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This gene is a member of the cobalamin transport protein family. It encodes a glycoprotein secreted by parietal cells of the gastric mucosa and is required for adequate absorption of vitamin B12. Vitamin B12 is necessary for erythrocyte maturation and mutations in this gene may lead to congenital pernicious anemia. [provided by RefSeq, Jul 2008] See more...
Aliases for CBLIF Gene
Aliases for CBLIF Gene
External Ids for CBLIF Gene
- HGNC: 4268
- Entrez Gene: 2694
- Ensembl: ENSG00000134812
- OMIM: 609342
- UniProtKB: P27352
Previous HGNC Symbols for CBLIF Gene
- GIF
Summaries for CBLIF Gene
-
This gene is a member of the cobalamin transport protein family. It encodes a glycoprotein secreted by parietal cells of the gastric mucosa and is required for adequate absorption of vitamin B12. Vitamin B12 is necessary for erythrocyte maturation and mutations in this gene may lead to congenital pernicious anemia. [provided by RefSeq, Jul 2008]
GeneCards Summary for CBLIF Gene
CBLIF (Cobalamin Binding Intrinsic Factor) is a Protein Coding gene. Diseases associated with CBLIF include Intrinsic Factor Deficiency and Congenital Intrinsic Factor Deficiency. Among its related pathways are Vitamin digestion and absorption and Selenium Micronutrient Network. An important paralog of this gene is TCN1.
UniProtKB/Swiss-Prot Summary for CBLIF Gene
-
Promotes absorption of the essential vitamin cobalamin (Cbl) in the ileum. After interaction with CUBN, the CBLIF-cobalamin complex is internalized via receptor-mediated endocytosis.
Additional gene information for CBLIF Gene
- Monarch Initiative
- Search for CBLIF at DataMed
- Search for CBLIF at HumanCyc
No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for CBLIF Gene
Genomics for CBLIF Gene
GeneHancer (GH) Regulatory Elements for CBLIF Gene
Promoters and enhancers for CBLIF Gene
| GeneHancer (GH) Identifier | GH Type | GH Score |
GH Sources | Gene Association Score | Total Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites |
Gene Targets |
|---|---|---|---|---|---|---|---|---|---|---|
| GH11J059849 | Enhancer | 0.4 | Ensembl | 750.6 | -1.7 | -1664 | 1.6 | PKNOX1 FOXK2 ZFHX2 | CBLIF STX3 lnc-TCN1-1 | |
| GH11J059845 | Promoter | 0.3 | EPDnew | 750.6 | +0.0 | 18 | 0.1 | CBLIF HSALNG0084431 | ||
| GH11J059846 | Enhancer | 0.2 | ENCODE | 750.6 | -0.1 | -146 | 0.2 | CBLIF lnc-TCN1-1 | ||
| GH11J059919 | Enhancer | 0.8 | Ensembl ENCODE | 11.4 | -73.5 | -73464 | 0.8 | CTCF CC2D1A RAD21 ZNF384 ARID2 REST CEBPB JUND DEK RFX5 | lnc-OOSP2-3 TCN1 CBLIF OOSP2 MS4A2 SRD5A3P1 | |
| GH11J059891 | Enhancer | 0.9 | Ensembl ENCODE | 10.7 | -46.5 | -46539 | 1 | SMARCE1 ZNF148 BACH1 SMARCA4 IKZF1 ATF1 PKNOX1 HDAC1 ZNF316 MTA2 | TCN1 CBLIF MS4A2 NONHSAG008417.2 piR-38351-077 OOSP3 |
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around CBLIF on UCSC Golden Path with GeneCards custom track
Genomic Locations for CBLIF Gene
Genomic Locations for CBLIF Gene
- chr11:59,829,268-59,845,537
- (GRCh38/hg38)
- Size:
- 16,270 bases
- Orientation:
- Minus strand
- chr11:59,596,741-59,612,974
- (GRCh37/hg19)
- Size:
- 16,234 bases
- Orientation:
- Minus strand
Genomic View for CBLIF Gene
Genes around CBLIF on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 11q12.1 by HGNC
- 11q12.1 by Entrez Gene
- 11q12.1 by Ensembl
CBLIF Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for CBLIF Gene
Proteins for CBLIF Gene
-
Protein details for CBLIF Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P27352-IF_HUMAN
- Recommended name:
- Cobalamin binding intrinsic factor
- Protein Accession:
- P27352
- B2RAN8
- B4DVZ1
Protein attributes for CBLIF Gene
- Size:
- 417 amino acids
- Molecular mass:
- 45416 Da
- Quaternary structure:
-
- Interacts with CUBN (via CUB domains).
