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Aliases for CBLN4 Gene

Aliases for CBLN4 Gene

  • Cerebellin 4 Precursor 2 3 5
  • Cerebellin-Like Glycoprotein 1 3 4
  • Cerebellin Precursor-Like 1 2 3
  • CBLNL1 3 4
  • Cerebellin-4 3

External Ids for CBLN4 Gene

Previous HGNC Symbols for CBLN4 Gene

  • CBLNL1

Previous GeneCards Identifiers for CBLN4 Gene

  • GC20M054005
  • GC20M054572
  • GC20M051353

Summaries for CBLN4 Gene

Entrez Gene Summary for CBLN4 Gene

  • This gene encodes a member of a family of small secreted proteins containing C1Q domains. Members of this family are involved in regulation of neurexin signalling during synapse development. The mouse homolog of the protein encoded by this gene competes with netrin to bind to the deleted in colorectal cancer receptor. [provided by RefSeq, Aug 2012]

GeneCards Summary for CBLN4 Gene

CBLN4 (Cerebellin 4 Precursor) is a Protein Coding gene. An important paralog of this gene is CBLN2.

UniProtKB/Swiss-Prot for CBLN4 Gene

  • May be involved in synaptic functions in the CNS. May play a role in CBLN3 export from the endoplasmic reticulum and secretion (By similarity).

Additional gene information for CBLN4 Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CBLN4 Gene

Genomics for CBLN4 Gene

GeneHancer (GH) Regulatory Elements for CBLN4 Gene

Promoters and enhancers for CBLN4 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH20J056005 Promoter 0.6 EPDnew 650.7 0.0 -22 0.1 SUZ12 CBLN4 LOC105372679
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around CBLN4 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the CBLN4 gene promoter:
  • Arnt
  • Nkx2-5
  • Bach1
  • FAC1
  • Tal-1beta
  • ITF-2
  • p53
  • GATA-1
  • TBP
  • Nkx6-1

Genomic Locations for CBLN4 Gene

Genomic Locations for CBLN4 Gene
8,118 bases
Minus strand
8,033 bases
Minus strand

Genomic View for CBLN4 Gene

Genes around CBLN4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CBLN4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CBLN4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CBLN4 Gene

Proteins for CBLN4 Gene

  • Protein details for CBLN4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein Accession:
    Secondary Accessions:
    • A8K0S5

    Protein attributes for CBLN4 Gene

    201 amino acids
    Molecular mass:
    21808 Da
    Quaternary structure:
    • Homohexamer; disulfide-linked homotrimers. The trimers are assembled via the globular C1q domains. The trimers associate via N-terminal cysteine residues to form disulfide-linked hexamers (By similarity). May form oligomers with CBLN1, CBLN2 and CBLN3 prior to secretion (By similarity). Strongly interacts with DCC in a NTN1-displaceable fashion (By similarity). Weakly binds to NRXN1 and NRXN2 long and short isoforms produced by alternative promoter usage. Interaction with NRXN3 short isoform is hardly detectable; no interaction at all with NRXN3 long isoform (By similarity).

neXtProt entry for CBLN4 Gene

Post-translational modifications for CBLN4 Gene

  • Glycosylation at posLast=8888 and posLast=2929
  • Modification sites at PhosphoSitePlus

Other Protein References for CBLN4 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for CBLN4 Gene

Domains & Families for CBLN4 Gene

Gene Families for CBLN4 Gene

Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted secreted proteins

Protein Domains for CBLN4 Gene

Suggested Antigen Peptide Sequences for CBLN4 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with CBLN4: view

No data available for UniProtKB/Swiss-Prot for CBLN4 Gene

Function for CBLN4 Gene

Molecular function for CBLN4 Gene

UniProtKB/Swiss-Prot Function:
May be involved in synaptic functions in the CNS. May play a role in CBLN3 export from the endoplasmic reticulum and secretion (By similarity).

Phenotypes From GWAS Catalog for CBLN4 Gene

genes like me logo Genes that share phenotypes with CBLN4: view

Animal Models for CBLN4 Gene

MGI Knock Outs for CBLN4:

Animal Model Products

  • Taconic Biosciences Mouse Models for CBLN4

miRNA for CBLN4 Gene

miRTarBase miRNAs that target CBLN4

Clone Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CBLN4 Gene

Localization for CBLN4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CBLN4 Gene

Secreted. Cell junction, synapse.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CBLN4 gene
Compartment Confidence
extracellular 4

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for CBLN4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0005615 extracellular space IEA --
GO:0030054 cell junction IEA --
GO:0045202 synapse IEA --
genes like me logo Genes that share ontologies with CBLN4: view

