The protein encoded by this gene was identified as a binding protein of the protein kinase C, delta (PRKCD). The expression of this gene in cultured cell lines is strongly induced by serum starvation. The expression of this protein was found to be down-regulated in various cancer cell lines, suggesting the possible tumor suppressor function of this protein. [provided by RefSeq,... See more...

Aliases for CAVIN3 Gene

Aliases for CAVIN3 Gene

  • Caveolae Associated Protein 3 2 3 5
  • Serum Deprivation Response Factor-Related Gene Product That Binds To C-Kinase 3 4
  • Sdr-Related Gene Product That Binds To C-Kinase 2 3
  • Protein Kinase C Delta Binding Protein 2 3
  • Caveolae-Associated Protein 3 3 4
  • Cavin-3 3 4
  • PRKCDBP 3 4
  • HSRBC 3 4
  • SRBC 3 4
  • Protein Kinase C, Delta Binding Protein 2
  • Protein Kinase C Delta-Binding Protein 4

External Ids for CAVIN3 Gene

Previous HGNC Symbols for CAVIN3 Gene

  • PRKCDBP

Summaries for CAVIN3 Gene

Entrez Gene Summary for CAVIN3 Gene

  • The protein encoded by this gene was identified as a binding protein of the protein kinase C, delta (PRKCD). The expression of this gene in cultured cell lines is strongly induced by serum starvation. The expression of this protein was found to be down-regulated in various cancer cell lines, suggesting the possible tumor suppressor function of this protein. [provided by RefSeq, Jul 2008]

GeneCards Summary for CAVIN3 Gene

CAVIN3 (Caveolae Associated Protein 3) is a Protein Coding gene. Diseases associated with CAVIN3 include Hereditary Spherocytosis. Among its related pathways are Circadian rythm related genes and ADP signalling through P2Y purinoceptor 12. An important paralog of this gene is CAVIN2.

UniProtKB/Swiss-Prot Summary for CAVIN3 Gene

  • Regulates the traffic and/or budding of caveolae (PubMed:19262564). Plays a role in caveola formation in a tissue-specific manner. Required for the formation of caveolae in smooth muscle but not in the lung and heart endothelial cells. Regulates the equilibrium between cell surface-associated and cell surface-dissociated caveolae by promoting the rapid release of caveolae from the cell surface. Plays a role in the regulation of the circadian clock. Modulates the period length and phase of circadian gene expression and also regulates expression and interaction of the core clock components PER1/2 and CRY1/2 (By similarity).

Additional gene information for CAVIN3 Gene

No data available for CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for CAVIN3 Gene

Genomics for CAVIN3 Gene

GeneHancer (GH) Regulatory Elements for CAVIN3 Gene

Promoters and enhancers for CAVIN3 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH11J006317 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 525.2 -0.4 -372 7 TEAD4 FOS CTCF EP300 POLR2A RCOR1 BCL11A TCF12 CBFB SMARCC1 CAVIN3 lnc-CAVIN3-1 OR56A1 TAF10 LOC101927825 piR-58605
GH11J006601 Promoter/Enhancer 2.4 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 12.1 -287.0 -286964 12.4 HNRNPK ZBTB40 EP300 CTCF SIN3A NRF1 TCF12 MYC POLR2G SP1 RRP8 ILK NONHSAG007540.2 TAF10 OLFML1 FAM160A2 ENSG00000251364 CAVIN3 DCHS1 ENSG00000254400
GH11J006742 Promoter/Enhancer 1.9 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 13.8 -424.6 -424600 6.7 SIN3A ZBTB5 RCOR1 MYC TRIM22 POLR2A RELA NR2F2 NCOR1 NFRKB GVINP1 MRPL17 lnc-OR2AG2-1 RRP8 OR2AG2 CAVIN3 ILK DCHS1 ENSG00000254641 TAF10
GH11J006400 Promoter/Enhancer 1.3 Ensembl ENCODE dbSUPER 9.4 -82.8 -82838 5.5 ZBTB40 SP1 TEAD4 RFX1 TOE1 RAD51 CBFB USF1 MXI1 GABPA SMPD1 HPX ARFIP2 TIMM10B CAVIN3 APBB1 lnc-HPX-2 RF00017-849
GH11J006438 Promoter/Enhancer 1.4 EPDnew Ensembl ENCODE 8.9 -118.8 -118768 3.8 EP300 CTCF POLR2G TEAD4 KDM6A FOXA1 REST MYC RAD21 ZBTB7A HPX lnc-TRIM3-2 SMPD1 CAVIN3 APBB1 HSALNG0082420
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around CAVIN3 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for CAVIN3

