Free for academic non-profit institutions. Other users need a Commercial license

CBR1 Gene(Protein Coding)

Carbonyl Reductase 1

GCID:
GC21P036069
GIFtS:
52
Genes Participants
UDN Logo

Aliases for CBR1 Gene

Aliases for CBR1 Gene

  • Carbonyl Reductase 1 2 3 5
  • Short Chain Dehydrogenase/Reductase Family 21C Member 1 3 4
  • NADPH-Dependent Carbonyl Reductase 1 3 4
  • Prostaglandin-E(2) 9-Reductase 3 4
  • Prostaglandin 9-Ketoreductase 3 4
  • SDR21C1 3 4
  • CBR 3 4
  • Short Chain Dehydrogenase/Reductase Family 21C, Member 1 2
  • 15-Hydroxyprostaglandin Dehydrogenase [NADP(+)] 4
  • 15-Hydroxyprostaglandin Dehydrogenase 3
  • Carbonyl Reductase (NADPH) 1 3
  • Carbonyl Reductase [NADPH] 1 3
  • EC 1.1.1.184 4
  • EC 1.1.1.197 4
  • EC 1.1.1.189 4
  • HCBR1 3
  • CRN 4

External Ids for CBR1 Gene

Previous HGNC Symbols for CBR1 Gene

  • CBR

Previous GeneCards Identifiers for CBR1 Gene

  • GC21P034019
  • GC21P036362
  • GC21P036364
  • GC21P037442
  • GC21P022920

Summaries for CBR1 Gene

Entrez Gene Summary for CBR1 Gene

  • The protein encoded by this gene belongs to the short-chain dehydrogenases/reductases (SDR) family, which function as NADPH-dependent oxidoreductases having wide specificity for carbonyl compounds, such as quinones, prostaglandins, and various xenobiotics. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Nov 2013]

GeneCards Summary for CBR1 Gene

CBR1 (Carbonyl Reductase 1) is a Protein Coding gene. Diseases associated with CBR1 include Retinitis Pigmentosa 58. Among its related pathways are Folate biosynthesis and Metabolism. Gene Ontology (GO) annotations related to this gene include oxidoreductase activity and carbonyl reductase (NADPH) activity. An important paralog of this gene is CBR3.

UniProtKB/Swiss-Prot for CBR1 Gene

  • NADPH-dependent reductase with broad substrate specificity. Catalyzes the reduction of a wide variety of carbonyl compounds including quinones, prostaglandins, menadione, plus various xenobiotics. Catalyzes the reduction of the antitumor anthracyclines doxorubicin and daunorubicin to the cardiotoxic compounds doxorubicinol and daunorubicinol. Can convert prostaglandin E2 to prostaglandin F2-alpha. Can bind glutathione, which explains its higher affinity for glutathione-conjugated substrates. Catalyzes the reduction of S-nitrosoglutathione.

Gene Wiki entry for CBR1 Gene

Additional gene information for CBR1 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CBR1 Gene

Genomics for CBR1 Gene

Products:

  1. Regulatory Element

GeneHancer (GH) Regulatory Elements for CBR1 Gene

Promoters and enhancers for CBR1 Gene
GeneHancer (GH) Identifier GH Type GH
Score		 GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites		 Gene Targets
GH21J036068 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE dbSUPER 666.8 +0.6 576 3 ARID4B SIN3A DMAP1 ZNF2 YY1 CBX5 ZNF213 SP3 SP5 NFYC CBR1 SETD4 RIMKLBP1 LINC01436 LOC105369306 LOC100133286
GH21J036059 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 38.6 -9.5 -9486 2.5 CLOCK SMAD1 ARID4B SIN3A DMAP1 YY1 SLC30A9 POLR2B CBX5 E2F8 SETD4 LOC105369295 LINC01436 CBR1 LOC105369306 RNU6-992P
GH21J036063 Enhancer 0.6 ENCODE 43.3 -5.9 -5857 1.2 RXRA MAFG CBFA2T3 DPF2 TCF12 SP1 SMARCA4 ZNF512 IKZF1 ZBTB33 CBR1 LINC01436 RNU6-992P LOC105369295 SETD4
GH21J036078 Enhancer 1.2 Ensembl ENCODE dbSUPER 16.8 +9.3 9316 2 HDAC1 NFRKB ZBTB40 YY1 CHAMP1 ZNF766 EGR1 CAVIN1 ZNF592 ZNF148 SETD4 LINC01436 CBR1 RIMKLBP1 LOC105369306 CBR3-AS1 LOC100133286
GH21J036076 Enhancer 1.1 Ensembl ENCODE dbSUPER 18.2 +7.3 7284 1.6 HDAC1 TEAD4 TAL1 TCF12 ZNF316 NCOR1 CBFA2T2 TRIM24 NFE2 MAFK LINC01436 CBR1 LOC105369306 SETD4 LOC100133286
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around CBR1 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the CBR1 gene promoter:

