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This gene encodes a member of the Cbl family of E3 ubiquitin ligases. Cbl proteins play important roles in cell signaling through the ubiquitination and subsequent downregulation of tyrosine kinases. Expression of this gene may be restricted to epithelial cells, and alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided ... See more...
Aliases for CBLC Gene
Aliases for CBLC Gene
- Cbl Proto-Oncogene C 2 3 5
- RNF57 2 3 4
- Cas-Br-M (Murine) Ecotropic Retroviral Transforming Sequence C 2 3
- Cas-Br-M (Murine) Ectropic Retroviral Transforming Sequence C 2 3
- Cbl Proto-Oncogene C, E3 Ubiquitin Protein Ligase 2 3
- RING-Type E3 Ubiquitin Transferase CBL-C 3 4
- E3 Ubiquitin-Protein Ligase CBL-C 3 4
- Signal Transduction Protein CBL-C 3 4
External Ids for CBLC Gene
- HGNC: 15961
- NCBI Entrez Gene: 23624
- Ensembl: ENSG00000142273
- OMIM®: 608453
- UniProtKB/Swiss-Prot: Q9ULV8
Previous GeneCards Identifiers for CBLC Gene
- GC19P045925
- GC19P045672
- GC19P049957
- GC19P049972
- GC19P045281
- GC19P041713
Summaries for CBLC Gene
-
This gene encodes a member of the Cbl family of E3 ubiquitin ligases. Cbl proteins play important roles in cell signaling through the ubiquitination and subsequent downregulation of tyrosine kinases. Expression of this gene may be restricted to epithelial cells, and alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Feb 2012]
GeneCards Summary for CBLC Gene
CBLC (Cbl Proto-Oncogene C) is a Protein Coding gene. Among its related pathways are Angiopoietin Like Protein 8 Regulatory Pathway and ErbB signaling pathway. Gene Ontology (GO) annotations related to this gene include calcium ion binding and ubiquitin-protein transferase activity. An important paralog of this gene is CBLB.
UniProtKB/Swiss-Prot Summary for CBLC Gene
-
Acts as an E3 ubiquitin-protein ligase, which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, and then transfers it to substrates promoting their degradation by the proteasome. Functionally coupled with the E2 ubiquitin-protein ligases UB2D1, UB2D2 and UB2D3. Regulator of EGFR mediated signal transduction; upon EGF activation, ubiquitinates EGFR. Isoform 1, but not isoform 2, inhibits EGF stimulated MAPK1 activation. Promotes ubiquitination of SRC phosphorylated at 'Tyr-419'. In collaboration with CD2AP may act as regulatory checkpoint for Ret signaling by modulating the rate of RET degradation after ligand activation; CD2AP converts it from an inhibitor to a promoter of RET degradation; the function limits the potency of GDNF on neuronal survival.
Additional gene information for CBLC Gene
No data available for Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for CBLC Gene
Genomics for CBLC Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for CBLC Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around CBLC on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for CBLC
- Top Transcription factor binding sites by QIAGEN in the CBLC gene promoter:
-
- AP-2gamma
- AP-4
- GCNF
- GCNF-1
- GCNF-2
- HEN1
- HTF
- NRF-2
- p300
- XBP-1
Genomic Locations for CBLC Gene
Latest Assembly
- chr19:44,777,855-44,800,652
- (GRCh38/hg38)
- Size:
- 22,798 bases
- Orientation:
- Plus strand
Previous Assembly
- chr19:45,281,126-45,303,909
- (GRCh37/hg19 by Entrez Gene)
- Size:
- 22,784 bases
- Orientation:
- Plus strand
Genomic View for CBLC Gene
Genes around CBLC on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 19q13.32 by HGNC
- 19q13.32 by Entrez Gene
- 19q13.32 by Ensembl
CBLC Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for CBLC Gene
Proteins for CBLC Gene
-
Protein details for CBLC Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q9ULV8-CBLC_HUMAN
- Recommended name:
- E3 ubiquitin-protein ligase CBL-C
- Protein Accession:
- Q9ULV8
- Q8N1E5
- Q9Y5Z2
- Q9Y5Z3
Protein attributes for CBLC Gene
- Size:
- 474 amino acids
- Molecular mass:
- 52456 Da
- Quaternary structure:
-
- Interacts with ubiquitin-conjugating enzyme E2 UBE2D2 and UBE2D3. Isoform 1 interacts with EGFR (tyrosine phosphorylated). Interacts with the SH3 domain proteins LYN and CRK. Interacts (via RING-type zinc finger) with TGFB1I1 (via LIM zinc-binding domain 2); the interaction is direct and enhances the E3 activity. Interacts directly with RET (inactive) and CD2AP; dissociates from RET upon RET activation by GDNF which also increases the interaction with CD2AP suggesting dissociation as CBLC:CD2AP complex. Interacts with SRC; the interaction is enhanced when SRC is phosphorylated at 'Tyr-419'.
