Aliases for CATSPERZ Gene

Aliases for CATSPERZ Gene

  • Catsper Channel Auxiliary Subunit Zeta 2 3 5
  • Cation Channel Sperm-Associated Protein Subunit Zeta 3 4
  • Testis-Expressed Protein 40 3 4
  • Testis Expressed 40 2 3
  • CatSper-Zeta 3 4
  • CatSperzeta 3 4
  • C11orf20 3 4
  • TEX40 3 4
  • Testis-Expressed Sequence 40 Protein 3
  • Chromosome 11 Open Reading Frame 20 2

External Ids for CATSPERZ Gene

Previous HGNC Symbols for CATSPERZ Gene

  • C11orf20
  • TEX40

Summaries for CATSPERZ Gene

GeneCards Summary for CATSPERZ Gene

CATSPERZ (Catsper Channel Auxiliary Subunit Zeta) is a Protein Coding gene.

UniProtKB/Swiss-Prot Summary for CATSPERZ Gene

  • Auxiliary component of the CatSper complex, a complex involved in sperm cell hyperactivation. Sperm cell hyperactivation is needed for sperm motility which is essential late in the preparation of sperm for fertilization. Required for a distribution of the CatSper complex in linear quadrilateral nanodomains along the flagellum, maximizing fertilization inside the mammalian female reproductive tract. Together with EFCAB9, associates with the CatSper channel pore and is required for the two-row structure of each single CatSper channel.

Additional gene information for CATSPERZ Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for CATSPERZ Gene

Genomics for CATSPERZ Gene

GeneHancer (GH) Regulatory Elements for CATSPERZ Gene

Promoters and enhancers for CATSPERZ Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH11J064282 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 750.4 -15.2 -15189 4.5 SIN3A ZNF24 ZBTB40 SP1 CTCF SIX5 POLR2A ATF1 CREB1 HCFC1 BAD lnc-BAD-1 CATSPERZ GPR137 SF1 POLA2 ENSG00000236935 IMMP1LP1 PLCB3 SYVN1
GH11J064300 Promoter/Enhancer 1.6 EPDnew Ensembl ENCODE 750.6 +1.3 1343 3 CTCF ZNF362 MYC CC2D1A L3MBTL2 MAX RAD21 NFIB GTF2F1 ZNF384 CATSPERZ piR-46887 PLCB3 SF1 POLA2 ZFPL1 NAALADL1 ENSG00000231680 lnc-TRMT112-4 ENSG00000257069
GH11J064291 Promoter 1 EPDnew Ensembl 750.4 -8.2 -8158 1.2 CTCF POLR2A EZH2 DPF2 ZFHX2 BCL6 ENSG00000257069 KCNK4 KCNK4-TEX40-001 CATSPERZ TRMT112 ENSG00000207024
GH11J064299 Promoter/Enhancer 0.7 Ensembl ENCODE 750.6 -0.8 -757 0.8 CTCF EZH2 RNF2 CATSPERZ piR-46887 TRMT112 KY994054-004 ENSG00000257069 KCNK4 KCNK4-TEX40-001
GH11J064205 Promoter/Enhancer 2 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 11.5 -92.8 -92763 4.4 ZBTB40 SP1 ZBTB6 SMARCE1 POLR2A MYC ETV6 ELF1 RELA L3MBTL2 FERMT3 TRPT1 PLCB3 ZFPL1 SF1 SYVN1 IMMP1LP1 FAU ENSG00000257086 GPR137
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around CATSPERZ on UCSC Golden Path with GeneCards custom track

Genomic Locations for CATSPERZ Gene

Genomic Locations for CATSPERZ Gene
chr11:64,300,358-64,304,770
(GRCh38/hg38)
Size:
4,413 bases
Orientation:
Plus strand
chr11:64,067,863-64,072,242
(GRCh37/hg19)
Size:
4,380 bases
Orientation:
Plus strand

Genomic View for CATSPERZ Gene

Genes around CATSPERZ on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CATSPERZ Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CATSPERZ Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CATSPERZ Gene

Proteins for CATSPERZ Gene

  • Protein details for CATSPERZ Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NTU4-CTSRZ_HUMAN
    Recommended name:
    Cation channel sperm-associated protein subunit zeta
    Protein Accession:
    Q9NTU4

    Protein attributes for CATSPERZ Gene

    Size:
    200 amino acids
    Molecular mass:
    22839 Da
    Quaternary structure:
    • Component of the CatSper complex. Interacts with EFCAB9; the interaction is direct, Ca(2+)-dependent and connects EFCAB9 with the CatSper complex. Dissociates from EFCAB9 at elevated pH.

neXtProt entry for CATSPERZ Gene

Post-translational modifications for CATSPERZ Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CATSPERZ Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for CATSPERZ Gene

Domains & Families for CATSPERZ Gene

Gene Families for CATSPERZ Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for CATSPERZ Gene

InterPro:
ProtoNet:
genes like me logo Genes that share domains with CATSPERZ: view

No data available for Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for CATSPERZ Gene

Function for CATSPERZ Gene

Molecular function for CATSPERZ Gene

UniProtKB/Swiss-Prot Function:
Auxiliary component of the CatSper complex, a complex involved in sperm cell hyperactivation. Sperm cell hyperactivation is needed for sperm motility which is essential late in the preparation of sperm for fertilization. Required for a distribution of the CatSper complex in linear quadrilateral nanodomains along the flagellum, maximizing fertilization inside the mammalian female reproductive tract. Together with EFCAB9, associates with the CatSper channel pore and is required for the two-row structure of each single CatSper channel.