Genomic Locations for CBR1 Gene

Genomic Locations for CBR1 Gene
chr21:36,069,924-36,073,177
(GRCh38/hg38)
Size:
3,254 bases
Orientation:
Plus strand
chr21:37,442,239-37,445,464
(GRCh37/hg19)

Genomic View for CBR1 Gene

Genes around CBR1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CBR1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CBR1 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for CBR1 Gene

Proteins for CBR1 Gene

Products:

  1. Antibody
  2. Protein
  3. Assay

  • Protein details for CBR1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P16152-CBR1_HUMAN
    Recommended name:
    Carbonyl reductase [NADPH] 1
    Protein Accession:
    P16152
    Secondary Accessions:
    • B2RBZ7
    • B4DFK7
    • Q3LHW8

    Protein attributes for CBR1 Gene

    Size:
    277 amino acids
    Molecular mass:
    30375 Da
    Quaternary structure:
    • Monomer.

    Three dimensional structures from OCA and Proteopedia for CBR1 Gene

    Alternative splice isoforms for CBR1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CBR1 Gene

Protein Expression for CBR1 Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Post-translational modifications for CBR1 Gene

  • Ubiquitination at Lys186 and Lys174
  • Modification sites at PhosphoSitePlus

Other Protein References for CBR1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for CBR1 Gene

Domains & Families for CBR1 Gene

Gene Families for CBR1 Gene

HGNC:
IUPHAR :
Human Protein Atlas (HPA):
  • Enzymes
  • Plasma proteins
  • Predicted intracellular proteins

Protein Domains for CBR1 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for CBR1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P16152

UniProtKB/Swiss-Prot:

CBR1_HUMAN :
  • Belongs to the short-chain dehydrogenases/reductases (SDR) family.
Family:
  • Belongs to the short-chain dehydrogenases/reductases (SDR) family.
genes like me logo Genes that share domains with CBR1: view

Function for CBR1 Gene

Products:

  1. Animal Model
  2. CRISPR
  3. miRNA
  4. Inhibitory RNA
  5. Clone
  6. Cell Line

Molecular function for CBR1 Gene

UniProtKB/Swiss-Prot Function:
NADPH-dependent reductase with broad substrate specificity. Catalyzes the reduction of a wide variety of carbonyl compounds including quinones, prostaglandins, menadione, plus various xenobiotics. Catalyzes the reduction of the antitumor anthracyclines doxorubicin and daunorubicin to the cardiotoxic compounds doxorubicinol and daunorubicinol. Can convert prostaglandin E2 to prostaglandin F2-alpha. Can bind glutathione, which explains its higher affinity for glutathione-conjugated substrates. Catalyzes the reduction of S-nitrosoglutathione.
UniProtKB/Swiss-Prot CatalyticActivity:
R-CHOH-R + NADP(+) = R-CO-R + NADPH.
UniProtKB/Swiss-Prot CatalyticActivity:
(5Z,13E)-(15S)-9-alpha,11-alpha,15-trihydroxyprosta-5,13-dienoate + NADP(+) = (5Z,13E)-(15S)-11-alpha,15-dihydroxy-9-oxoprosta-5,13-dienoate + NADPH.
UniProtKB/Swiss-Prot CatalyticActivity:
(13E)-(15S)-11-alpha,15-dihydroxy-9-oxoprost-13-enoate + NADP(+) = (13E)-11-alpha-hydroxy-9,15-dioxoprost-13-enoate + NADPH.
UniProtKB/Swiss-Prot EnzymeRegulation:
Inhibited by quercetin, rutenin and its derivatives.
UniProtKB/Swiss-Prot BiophysicochemicalProperties:
Kinetic parameters: KM=30 uM for S-nitrosoglutathione {ECO:0000269 PubMed:17344335, ECO:0000269 PubMed:18826943}; KM=22 uM for menadione {ECO:0000269 PubMed:17344335, ECO:0000269 PubMed:18826943}; KM=309 uM for prostaglandin E2 {ECO:0000269 PubMed:17344335, ECO:0000269 PubMed:18826943}; KM=173 uM for daunorubicin {ECO:0000269 PubMed:17344335, ECO:0000269 PubMed:18826943}; KM=247 uM for NADPH {ECO:0000269 PubMed:17344335, ECO:0000269 PubMed:18826943};
GENATLAS Biochemistry:
carbonyl reductase,NADPH-dependent oxidoreductase,cytosolic,involved in the metabolism of many carbonyl compounds,including antitumor anthracyne antibiotics