Pathways & Interactions for CBLN4 Gene

SuperPathways for CBLN4 Gene

No Data Available

Interacting Proteins for CBLN4 Gene

Gene Ontology (GO) - Biological Process for CBLN4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0009306 protein secretion IEA --
genes like me logo Genes that share ontologies with CBLN4: view

No data available for Pathways by source and SIGNOR curated interactions for CBLN4 Gene

Drugs & Compounds for CBLN4 Gene

No Compound Related Data Available

Transcripts for CBLN4 Gene

mRNA/cDNA for CBLN4 Gene

(1) REFSEQ mRNAs :
(7) Additional mRNA sequences :
(23) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for CBLN4 Gene

Cerebellin 4 precursor:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for CBLN4 Gene

No ASD Table

Relevant External Links for CBLN4 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for CBLN4 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CBLN4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CBLN4 Gene

This gene is overexpressed in Brain - Frontal Cortex (BA9) (x9.6), Brain - Anterior cingulate cortex (BA24) (x7.6), Brain - Hypothalamus (x6.8), Brain - Cortex (x6.2), and Brain - Amygdala (x4.8).

Protein differential expression in normal tissues from HIPED for CBLN4 Gene

This gene is overexpressed in Plasma (32.8) and Cerebrospinal fluid (24.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for CBLN4 Gene

NURSA nuclear receptor signaling pathways regulating expression of CBLN4 Gene:


SOURCE GeneReport for Unigene cluster for CBLN4 Gene:


Evidence on tissue expression from TISSUES for CBLN4 Gene

  • Nervous system(4.5)
genes like me logo Genes that share expression patterns with CBLN4: view

No data available for Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for CBLN4 Gene

Orthologs for CBLN4 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CBLN4 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia CBLN4 34 33
  • 99.83 (n)
(Canis familiaris)
Mammalia CBLN4 34 33
  • 93.2 (n)
(Bos Taurus)
Mammalia CBLN4 34 33
  • 91.15 (n)
(Mus musculus)
Mammalia Cbln4 16 34 33
  • 88.89 (n)
(Rattus norvegicus)
Mammalia Cbln4 33
  • 88.55 (n)
(Ornithorhynchus anatinus)
Mammalia CBLN4 34
  • 82 (a)
(Monodelphis domestica)
Mammalia CBLN4 34
  • 78 (a)
(Gallus gallus)
Aves CBLN4 34 33
  • 86.91 (n)
(Anolis carolinensis)
Reptilia CBLN4 34
  • 94 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia cbln4 33
  • 76.63 (n)
African clawed frog
(Xenopus laevis)
Amphibia MGC64424 33
(Danio rerio)
Actinopterygii cbln4 34 33
  • 75.25 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 35 (a)
Species where no ortholog for CBLN4 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CBLN4 Gene

Gene Tree for CBLN4 (if available)
Gene Tree for CBLN4 (if available)
Evolutionary constrained regions (ECRs) for CBLN4: view image

Paralogs for CBLN4 Gene

(4) SIMAP similar genes for CBLN4 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with CBLN4: view

Variants for CBLN4 Gene

Sequence variations from dbSNP and Humsavar for CBLN4 Gene

SNP ID Clin Chr 20 pos Variation AA Info Type
rs1000223400 -- 56,005,370(-) C/T 5_prime_UTR_variant
rs1000251847 -- 56,002,129(-) T/C intron_variant
rs1000300008 -- 56,000,071(-) G/A intron_variant
rs1000351889 -- 55,999,768(-) T/G intron_variant
rs1000572286 -- 56,005,531(-) G/A upstream_transcript_variant

Variation tolerance for CBLN4 Gene

Residual Variation Intolerance Score: 29.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.12; 2.66% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CBLN4 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for CBLN4 Gene

Disorders for CBLN4 Gene

Additional Disease Information for CBLN4

No disorders were found for CBLN4 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CBLN4 Gene

Publications for CBLN4 Gene

  1. Precerebellin-related genes and precerebellin 1 peptide in the adrenal gland of the rat: expression pattern, localization, developmental regulation and effects on corticosteroidogenesis. (PMID: 19212655) Rucinski M … Malendowicz LK (International journal of molecular medicine 2009) 3 22 58
  2. Signal peptide prediction based on analysis of experimentally verified cleavage sites. (PMID: 15340161) Zhang Z … Henzel WJ (Protein science : a publication of the Protein Society 2004) 3 4 58
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  4. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark HF … Gray A (Genome research 2003) 3 4 58
  5. The DNA sequence and comparative analysis of human chromosome 20. (PMID: 11780052) Deloukas P … Rogers J (Nature 2001) 3 4 58

Products for CBLN4 Gene

Sources for CBLN4 Gene

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