Aliases for CBLC Gene
- Cbl Proto-Oncogene C 2 3 5
- RNF57 2 3 4
- Cas-Br-M (Murine) Ecotropic Retroviral Transforming Sequence C 2 3
- Cas-Br-M (Murine) Ectropic Retroviral Transforming Sequence C 2 3
- Cbl Proto-Oncogene C, E3 Ubiquitin Protein Ligase 2 3
- RING-Type E3 Ubiquitin Transferase CBL-C 3 4
- E3 Ubiquitin-Protein Ligase CBL-C 3 4
- Signal Transduction Protein CBL-C 3 4
External Ids for CBLC Gene
Previous GeneCards Identifiers for CBLC Gene
This gene encodes a member of the Cbl family of E3 ubiquitin ligases. Cbl proteins play important roles in cell signaling through the ubiquitination and subsequent downregulation of tyrosine kinases. Expression of this gene may be restricted to epithelial cells, and alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Feb 2012]
GeneCards Summary for CBLC Gene
CBLC (Cbl Proto-Oncogene C) is a Protein Coding gene. Among its related pathways are Angiopoietin Like Protein 8 Regulatory Pathway and ErbB signaling pathway. Gene Ontology (GO) annotations related to this gene include calcium ion binding and ubiquitin-protein transferase activity. An important paralog of this gene is CBLB.
UniProtKB/Swiss-Prot Summary for CBLC Gene
Acts as an E3 ubiquitin-protein ligase, which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, and then transfers it to substrates promoting their degradation by the proteasome. Functionally coupled with the E2 ubiquitin-protein ligases UB2D1, UB2D2 and UB2D3. Regulator of EGFR mediated signal transduction; upon EGF activation, ubiquitinates EGFR. Isoform 1, but not isoform 2, inhibits EGF stimulated MAPK1 activation. Promotes ubiquitination of SRC phosphorylated at 'Tyr-419'. In collaboration with CD2AP may act as regulatory checkpoint for Ret signaling by modulating the rate of RET degradation after ligand activation; CD2AP converts it from an inhibitor to a promoter of RET degradation; the function limits the potency of GDNF on neuronal survival.