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Aliases for CATSPERZ Gene
Aliases for CATSPERZ Gene
External Ids for CATSPERZ Gene
- HGNC: 19231
- NCBI Entrez Gene: 25858
- Ensembl: ENSG00000219435
- OMIM®: 617511
- UniProtKB/Swiss-Prot: Q9NTU4
Previous HGNC Symbols for CATSPERZ Gene
- C11orf20
- TEX40
Summaries for CATSPERZ Gene
GeneCards Summary for CATSPERZ Gene
CATSPERZ (Catsper Channel Auxiliary Subunit Zeta) is a Protein Coding gene.
UniProtKB/Swiss-Prot Summary for CATSPERZ Gene
-
Auxiliary component of the CatSper complex, a complex involved in sperm cell hyperactivation. Sperm cell hyperactivation is needed for sperm motility which is essential late in the preparation of sperm for fertilization. Required for a distribution of the CatSper complex in linear quadrilateral nanodomains along the flagellum, maximizing fertilization inside the mammalian female reproductive tract. Together with EFCAB9, associates with the CatSper channel pore and is required for the two-row structure of each single CatSper channel.
Additional gene information for CATSPERZ Gene
- HGNC (19231)
- NCBI Entrez Gene (25858)
- Ensembl (ENSG00000219435)
- OMIM® (617511)
- UniProtKB/Swiss-Prot (Q9NTU4)
- Open Targets Platform(ENSG00000219435)
- Search for CATSPERZ at DataMed
- Search for CATSPERZ at HumanCyc
No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for CATSPERZ Gene
Genomics for CATSPERZ Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for CATSPERZ Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around CATSPERZ on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for CATSPERZ
Genomic Locations for CATSPERZ Gene
Latest Assembly
- chr11:64,300,358-64,304,770
- (GRCh38/hg38)
- Size:
- 4,413 bases
- Orientation:
- Plus strand
Previous Assembly
- chr11:64,067,830-64,072,242
- (GRCh37/hg19 by Entrez Gene)
- Size:
- 4,413 bases
- Orientation:
- Plus strand
- chr11:64,067,863-64,072,242
- (GRCh37/hg19 by Ensembl)
- Size:
- 4,380 bases
- Orientation:
- Plus strand
Genomic View for CATSPERZ Gene
Genes around CATSPERZ on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 11q13.1 by HGNC
- 11q13.1 by Entrez Gene
- 11q13.1 by Ensembl
CATSPERZ Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for CATSPERZ Gene
Proteins for CATSPERZ Gene
-
Protein details for CATSPERZ Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q9NTU4-CTSRZ_HUMAN
- Recommended name:
- Cation channel sperm-associated protein subunit zeta
- Protein Accession:
- Q9NTU4
Protein attributes for CATSPERZ Gene
- Size:
- 200 amino acids
- Molecular mass:
- 22839 Da
- Quaternary structure:
-
- Component of the CatSper complex. Interacts with EFCAB9; the interaction is direct, Ca(2+)-dependent and connects EFCAB9 with the CatSper complex. Dissociates from EFCAB9 at elevated pH.
Post-translational modifications for CATSPERZ Gene
Other Protein References for CATSPERZ Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibodies for research
-
Custom Antibody ServicesOriGene Antibodies for CATSPERZ
- Invitrogen Antibodies for CATSPERZ (AFLGC-CATSPERZ)
-
Custom Antibody ServicesProSci Antibodies for CATSPERZ
Protein products for research
-
OriGene Purified Proteins for CATSPERZ
- Search Origene for MassSpec and Protein Over-expression Lysates for CATSPERZ
- Origene Custom Protein Services for CATSPERZ
- antibodies-online: Show 3 available TEX40 Proteins ranked by validation data
- Compare Top TEX40 Proteins
-
Quality Products:
Assay products for research
No data available for DME Specific Peptides for CATSPERZ Gene
Domains & Families for CATSPERZ Gene
Gene Families for CATSPERZ Gene
- Human Protein Atlas (HPA):
-
- Predicted intracellular proteins
No data available for Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for CATSPERZ Gene
Function for CATSPERZ Gene
Molecular function for CATSPERZ Gene
- UniProtKB/Swiss-Prot Function:
- Auxiliary component of the CatSper complex, a complex involved in sperm cell hyperactivation. Sperm cell hyperactivation is needed for sperm motility which is essential late in the preparation of sperm for fertilization. Required for a distribution of the CatSper complex in linear quadrilateral nanodomains along the flagellum, maximizing fertilization inside the mammalian female reproductive tract. Together with EFCAB9, associates with the CatSper channel pore and is required for the two-row structure of each single CatSper channel.