Post-translational modifications for CBLIF Gene
Other Protein References for CBLIF Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- Atlas Antibodies Anti-GIF Antibody (HPA039908) and Anti-GIF Antibody (HPA040774)
-
Creative Biolabs
- Recombinant Anti-Human GIF Antibody
- Recombinant Anti-Human GIF Antibody Fab Fragment
- Mouse Anti-GIF Recombinant Antibody (CBLG1-1160)
- Mouse Anti-GIF Recombinant Antibody (CBLG1-1162)
- Mouse Anti-GIF Recombinant Antibody (139-1A11)
- Rabbit Anti-GIF Recombinant Antibody (CBLG1-1157)
- Rabbit Anti-GIF Recombinant Antibody (CBLG1-1159)
- Rabbit Anti-GIF Recombinant Antibody (CBLG1-1158)
- Mouse Anti-GIF Recombinant Antibody (139-1B8)
- Mouse Anti-GIF Recombinant Antibody (1D9)
- Rabbit Anti-GIF Recombinant Antibody (12)
- Hi-Affi™ Recombinant Rabbit Anti-GIF Monoclonal Antibody (DS1440AB)
-
Custom Antibody ServicesOriGene Antibodies for CBLIF
- Novus Biologicals Antibodies for CBLIF
-
Abcam antibodies for CBLIF
- Invitrogen Antibodies for CBLIF (AFLGC-GIF)
- Sino Biological Antibodies for CBLIF
Protein Products
- Atlas Antibodies PrEST Antigen GIF (APrEST80588) and PrEST Antigen GIF (APrEST80589)
-
Creative Biomart
- Recombinant Human GIF, His-tagged (GIF-27374TH)
- Recombinant Human Gastric Intrinsic Factor (vitamin B synthesis)
- Recombinant Human GIF, His-tagged (GIF-27373TH)
- Recombinant Human GIF, His tagged
- Recombinant Human GIF, His-tagged (GIF-1288H)
- Recombinant Human GIF cell lysate
- Recombinant Human GIF Protein, His-tagged
- Recombinant Human GIF protein, His & T7-tagged
- Recombinant Human GIF Protein
-
OriGene Purified Proteins for CBLIF
- Search Origene for MassSpec and Protein Over-expression Lysates for CBLIF
- Origene Custom Protein Services for CBLIF
- Sino Biological Recombinant Proteins for CBLIF
- Sino Biological Cell Lysates for CBLIF
- ProSpec Recombinant Proteins for CBLIF
-
Abcam proteins for CBLIF
Assay Products
- G Biosciences Immunotag™ Human GIF (Gastric Intrinsic Factor) ELISA
- RayBiotech Custom Human Gastric Intrinsic Factor ELISA
- Creative Diagnostics Intrinsic Factor IgG ELISA Kit and Intrinsic Factor Ab ELISA Kit
- Novus Biologicals ELISA Kits for CBLIF
-
Boster Bio ELISA Kits for CBLIF
- Sino Biological Assays for CBLIF
No data available for DME Specific Peptides for CBLIF Gene
Domains & Families for CBLIF Gene
Gene Families for CBLIF Gene
- Human Protein Atlas (HPA):
-
- Disease related genes
- Predicted secreted proteins
Protein Domains for CBLIF Gene
- Blocks:
- InterPro:
- ProtoNet:
Suggested Antigen Peptide Sequences for CBLIF Gene
- GenScript: Design optimal peptide antigens:
-
- Intrinsic factor (IF_HUMAN)
Graphical View of Domain Structure for InterPro Entry
P27352- Family:
-
- Belongs to the eukaryotic cobalamin transport proteins family.
