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Aliases for CATSPERG Gene

Aliases for CATSPERG Gene

  • Cation Channel Sperm Associated Auxiliary Subunit Gamma 2 3 5
  • Cation Channel Sperm-Associated Protein Subunit Gamma 3 4
  • Catsper Channel Auxiliary Subunit Gamma 2 3
  • C19orf15 3 4
  • Cation Channel, Sperm-Associated, Gamma 2
  • Chromosome 19 Open Reading Frame 15 2

External Ids for CATSPERG Gene

Previous HGNC Symbols for CATSPERG Gene

  • C19orf15

Previous GeneCards Identifiers for CATSPERG Gene

  • GC19P043521
  • GC19P038826
  • GC19P035274

Summaries for CATSPERG Gene

Entrez Gene Summary for CATSPERG Gene

  • CATSPERG is a subunit of the CATSPER (see CATSPER1; MIM 606389) sperm calcium channel, which is required for sperm hyperactivated motility and male fertility (Wang et al., 2009 [PubMed 19516020]).[supplied by OMIM, Jul 2010]

GeneCards Summary for CATSPERG Gene

CATSPERG (Cation Channel Sperm Associated Auxiliary Subunit Gamma) is a Protein Coding gene. Among its related pathways are Fertilization.

UniProtKB/Swiss-Prot for CATSPERG Gene

  • Probably involved in sperm cell hyperactivation via its association with CATSPER1. Sperm cell hyperactivation is needed for sperm motility which is essential late in the preparation of sperm for fertilization.

Additional gene information for CATSPERG Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CATSPERG Gene

Genomics for CATSPERG Gene

GeneHancer (GH) Regulatory Elements for CATSPERG Gene

Promoters and enhancers for CATSPERG Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH19J038336 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 620.8 +0.7 724 2.6 HDGF ZNF652 SP1 CC2D1A CTCF ELF3 MNT SIX5 MLLT1 ZNF121 CATSPERG HNRNPL ZNF527 ZNF571 ZFP30 ZNF573 ZNF793 ZNF607 ENSG00000269688 C19orf33
GH19J038337 Enhancer 0.5 ENCODE 600.7 -0.6 -629 0 ZNF138 ZNF18 ZNF335 LARP7 ZNF416 ZNF493 CATSPERG ZFP30 ZNF793 ZNF607 ZNF573 ZNF527 ZNF781 ZNF540 ENSG00000267152 GC19P038332
GH19J038335 Enhancer 0.4 ENCODE 600.7 -0.7 -749 0 ZNF138 ZNF493 CATSPERG ZNF793 ZNF607 ZFP30 ZNF527 ZNF781 ZNF540 ENSG00000267152 GC19P038332
GH19J038262 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE dbSUPER 24.8 -69.9 -69909 6.7 SP1 ELF3 CBFA2T2 MLLT1 ZNF121 ZNF384 ZSCAN21 MAFK YY1 SP7 C19orf33 SPINT2 PIR58569 HNRNPL ZNF571 ZNF875 ZFP30 ZNF527 CATSPERG ZNF607
GH19J038312 Promoter/Enhancer 2.6 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 19.7 -18.2 -18155 9.9 SP1 ZFX CC2D1A CBFA2T2 NKRF MLLT1 ZNF121 CEBPG GTF2F1 CSDE1 KCNK6 YIF1B HNRNPL C19orf33 ZNF527 ZNF571 ZNF573 ZFP30 ENSG00000269688 ZNF607
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around CATSPERG on UCSC Golden Path with GeneCards custom track

Genomic Locations for CATSPERG Gene

Genomic Locations for CATSPERG Gene
chr19:38,335,775-38,370,949
(GRCh38/hg38)
Size:
35,175 bases
Orientation:
Plus strand
chr19:38,826,415-38,861,589
(GRCh37/hg19)
Size:
35,175 bases
Orientation:
Plus strand

Genomic View for CATSPERG Gene

Genes around CATSPERG on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CATSPERG Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CATSPERG Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CATSPERG Gene

Proteins for CATSPERG Gene

  • Protein details for CATSPERG Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6ZRH7-CTSRG_HUMAN
    Recommended name:
    Cation channel sperm-associated protein subunit gamma
    Protein Accession:
    Q6ZRH7
    Secondary Accessions:
    • A6NEG6
    • Q659E1

    Protein attributes for CATSPERG Gene

    Size:
    1159 amino acids
    Molecular mass:
    133032 Da
    Quaternary structure:
    • Component of the CatSper complex.
    SequenceCaution:
    • Sequence=BAC87333.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for CATSPERG Gene

