
- Find your target
- Browse Primary Antibodies
- Browse Conjugated Primary Antibodies
- Browse Secondary Antibodies
- Browse ELISA Kits
- Browse Matched Antibody Pairs
- Browse Proteins and Peptides
- Search Knockout (KO) Validated Antibodies
- Browse Monoclonal Antibodies
- Browse Recombinant Antibodies
- ApexBio compounds for CBR1
- VectorBuilder Custom and pre-made DNA vectors for CBR1 (ie. gene expression, shRNA knockdown, CRISPR)
- VectorBuilder Viral vectors for CBR1 (ie. lentivirus, AAV, adenovirus)
- VectorBuilder CRISPR vectors for CBR1 (ie. knockout, knockin, CRISPRa, CRISPRi)
- VectorBuilder Virus packaging for CBR1 CRISPR vectors (ie. lentivirus, AAV, adenovirus)
- VectorBuilder Stable cell line generation for CBR1
- Addgene plasmids for CBR1
- antibodies-online: Show 25 available CBR1 Antibodies ranked by validation data
- Compare Top CBR1 Antibodies
- antibodies-online: Show 8 available CBR1 Elisa Kits ranked by validation data
- Compare Top CBR1 Elisa Kits
- Quality Products:
- antibodies-online: Show 25 available CBR1 Proteins ranked by validation data
- Compare Top CBR1 Proteins
- Santa Cruz Biotechnology (SCBT) Antibodies for CBR1
- Search Santa Cruz Biotechnology (SCBT) for CBR1 siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for CBR1
- Horizon Cell Lines for CBR1
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for CBR1
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for CBR1
- Search GeneCopoeia for miRNA 3'UTR Target clone products for CBR1
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CBR1
Sources for CBR1 Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM® (Updated: 05-Mar-2021)
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) UniProtKB/TrEMBL
- (14) InterPro
- (15) ProtoNet
- (16) Blocks
- (17) MGI
- (18) IUBMB
- (19) KEGG
- (20) MINT
- (21) STRING
- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) ASD
- (28) SAGE
- (29) SOURCE
- (30) HomoloGene
- (31) PanEnsembl
- (32) euGenes
- (33) SGD
- (34) FlyBase
- (35) WormBase
- (36) Pseudogene
- (37) DGV
- (38) dbSNP
- (39) GenAtlas
- (40) HGMD
- (41) GAD
- (42) BGMUT
- (43) HuGE
- (44) Atlas
- (45) GenBank
- (46) HORDE
- (47) HUGE
- (48) IMGT
- (49) Leiden
- (50) miRBase
- (51) DME
- (52) OriGene
- (53) PubMed
- (54) R&D Systems
- (55) TGDB
- (56) Tocris
- (57) Abcam
- (58) Novus Biologicals
- (59) ProSpec
- (60) Sino Biological
- (61) GenScript
- (62) Qiagen
- (63) OCA
- (64) Proteopedia
- (65) MOPED
- (66) neXtProt
- (67) Reactome
- (68) GeneGo (Thomson Reuters)
- (69) DISEASES
- (70) SIMAP
- (71) GenomeRNAi
- (72) LifeMap
- (73) miRTarBase
- (74) MalaCards
- (75) Invitrogen
- (76) BitterDB
- (77) ESI-BIO
- (78) RefSeq
- (79) BioSystems
- (80) MaxQB
- (81) IUPHAR
- (82) BioGPS
- (83) Illumina
- (84) COMPARTMENTS
- (85) HOMER
- (86) PaxDb
- (87) ApexBio
- (88) Addgene
- (89) antibodies-online
- (90) CYP
- (91) NONCODE
- (92) TreeFam
- (93) PathCards
- (94) GeneReviews
- (95) GeneTex
- (96) Taconic Biosciences
- (97) GTEx
- (98) ProteomicsDB
- (99) SCBT
- (100) DGIdb
- (101) ClinicalTrials
- (102) RVIS
- (103) SIGNOR
- (104) diseasecard
- (105) NIH Rare Diseases
- (106) Orphanet
- (107) UMLS
- (108) GTR
- (109) Disease Ontology
- (110) MedlinePlus Genetics
- (111) MeSH
- (112) MedlinePlus
- (113) CDC
- (114) NINDS
- (115) NCBI Bookshelf
- (116) ClinVar
- (117) Gene Damage Index
- (118) HPO
- (119) UDN
- (120) VISTA
- (121) FANTOM5
- (122) ENCODE
- (123) ProSci
- (124) Horizon
- (125) The Signaling Pathways Project (SPP)
- (126) IID
- (127) VectorBuilder
- (128) SNPedia
- (129) BRCA Exchange
- (130) CIViC
- (131) ProteoGenix
- (132) dbSUPER
- (133) TISSUES
- (134) Gene ORGANizer
- (135) abm
- (136) Human Protein Atlas
- (137) GWAS Catalog
- (138) Monarch Initiative
- (139) DataMed
- (140) HumanCyc
- (141) UCNEbase
- (142) EPDnew
- (143) Applied Biosystems
- (144) GlyConnect
- (145) Aminode
- (146) GeneCopoeia
- (147) GPS-Prot
- (148) RNAcentral
- (149) LncRNADisease
- (150) LOVD
- (151) miR2Disease
- (152) DiseaseEnhancer
- (153) Boster Bio
- (154) Biorbyt
- (155) Biocompare
- (156) Mastermind
- (157) CTD^2 Dashboard
- (158) CraniofacialAtlas
- (159) GeneImprint
- (160) Synthego
- (161) ENA
- (162) GtRNAdb
- (163) LncBase
- (164) LncBook
- (165) LNCipedia
- (166) Modomics
- (167) PDBe
- (168) Rfam
- (169) SILVA
- (170) snOPY
- (171) SRPDB
- (172) GENCODE
- (173) TarBase
- (174) Open Targets Platform
- (175) 5SRRNADB
- (176) snoDB
- (177) MirGeneDB