- Miscellaneous:
-
- This protein has one functional calcium-binding site.
Three dimensional structures from OCA and Proteopedia for CBLC Gene
Post-translational modifications for CBLC Gene
- Phosphorylated on multiple tyrosine residues by SRC. Isoform 1, but not isoform 2, is phosphorylated on tyrosines by EGFR.
- Autoubiquitinated when phosphorylated at Tyr-341, enhanced by SRC; suggesting proteasomal degradation.
- Modification sites at PhosphoSitePlus
- Modification sites at neXtProt
Other Protein References for CBLC Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibodies for research
- LifeSpan BioSciences CBLC Antibody
-
Custom Antibody ServicesOriGene Antibodies for CBLC
- Novus Biologicals Antibodies for CBLC
-
Abcam antibodies for CBLC
- Invitrogen Antibodies for CBLC (AFLGC-Cblc)
-
Santa Cruz Biotechnology (SCBT) Antibodies for CBLC
- Sino Biological Antibodies for CBLC
Protein products for research
-
OriGene Purified Proteins for CBLC
- Search Origene for MassSpec and Protein Over-expression Lysates for CBLC
- Origene Custom Protein Services for CBLC
- Sino Biological Recombinant Proteins for CBLC
- Sino Biological Cell Lysates for CBLC
-
Abcam proteins for CBLC
Assay products for research
- antibodies-online: Show 4 available CBLC Elisa Kits ranked by validation data
- Compare Top CBLC Elisa Kits
-
Quality Products:
No data available for DME Specific Peptides for CBLC Gene
Domains & Families for CBLC Gene
Gene Families for CBLC Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Cancer-related genes
- Enzymes
- Predicted intracellular proteins
Protein Domains for CBLC Gene
- InterPro:
- Blocks:
-
- Zn-finger, RING
- Adaptor protein Cbl, N-terminal
Suggested Antigen Peptide Sequences for CBLC Gene
- GenScript: Design optimal peptide antigens:
-
- SH3-binding protein CBL-C (CBLC_HUMAN)
Graphical View of Domain Structure for InterPro Entry
Q9ULV8UniProtKB/Swiss-Prot:
CBLC_HUMAN :- EF-hand-like and Sh2-like domains are required for N-terminal inhibition of E3 activity.
- Domain:
-
- EF-hand-like and Sh2-like domains are required for N-terminal inhibition of E3 activity.
- The N-terminus is composed of the phosphotyrosine binding (PTB) domain, a short linker region and the RING-type zinc finger. The PTB domain, which is also called TKB (tyrosine kinase binding) domain, is composed of three different subdomains: a four-helix bundle (4H), a calcium-binding EF hand and a divergent SH2 domain.
- The RING-type zinc finger domain mediates binding to an E2 ubiquitin-conjugating enzyme.