Post-translational modifications for CATSPERG Gene

  • Glycosylation at isoforms=355 and isoforms=426
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for CATSPERG Gene

Domains & Families for CATSPERG Gene

Gene Families for CATSPERG Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted membrane proteins
  • Predicted secreted proteins
  • Transporters

Protein Domains for CATSPERG Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for CATSPERG Gene

GenScript: Design optimal peptide antigens:
  • Cation channel sperm-associated protein subunit gamma (CTSRG_HUMAN)
  • C19orf15 protein (Q32MQ2_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q6ZRH7

UniProtKB/Swiss-Prot:

CTSRG_HUMAN :
  • Belongs to the CATSPERG family.
Family:
  • Belongs to the CATSPERG family.
genes like me logo Genes that share domains with CATSPERG: view

Function for CATSPERG Gene

Molecular function for CATSPERG Gene

UniProtKB/Swiss-Prot Function:
Probably involved in sperm cell hyperactivation via its association with CATSPER1. Sperm cell hyperactivation is needed for sperm motility which is essential late in the preparation of sperm for fertilization.

Phenotypes From GWAS Catalog for CATSPERG Gene

genes like me logo Genes that share phenotypes with CATSPERG: view

Animal Model Products

CRISPR Products

miRNA for CATSPERG Gene

miRTarBase miRNAs that target CATSPERG

Clone Products

  • Applied Biological Materials (abm): Clones for CATSPERG - Now 50% OFF >
  • * CATSPERG as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
  • * CATSPERG tags and reporters available: His, HA, Myc, Flag, GFP, RFP, Luciferase - Browse All

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CATSPERG Gene

Localization for CATSPERG Gene

Subcellular locations from UniProtKB/Swiss-Prot for CATSPERG Gene

Membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CATSPERG gene
Compartment Confidence
plasma membrane 4

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Nucleoli (2)
  • Nucleus (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for CATSPERG Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
GO:0031514 motile cilium IBA 21873635
GO:0036128 CatSper complex ISS,IEA --
genes like me logo Genes that share ontologies with CATSPERG: view

Pathways & Interactions for CATSPERG Gene

PathCards logo

SuperPathways for CATSPERG Gene

SuperPathway Contained pathways
1 Fertilization
genes like me logo Genes that share pathways with CATSPERG: view

Pathways by source for CATSPERG Gene

3 Reactome pathways for CATSPERG Gene

Interacting Proteins for CATSPERG Gene

Gene Ontology (GO) - Biological Process for CATSPERG Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007275 multicellular organism development IEA --
GO:0007283 spermatogenesis IEA --
GO:0030154 cell differentiation IEA --
GO:0032570 response to progesterone TAS --
GO:0035036 sperm-egg recognition TAS --
genes like me logo Genes that share ontologies with CATSPERG: view

No data available for SIGNOR curated interactions for CATSPERG Gene

Drugs & Compounds for CATSPERG Gene

No Compound Related Data Available

Transcripts for CATSPERG Gene

mRNA/cDNA for CATSPERG Gene

Unigene Clusters for CATSPERG Gene

Catsper channel auxiliary subunit gamma:
Representative Sequences:

CRISPR Products

Clone Products

  • Applied Biological Materials (abm): Clones for CATSPERG - Now 50% OFF >
  • * CATSPERG as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
  • * CATSPERG tags and reporters available: His, HA, Myc, Flag, GFP, RFP, Luciferase - Browse All

Alternative Splicing Database (ASD) splice patterns (SP) for CATSPERG Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b · 6c ^ 7 ^ 8a · 8b · 8c ^ 9 ^ 10a · 10b ^ 11 ^ 12 ^ 13 ^ 14a · 14b ^ 15 ^ 16a · 16b ^
SP1: - - - - - - - -
SP2: - - - - - - -
SP3: - - - -
SP4: - - - - - -
SP5: - - - - -
SP6:
SP7:
SP8:
SP9: -
SP10:

ExUns: 17 ^ 18 ^ 19a · 19b ^ 20 ^ 21 ^ 22 ^ 23 ^ 24a · 24b ^ 25a · 25b ^ 26 ^ 27 ^ 28 ^ 29a · 29b ^ 30 ^ 31a · 31b
SP1: - - -
SP2: - -
SP3: - - -
SP4:
SP5:
SP6: -
SP7:
SP8:
SP9:
SP10:

Relevant External Links for CATSPERG Gene

GeneLoc Exon Structure for
CATSPERG
ECgene alternative splicing isoforms for
CATSPERG

Expression for CATSPERG Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CATSPERG Gene

mRNA differential expression in normal tissues according to GTEx for CATSPERG Gene

This gene is overexpressed in Testis (x25.7).

