Aliases for CBLIF Gene
External Ids for CBLIF Gene
Previous HGNC Symbols for CBLIF Gene
This gene is a member of the cobalamin transport protein family. It encodes a glycoprotein secreted by parietal cells of the gastric mucosa and is required for adequate absorption of vitamin B12. Vitamin B12 is necessary for erythrocyte maturation and mutations in this gene may lead to congenital pernicious anemia. [provided by RefSeq, Jul 2008]
GeneCards Summary for CBLIF Gene
CBLIF (Cobalamin Binding Intrinsic Factor) is a Protein Coding gene. Diseases associated with CBLIF include Intrinsic Factor Deficiency and Congenital Intrinsic Factor Deficiency. Among its related pathways are Vitamin digestion and absorption and Selenium Micronutrient Network. An important paralog of this gene is TCN1.
UniProtKB/Swiss-Prot Summary for CBLIF Gene
Promotes absorption of the essential vitamin cobalamin (Cbl) in the ileum. After interaction with CUBN, the CBLIF-cobalamin complex is internalized via receptor-mediated endocytosis.