Function for CBLIF Gene
Molecular function for CBLIF Gene
- UniProtKB/Swiss-Prot Function:
- Promotes absorption of the essential vitamin cobalamin (Cbl) in the ileum. After interaction with CUBN, the CBLIF-cobalamin complex is internalized via receptor-mediated endocytosis.
Phenotypes From GWAS Catalog for CBLIF Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0031419 | cobalamin binding | IDA | 14695536 |
Phenotypes for CBLIF Gene
- MGI mutant phenotypes for CBLIF:
- inferred from 1 alleles
- GenomeRNAi human phenotypes for CBLIF:
-
- Increased shRNA abundance (Z-score > 2)
- Synthetic lethal with c-Myc after tamoxifen stimulation
- Decreased viability in esophageal squamous lineage
- Decreased shRNA abundance (Z-score < -2)
- Decreased viability
- no effect
- Increased vaccinia virus (VACV) infection
- Resistant to vaccinia virus (VACV-A4L) infection
- shRNA abundance <= 50%
Animal Models for CBLIF Gene
- MGI Knock Outs for CBLIF:
-
- Cblif Cblif<tm1a(KOMP)Wtsi>
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
CRISPR Products
-
OriGene CRISPR knockouts for CBLIF
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for CBLIF
- genomics-online: gRNA clones - Search for available Intrinsic Factor gRNA products
- Overview of 111 available Intrinsic Factor gene related products
- Applied Biological Materials (abm): CRISPR Clones for CBLIF - Select products 50% OFF >
- * CBLIF CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * CBLIF CRISPR applications: KO, Activation, Repression, and more - Browse All
miRNA Products
Inhibitory RNA Products
- Origene sirna, shrna, and RNAi products in human, mouse, rat for CBLIF
- Browse OriGene Inhibitory RNA Products For CBLIF
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CBLIF
- genomics-online: shRNA clones - Search for available Intrinsic Factor shRNA products
- Overview of 111 available Intrinsic Factor gene related products
Clone Products
- Sino Biological Human cDNA Clone for CBLIF
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for CBLIF
- Applied Biological Materials (abm): Clones for CBLIF - Select products 50% OFF >
- * CBLIF as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * CBLIF tags and reporters available: His, HA, Myc, Flag, GFP, RFP, Luciferase - Browse All
Cell Line Products
-
Horizon Cell Lines for CBLIF
No data available for Enzyme Numbers (IUBMB) , miRNA , Transcription Factor Targets and HOMER Transcription for CBLIF Gene
Localization for CBLIF Gene
Subcellular locations from UniProtKB/Swiss-Prot for CBLIF Gene
- Secreted.