Protein differential expression in normal tissues from HIPED for CATSPERG Gene

This gene is overexpressed in Spinal cord (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for CATSPERG Gene



Protein tissue co-expression partners for CATSPERG Gene

NURSA nuclear receptor signaling pathways regulating expression of CATSPERG Gene:

CATSPERG

SOURCE GeneReport for Unigene cluster for CATSPERG Gene:

Hs.324335
genes like me logo Genes that share expression patterns with CATSPERG: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for CATSPERG Gene

Orthologs for CATSPERG Gene

This gene was present in the common ancestor of chordates.

Orthologs for CATSPERG Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CATSPERG 35 34
  • 99.29 (n)
OneToOne
dog
(Canis familiaris)
Mammalia CATSPERG 35 34
  • 81.72 (n)
OneToOne
cow
(Bos Taurus)
Mammalia CATSPERG 35 34
  • 81.2 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Catsperg1 35 34
  • 67.83 (n)
OneToMany
Catsperg2 17 35
  • 55 (a)
rat
(Rattus norvegicus)
Mammalia Catsperg1 34
  • 66.93 (n)
oppossum
(Monodelphis domestica)
Mammalia CATSPERG 35
  • 51 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CATSPERG 35
  • 48 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia -- 35
  • 43 (a)
OneToMany
-- 35
  • 41 (a)
OneToMany
-- 35
  • 41 (a)
OneToMany
Species where no ortholog for CATSPERG was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for CATSPERG Gene

ENSEMBL:
Gene Tree for CATSPERG (if available)
TreeFam:
Gene Tree for CATSPERG (if available)
Aminode:
Evolutionary constrained regions (ECRs) for CATSPERG: view image

Paralogs for CATSPERG Gene

(50) SIMAP similar genes for CATSPERG Gene using alignment to 7 proteins:

  • CTSRG_HUMAN
  • B8ZZI7_HUMAN
  • F8WDD6_HUMAN
  • H9KV36_HUMAN
  • K7EQR6_HUMAN
  • K7EQY4_HUMAN
  • M0QZ16_HUMAN
genes like me logo Genes that share paralogs with CATSPERG: view

No data available for Paralogs for CATSPERG Gene

Variants for CATSPERG Gene

Sequence variations from dbSNP and Humsavar for CATSPERG Gene

SNP ID Clin Chr 19 pos Variation AA Info Type
rs1000060846 -- 38,352,453(+) C/A genic_upstream_transcript_variant, intron_variant
rs1000138922 -- 38,340,897(+) G/C/T genic_upstream_transcript_variant, intron_variant
rs1000171924 -- 38,355,368(+) A/C genic_upstream_transcript_variant, intron_variant
rs1000203160 -- 38,355,779(+) C/T genic_upstream_transcript_variant, intron_variant
rs1000409973 -- 38,361,470(+) G/A intron_variant

Structural Variations from Database of Genomic Variants (DGV) for CATSPERG Gene

Variant ID Type Subtype PubMed ID
esv22727 CNV loss 19812545
esv2718532 CNV deletion 23290073
nsv1064275 CNV loss 25217958
nsv1152248 CNV deletion 26484159
nsv470140 CNV gain 18288195
nsv833822 CNV loss 17160897
nsv833823 CNV loss 17160897
nsv953296 CNV deletion 24416366

Variation tolerance for CATSPERG Gene

Residual Variation Intolerance Score: 11.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.74; 66.44% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CATSPERG Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CATSPERG

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CATSPERG Gene

Disorders for CATSPERG Gene

Additional Disease Information for CATSPERG

No disorders were found for CATSPERG Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CATSPERG Gene

Publications for CATSPERG Gene

  1. A novel, single, transmembrane protein CATSPERG is associated with CATSPER1 channel protein. (PMID: 19516020) Wang H … Ren D (Biology of reproduction 2009) 2 3 58
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  3. Genome-wide CRISPR screen identifies HNRNPL as a prostate cancer dependency regulating RNA splicing. (PMID: 28611215) Fei T … Brown M (Proceedings of the National Academy of Sciences of the United States of America 2017) 3 58
  4. Charting the landscape of tandem BRCT domain-mediated protein interactions. (PMID: 22990118) Woods NT … Monteiro AN (Science signaling 2012) 3 58
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. (PMID: 21873635) Gaudet P … Thomas PD (Briefings in bioinformatics 2011) 3 58

Products for CATSPERG Gene

Sources for CATSPERG Gene

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