Function for CBLC Gene
Molecular function for CBLC Gene
- UniProtKB/Swiss-Prot Function:
- Acts as an E3 ubiquitin-protein ligase, which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, and then transfers it to substrates promoting their degradation by the proteasome. Functionally coupled with the E2 ubiquitin-protein ligases UB2D1, UB2D2 and UB2D3. Regulator of EGFR mediated signal transduction; upon EGF activation, ubiquitinates EGFR. Isoform 1, but not isoform 2, inhibits EGF stimulated MAPK1 activation. Promotes ubiquitination of SRC phosphorylated at 'Tyr-419'. In collaboration with CD2AP may act as regulatory checkpoint for Ret signaling by modulating the rate of RET degradation after ligand activation; CD2AP converts it from an inhibitor to a promoter of RET degradation; the function limits the potency of GDNF on neuronal survival.
- UniProtKB/Swiss-Prot CatalyticActivity:
- Reaction=S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.; EC=2.3.2.27; Evidence={ECO:0000269|PubMed:14661060, ECO:0000269|PubMed:20525694, ECO:0000269|PubMed:23145173};.
- UniProtKB/Swiss-Prot EnzymeRegulation:
- Phosphorylation at Tyr-341 is necessary and sufficient for the activation of E3 activity.
Enzyme Numbers (IUBMB) for CBLC Gene
Phenotypes From GWAS Catalog for CBLC Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0001784 | phosphotyrosine residue binding | IEA,IDA | 14661060 |
| GO:0004842 | ubiquitin-protein transferase activity | IEA | -- |
| GO:0005154 | epidermal growth factor receptor binding | IDA | 10362357 |
| GO:0005509 | calcium ion binding | IEA | -- |
| GO:0005515 | protein binding | IPI | 32296183 |
Phenotypes for CBLC Gene
- MGI mutant phenotypes for CBLC:
- inferred from 1 alleles
- GenomeRNAi human phenotypes for CBLC:
Animal Models for CBLC Gene
- MGI Knock Outs for CBLC:
-
- Cblc Cblc<tm1Pngr>
Animal Models for research
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
CRISPR products for research
- Applied Biological Materials (abm): CRISPR Clones for CBLC - Starting at $85 >
- * CBLC CRISPR as ready-to-use vector or virus: Non-viral | Lenti- | Adeno- | AAV- | siRNA - Browse All
- * Cas9 Nucleases, Nickases, Null Mutants, and GFP tag also available.
-
OriGene CRISPR knockouts for CBLC
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for CBLC
-
Santa Cruz Biotechnology (SCBT) CRISPR for CBLC
miRNA for CBLC Gene
- miRTarBase miRNAs that target CBLC
miRNA products for research
Inhibitory RNAs for research
- Origene shrna, sirna, and RNAi products in human, mouse, rat for CBLC
- Browse OriGene Inhibitory RNA Products For CBLC
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CBLC
Clone products for research
- Applied Biological Materials (abm): Clones for CBLC - Starting at $45 >
- * CBLC as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Retro- | Protein Vector - Browse All
- * Viral Packaging Services and High Titer Production Services also available.