Phenotypes From GWAS Catalog for CATSPERZ Gene
Phenotypes for CATSPERZ Gene
- MGI mutant phenotypes for CATSPERZ:
- inferred from 2 alleles
Animal Models for CATSPERZ Gene
Animal Models for research
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
CRISPR products for research
- Applied Biological Materials (abm): CRISPR Clones for CATSPERZ - Starting at $85 >
- * CATSPERZ CRISPR as ready-to-use vector or virus: Non-viral | Lenti- | Adeno- | AAV- | siRNA - Browse All
- * Cas9 Nucleases, Nickases, Null Mutants, and GFP tag also available.
-
OriGene CRISPR knockouts for CATSPERZ
miRNA products for research
Inhibitory RNAs for research
- Origene shrna, sirna, and RNAi products in human, mouse, rat for CATSPERZ
- Browse OriGene Inhibitory RNA Products For CATSPERZ
Clone products for research
- Applied Biological Materials (abm): Clones for CATSPERZ - Starting at $45 >
- * CATSPERZ as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Retro- | Protein Vector - Browse All
- * Viral Packaging Services and High Titer Production Services also available.
- Sino Biological Human cDNA Clone for CATSPERZ
Cell Lines for research
-
Horizon Cell Lines for CATSPERZ
No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for CATSPERZ Gene
Localization for CATSPERZ Gene
Subcellular locations from UniProtKB/Swiss-Prot for CATSPERZ Gene
- Cell projection, cilium, flagellum membrane. Peripheral membrane protein. Note=Specifically located in the principal piece of sperm tail (PubMed:28226241). Although it does not contain a transmembrane domain, localizes with the CatSper complex at the flagellum membrane (PubMed:28226241). {ECO:0000269 PubMed:28226241}.
| Compartment | Confidence |
|---|---|
| plasma membrane | 4 |
| nucleus | 3 |
| cytosol | 1 |
- Nucleoplasm (2)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005737 | cytoplasm | IDA | -- |
| GO:0005886 | plasma membrane | IEA | -- |
| GO:0005929 | cilium | IEA | -- |
| GO:0016020 | membrane | IEA | -- |
| GO:0031514 | motile cilium | IEA | -- |
Pathways & Interactions for CATSPERZ Gene
Interacting Proteins for CATSPERZ Gene
GPS-Prot Interaction Network for CATSPERZ
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0007140 | male meiotic nuclear division | ISS | -- |
| GO:0007283 | spermatogenesis | ISS | -- |
| GO:0030154 | cell differentiation | IEA | -- |
| GO:0030317 | flagellated sperm motility | IEA,ISS | -- |
| GO:0048240 | sperm capacitation | IEA,ISS | -- |
No data available for Pathways by source and SIGNOR curated interactions for CATSPERZ Gene
Transcripts for CATSPERZ Gene
mRNA/cDNA for CATSPERZ Gene
- 1 REFSEQ mRNAs :
- 1 NCBI additional mRNA sequence :
- 3 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000328404 780 nts (view in UCSC)
- ENST00000535981 392 nts (view in UCSC)
- ENST00000539943 917 nts (view in UCSC)
CRISPR products for research
- Applied Biological Materials (abm): CRISPR Clones for CATSPERZ - Starting at $85 >
- * CATSPERZ CRISPR as ready-to-use vector or virus: Non-viral | Lenti- | Adeno- | AAV- | siRNA - Browse All
- * Cas9 Nucleases, Nickases, Null Mutants, and GFP tag also available.
-
OriGene CRISPR knockouts for CATSPERZ
miRNA products for research
Inhibitory RNAs for research
- Origene shrna, sirna, and RNAi products in human, mouse, rat for CATSPERZ
- Browse OriGene Inhibitory RNA Products For CATSPERZ
Clone products for research
- Applied Biological Materials (abm): Clones for CATSPERZ - Starting at $45 >
- * CATSPERZ as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Retro- | Protein Vector - Browse All
- * Viral Packaging Services and High Titer Production Services also available.