Enzyme Numbers (IUBMB) for CBR1 Gene

Phenotypes From GWAS Catalog for CBR1 Gene

Gene Ontology (GO) - Molecular Function for CBR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004090 carbonyl reductase (NADPH) activity IDA 18449627
GO:0005515 protein binding IPI 17353931
GO:0016491 oxidoreductase activity IEA --
GO:0016655 oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor IDA 19442656
GO:0047021 15-hydroxyprostaglandin dehydrogenase (NADP+) activity IEA --
genes like me logo Genes that share ontologies with CBR1: view
genes like me logo Genes that share phenotypes with CBR1: view

Animal Model Products

Clone Products

  • Addgene plasmids for CBR1

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CBR1 Gene

Localization for CBR1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CBR1 Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CBR1 gene
Compartment Confidence
extracellular 5
cytosol 5
nucleus 2
mitochondrion 1
endoplasmic reticulum 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (3)
  • Nucleus (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for CBR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005829 cytosol TAS --
GO:0070062 extracellular exosome HDA 19056867
GO:1903561 extracellular vesicle HDA 24769233
genes like me logo Genes that share ontologies with CBR1: view

Pathways & Interactions for CBR1 Gene

genes like me logo Genes that share pathways with CBR1: view

Gene Ontology (GO) - Biological Process for CBR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0017144 drug metabolic process IDA 18449627
GO:0019371 cyclooxygenase pathway TAS --
GO:0030855 epithelial cell differentiation IEP 21492153
GO:0042373 vitamin K metabolic process IDA 18449627
GO:0055114 oxidation-reduction process IDA,IEA 19442656
genes like me logo Genes that share ontologies with CBR1: view

No data available for SIGNOR curated interactions for CBR1 Gene

Drugs & Compounds for CBR1 Gene

Products:

  1. Drug

(25) Drugs for CBR1 Gene - From: DrugBank, PharmGKB, ApexBio, DGIdb, FDA Approved Drugs, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Doxorubicin Approved, Investigational Pharma Enzyme, substrate Topo II inhibitor,immunosuppresive antineoplastic antibiotic 1828
Acetohexamide Approved, Investigational, Withdrawn Pharma Enzyme, substrate 4
Haloperidol Approved Pharma Antagonist, Pore Blocker, Enzyme, substrate Antipsychotic drug 155
Lubiprostone Approved, Investigational Pharma Activator, Enzyme, substrate 46
Amrubicin Approved, Investigational Pharma Enzyme Topoisomerase II inhibitor, anthracycline agent 20

(33) Additional Compounds for CBR1 Gene - From: HMDB and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
nadph
  • 2'-(Dihydrogen phosphate) 5'-(trihydrogen pyrophosphate) adenosine 5'-ester with 1,4-dihydro-1-b-D-ribofuranosylnicotinamide
  • 2'-(Dihydrogen phosphate) 5'-(trihydrogen pyrophosphate) adenosine 5'-ester with 1,4-dihydro-1-beta-delta-ribofuranosylnicotinamide
  • Adenosine 5'-(trihydrogen diphosphate) 2'-(dihydrogen phosphate) p'-5'-ester with 1,4-dihydro-1-beta-D-ribofuranosyl-3-pyridinecarboxamide
  • Adenosine 5'-(trihydrogen diphosphate) 2'-(dihydrogen phosphate) p'-5'-ester with 1,4-dihydro-1-beta-delta-ribofuranosyl-3-pyridinecarboxamide
  • b-NADPH
 53-57-6
(13E)-11a-Hydroxy-9,15-dioxoprost-13-enoic acid
  • (13E)-11alpha-Hydroxy-9,15-dioxoprost-13-en-1-Oic acid
  • (13E)-11alpha-Hydroxy-9,15-dioxoprost-13-enoate
  • (13E)-11a-Hydroxy-9,15-dioxoprost-13-en-1-Oate
  • (13E)-11a-Hydroxy-9,15-dioxoprost-13-en-1-Oic acid
  • (13E)-11alpha-Hydroxy-9,15-dioxoprost-13-en-1-Oate
 22973-19-9
1-Oxo-1H-2-benzopyran-3-carboxaldehyde
  • 3-Formylisocoumarin
  • Artemidinal
  • Isocoumarin-3-carboxaldehyde
 34328-51-3
2-(dimethylamino)acetaldehyde
2-(methylamino)acetaldehyde

