Aliases for CAVIN3 Gene
External Ids for CAVIN3 Gene
Previous HGNC Symbols for CAVIN3 Gene
The protein encoded by this gene was identified as a binding protein of the protein kinase C, delta (PRKCD). The expression of this gene in cultured cell lines is strongly induced by serum starvation. The expression of this protein was found to be down-regulated in various cancer cell lines, suggesting the possible tumor suppressor function of this protein. [provided by RefSeq, Jul 2008]
GeneCards Summary for CAVIN3 Gene
CAVIN3 (Caveolae Associated Protein 3) is a Protein Coding gene. Diseases associated with CAVIN3 include Hereditary Spherocytosis. Among its related pathways are Circadian rythm related genes and ADP signalling through P2Y purinoceptor 12. An important paralog of this gene is CAVIN2.
UniProtKB/Swiss-Prot Summary for CAVIN3 Gene
Regulates the traffic and/or budding of caveolae (PubMed:19262564). Plays a role in caveola formation in a tissue-specific manner. Required for the formation of caveolae in smooth muscle but not in the lung and heart endothelial cells. Regulates the equilibrium between cell surface-associated and cell surface-dissociated caveolae by promoting the rapid release of caveolae from the cell surface. Plays a role in the regulation of the circadian clock. Modulates the period length and phase of circadian gene expression and also regulates expression and interaction of the core clock components PER1/2 and CRY1/2 (By similarity).