- Sino Biological Human cDNA Clone for CATSPERZ
Relevant External Links for CATSPERZ Gene
- GeneLoc Exon Structure for
- CATSPERZ
Expression for CATSPERZ Gene
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for CATSPERZ
Evidence on tissue expression from TISSUES for CATSPERZ Gene
- Kidney(4.1)
No Expression Related Data Available
Primer products for research
-
OriGene qPCR primer pairs for CATSPERZ
No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for CATSPERZ Gene
Orthologs for CATSPERZ Gene
This gene was present in the common ancestor of mammals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | TEX40 30 31 |
|
OneToOne | |
| Dog (Canis familiaris) |
Mammalia | TEX40 30 |
|
||
| Cow (Bos Taurus) |
Mammalia | TEX40 30 |
|
||
| Mouse (Mus musculus) |
Mammalia | Tex40 30 31 |
|
OneToOne | |
| Catsperz 17 |
|
- Species where no ortholog for CATSPERZ was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Baker's yeast (Saccharomyces cerevisiae)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chicken (Gallus gallus)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Fruit Fly (Drosophila melanogaster)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Lizard (Anolis carolinensis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Oppossum (Monodelphis domestica)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Platypus (Ornithorhynchus anatinus)
- Rainbow Trout (Oncorhynchus mykiss)
- Rat (Rattus norvegicus)
- Rice (Oryza sativa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Vase (Ciona intestinalis)
- Sea Squirt (Ciona savignyi)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Thale Cress (Arabidopsis thaliana)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Tropical Clawed Frog (Silurana tropicalis)
- Wheat (Triticum aestivum)
- Worm (Caenorhabditis elegans)
- Zebrafish (Danio rerio)
Evolution for CATSPERZ Gene
- ENSEMBL:
- Gene Tree for CATSPERZ (if available)
- TreeFam:
- Gene Tree for CATSPERZ (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for CATSPERZ: view image
Paralogs for CATSPERZ Gene
No data available for Paralogs for CATSPERZ Gene
Variants for CATSPERZ Gene
Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for CATSPERZ Gene
| SNP ID | Clinical significance and condition | Chr 11 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs2286614 | - |
p.Pro68Leu |
All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).
Gene Damage Index Score:
3.96;
59.85% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for CATSPERZ Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- CATSPERZ
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CATSPERZ Gene
Disorders for CATSPERZ Gene
Additional Disease Information for CATSPERZ
- Atlas
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
- Open Targets Platform
- Open Targets Platform
No disorders were found for CATSPERZ Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CATSPERZ Gene
Publications for CATSPERZ Gene
- CatSperζ regulates the structural continuity of sperm Ca2+ signaling domains and is required for normal fertility. (PMID: 28226241) Chung JJ … Clapham DE (eLife 2017) 2 3 4
- Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PMID: 11230166) Wiemann S … Poustka A (Genome research 2001) 3 4
- Proteomic analyses reveal lower expression of TEX40 and ATP6V0A2 proteins related to calcium ion entry and acrosomal acidification in asthenozoospermic males. (PMID: 30550884) Sinha A … Yadav S (Life sciences 2019) 3
- Low frequency of ESRRA-C11orf20 fusion gene in ovarian carcinomas. (PMID: 24504521) Micci F … Heim S (PLoS biology 2014) 3
- Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. (PMID: 21873635) Gaudet P … Thomas PD (Briefings in bioinformatics 2011) 3
ExternalLinks
Products for CATSPERZ Gene
- Custom Antibody ServicesOriGene Antibodies for CATSPERZ
- Browse OriGene ELISA Kits
- Custom Assay Services
- OriGene Purified Proteins for CATSPERZ
- Search Origene for MassSpec and Protein Over-expression Lysates for CATSPERZ
- Origene Custom Protein Services for CATSPERZ
- Origene shrna, sirna, and RNAi products in human, mouse, rat for CATSPERZ
- Browse OriGene Inhibitory RNA Products For CATSPERZ
- OriGene qPCR primer pairs for CATSPERZ
- OriGene CRISPR knockouts for CATSPERZ
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For CATSPERZ
- Sino Biological Human cDNA Clone for CATSPERZ
- Browse Sino Biological Recombinant Proteins
- Browse Sino Biological Cell Lysates
- Browse Sino Biological Antibodies