(1) ApexBio Compounds for CBR1 Gene

Compound Action Cas Number
N6022 GSNOR inhibitor 1208315-24-5
genes like me logo Genes that share compounds with CBR1: view

Drug Products

Transcripts for CBR1 Gene

Products:

  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
  4. Clone

mRNA/cDNA for CBR1 Gene

(306) Selected AceView cDNA sequences:
(10) Additional mRNA sequences :
(2) REFSEQ mRNAs :
(5) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for CBR1 Gene

Carbonyl reductase 1:
Representative Sequences:

Clone Products

  • Addgene plasmids for CBR1

Alternative Splicing Database (ASD) splice patterns (SP) for CBR1 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b ^ 3 ^ 4a · 4b · 4c
SP1: - - -
SP2: -
SP3: - -
SP4:

Relevant External Links for CBR1 Gene

GeneLoc Exon Structure for
CBR1
ECgene alternative splicing isoforms for
CBR1

Expression for CBR1 Gene

Products:

  1. Primer
  2. Gene Expression Assay

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CBR1 Gene

mRNA expression in normal human tissues for CBR1 Gene
mRNA expression by GTEx for CBR1 GenemRNA expression by BioGPS for CBR1 Gene

Protein differential expression in normal tissues from HIPED for CBR1 Gene

This gene is overexpressed in Liver, secretome (7.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for CBR1 Gene



Protein tissue co-expression partners for CBR1 Gene

NURSA nuclear receptor signaling pathways regulating expression of CBR1 Gene:

CBR1

SOURCE GeneReport for Unigene cluster for CBR1 Gene:

Hs.88778

Evidence on tissue expression from TISSUES for CBR1 Gene

  • Nervous system(4.9)
  • Skin(4.4)
  • Liver(3.3)
  • Lung(2.4)
  • Kidney(2.3)
  • Intestine(2.1)
genes like me logo Genes that share expression patterns with CBR1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for CBR1 Gene

Orthologs for CBR1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for CBR1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
 Mammalia CBR1 34 33
  • 99.04 (n)
 OneToOne
dog
(Canis familiaris)
 Mammalia -- 34
  • 88 (a)
 OneToMany
LOC610164 33
  • 86.88 (n)
-- 34
  • 79 (a)
 OneToMany
-- 34
  • 74 (a)
 OneToMany
cow
(Bos Taurus)
 Mammalia -- 34
  • 88 (a)
 OneToMany
CBR1 33
  • 86.4 (n)
MGC127133 34
  • 78 (a)
 OneToMany
mouse
(Mus musculus)
 Mammalia Cbr1 16 34 33
  • 83.87 (n)
rat
(Rattus norvegicus)
 Mammalia Cbr1 33
  • 83.63 (n)
oppossum
(Monodelphis domestica)
 Mammalia -- 34
  • 83 (a)
 ManyToMany
-- 34
  • 82 (a)
 ManyToMany
-- 34
  • 73 (a)
 ManyToMany
platypus
(Ornithorhynchus anatinus)
 Mammalia -- 34
  • 77 (a)
 OneToMany
chicken
(Gallus gallus)
 Aves CBR1 34 33
  • 72.12 (n)
 OneToMany
lizard
(Anolis carolinensis)
 Reptilia -- 34
  • 77 (a)
 ManyToMany
-- 34
  • 75 (a)
 ManyToMany
tropical clawed frog
(Silurana tropicalis)
 Amphibia cbr3 33
  • 71.83 (n)
Str.11980 33
African clawed frog
(Xenopus laevis)
 Amphibia Xl.21423 33
zebrafish
(Danio rerio)
 Actinopterygii cbr1 34 33 33
  • 64.48 (n)
 OneToMany
rainbow trout
(Oncorhynchus mykiss)
 Actinopterygii Omy.9689 33
thale cress
(Arabidopsis thaliana)
 eudicotyledons AT5G61830 33
  • 46.04 (n)
rice
(Oryza sativa)
 Liliopsida Os01g0929500 33
  • 49.62 (n)
sea squirt
(Ciona savignyi)
 Ascidiacea Cin.1580 33
sea squirt
(Ciona intestinalis)
 Ascidiacea Cin.1580 33
Species where no ortholog for CBR1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CBR1 Gene