| Compartment | Confidence |
|---|---|
| plasma membrane | 5 |
| extracellular | 5 |
| endosome | 5 |
| lysosome | 4 |
| cytosol | 2 |
| mitochondrion | 1 |
| nucleus | 1 |
| endoplasmic reticulum | 1 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005576 | extracellular region | TAS | -- |
| GO:0005615 | extracellular space | IDA | 14695536 |
| GO:0005768 | endosome | TAS | -- |
| GO:0005902 | microvillus | IDA | 8886952 |
| GO:0016324 | apical plasma membrane | IDA | 8886952 |
No data available for Subcellular locations from the Human Protein Atlas (HPA) for CBLIF Gene
Pathways & Interactions for CBLIF Gene
Pathways by source for CBLIF Gene
2 BioSystems pathways for CBLIF Gene
1 KEGG pathway for CBLIF Gene
Interacting Proteins for CBLIF Gene
GPS-Prot Interaction Network for CBLIF
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006811 | ion transport | IEA | -- |
| GO:0006824 | cobalt ion transport | IEA | -- |
| GO:0009235 | cobalamin metabolic process | TAS | -- |
| GO:0015889 | cobalamin transport | IMP | 15738392 |
No data available for SIGNOR curated interactions for CBLIF Gene
Drugs & Compounds for CBLIF Gene
Drug Products
- Atlas Antibodies PrEST Antigen GIF (APrEST80588) and PrEST Antigen GIF (APrEST80589)
-
Creative Biomart
- Recombinant Human GIF, His-tagged (GIF-27374TH)
- Recombinant Human Gastric Intrinsic Factor (vitamin B synthesis)
- Recombinant Human GIF, His-tagged (GIF-27373TH)
- Recombinant Human GIF, His tagged
- Recombinant Human GIF, His-tagged (GIF-1288H)
- Recombinant Human GIF cell lysate
- Recombinant Human GIF Protein, His-tagged
- Recombinant Human GIF protein, His & T7-tagged
- Recombinant Human GIF Protein
Transcripts for CBLIF Gene
mRNA/cDNA for CBLIF Gene
- (1) REFSEQ mRNAs :
- (5) Additional mRNA sequences :
- (33) Selected AceView cDNA sequences:
- (5) Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000257248 1511 bps (ENST00000257248.2)
- ENST00000525058 1623 bps (ENST00000525058.5)
- ENST00000533067 386 bps (ENST00000533067.1)
- ENST00000533847 745 bps (ENST00000533847.1)
- ENST00000532070 977 bps (ENST00000532070.1)
CRISPR Products
-
OriGene CRISPR knockouts for CBLIF
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for CBLIF
- genomics-online: gRNA clones - Search for available Intrinsic Factor gRNA products
- Overview of 111 available Intrinsic Factor gene related products
- Applied Biological Materials (abm): CRISPR Clones for CBLIF - Select products 50% OFF >
- * CBLIF CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * CBLIF CRISPR applications: KO, Activation, Repression, and more - Browse All
miRNA Products
Inhibitory RNA Products
- Origene sirna, shrna, and RNAi products in human, mouse, rat for CBLIF
- Browse OriGene Inhibitory RNA Products For CBLIF
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CBLIF
- genomics-online: shRNA clones - Search for available Intrinsic Factor shRNA products
- Overview of 111 available Intrinsic Factor gene related products
Clone Products
- Sino Biological Human cDNA Clone for CBLIF
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for CBLIF
- Applied Biological Materials (abm): Clones for CBLIF - Select products 50% OFF >
- * CBLIF as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * CBLIF tags and reporters available: His, HA, Myc, Flag, GFP, RFP, Luciferase - Browse All
Expression for CBLIF Gene
NURSA nuclear receptor signaling pathways regulating expression of CBLIF Gene:
CBLIFSOURCE GeneReport for Unigene cluster for CBLIF Gene:
Hs.110014mRNA Expression by UniProt/SwissProt for CBLIF Gene:
P27352-IF_HUMAN
Tissue specificity:
Gastric mucosa.