-
- MG207210
- MG220739
- MR207210
- MR207210L3
- MR207210L4
- MR220739
- MR220739L3
- MR220739L4
- RC205130
- RC205130L1
- RC205130L2
- RC205130L3
- RC205130L4
- RC225700
- RC225700L3
- RC225700L4
- RG205130
- RG225700
- RR201072
- RR201072L3
- RR201072L4
- MR207210L3V
- MR207210L4V
- MR220739L3V
- MR220739L4V
- RC205130L1V
- RC205130L2V
- RC205130L3V
- RC205130L4V
- RC225700L3V
- RC225700L4V
- RR201072L3V
- RR201072L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Addgene plasmids for CBLC
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for CBLC
Cell Lines for research
-
Horizon Cell Lines for CBLC
No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CBLC Gene
Localization for CBLC Gene
| Compartment | Confidence |
|---|---|
| plasma membrane | 3 |
| nucleus | 3 |
| cytosol | 2 |
| extracellular | 1 |
| endosome | 1 |
| lysosome | 1 |
- Aggresome (2)
- Nucleoplasm (2)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005886 | plasma membrane | IBA | 21873635 |
| GO:0045121 | membrane raft | IBA | 21873635 |
No data available for Subcellular locations from UniProtKB/Swiss-Prot for CBLC Gene
Pathways & Interactions for CBLC Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Angiopoietin Like Protein 8 Regulatory Pathway | ||
| 2 | Endocytosis | ||
| 3 | Ubiquitin mediated proteolysis | ||
| 4 | EGF/EGFR Signaling Pathway | ||
| 5 | ErbB signaling pathway | ||
Pathways by source for CBLC Gene
4 BioSystems pathways for CBLC Gene
2 KEGG pathways for CBLC Gene
SIGNOR curated interactions for CBLC Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006511 | ubiquitin-dependent protein catabolic process | IDA | 14661060 |
| GO:0007165 | signal transduction | IBA | 21873635 |
| GO:0007166 | cell surface receptor signaling pathway | IEA | -- |
| GO:0007175 | negative regulation of epidermal growth factor-activated receptor activity | IDA | 10362357 |
| GO:0016567 | protein ubiquitination | IEA,IDA | 14661060 |
Drugs & Compounds for CBLC Gene
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
|---|---|---|---|---|---|---|
| pyrophosphate |
|
14000-31-8 |
|
Transcripts for CBLC Gene
mRNA/cDNA for CBLC Gene
- 2 REFSEQ mRNAs :
- 5 NCBI additional mRNA sequence :
- 3 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000341505 1441 nts (view in UCSC)
- ENST00000647063 691 nts (view in UCSC)
- ENST00000647358 1576 nts (view in UCSC)
CRISPR products for research
- Applied Biological Materials (abm): CRISPR Clones for CBLC - Starting at $85 >
- * CBLC CRISPR as ready-to-use vector or virus: Non-viral | Lenti- | Adeno- | AAV- | siRNA - Browse All
- * Cas9 Nucleases, Nickases, Null Mutants, and GFP tag also available.
-
OriGene CRISPR knockouts for CBLC
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for CBLC
-
Santa Cruz Biotechnology (SCBT) CRISPR for CBLC
miRNA products for research
Inhibitory RNAs for research
- Origene shrna, sirna, and RNAi products in human, mouse, rat for CBLC
- Browse OriGene Inhibitory RNA Products For CBLC
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CBLC
Clone products for research
- Applied Biological Materials (abm): Clones for CBLC - Starting at $45 >
- * CBLC as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Retro- | Protein Vector - Browse All
- * Viral Packaging Services and High Titer Production Services also available.
-
- MG207210
- MG220739
- MR207210
- MR207210L3
- MR207210L4
- MR220739
- MR220739L3
- MR220739L4
- RC205130
- RC205130L1
- RC205130L2
- RC205130L3
- RC205130L4
- RC225700
- RC225700L3
- RC225700L4
- RG205130
- RG225700
- RR201072
- RR201072L3
- RR201072L4
- MR207210L3V
- MR207210L4V
- MR220739L3V
- MR220739L4V
- RC205130L1V
- RC205130L2V
- RC205130L3V
- RC205130L4V
- RC225700L3V
- RC225700L4V
- RR201072L3V
- RR201072L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Addgene plasmids for CBLC
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for CBLC
| ExUns: | 1 | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | |||||||||||||||||||||
| SP2: | - |
Relevant External Links for CBLC Gene
- GeneLoc Exon Structure for
- CBLC
Expression for CBLC Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
mRNA differential expression in normal tissues according to GTEx for CBLC Gene
This gene is overexpressed in Esophagus - Mucosa (x6.7), Skin - Not Sun Exposed (Suprapubic) (x6.5), Colon - Transverse (x6.3), and Skin - Sun Exposed (Lower leg) (x5.9).
