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CBLC Gene(Protein Coding)

Cbl Proto-Oncogene C

GCID:
GC19P044777
GIFtS:
46
Genes Participants
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Aliases for CBLC Gene

Aliases for CBLC Gene

  • Cbl Proto-Oncogene C 2 3 5
  • Cas-Br-M (Murine) Ecotropic Retroviral Transforming Sequence C 2 3
  • Cas-Br-M (Murine) Ectropic Retroviral Transforming Sequence C 2 3
  • Cbl Proto-Oncogene C, E3 Ubiquitin Protein Ligase 2 3
  • RING-Type E3 Ubiquitin Transferase CBL-C 3 4
  • Signal Transduction Protein CBL-C 3 4
  • SH3-Binding Protein CBL-3 3 4
  • SH3-Binding Protein CBL-C 3 4
  • RING Finger Protein 57 3 4
  • RNF57 3 4
  • Cbl Proto-Oncogene, E3 Ubiquitin Protein Ligase C 3
  • E3 Ubiquitin-Protein Ligase CBL-C 3
  • EC 2.3.2.27 4
  • CBL-SL 3
  • CBL-3 3
  • CBL3 4

External Ids for CBLC Gene

Previous GeneCards Identifiers for CBLC Gene

  • GC19P045925
  • GC19P045672
  • GC19P049957
  • GC19P049972
  • GC19P045281
  • GC19P041713

Summaries for CBLC Gene

Entrez Gene Summary for CBLC Gene

  • This gene encodes a member of the Cbl family of E3 ubiquitin ligases. Cbl proteins play important roles in cell signaling through the ubiquitination and subsequent downregulation of tyrosine kinases. Expression of this gene may be restricted to epithelial cells, and alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Feb 2012]

CIViC summary for CBLC Gene

GeneCards Summary for CBLC Gene

CBLC (Cbl Proto-Oncogene C) is a Protein Coding gene. Among its related pathways are Chronic myeloid leukemia and Angiopoietin Like Protein 8 Regulatory Pathway. Gene Ontology (GO) annotations related to this gene include calcium ion binding and ubiquitin-protein transferase activity. An important paralog of this gene is CBLB.

UniProtKB/Swiss-Prot for CBLC Gene

  • Acts as an E3 ubiquitin-protein ligase, which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, and then transfers it to substrates promoting their degradation by the proteasome. Functionally coupled with the E2 ubiquitin-protein ligases UB2D1, UB2D2 and UB2D3. Regulator of EGFR mediated signal transduction; upon EGF activation, ubiquitinates EGFR. Isoform 1, but not isoform 2, inhibits EGF stimulated MAPK1 activation. Promotes ubiquitination of SRC phosphorylated at Tyr-419. In collaboration with CD2AP may act as regulatory checkpoint for Ret signaling by modulating the rate of RET degradation after ligand activation; CD2AP converts it from an inhibitor to a promoter of RET degradation; the function limits the potency of GDNF on neuronal survival.

Gene Wiki entry for CBLC Gene

Additional gene information for CBLC Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CBLC Gene

Genomics for CBLC Gene

Products:

  1. Regulatory Element

GeneHancer (GH) Regulatory Elements for CBLC Gene

Promoters and enhancers for CBLC Gene
GeneHancer (GH) Identifier GH Type GH
Score		 GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites		 Gene Targets
GH19I044772 Promoter/Enhancer 2.1 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 563.8 -2.2 -2150 6.7 FOXA2 ATF1 ARNT ZFP64 ARID4B DMAP1 ZNF48 YY1 ZNF766 ATF7 CBLC CEACAM19 BCAM GC19M044777 ENSG00000236807 GC19M044733
GH19I044779 Enhancer 0.4 Ensembl dbSUPER 550.8 +1.4 1440 0.2 CBLC GC19M044777 PIR44195 GC19M044733
GH19I044740 Promoter/Enhancer 2.8 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 5.4 -27.8 -27844 19.4 YBX1 FEZF1 IRF4 YY1 ZNF213 E2F8 ZNF143 ZNF548 ZNF263 SP3 BCL3 ZNF45 ZNF224 ZNF155 ZNF180 ZNF284 ZNF225 ZNF234 CLASRP ZNF235
GH19I045418 Enhancer 1.2 Ensembl ENCODE dbSUPER 4.9 +641.9 641940 2 HDGF PKNOX1 BATF IRF4 EGR1 SCRT2 ZNF207 ZNF143 ETV6 BCLAF1 CD3EAP CBLC PIR48099 MIR6088 ERCC1
GH19I044716 Enhancer 0.4 dbSUPER 12.8 -61.1 -61099 0.2 HLF CEBPA CEBPG ENSG00000266903 BCL3 ENSG00000236807 ENSG00000253027 CBLC CEACAM16
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around CBLC on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the CBLC gene promoter:

