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Aliases for CBLN2 Gene

Aliases for CBLN2 Gene

  • Cerebellin 2 Precursor 2 3 5
  • Cerebellin-2 3

External Ids for CBLN2 Gene

Previous GeneCards Identifiers for CBLN2 Gene

  • GC18U990007
  • GC18M068352
  • GC18M068354
  • GC18M070203
  • GC18M066922

Summaries for CBLN2 Gene

GeneCards Summary for CBLN2 Gene

CBLN2 (Cerebellin 2 Precursor) is a Protein Coding gene. An important paralog of this gene is CBLN1.

UniProtKB/Swiss-Prot for CBLN2 Gene

  • May play role in synaptogenesis induction.

Additional gene information for CBLN2 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CBLN2 Gene

Genomics for CBLN2 Gene

GeneHancer (GH) Regulatory Elements for CBLN2 Gene

Promoters and enhancers for CBLN2 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH18I072544 Promoter 0.9 EPDnew 550.2 +94.0 93983 0.1 CTCF ZNF654 RAD21 ZNF335 SMC3 ZNF143 PRDM10 EZH2 CBLN2 GC18M072550 LOC105372189
GH18I072543 Promoter 0.6 EPDnew 550.2 +94.9 94947 0.1 EZH2 CBLN2 GC18M072550 LOC105372189
GH18I072637 Enhancer 0.3 FANTOM5 554.5 +0.7 712 0.1 MXI1 CBLN2 NETO1 PIR37044
GH18I072869 Enhancer 0.7 FANTOM5 ENCODE 1.2 -230.9 -230949 0.8 CTCF CTBP2 EZH2 NETO1 CBLN2 LOC100505797 GC18P073256
GH18I072674 Enhancer 1 FANTOM5 ENCODE 0.3 -36.8 -36772 1.1 SMAD1 EBF1 BATF IRF4 RELA POLR2A ATF7 ETV6 BCLAF1 IKZF2 CBLN2 ENSG00000265579
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around CBLN2 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the CBLN2 gene promoter:

Genomic Locations for CBLN2 Gene

Genomic Locations for CBLN2 Gene
102,624 bases
Minus strand

Genomic View for CBLN2 Gene

Genes around CBLN2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CBLN2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CBLN2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CBLN2 Gene

Proteins for CBLN2 Gene

  • Protein details for CBLN2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein Accession:
    Secondary Accessions:
    • Q53Z56

    Protein attributes for CBLN2 Gene

    224 amino acids
    Molecular mass:
    24084 Da
    Quaternary structure:
    • May form homooligomers or heterooligomers with CBLN1 and CBLN3 prior to secretion. Once secreted, does not interact with other CBLN family members. Interacts with GRID2, and more weakly with GRID1. Interacts with NRXN1 and NRXN2 long and short isoforms produced by alternative promoter usage. Weakly interacts with NRXN3 short isoform and not at all with NRXN3 long isoform (By similarity).

neXtProt entry for CBLN2 Gene

Post-translational modifications for CBLN2 Gene

  • Glycosylation at posLast=5353 and Asn110
  • Modification sites at PhosphoSitePlus

Other Protein References for CBLN2 Gene

No data available for DME Specific Peptides for CBLN2 Gene

Domains & Families for CBLN2 Gene

Gene Families for CBLN2 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted secreted proteins

Protein Domains for CBLN2 Gene

Suggested Antigen Peptide Sequences for CBLN2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with CBLN2: view

No data available for UniProtKB/Swiss-Prot for CBLN2 Gene

Function for CBLN2 Gene

Molecular function for CBLN2 Gene

UniProtKB/Swiss-Prot Function:
May play role in synaptogenesis induction.

Phenotypes From GWAS Catalog for CBLN2 Gene

genes like me logo Genes that share phenotypes with CBLN2: view

Animal Models for CBLN2 Gene

MGI Knock Outs for CBLN2:

Animal Model Products

  • Taconic Biosciences Mouse Models for CBLN2

Clone Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CBLN2 Gene

Localization for CBLN2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CBLN2 Gene


Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CBLN2 gene
Compartment Confidence
extracellular 4
plasma membrane 2
mitochondrion 1
lysosome 1

Gene Ontology (GO) - Cellular Components for CBLN2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space IEA --
genes like me logo Genes that share ontologies with CBLN2: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for CBLN2 Gene

Pathways & Interactions for CBLN2 Gene

SuperPathways for CBLN2 Gene

No Data Available

Interacting Proteins for CBLN2 Gene

STRING Interaction Network Preview (showing 2 interactants - click image to see details)
Selected Interacting proteins: Q8IUK8-CBLN2_HUMAN ENSP00000269503 for CBLN2 Gene via IID STRING