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for CBLC
SOURCE GeneReport for Unigene cluster for CBLC Gene:
Hs.466907mRNA Expression by UniProt/SwissProt for CBLC Gene:
Q9ULV8-CBLC_HUMAN
Tissue specificity:
Ubiquitous.
Evidence on tissue expression from TISSUES for CBLC Gene
- Skin(4.3)
Primer products for research
-
OriGene qPCR primer pairs for CBLC
-
OriGene qPCR primer pairs and template standards for CBLC
Gene Expression Assays for research
No data available for Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for CBLC Gene
Orthologs for CBLC Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | CBLC 29 30 |
|
OneToOne | |
| Cow (Bos Taurus) |
Mammalia | CBLC 29 30 |
|
OneToOne | |
| Dog (Canis familiaris) |
Mammalia | CBLC 29 30 |
|
OneToOne | |
| Rat (Rattus norvegicus) |
Mammalia | Cblc 29 |
|
||
| Mouse (Mus musculus) |
Mammalia | Cblc 29 16 30 |
|
OneToOne | |
| Oppossum (Monodelphis domestica) |
Mammalia | CBLC 30 |
|
OneToOne | |
| Platypus (Ornithorhynchus anatinus) |
Mammalia | CBLC 30 |
|
OneToOne | |
| Lizard (Anolis carolinensis) |
Reptilia | CBLC 30 |
|
OneToOne | |
| Zebrafish (Danio rerio) |
Actinopterygii | CBLC 30 |
|
OneToOne | |
| Fruit Fly (Drosophila melanogaster) |
Insecta | Cbl 30 |
|
OneToMany | |
| Worm (Caenorhabditis elegans) |
Secernentea | sli-1 30 |
|
OneToMany | |
| Sea Squirt (Ciona savignyi) |
Ascidiacea | -- 30 |
|
OneToMany |
- Species where no ortholog for CBLC was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Baker's yeast (Saccharomyces cerevisiae)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chicken (Gallus gallus)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Rainbow Trout (Oncorhynchus mykiss)
- Rice (Oryza sativa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Vase (Ciona intestinalis)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Thale Cress (Arabidopsis thaliana)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Tropical Clawed Frog (Silurana tropicalis)
- Wheat (Triticum aestivum)
Evolution for CBLC Gene
- ENSEMBL:
- Gene Tree for CBLC (if available)
- TreeFam:
- Gene Tree for CBLC (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for CBLC: view image
- Alliance of Genome Resources:
- Additional Orthologs for CBLC
Paralogs for CBLC Gene
Variants for CBLC Gene
Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for CBLC Gene
| SNP ID | Clinical significance and condition | Chr 19 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs766618955 | Likely Benign: not provided | 44,778,294(+) |
C/G NM_012116.4(CBLC):c.353+10C>G |
INTRON | |
| rs3208856 | -- |
p.His405Tyr |
All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).