Genomic Locations for CBLC Gene

Genomic Locations for CBLC Gene
chr19:44,777,861-44,800,646
(GRCh38/hg38)
Size:
22,786 bases
Orientation:
Plus strand
chr19:45,281,126-45,303,903
(GRCh37/hg19)

Genomic View for CBLC Gene

Genes around CBLC on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CBLC Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CBLC Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for CBLC Gene

Proteins for CBLC Gene

Products:

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  3. Assay

  • Protein details for CBLC Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9ULV8-CBLC_HUMAN
    Recommended name:
    E3 ubiquitin-protein ligase CBL-C
    Protein Accession:
    Q9ULV8
    Secondary Accessions:
    • Q8N1E5
    • Q9Y5Z2
    • Q9Y5Z3

    Protein attributes for CBLC Gene

    Size:
    474 amino acids
    Molecular mass:
    52456 Da
    Quaternary structure:
    • Interacts with ubiquitin-conjugating enzyme E2 UBE2D2 and UBE2D3. Isoform 1 interacts with EGFR (tyrosine phosphorylated). Interacts with the SH3 domain proteins LYN and CRK. Interacts (via RING-type zinc finger) with TGFB1I1 (via LIM zinc-binding domain 2); the interaction is direct and enhances the E3 activity. Interacts directly with RET (inactive) and CD2AP; dissociates from RET upon RET activation by GDNF which also increases the interaction with CD2AP suggesting dissociation as CBLC:CD2AP complex. Interacts with SRC; the interaction is enhanced when SRC is phosphorylated at Tyr-419.
    Miscellaneous:
    • This protein has one functional calcium-binding site.

    Three dimensional structures from OCA and Proteopedia for CBLC Gene

    Alternative splice isoforms for CBLC Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CBLC Gene

Post-translational modifications for CBLC Gene

  • Autoubiquitinated when phosphorylated at Tyr-341, enhanced by SRC; suggesting proteasomal degradation.
  • Phosphorylated on multiple tyrosine residues by SRC. Isoform 1, but not isoform 2, is phosphorylated on tyrosines by EGFR.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CBLC Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for CBLC Gene

Domains & Families for CBLC Gene

Gene Families for CBLC Gene

HGNC:
Human Protein Atlas (HPA):
  • Cancer-related genes
  • Enzymes
  • Predicted intracellular proteins

Protein Domains for CBLC Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for CBLC Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9ULV8

UniProtKB/Swiss-Prot:

CBLC_HUMAN :
  • EF-hand-like and Sh2-like domains are required for N-terminal inhibition of E3 activity.
Domain:
  • EF-hand-like and Sh2-like domains are required for N-terminal inhibition of E3 activity.
  • The N-terminus is composed of the phosphotyrosine binding (PTB) domain, a short linker region and the RING-type zinc finger. The PTB domain, which is also called TKB (tyrosine kinase binding) domain, is composed of three different subdomains: a four-helix bundle (4H), a calcium-binding EF hand and a divergent SH2 domain.
  • The RING-type zinc finger domain mediates binding to an E2 ubiquitin-conjugating enzyme.
genes like me logo Genes that share domains with CBLC: view

Function for CBLC Gene

Products:

  1. Animal Model
  2. CRISPR
  3. miRNA
  4. Inhibitory RNA
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  6. Cell Line

Molecular function for CBLC Gene

UniProtKB/Swiss-Prot CatalyticActivity:
S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.
UniProtKB/Swiss-Prot EnzymeRegulation:
Phosphorylation at Tyr-341 is necessary and sufficient for the activation of E3 activity.
UniProtKB/Swiss-Prot Function:
Acts as an E3 ubiquitin-protein ligase, which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, and then transfers it to substrates promoting their degradation by the proteasome. Functionally coupled with the E2 ubiquitin-protein ligases UB2D1, UB2D2 and UB2D3. Regulator of EGFR mediated signal transduction; upon EGF activation, ubiquitinates EGFR. Isoform 1, but not isoform 2, inhibits EGF stimulated MAPK1 activation. Promotes ubiquitination of SRC phosphorylated at Tyr-419. In collaboration with CD2AP may act as regulatory checkpoint for Ret signaling by modulating the rate of RET degradation after ligand activation; CD2AP converts it from an inhibitor to a promoter of RET degradation; the function limits the potency of GDNF on neuronal survival.