Genomic Locations for CAVIN3 Gene

Genomic Locations for CAVIN3 Gene
chr11:6,318,946-6,320,532
(GRCh38/hg38)
Size:
1,587 bases
Orientation:
Minus strand
chr11:6,340,176-6,341,877
(GRCh37/hg19)
Size:
1,702 bases
Orientation:
Minus strand

Genomic View for CAVIN3 Gene

Genes around CAVIN3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CAVIN3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CAVIN3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CAVIN3 Gene

Proteins for CAVIN3 Gene

  • Protein details for CAVIN3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q969G5-CAVN3_HUMAN
    Recommended name:
    Caveolae-associated protein 3
    Protein Accession:
    Q969G5

    Protein attributes for CAVIN3 Gene

    Size:
    261 amino acids
    Molecular mass:
    27701 Da
    Quaternary structure:
    • Component of the CAVIN complex composed of CAVIN1, CAVIN2, CAVIN3 and CAVIN4. Interacts with PRKCD and with phosphatidylserine. Phosphatidylserine may form a bridge between PKC and PKC-binding partners and stabilize the binding. Interacts with PER2. Interacts with CAVIN1 (By similarity). Interacts (via leucine-zipper domain) with CAV1 in a cholesterol-sensitive manner (PubMed:19262564). Interacts with EPS15L1 (PubMed:19262564).

neXtProt entry for CAVIN3 Gene

Post-translational modifications for CAVIN3 Gene

Other Protein References for CAVIN3 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for CAVIN3 Gene

Domains & Families for CAVIN3 Gene

Gene Families for CAVIN3 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for CAVIN3 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for CAVIN3 Gene

GenScript: Design optimal peptide antigens:
  • Serum deprivation response factor-related gene product that binds to C-kinase (PRDBP_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q969G5

UniProtKB/Swiss-Prot:

CAVN3_HUMAN :
  • The leucine-zipper domain is essential for its localization in the caveolae and for its interaction with CAV1 and EPS15L1.
  • Belongs to the CAVIN family.
Domain:
  • The leucine-zipper domain is essential for its localization in the caveolae and for its interaction with CAV1 and EPS15L1.
Family:
  • Belongs to the CAVIN family.
genes like me logo Genes that share domains with CAVIN3: view

Function for CAVIN3 Gene

Molecular function for CAVIN3 Gene

UniProtKB/Swiss-Prot Function:
Regulates the traffic and/or budding of caveolae (PubMed:19262564). Plays a role in caveola formation in a tissue-specific manner. Required for the formation of caveolae in smooth muscle but not in the lung and heart endothelial cells. Regulates the equilibrium between cell surface-associated and cell surface-dissociated caveolae by promoting the rapid release of caveolae from the cell surface. Plays a role in the regulation of the circadian clock. Modulates the period length and phase of circadian gene expression and also regulates expression and interaction of the core clock components PER1/2 and CRY1/2 (By similarity).
UniProtKB/Swiss-Prot Induction:
Down-regulated in breast and lung cancer cell lines.