ENSEMBL:
Gene Tree for CBR1 (if available)
TreeFam:
Gene Tree for CBR1 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for CBR1: view image

Paralogs for CBR1 Gene

Paralogs for CBR1 Gene

(1) SIMAP similar genes for CBR1 Gene using alignment to 4 proteins:

  • CBR1_HUMAN
  • A8MTM1_HUMAN
  • B4DFK7_HUMAN
  • E9PQ63_HUMAN

Pseudogenes.org Pseudogenes for CBR1 Gene

genes like me logo Genes that share paralogs with CBR1: view

Variants for CBR1 Gene

Products:

  1. SNP Genotyping and Copy Number Assay

Sequence variations from dbSNP and Humsavar for CBR1 Gene

SNP ID Clin Chr 21 pos Variation AA Info Type
rs1000335693 -- 36,070,386(+) G/A coding_sequence_variant, missense_variant
rs1000643873 -- 36,071,386(+) T/G intron_variant
rs1000673305 -- 36,071,663(+) A/G intron_variant
rs1000857332 -- 36,073,350(+) T/A downstream_transcript_variant
rs1002191556 -- 36,071,189(+) G/C intron_variant

Structural Variations from Database of Genomic Variants (DGV) for CBR1 Gene

Variant ID Type Subtype PubMed ID
esv2751927 CNV gain 17911159
nsv459247 CNV loss 19166990
nsv470899 CNV loss 18288195
nsv587461 CNV loss 21841781
nsv964547 CNV deletion 23825009

Variation tolerance for CBR1 Gene

Residual Variation Intolerance Score: 69.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.49; 29.10% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CBR1 Gene

Human Gene Mutation Database (HGMD)
CBR1
SNPedia medical, phenotypic, and genealogical associations of SNPs for
CBR1

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CBR1 Gene

Disorders for CBR1 Gene

MalaCards: The human disease database

(1) MalaCards diseases for CBR1 Gene - From: HGMD and DISEASES

Disorder Aliases PubMed IDs
retinitis pigmentosa 58
  • rp58
- elite association - COSMIC cancer census association via MalaCards
Search CBR1 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for CBR1

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with CBR1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CBR1 Gene

Publications for CBR1 Gene

  1. Pharmacogenetics of human carbonyl reductase 1 (CBR1) in livers from black and white donors. (PMID: 19022938) Gonzalez-Covarrubias V … Blanco JG (Drug metabolism and disposition: the biological fate of chemicals 2009) 3 22 44 58
  2. Inhibition of polymorphic human carbonyl reductase 1 (CBR1) by the cardioprotectant flavonoid 7-monohydroxyethyl rutoside (monoHER). (PMID: 18449627) Gonzalez-Covarrubias V … Blanco JG (Pharmaceutical research 2008) 3 4 22 58
  3. CBR1 and CBR3 pharmacogenetics and their influence on doxorubicin disposition in Asian breast cancer patients. (PMID: 19016765) Lal S … Chowbay B (Cancer science 2008) 3 22 44 58
  4. Human carbonyl reductase 1 is an S-nitrosoglutathione reductase. (PMID: 18826943) Bateman RL … Shokat KM (The Journal of biological chemistry 2008) 3 4 22 58
  5. A functional genetic polymorphism on human carbonyl reductase 1 (CBR1 V88I) impacts on catalytic activity and NADPH binding affinity. (PMID: 17344335) Gonzalez-Covarrubias V … Blanco JG (Drug metabolism and disposition: the biological fate of chemicals 2007) 3 4 22 58

Products for CBR1 Gene

  • Addgene plasmids for CBR1

Sources for CBR1 Gene

Content
Loading form....