- Browse Sino Biological Assays
- Browse cDNA Clones
- Browse ELISA Kits
- Browse CRO Services
- High-throughput Antibody Production Service
- Protein Production Service
- Epitope Tag Antibodies & Reporter Protein Antibodies
- Lentiviral ORF Clones
- Invitrogen Antibodies for CATSPERZ (AFLGC-CATSPERZ)
- VectorBuilder Custom and pre-made DNA vectors for CATSPERZ (ie. gene expression, shRNA knockdown, CRISPR)
- VectorBuilder Viral vectors for CATSPERZ (ie. lentivirus, AAV, adenovirus)
- VectorBuilder CRISPR vectors for CATSPERZ (ie. knockout, knockin, CRISPRa, CRISPRi)
- VectorBuilder Virus packaging for CATSPERZ CRISPR vectors (ie. lentivirus, AAV, adenovirus)
- VectorBuilder Stable cell line generation for CATSPERZ
- antibodies-online: Show 20 available TEX40 Antibodies ranked by validation data
- Compare Top TEX40 Antibodies
- antibodies-online: Search results for available TEX40 related products ranked by validation data
- antibodies-online: Show 3 available TEX40 Proteins ranked by validation data
- Compare Top TEX40 Proteins
- Quality Products:
- Custom Antibody ServicesProSci Antibodies for CATSPERZ
- Search for CATSPERZ Proteins at ProSci
- Horizon Cell Lines for CATSPERZ
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for knockout CRISPR/Cas9 clones, lentivirus, and/or AAV products for CATSPERZ
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles, and/or promoter clone products for CATSPERZ
- Search GeneCopoeia for miRNA 3'UTR Target clone products for CATSPERZ
- Search GeneCopoeia for shRNA, lentivirus, and/or AAV clone products for CATSPERZ
Sources for CATSPERZ Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM® (Updated: 05-Mar-2021)
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) UniProtKB/TrEMBL
- (14) InterPro
- (15) ProtoNet
- (16) Blocks
- (17) MGI
- (18) IUBMB
- (19) KEGG
- (20) MINT
- (21) STRING
- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) ASD
- (28) SAGE
- (29) SOURCE
- (30) HomoloGene
- (31) PanEnsembl
- (32) euGenes
- (33) SGD
- (34) FlyBase
- (35) WormBase
- (36) Pseudogene
- (37) DGV
- (38) dbSNP
- (39) GenAtlas
- (40) HGMD
- (41) GAD
- (42) BGMUT
- (43) HuGE
- (44) Atlas
- (45) GenBank
- (46) HORDE
- (47) HUGE
- (48) IMGT
- (49) Leiden
- (50) miRBase
- (51) DME
- (52) OriGene
- (53) PubMed
- (54) R&D Systems
- (55) TGDB
- (56) Tocris
- (57) Abcam
- (58) Novus Biologicals
- (59) ProSpec
- (60) Sino Biological
- (61) GenScript
- (62) Qiagen
- (63) OCA
- (64) Proteopedia
- (65) MOPED
- (66) neXtProt
- (67) Reactome
- (68) GeneGo (Thomson Reuters)
- (69) DISEASES
- (70) SIMAP
- (71) GenomeRNAi
- (72) LifeMap
- (73) miRTarBase
- (74) MalaCards
- (75) Invitrogen
- (76) BitterDB
- (77) ESI-BIO
- (78) RefSeq
- (79) BioSystems
- (80) MaxQB
- (81) IUPHAR
- (82) BioGPS
- (83) Illumina
- (84) COMPARTMENTS
- (85) HOMER
- (86) PaxDb
- (87) ApexBio
- (88) Addgene
- (89) antibodies-online
- (90) CYP
- (91) NONCODE
- (92) TreeFam
- (93) PathCards
- (94) GeneReviews
- (95) GeneTex
- (96) Taconic Biosciences
- (97) GTEx
- (98) ProteomicsDB
- (99) SCBT
- (100) DGIdb
- (101) ClinicalTrials
- (102) RVIS
- (103) SIGNOR
- (104) diseasecard
- (105) NIH Rare Diseases
- (106) Orphanet
- (107) UMLS
- (108) GTR
- (109) Disease Ontology
- (110) MedlinePlus Genetics
- (111) MeSH
- (112) MedlinePlus
- (113) CDC
- (114) NINDS
- (115) NCBI Bookshelf
- (116) ClinVar
- (117) Gene Damage Index
- (118) HPO
- (119) UDN
- (120) VISTA
- (121) FANTOM5
- (122) ENCODE
- (123) ProSci
- (124) Horizon
- (125) The Signaling Pathways Project (SPP)
- (126) IID
- (127) VectorBuilder
- (128) SNPedia
- (129) BRCA Exchange
- (130) CIViC
- (131) ProteoGenix
- (132) dbSUPER
- (133) TISSUES
- (134) Gene ORGANizer
- (135) abm
- (136) Human Protein Atlas
- (137) GWAS Catalog
- (138) Monarch Initiative
- (139) DataMed
- (140) HumanCyc
- (141) UCNEbase
- (142) EPDnew
- (143) Applied Biosystems
- (144) GlyConnect
- (145) Aminode
- (146) GeneCopoeia
- (147) GPS-Prot
- (148) RNAcentral
- (149) LncRNADisease
- (150) LOVD
- (151) miR2Disease
- (152) DiseaseEnhancer
- (153) Boster Bio
- (154) Biorbyt
- (155) Biocompare
- (156) Mastermind
- (157) CTD^2 Dashboard
- (158) CraniofacialAtlas
- (159) GeneImprint
- (160) Synthego
- (161) ENA
- (162) GtRNAdb
- (163) LncBase
- (164) LncBook
- (165) LNCipedia
- (166) Modomics
- (167) PDBe
- (168) Rfam
- (169) SILVA
- (170) snOPY
- (171) SRPDB
- (172) GENCODE
- (173) TarBase
- (174) Open Targets Platform
- (175) 5SRRNADB
- (176) snoDB
- (177) MirGeneDB