Phenotypes From GWAS Catalog for CAVIN3 Gene

Gene Ontology (GO) - Molecular Function for CAVIN3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005080 protein kinase C binding IBA 21873635
GO:0005515 protein binding IPI 19262564
genes like me logo Genes that share ontologies with CAVIN3: view
genes like me logo Genes that share phenotypes with CAVIN3: view

Animal Models for CAVIN3 Gene

MGI Knock Outs for CAVIN3:

Animal Model Products

CRISPR Products

miRNA for CAVIN3 Gene

miRTarBase miRNAs that target CAVIN3

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CAVIN3

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CAVIN3 Gene

Localization for CAVIN3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CAVIN3 Gene

Cytoplasm. Membrane, caveola. Cytoplasm, cytosol. Note=Localizes in the caveolae in a caveolin-dependent manner. {ECO:0000269 PubMed:19262564}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CAVIN3 gene
Compartment Confidence
plasma membrane 5
cytosol 4
nucleus 3
extracellular 2
cytoskeleton 1
mitochondrion 1
endoplasmic reticulum 1
endosome 1
lysosome 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Plasma membrane (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for CAVIN3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IBA,ISS --
GO:0005829 cytosol IEA --
GO:0005901 caveola IDA,IEA 19525939
GO:0016020 membrane IEA --
GO:0032991 protein-containing complex IDA 24013648
genes like me logo Genes that share ontologies with CAVIN3: view

Pathways & Interactions for CAVIN3 Gene

genes like me logo Genes that share pathways with CAVIN3: view

Pathways by source for CAVIN3 Gene

1 BioSystems pathway for CAVIN3 Gene
1 PharmGKB pathway for CAVIN3 Gene

Gene Ontology (GO) - Biological Process for CAVIN3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0030866 cortical actin cytoskeleton organization IEA --
GO:0032922 circadian regulation of gene expression ISS,IEA --
GO:0048511 rhythmic process IEA --
GO:0051898 negative regulation of protein kinase B signaling IEA --
GO:0070374 positive regulation of ERK1 and ERK2 cascade IEA --
genes like me logo Genes that share ontologies with CAVIN3: view

No data available for SIGNOR curated interactions for CAVIN3 Gene

Drugs & Compounds for CAVIN3 Gene

(124) Additional Compounds for CAVIN3 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
PS(14:0/14:0)
  • 1-Myristoyl-2-myristoyl-sn-glycero-3-phosphoserine
  • Phosphatidylserine(14:0/14:0)
  • Phosphatidylserine(28:0)
  • PS(28:0)
  • pSer(14:0/14:0)
PS(14:0/14:1(9Z))
  • 1-Myristoyl-2-myristoleoyl-sn-glycero-3-phosphoserine
  • Phosphatidylserine(14:0/14:1)
  • Phosphatidylserine(14:0/14:1n5)
  • Phosphatidylserine(14:0/14:1W5)
  • Phosphatidylserine(28:1)
PS(14:0/16:0)
  • 1-Myristoyl-2-palmitoyl-sn-glycero-3-phosphoserine
  • Phosphatidylserine(14:0/16:0)
  • Phosphatidylserine(30:0)
  • PS(30:0)
  • pSer(14:0/16:0)
PS(14:0/16:1(9Z))
  • 1-Myristoyl-2-palmitoleoyl-sn-glycero-3-phosphoserine
  • Phosphatidylserine(14:0/16:1)
  • Phosphatidylserine(14:0/16:1n7)
  • Phosphatidylserine(14:0/16:1W7)
  • Phosphatidylserine(30:1)
PS(14:0/18:0)
  • 1-Myristoyl-2-stearoyl-sn-glycero-3-phosphoserine
  • Phosphatidylserine(14:0/18:0)
  • Phosphatidylserine(32:0)
  • PS(32:0)
  • pSer(14:0/18:0)
genes like me logo Genes that share compounds with CAVIN3: view

Transcripts for CAVIN3 Gene

mRNA/cDNA for CAVIN3 Gene

1 REFSEQ mRNAs :
4 NCBI additional mRNA sequence :
4 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CAVIN3

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for CAVIN3 Gene

No ASD Table

Relevant External Links for CAVIN3 Gene

GeneLoc Exon Structure for
CAVIN3

Expression for CAVIN3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for CAVIN3

mRNA Expression by UniProt/SwissProt for CAVIN3 Gene:

Q969G5-CAVN3_HUMAN
Tissue specificity: Skeletal muscle, liver, stomach, lung, kidney and heart (at protein level). Strongly expressed in mammary and epithelial cells.