Enzyme Numbers (IUBMB) for CBLC Gene

Phenotypes From GWAS Catalog for CBLC Gene

Gene Ontology (GO) - Molecular Function for CBLC Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001784 phosphotyrosine residue binding IDA 14661060
GO:0004842 ubiquitin-protein transferase activity IEA --
GO:0004871 signal transducer activity IEA --
GO:0005154 epidermal growth factor receptor binding IDA 10362357
GO:0005509 calcium ion binding IEA --
genes like me logo Genes that share ontologies with CBLC: view
genes like me logo Genes that share phenotypes with CBLC: view

Animal Models for CBLC Gene

MGI Knock Outs for CBLC:

Animal Model Products

miRNA for CBLC Gene

miRTarBase miRNAs that target CBLC

Clone Products

  • Addgene plasmids for CBLC

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CBLC Gene

Localization for CBLC Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CBLC gene
Compartment Confidence
extracellular 5
nucleus 4
plasma membrane 3
cytosol 2
lysosome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoplasm (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for CBLC Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005886 plasma membrane IBA --
GO:0045121 membrane raft IBA --
GO:0070062 extracellular exosome IDA,HDA 23376485
genes like me logo Genes that share ontologies with CBLC: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for CBLC Gene

Pathways & Interactions for CBLC Gene

genes like me logo Genes that share pathways with CBLC: view

SIGNOR curated interactions for CBLC Gene

Inactivates:
Is activated by:
Is inactivated by:

Gene Ontology (GO) - Biological Process for CBLC Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007166 cell surface receptor signaling pathway IEA --
GO:0007175 negative regulation of epidermal growth factor-activated receptor activity IDA 10362357
GO:0016567 protein ubiquitination IDA 14661060
GO:0023051 regulation of signaling IEA --
GO:0042059 negative regulation of epidermal growth factor receptor signaling pathway IDA 10362357
genes like me logo Genes that share ontologies with CBLC: view

Drugs & Compounds for CBLC Gene

Products:

  1. Drug

(5) Drugs for CBLC Gene - From: HMDB and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Phosphoric acid Approved Pharma 0
Adenosine monophosphate Approved, Investigational Nutra 0
calcium Approved Nutra 0
ATP Investigational Nutra Agonist 0

(1) Additional Compounds for CBLC Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
pyrophosphate
  • (4-)Diphosphoric acid ion
  • (P2O74-)Diphosphate
  • Diphosphate
  • Diphosphoric acid
  • PPi
 14000-31-8
genes like me logo Genes that share compounds with CBLC: view

Transcripts for CBLC Gene

Products:

  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
  4. Clone

mRNA/cDNA for CBLC Gene

(6) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(38) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for CBLC Gene

Cbl proto-oncogene, E3 ubiquitin protein ligase C:
Representative Sequences:

Clone Products

  • Addgene plasmids for CBLC

Alternative Splicing Database (ASD) splice patterns (SP) for CBLC Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11
SP1:
SP2: -

Relevant External Links for CBLC Gene

GeneLoc Exon Structure for
CBLC
ECgene alternative splicing isoforms for
CBLC

Expression for CBLC Gene

Products:

  1. Primer
  2. Gene Expression Assay

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CBLC Gene

mRNA expression in normal human tissues for CBLC Gene
mRNA expression by BioGPS for CBLC GenemRNA expression by GTEx for CBLC Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CBLC Gene

This gene is overexpressed in Esophagus - Mucosa (x6.7), Skin - Not Sun Exposed (Suprapubic) (x6.5), Colon - Transverse (x6.3), and Skin - Sun Exposed (Lower leg) (x5.9).

NURSA nuclear receptor signaling pathways regulating expression of CBLC Gene:

CBLC

SOURCE GeneReport for Unigene cluster for CBLC Gene:

Hs.466907

mRNA Expression by UniProt/SwissProt for CBLC Gene:

Q9ULV8-CBLC_HUMAN
Tissue specificity: Ubiquitous.