Residual Variation Intolerance Score:
70.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
8.08;
84.44% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for CBLC Gene
SNP Genotyping and Copy Number Assays for research
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CBLC Gene
Disorders for CBLC Gene
Additional Disease Information for CBLC
- Atlas
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
- Open Targets Platform
- Open Targets Platform
No disorders were found for CBLC Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CBLC Gene
Publications for CBLC Gene
- cbl-3: a new mammalian cbl family protein. (PMID: 10362357) Keane MM … Lipkowitz S (Oncogene 1999) 2 3 4 22
- CD2AP and Cbl-3/Cbl-c constitute a critical checkpoint in the regulation of ret signal transduction. (PMID: 18753381) Tsui CC … Pierchala BA (The Journal of neuroscience : the official journal of the Society for Neuroscience 2008) 3 4 22
- Molecular cloning and characterization of a novel cbl-family gene, cbl-c. (PMID: 10571044) Kim M … Yamamoto T (Gene 1999) 2 3 4
- Cbl-c ubiquitin ligase activity is increased via the interaction of its RING finger domain with a LIM domain of the paxillin homolog, Hic 5. (PMID: 23145173) Ryan PE … Lipkowitz S (PloS one 2012) 3 4
- Structural flexibility regulates phosphopeptide-binding activity of the tyrosine kinase binding domain of Cbl-c. (PMID: 22888118) Takeshita K … Nakagawa A (Journal of biochemistry 2012) 3 4
ExternalLinks
Products for CBLC Gene
- Custom Antibody ServicesOriGene Antibodies for CBLC
- Browse OriGene ELISA Kits
- Custom Assay Services
- OriGene Purified Proteins for CBLC
- Search Origene for MassSpec and Protein Over-expression Lysates for CBLC
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- Origene shrna, sirna, and RNAi products in human, mouse, rat for CBLC
- Browse OriGene Inhibitory RNA Products For CBLC
- OriGene qPCR primer pairs for CBLC
- OriGene qPCR primer pairs and template standards for CBLC
- OriGene CRISPR knockouts for CBLC
- MG207210
- MG220739
- MR207210
- MR207210L3
- MR207210L4
- MR220739
- MR220739L3
- MR220739L4
- RC205130
- RC205130L1
- RC205130L2
- RC205130L3
- RC205130L4
- RC225700
- RC225700L3
- RC225700L4
- RG205130
- RG225700
- RR201072
- RR201072L3
- RR201072L4
- MR207210L3V
- MR207210L4V
- MR220739L3V
- MR220739L4V
- RC205130L1V
- RC205130L2V
- RC205130L3V
- RC205130L4V
- RC225700L3V
- RC225700L4V
- RR201072L3V
- RR201072L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For CBLC
- Browse Sino Biological cDNA Clones
- Sino Biological Recombinant Proteins for CBLC
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- Browse Sino Biological Assays
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- Browse Antibodies
- Browse ELISA Kits
- Browse CRO Services
- High-throughput Antibody Production Service
- Protein Production Service
- Epitope Tag Antibodies & Reporter Protein Antibodies
- Lentiviral ORF Clones
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- Browse Antibodies
- Browse Peptides and Proteins
- Browse Lysates
- Browse ELISA Kits
- Abcam antibodies for CBLC
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- Find your target
- Browse Primary Antibodies
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- Browse ELISA Kits
- Browse Matched Antibody Pairs
- Browse Proteins and Peptides
- Search Knockout (KO) Validated Antibodies
- Browse Monoclonal Antibodies
- Browse Recombinant Antibodies
- Invitrogen Antibodies for CBLC (AFLGC-Cblc)
- VectorBuilder Custom and pre-made DNA vectors for CBLC (ie. gene expression, shRNA knockdown, CRISPR)
- VectorBuilder Viral vectors for CBLC (ie. lentivirus, AAV, adenovirus)
- VectorBuilder CRISPR vectors for CBLC (ie. knockout, knockin, CRISPRa, CRISPRi)
