Aliases for CAVIN4 Gene
External Ids for CAVIN4 Gene
Previous HGNC Symbols for CAVIN4 Gene
This gene encodes a protein containing two coiled-coil regions. The encoded protein promotes Rho/ROCK (Rho-kinase) signaling in cardiac muscles cells, and may facilitate myofibrillar organization. [provided by RefSeq, Jun 2013]
GeneCards Summary for CAVIN4 Gene
CAVIN4 (Caveolae Associated Protein 4) is a Protein Coding gene. Diseases associated with CAVIN4 include Lipodystrophy, Congenital Generalized, Type 4 and Spinal Muscular Atrophy With Lower Extremity Predominance. An important paralog of this gene is CAVIN2.
UniProtKB/Swiss-Prot Summary for CAVIN4 Gene
Modulates the morphology of formed caveolae in cardiomyocytes, but is not required for caveolar formation. Facilitates the recruitment of MAPK1/3 to caveolae within cardiomyocytes and regulates alpha-1 adrenergic receptor-induced hypertrophic responses in cardiomyocytes through MAPK1/3 activation. Contributes to proper membrane localization and stabilization of caveolin-3 (CAV3) in cardiomyocytes (By similarity). Induces RHOA activation and activates NPPA transcription and myofibrillar organization through the Rho/ROCK signaling pathway (PubMed:18332105).