Aliases for CBLB Gene
- Cbl Proto-Oncogene B 2 3 5
- RNF56 2 3 4
- Cas-Br-M (Murine) Ecotropic Retroviral Transforming Sequence B 2 3
- Cbl Proto-Oncogene B, E3 Ubiquitin Protein Ligase 2 3
- Casitas B-Lineage Lymphoma Proto-Oncogene B 3 4
- RING-Type E3 Ubiquitin Transferase CBL-B 3 4
- E3 Ubiquitin-Protein Ligase CBL-B 3 4
- Signal Transduction Protein CBL-B 3 4
External Ids for CBLB Gene
Previous GeneCards Identifiers for CBLB Gene
This gene encodes an E3 ubiquitin-protein ligase which promotes proteosome-mediated protein degradation by transferring ubiquitin from an E2 ubiquitin-conjugating enzyme to a substrate. The encoded protein is involved in the regulation of immune response by limiting T-cell receptor, B-cell receptor, and high affinity immunoglobulin epsilon receptor activation. Studies in mouse suggest that this gene is involved in antifungal host defense and that its inhibition leads to increased fungal killing. Manipulation of this gene may be beneficial in implementing immunotherapies for a variety of conditions, including cancer, autoimmune diseases, allergies, and infections. [provided by RefSeq, Sep 2017]
GeneCards Summary for CBLB Gene
CBLB (Cbl Proto-Oncogene B) is a Protein Coding gene. Diseases associated with CBLB include Lymphoma and Lipomatosis, Multiple Symmetric. Among its related pathways are Class I MHC mediated antigen processing and presentation and T cell receptor signaling pathway. Gene Ontology (GO) annotations related to this gene include calcium ion binding and ubiquitin-protein transferase activity. An important paralog of this gene is CBL.
UniProtKB/Swiss-Prot Summary for CBLB Gene
E3 ubiquitin-protein ligase which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, and transfers it to substrates, generally promoting their degradation by the proteasome. Negatively regulates TCR (T-cell receptor), BCR (B-cell receptor) and FCER1 (high affinity immunoglobulin epsilon receptor) signal transduction pathways. In naive T-cells, inhibits VAV1 activation upon TCR engagement and imposes a requirement for CD28 costimulation for proliferation and IL-2 production. Also acts by promoting PIK3R1/p85 ubiquitination, which impairs its recruitment to the TCR and subsequent activation. In activated T-cells, inhibits PLCG1 activation and calcium mobilization upon restimulation and promotes anergy. In B-cells, acts by ubiquitinating SYK and promoting its proteasomal degradation. Slightly promotes SRC ubiquitination. May be involved in EGFR ubiquitination and internalization. May be functionally coupled with the E2 ubiquitin-protein ligase UB2D3. In association with CBL, required for proper feedback inhibition of ciliary platelet-derived growth factor receptor-alpha (PDGFRA) signaling pathway via ubiquitination and internalization of PDGFRA (By similarity).