Evidence on tissue expression from TISSUES for CBLIF Gene
- Stomach(4.9)
- Intestine(4.5)
- Thyroid gland(2)
Phenotype-based relationships between genes and organs from Gene ORGANizer for CBLIF Gene
Germ Layers:
- ectoderm
- endoderm
- mesoderm
Systems:
- cardiovascular
- digestive
- immune
- integumentary
- nervous
- skeleton
Regions:
Head and neck:
- brain
- cerebellum
- head
Abdomen:
- intestine
- large intestine
- small intestine
- stomach
Limb:
- femur
- lower limb
- thigh
General:
- blood
- peripheral nerve
- peripheral nervous system
- red blood cell
- skin
- spinal column
- vertebrae
- white blood cell
Primer Products
-
OriGene qPCR primer pairs for CBLIF
-
OriGene qPCR primer pairs and template standards for CBLIF
- genomics-online: primer clones - Search for available Intrinsic Factor Primer products
- Overview of 111 available Intrinsic Factor gene related products
No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression and Protein tissue co-expression partners for CBLIF Gene
Orthologs for CBLIF Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | GIF 33 32 |
|
OneToOne | |
| mouse (Mus musculus) |
Mammalia | Gif 33 32 |
|
OneToOne | |
| Cblif 17 |
|
||||
| cow (Bos Taurus) |
Mammalia | GIF 33 32 |
|
OneToOne | |
| rat (Rattus norvegicus) |
Mammalia | Gif 32 |
|
||
| dog (Canis familiaris) |
Mammalia | GIF 33 32 |
|
OneToOne | |
| platypus (Ornithorhynchus anatinus) |
Mammalia | GIF 33 |
|
OneToOne | |
| oppossum (Monodelphis domestica) |
Mammalia | GIF 33 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | GIF 33 32 |
|
OneToOne | |
| lizard (Anolis carolinensis) |
Reptilia | GIF 33 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | gif 32 |
|
||
| sea squirt (Ciona savignyi) |
Ascidiacea | -- 33 |
|
OneToMany |
- Species where no ortholog for CBLIF was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
- zebrafish (Danio rerio)
Evolution for CBLIF Gene
- ENSEMBL:
- Gene Tree for CBLIF (if available)
- TreeFam:
- Gene Tree for CBLIF (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for CBLIF: view image
Paralogs for CBLIF Gene
Variants for CBLIF Gene
| SNP ID | Clin | Chr 11 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs115964827 | uncertain-significance, Intrinsic factor deficiency | 59,843,888(-) | C/T | coding_sequence_variant, missense_variant | |
| rs11825834 | likely-benign, not provided, - | 59,843,942(-) | C/T | coding_sequence_variant, missense_variant | |
| rs121434322 | uncertain-significance, Intrinsic factor deficiency, Hereditary intrinsic factor deficiency (IFD) [MIM:261000] | 59,843,998(-) | G/A/T | coding_sequence_variant, missense_variant, stop_gained | |
| rs139444835 | uncertain-significance, Intrinsic factor deficiency | 59,843,917(-) | T/C | coding_sequence_variant, missense_variant | |
| rs144916324 | uncertain-significance, Intrinsic factor deficiency, not provided | 59,843,981(-) | A/T | coding_sequence_variant, missense_variant |
Residual Variation Intolerance Score:
82.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
2.35;
41.73% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for CBLIF Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- CBLIF
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for CBLIF Gene
Disorders for CBLIF Gene
(21) MalaCards diseases for CBLIF Gene - From: OMIM, ClinVar, GTR, Orphanet, DISEASES, Novoseek, and GeneCards
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| intrinsic factor deficiency |
|
|
| congenital intrinsic factor deficiency |
|
|
| pernicious anemia |
|
|
| megaloblastic anemia |
|
|
| megaloblastic anemia 1 |
|
|
Search CBLIF in MalaCards
View complete list of genes associated with diseases
UniProtKB/Swiss-Prot
IF_HUMAN- Hereditary intrinsic factor deficiency (IFD) [MIM:261000]: Autosomal recessive disorder characterized by megaloblastic anemia. {ECO:0000269 PubMed:15738392}. Note=The disease is caused by mutations affecting the gene represented in this entry.