- VectorBuilder Virus packaging for CBLC CRISPR vectors (ie. lentivirus, AAV, adenovirus)
- VectorBuilder Stable cell line generation for CBLC
- Addgene plasmids for CBLC
- antibodies-online: Show 56 available CBLC Antibodies ranked by validation data
- Compare Top CBLC Antibodies
- antibodies-online: Show 4 available CBLC Elisa Kits ranked by validation data
- Compare Top CBLC Elisa Kits
- Quality Products:
- antibodies-online: Show 5 available CBLC Proteins ranked by validation data
- Compare Top CBLC Proteins
- Santa Cruz Biotechnology (SCBT) Antibodies for CBLC
- Search Santa Cruz Biotechnology (SCBT) for CBLC siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for CBLC
- Horizon Cell Lines for CBLC
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for CBLC
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for CBLC
- Search GeneCopoeia for miRNA 3'UTR Target clone products for CBLC
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CBLC
Sources for CBLC Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM® (Updated: 05-Apr-2021)
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) UniProtKB/TrEMBL
- (14) InterPro
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) ASD
- (27) SAGE
- (28) SOURCE
- (29) HomoloGene
- (30) PanEnsembl
- (31) euGenes
- (32) SGD
- (33) FlyBase
- (34) WormBase
- (35) Pseudogene
- (36) DGV
- (37) dbSNP
- (38) GenAtlas
- (39) HGMD
- (40) GAD
- (41) BGMUT
- (42) HuGE
- (43) Atlas
- (44) GenBank
- (45) HORDE
- (46) HUGE
- (47) IMGT
- (48) Leiden
- (49) miRBase
- (50) DME
- (51) OriGene
- (52) PubMed
- (53) R&D Systems
- (54) Tocris
- (55) Abcam
- (56) Novus Biologicals
- (57) ProSpec
- (58) Sino Biological
- (59) GenScript
- (60) Qiagen
- (61) OCA
- (62) Proteopedia
- (63) MOPED
- (64) neXtProt
- (65) Reactome
- (66) GeneGo (Thomson Reuters)
- (67) DISEASES
- (68) SIMAP
- (69) GenomeRNAi
- (70) LifeMap
- (71) miRTarBase
- (72) MalaCards
- (73) Invitrogen
- (74) BitterDB
- (75) ESI-BIO
- (76) RefSeq
- (77) BioSystems
- (78) MaxQB
- (79) IUPHAR
- (80) BioGPS
- (81) Illumina
- (82) COMPARTMENTS
- (83) HOMER
- (84) PaxDb
- (85) ApexBio
- (86) Addgene
- (87) antibodies-online
- (88) CYP
- (89) NONCODE
- (90) TreeFam
- (91) PathCards
- (92) GeneReviews
- (93) GeneTex
- (94) Taconic Biosciences
- (95) GTEx
- (96) ProteomicsDB
- (97) SCBT
- (98) DGIdb
- (99) ClinicalTrials
- (100) RVIS
- (101) SIGNOR
- (102) diseasecard
- (103) NIH Rare Diseases
- (104) Orphanet
- (105) UMLS
- (106) GTR
- (107) Disease Ontology
- (108) MedlinePlus Genetics
- (109) MeSH
- (110) MedlinePlus
- (111) CDC
- (112) NINDS
- (113) NCBI Bookshelf
- (114) ClinVar
- (115) Gene Damage Index
- (116) HPO
- (117) UDN
- (118) VISTA
- (119) FANTOM5
- (120) ENCODE
- (121) ProSci
- (122) Horizon
- (123) The Signaling Pathways Project (SPP)
- (124) IID
- (125) VectorBuilder
- (126) SNPedia
- (127) BRCA Exchange
- (128) CIViC
- (129) ProteoGenix
- (130) dbSUPER
- (131) TISSUES
- (132) Gene ORGANizer
- (133) abm
- (134) Human Protein Atlas
- (135) GWAS Catalog
- (136) Monarch Initiative
- (137) DataMed
- (138) HumanCyc
- (139) UCNEbase
- (140) EPDnew
- (141) Applied Biosystems
- (142) GlyConnect
- (143) Aminode
- (144) GeneCopoeia
- (145) GPS-Prot
- (146) RNAcentral
- (147) LncRNADisease
- (148) LOVD
- (149) miR2Disease
- (150) DiseaseEnhancer
- (151) Boster Bio
- (152) Biorbyt
- (153) Biocompare
- (154) Mastermind
- (155) CTD^2 Dashboard
- (156) CraniofacialAtlas
- (157) GeneImprint
- (158) Synthego
- (159) ENA
- (160) GtRNAdb
- (161) LncBase
- (162) LncBook
- (163) LNCipedia
- (164) Modomics
- (165) PDBe
- (166) Rfam
- (167) SILVA
- (168) snOPY
- (169) SRPDB
- (170) GENCODE
- (171) TarBase
- (172) Open Targets Platform
- (173) 5SRRNADB
- (174) snoDB
- (175) MirGeneDB
- (176) Alliance of Genome Resources