Evidence on tissue expression from TISSUES for CBLC Gene

  • Skin(4.2)
genes like me logo Genes that share expression patterns with CBLC: view

No data available for Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for CBLC Gene

Orthologs for CBLC Gene

This gene was present in the common ancestor of animals.

Orthologs for CBLC Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
 Mammalia CBLC 33 34
  • 90.19 (n)
cow
(Bos Taurus)
 Mammalia CBLC 33 34
  • 86.21 (n)
dog
(Canis familiaris)
 Mammalia CBLC 33 34
  • 83.57 (n)
rat
(Rattus norvegicus)
 Mammalia Cblc 33
  • 80.22 (n)
mouse
(Mus musculus)
 Mammalia Cblc 33 16 34
  • 80.02 (n)
oppossum
(Monodelphis domestica)
 Mammalia CBLC 34
  • 57 (a)
 OneToOne
platypus
(Ornithorhynchus anatinus)
 Mammalia CBLC 34
  • 31 (a)
 OneToOne
lizard
(Anolis carolinensis)
 Reptilia CBLC 34
  • 55 (a)
 OneToOne
zebrafish
(Danio rerio)
 Actinopterygii CBLC 34
  • 40 (a)
 OneToOne
fruit fly
(Drosophila melanogaster)
 Insecta Cbl 34
  • 22 (a)
 OneToMany
worm
(Caenorhabditis elegans)
 Secernentea sli-1 34
  • 32 (a)
 OneToMany
sea squirt
(Ciona savignyi)
 Ascidiacea -- 34
  • 47 (a)
 OneToMany
Species where no ortholog for CBLC was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for CBLC Gene

ENSEMBL:
Gene Tree for CBLC (if available)
TreeFam:
Gene Tree for CBLC (if available)

Paralogs for CBLC Gene

Paralogs for CBLC Gene

(2) SIMAP similar genes for CBLC Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with CBLC: view

Variants for CBLC Gene

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  1. SNP Genotyping and Copy Number Assay

Sequence variations from dbSNP and Humsavar for CBLC Gene

SNP ID Clin Chr 19 pos Variation AA Info Type
rs1000151116 -- 44,783,862(+) C/T intron_variant
rs1000593338 -- 44,778,172(+) C/T coding_sequence_variant, missense_variant, non_coding_transcript_variant
rs1000666675 -- 44,777,999(+) G/T coding_sequence_variant, missense_variant, non_coding_transcript_variant
rs1000690482 -- 44,798,287(+) C/G genic_downstream_transcript_variant, intron_variant
rs1000755141 -- 44,792,976(+) G/A genic_downstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for CBLC Gene

Variant ID Type Subtype PubMed ID
nsv2506 CNV deletion 18451855
nsv833841 CNV loss 17160897

Variation tolerance for CBLC Gene

Residual Variation Intolerance Score: 70.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 8.08; 84.44% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CBLC Gene

Human Gene Mutation Database (HGMD)
CBLC
SNPedia medical, phenotypic, and genealogical associations of SNPs for
CBLC

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CBLC Gene

Disorders for CBLC Gene

Additional Disease Information for CBLC

ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for CBLC Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CBLC Gene

Publications for CBLC Gene

  1. cbl-3: a new mammalian cbl family protein. (PMID: 10362357) Keane MM … Lipkowitz S (Oncogene 1999) 2 3 4 22 58
  2. CD2AP and Cbl-3/Cbl-c constitute a critical checkpoint in the regulation of ret signal transduction. (PMID: 18753381) Tsui CC … Pierchala BA (The Journal of neuroscience : the official journal of the Society for Neuroscience 2008) 3 4 22 58
  3. Molecular cloning and characterization of a novel cbl-family gene, cbl-c. (PMID: 10571044) Kim M … Yamamoto T (Gene 1999) 2 3 4 58
  4. Structural flexibility regulates phosphopeptide-binding activity of the tyrosine kinase binding domain of Cbl-c. (PMID: 22888118) Takeshita K … Nakagawa A (Journal of biochemistry 2012) 3 4 58
  5. Cbl-c ubiquitin ligase activity is increased via the interaction of its RING finger domain with a LIM domain of the paxillin homolog, Hic 5. (PMID: 23145173) Ryan PE … Lipkowitz S (PloS one 2012) 3 4 58

Products for CBLC Gene

  • Addgene plasmids for CBLC

Sources for CBLC Gene

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