Additional Disease Information for CBLIF
No data available for Genatlas for CBLIF Gene
Publications for CBLIF Gene
- Structural basis for receptor recognition of vitamin-B(12)-intrinsic factor complexes. (PMID: 20237569) Andersen CB … Andersen GR (Nature 2010) 3 4 23 56
- Crystal structure of human intrinsic factor: cobalamin complex at 2.6-A resolution. (PMID: 17954916) Mathews FS … Sukumar N (Proceedings of the National Academy of Sciences of the United States of America 2007) 3 4 23 56
- Hereditary juvenile cobalamin deficiency caused by mutations in the intrinsic factor gene. (PMID: 15738392) Tanner SM … de la Chapelle A (Proceedings of the National Academy of Sciences of the United States of America 2005) 3 4 23 56
- A genetic polymorphism in the coding region of the gastric intrinsic factor gene (GIF) is associated with congenital intrinsic factor deficiency. (PMID: 14695536) Gordon MM … Alpers DH (Human mutation 2004) 3 4 23 56
- Human gastric intrinsic factor: characterization of cDNA and genomic clones and localization to human chromosome 11. (PMID: 2071148) Hewitt JE … Alpers DH (Genomics 1991) 2 3 4 56
Products for CBLIF Gene
- Custom Antibody ServicesOriGene Antibodies for CBLIF
- Browse OriGene ELISA Kits
- Custom Assay Services
- OriGene Purified Proteins for CBLIF
- Search Origene for MassSpec and Protein Over-expression Lysates for CBLIF
- Origene Custom Protein Services for CBLIF
- Origene sirna, shrna, and RNAi products in human, mouse, rat for CBLIF
- Browse OriGene Inhibitory RNA Products For CBLIF
- OriGene qPCR primer pairs for CBLIF
- OriGene qPCR primer pairs and template standards for CBLIF
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- Sino Biological Human cDNA Clone for CBLIF
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- Browse Recombinant Proteins
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- High-throughput Antibody Production Service
- Protein Production Service
- Epitope Tag Antibodies & Reporter Protein Antibodies
- Lentiviral ORF Clones
- Novus Biologicals Antibodies for CBLIF
- Novus Biologicals proteins and lysates for CBLIF
- Novus Biologicals ELISA Kits for CBLIF
- Browse Antibodies
- Browse Peptides and Proteins
- Browse Lysates
- Browse ELISA Kits
- Abcam antibodies for CBLIF
- Abcam proteins for CBLIF
- Find your target
- Browse Primary Antibodies
- Browse Conjugated Primary Antibodies
- Browse Secondary Antibodies
- Browse ELISA Kits
- Browse Matched Antibody Pairs
- Browse Proteins and Peptides
- Search Knockout (KO) Validated Antibodies
- Browse Monoclonal Antibodies
- Browse Recombinant Antibodies
- antibodies-online: Show 17 available Intrinsic Factor Antibodies ranked by validation data
- Compare Top Intrinsic Factor Antibodies
- antibodies-online: Show 39 available Intrinsic Factor Elisa Kits ranked by validation data
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- Quality Products:
- antibodies-online: Show 18 available Intrinsic Factor Proteins ranked by validation data
- Compare Top Intrinsic Factor Proteins
- Horizon Cell Lines for CBLIF
- genomics-online: cdna clones - Search for available Intrinsic Factor CDNA products
- Overview of 111 available Intrinsic Factor gene related products
- orf clones - Search for available Intrinsic Factor ORF products
- Overview of 111 available Intrinsic Factor gene related products
- genomics-online: gRNA clones - Search for available Intrinsic Factor gRNA products
- Overview of 111 available Intrinsic Factor gene related products
- genomics-online: primer clones - Search for available Intrinsic Factor Primer products
- Overview of 111 available Intrinsic Factor gene related products
- genomics-online: shRNA clones - Search for available Intrinsic Factor shRNA products
- Overview of 111 available Intrinsic Factor gene related products
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for CBLIF
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for CBLIF
- Search GeneCopoeia for miRNA 3'UTR Target clone products for CBLIF
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CBLIF
- Browse Boster Bio Antibodies
- Boster Bio ELISA Kits for CBLIF
Sources for CBLIF Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) UniProtKB/TrEMBL
- (14) InterPro
- (15) ProtoNet
- (16) Blocks
- (17) MGI
- (18) IUBMB
- (19) KEGG
- (20) MINT
- (21) STRING
- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) AceView
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