Evidence on tissue expression from TISSUES for CAVIN3 Gene

  • Skin(4.4)
  • Liver(4.1)
  • Lung(2.3)
  • Muscle(2.1)
genes like me logo Genes that share expression patterns with CAVIN3: view

No data available for mRNA expression in normal human tissues , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for CAVIN3 Gene

Orthologs for CAVIN3 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CAVIN3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PRKCDBP 31 30
  • 99.74 (n)
OneToOne
cow
(Bos Taurus)
Mammalia PRKCDBP 31 30
  • 85.66 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia Prkcdbp 30
  • 84.58 (n)
dog
(Canis familiaris)
Mammalia PRKCDBP 31 30
  • 83.91 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Prkcdbp 31 30
  • 82.94 (n)
OneToOne
Cavin3 17
oppossum
(Monodelphis domestica)
Mammalia PRKCDBP 31
  • 74 (a)
OneToOne
chicken
(Gallus gallus)
Aves PRKCDBP 31
  • 25 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia PRKCDBP 31
  • 21 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii sdprb 31
  • 19 (a)
ManyToMany
sdpra 31
  • 17 (a)
ManyToMany
Species where no ortholog for CAVIN3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CAVIN3 Gene

ENSEMBL:
Gene Tree for CAVIN3 (if available)
TreeFam:
Gene Tree for CAVIN3 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for CAVIN3: view image

Paralogs for CAVIN3 Gene

Paralogs for CAVIN3 Gene

genes like me logo Genes that share paralogs with CAVIN3: view

Variants for CAVIN3 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for CAVIN3 Gene

SNP ID Clinical significance and condition Chr 11 pos Variation AA Info Type
rs1051992 - p.Leu158Pro
rs10839551 - p.Ala104Thr
rs12294600 - p.Leu255Phe
rs2682123 - p.Arg8Pro

Additional dbSNP identifiers (rs#s) for CAVIN3 Gene

Structural Variations from Database of Genomic Variants (DGV) for CAVIN3 Gene

Variant ID Type Subtype PubMed ID
nsv1046738 CNV loss 25217958
nsv519454 CNV loss 19592680

Variation tolerance for CAVIN3 Gene

Residual Variation Intolerance Score: 76% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.15; 61.52% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CAVIN3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CAVIN3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CAVIN3 Gene

Disorders for CAVIN3 Gene

MalaCards: The human disease database

(1) MalaCards diseases for CAVIN3 Gene - From: DISEASES

Disorder Aliases PubMed IDs
hereditary spherocytosis
  • spherocytosis, type 1
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for CAVIN3

genes like me logo Genes that share disorders with CAVIN3: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CAVIN3 Gene

Publications for CAVIN3 Gene

  1. Inactivation of human SRBC, located within the 11p15.5-p15.4 tumor suppressor region, in breast and lung cancers. (PMID: 11691816) Xu XL … Minna JD (Cancer research 2001) 3 4 23 54
  2. A protein kinase Cdelta-binding protein SRBC whose expression is induced by serum starvation. (PMID: 9054438) Izumi Y … Ohno S (The Journal of biological chemistry 1997) 2 3 23 54
  3. Frequent inactivation of hSRBC in ovarian cancers by promoter CpG island hypermethylation. (PMID: 20423276) Tong SY … Lee SK (Acta obstetricia et gynecologica Scandinavica 2010) 3 23 54
  4. SRBC/cavin-3 is a caveolin adapter protein that regulates caveolae function. (PMID: 19262564) McMahon KA … Anderson RG (The EMBO journal 2009) 3 4 54
  5. Expression of the candidate tumor suppressor gene hSRBC is frequently lost in primary lung cancers with and without DNA methylation. (PMID: 15940253) Zöchbauer-Müller S … Minna JD (Oncogene 2005) 3 23 54

Products for CAVIN3 Gene

Sources for CAVIN3 Gene