Phenotypes From GWAS Catalog for CATSPERZ Gene

Phenotypes for CATSPERZ Gene

genes like me logo Genes that share phenotypes with CATSPERZ: view

Animal Models for CATSPERZ Gene

MGI Knock Outs for CATSPERZ:

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for CATSPERZ Gene

Localization for CATSPERZ Gene

Subcellular locations from UniProtKB/Swiss-Prot for CATSPERZ Gene

Cell projection, cilium, flagellum membrane; Peripheral membrane protein. Note=Specifically located in the principal piece of sperm tail (PubMed:28226241). Although it does not contain a transmembrane domain, localizes with the CatSper complex at the flagellum membrane (PubMed:28226241). {ECO:0000269 PubMed:28226241}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CATSPERZ gene
Compartment Confidence
plasma membrane 4
nucleus 3
cytosol 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for CATSPERZ Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA --
GO:0005886 plasma membrane IEA --
GO:0005929 cilium IEA --
GO:0016020 membrane IEA --
GO:0031514 motile cilium IEA --
genes like me logo Genes that share ontologies with CATSPERZ: view

Pathways & Interactions for CATSPERZ Gene

PathCards logo

SuperPathways for CATSPERZ Gene

No Data Available

Interacting Proteins for CATSPERZ Gene

STRING Interaction Network Preview (showing top 5 STRING interactants - click image to see top 25)
STRING Interaction Network
Selected Interacting proteins: ENSP00000443917 Q9NTU4-CTSRZ_HUMAN for CATSPERZ Gene via STRING IID

Gene Ontology (GO) - Biological Process for CATSPERZ Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007140 male meiotic nuclear division ISS --
GO:0007283 spermatogenesis ISS --
GO:0030154 cell differentiation IEA --
GO:0030317 flagellated sperm motility IEA,ISS --
GO:0048240 sperm capacitation IEA,ISS --
genes like me logo Genes that share ontologies with CATSPERZ: view

No data available for Pathways by source and SIGNOR curated interactions for CATSPERZ Gene

Drugs & Compounds for CATSPERZ Gene

No Compound Related Data Available

Transcripts for CATSPERZ Gene

mRNA/cDNA for CATSPERZ Gene

(1) REFSEQ mRNAs :
(1) Additional mRNA sequences :
(3) Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Alternative Splicing Database (ASD) splice patterns (SP) for CATSPERZ Gene

No ASD Table

Relevant External Links for CATSPERZ Gene

GeneLoc Exon Structure for
CATSPERZ
ECgene alternative splicing isoforms for
CATSPERZ

Expression for CATSPERZ Gene

NURSA nuclear receptor signaling pathways regulating expression of CATSPERZ Gene:

CATSPERZ

Evidence on tissue expression from TISSUES for CATSPERZ Gene

  • Kidney(4.1)
No Expression Related Data Available

Primer Products

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for CATSPERZ Gene

Orthologs for CATSPERZ Gene

This gene was present in the common ancestor of mammals.

Orthologs for CATSPERZ Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TEX40 33 32
  • 99.5 (n)
OneToOne
dog
(Canis familiaris)
Mammalia TEX40 32
  • 77.15 (n)
cow
(Bos Taurus)
Mammalia TEX40 32
  • 71.6 (n)
mouse
(Mus musculus)
Mammalia Tex40 33 32
  • 65.43 (n)
OneToOne
Catsperz 17
Species where no ortholog for CATSPERZ was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for CATSPERZ Gene

ENSEMBL:
Gene Tree for CATSPERZ (if available)
TreeFam:
Gene Tree for CATSPERZ (if available)
Aminode:
Evolutionary constrained regions (ECRs) for CATSPERZ: view image

Paralogs for CATSPERZ Gene

No data available for Paralogs for CATSPERZ Gene

Variants for CATSPERZ Gene

Sequence variations from dbSNP and Humsavar for CATSPERZ Gene

SNP ID Clin Chr 11 pos Variation AA Info Type
rs1001840955 -- 64,304,310(+) C/T intron_variant
rs1001907775 -- 64,299,628(+) C/G upstream_transcript_variant
rs1002963449 -- 64,299,254(+) G/A upstream_transcript_variant
rs1003444081 -- 64,302,908(+) G/T intron_variant
rs1003496263 -- 64,299,053(+) A/G upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for CATSPERZ Gene

Variant ID Type Subtype PubMed ID
dgv1963n54 CNV loss 21841781
nsv357 CNV insertion 18451855
nsv469961 CNV loss 18288195
nsv832186 CNV loss 17160897
nsv951010 CNV deletion 24416366

Variation tolerance for CATSPERZ Gene

Gene Damage Index Score: 3.96; 59.85% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CATSPERZ Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CATSPERZ

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CATSPERZ Gene

Disorders for CATSPERZ Gene

Additional Disease Information for CATSPERZ

No disorders were found for CATSPERZ Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CATSPERZ Gene

Publications for CATSPERZ Gene

  1. CatSperζ regulates the structural continuity of sperm Ca2+ signaling domains and is required for normal fertility. (PMID: 28226241) Chung JJ … Clapham DE (eLife 2017) 2 3 4 56
  2. Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PMID: 11230166) Wiemann S … Poustka A (Genome research 2001) 3 4 56
  3. Proteomic analyses reveal lower expression of TEX40 and ATP6V0A2 proteins related to calcium ion entry and acrosomal acidification in asthenozoospermic males. (PMID: 30550884) Sinha A … Yadav S (Life sciences 2019) 3 56
  4. Low frequency of ESRRA-C11orf20 fusion gene in ovarian carcinomas. (PMID: 24504521) Micci F … Heim S (PLoS biology 2014) 3 56
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. (PMID: 21873635) Gaudet P … Thomas PD (Briefings in bioinformatics 2011) 3 56

Products for CATSPERZ Gene

Sources for CATSPERZ Gene