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This gene encodes a member of the Cbl family of E3 ubiquitin ligases. Cbl proteins play important roles in cell signaling through the ubiquitination and subsequent downregulation of tyrosine kinases. Expression of this gene may be restricted to epithelial cells, and alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Feb 2012]
CBLC (Cbl Proto-Oncogene C) is a Protein Coding gene. Among its related pathways are EGF/EGFR Signaling Pathway and ErbB signaling pathway. Gene Ontology (GO) annotations related to this gene include calcium ion binding and ubiquitin-protein transferase activity. An important paralog of this gene is CBL.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0001784 | phosphotyrosine residue binding | IEA,IDA | 14661060 |
GO:0004842 | ubiquitin-protein transferase activity | IEA | -- |
GO:0005154 | epidermal growth factor receptor binding | IDA | 10362357 |
GO:0005509 | calcium ion binding | IEA | -- |
GO:0008270 | zinc ion binding | TAS | 10362357 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005886 | plasma membrane | IBA | 21873635 |
GO:0045121 | membrane raft | IBA | 21873635 |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Angiopoietin Like Protein 8 Regulatory Pathway | ||
2 | Endocytosis | ||
3 | Ubiquitin mediated proteolysis | ||
4 | EGF/EGFR Signaling Pathway | ||
5 | ErbB signaling pathway |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0006511 | ubiquitin-dependent protein catabolic process | IDA | 14661060 |
GO:0007165 | signal transduction | IBA | 21873635 |
GO:0007166 | cell surface receptor signaling pathway | IEA | -- |
GO:0007175 | negative regulation of epidermal growth factor-activated receptor activity | IDA | 10362357 |
GO:0016567 | protein ubiquitination | IEA,IDA | 14661060 |
Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
---|---|---|---|---|---|---|
Phosphoric acid | Approved | Pharma | 0 | |||
Adenosine monophosphate | Approved, Investigational | Nutra | 0 | |||
ATP | Investigational | Nutra | Agonist, Activator, Partial agonist, Antagonist, Full agonist, Gating inhibitor, Pore Blocker, Potentiation | 0 | ||
Calcium | Nutra | 6556 |
Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
---|---|---|---|---|---|---|
pyrophosphate |
|
14000-31-8 |
|
ExUns: | 1 | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11 |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
SP1: | |||||||||||||||||||||
SP2: | - |
This gene was present in the common ancestor of animals.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | CBLC 30 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | CBLC 30 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | CBLC 30 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | Cblc 30 |
|
||
Mouse (Mus musculus) |
Mammalia | Cblc 30 17 31 |
|
OneToOne | |
Oppossum (Monodelphis domestica) |
Mammalia | CBLC 31 |
|
OneToOne | |
Platypus (Ornithorhynchus anatinus) |
Mammalia | CBLC 31 |
|
OneToOne | |
Lizard (Anolis carolinensis) |
Reptilia | CBLC 31 |
|
OneToOne | |
Zebrafish (Danio rerio) |
Actinopterygii | CBLC 31 |
|
OneToOne | |
Fruit Fly (Drosophila melanogaster) |
Insecta | Cbl 31 |
|
OneToMany | |
Worm (Caenorhabditis elegans) |
Secernentea | sli-1 31 |
|
OneToMany | |
Sea Squirt (Ciona savignyi) |
Ascidiacea | -- 31 |
|
OneToMany |
No disorders were found for CBLC Gene.