Gene Ontology (GO) - Biological Process for CBLN2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0051965 positive regulation of synapse assembly IEA --
genes like me logo Genes that share ontologies with CBLN2: view

No data available for Pathways by source and SIGNOR curated interactions for CBLN2 Gene

Drugs & Compounds for CBLN2 Gene

No Compound Related Data Available

Transcripts for CBLN2 Gene

Unigene Clusters for CBLN2 Gene

Cerebellin 2 precursor:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for CBLN2 Gene

No ASD Table

Relevant External Links for CBLN2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for CBLN2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CBLN2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CBLN2 Gene

This gene is overexpressed in Brain - Frontal Cortex (BA9) (x14.3), Brain - Cortex (x13.0), and Brain - Anterior cingulate cortex (BA24) (x11.4).

Protein differential expression in normal tissues from HIPED for CBLN2 Gene

This gene is overexpressed in Pancreatic juice (64.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for CBLN2 Gene

Protein tissue co-expression partners for CBLN2 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of CBLN2 Gene:


SOURCE GeneReport for Unigene cluster for CBLN2 Gene:


Evidence on tissue expression from TISSUES for CBLN2 Gene

  • Nervous system(4.6)
genes like me logo Genes that share expression patterns with CBLN2: view

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for CBLN2 Gene

Orthologs for CBLN2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CBLN2 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia CBLN2 33 34
  • 100 (n)
(Monodelphis domestica)
Mammalia CBLN2 34
  • 99 (a)
(Ornithorhynchus anatinus)
Mammalia CBLN2 34
  • 99 (a)
(Bos Taurus)
Mammalia CBLN2 33 34
  • 91.07 (n)
(Mus musculus)
Mammalia Cbln2 33 16 34
  • 89.58 (n)
(Canis familiaris)
Mammalia CBLN2 33 34
  • 89.14 (n)
(Rattus norvegicus)
Mammalia Cbln2 33
  • 88.99 (n)
(Gallus gallus)
Aves CBLN2 33 34
  • 88.89 (n)
(Anolis carolinensis)
Reptilia CBLN2 34
  • 91 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia cbln2 33
  • 80.49 (n)
African clawed frog
(Xenopus laevis)
Amphibia cbln2-prov 33
(Danio rerio)
Actinopterygii cbln2b 34
  • 81 (a)
cbln2a 34
  • 77 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 36 (a)
Species where no ortholog for CBLN2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CBLN2 Gene

Gene Tree for CBLN2 (if available)
Gene Tree for CBLN2 (if available)

Paralogs for CBLN2 Gene

Paralogs for CBLN2 Gene

(5) SIMAP similar genes for CBLN2 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with CBLN2: view

Variants for CBLN2 Gene

Sequence variations from dbSNP and Humsavar for CBLN2 Gene

SNP ID Clin Chr 18 pos Variation AA Info Type
rs1000077594 -- 72,606,465(-) G/A genic_upstream_transcript_variant, intron_variant
rs1000099159 -- 72,567,404(-) C/A genic_upstream_transcript_variant, intron_variant
rs1000102619 -- 72,587,525(-) A/G genic_upstream_transcript_variant, intron_variant
rs1000136102 -- 72,609,921(-) T/G genic_upstream_transcript_variant, intron_variant
rs1000148677 -- 72,549,626(-) C/A/T genic_upstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for CBLN2 Gene

Variant ID Type Subtype PubMed ID
esv3643061 CNV loss 21293372
esv3893139 CNV gain 25118596
nsv833693 CNV gain 17160897

Variation tolerance for CBLN2 Gene

Residual Variation Intolerance Score: 36.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.52; 29.48% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CBLN2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CBLN2 Gene

Disorders for CBLN2 Gene

Additional Disease Information for CBLN2

No disorders were found for CBLN2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CBLN2 Gene

Publications for CBLN2 Gene

  1. Genome-wide association analysis of susceptibility and clinical phenotype in multiple sclerosis. (PMID: 19010793) Baranzini SE … Oksenberg JR (Human molecular genetics 2009) 3 44 58
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  4. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark HF … Gray A (Genome research 2003) 3 4 58
  5. Genomic structure and mapping of precerebellin and a precerebellin-related gene. (PMID: 7877445) Kavety B … Morgan JI (Brain research. Molecular brain research 1994) 2 3 58

Products for CBLN2 Gene

Sources for CBLN2 Gene

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