CATSPERG is a subunit of the CATSPER (see CATSPER1; MIM 606389) sperm calcium channel, which is required for sperm hyperactivated motility and male fertility (Wang et al., 2009 [PubMed 19516020]).[supplied by OMIM, Jul 2010] See more...

Aliases for CATSPERG Gene

Aliases for CATSPERG Gene

  • Cation Channel Sperm Associated Auxiliary Subunit Gamma 2 3 5
  • Cation Channel Sperm-Associated Protein Subunit Gamma 3 4
  • Catsper Channel Auxiliary Subunit Gamma 2 3
  • C19orf15 3 4
  • Cation Channel, Sperm-Associated, Gamma 2
  • Chromosome 19 Open Reading Frame 15 2

External Ids for CATSPERG Gene

Previous HGNC Symbols for CATSPERG Gene

  • C19orf15

Previous GeneCards Identifiers for CATSPERG Gene

  • GC19P043521
  • GC19P038826
  • GC19P035274

Summaries for CATSPERG Gene

Entrez Gene Summary for CATSPERG Gene

  • CATSPERG is a subunit of the CATSPER (see CATSPER1; MIM 606389) sperm calcium channel, which is required for sperm hyperactivated motility and male fertility (Wang et al., 2009 [PubMed 19516020]).[supplied by OMIM, Jul 2010]

GeneCards Summary for CATSPERG Gene

CATSPERG (Cation Channel Sperm Associated Auxiliary Subunit Gamma) is a Protein Coding gene. Among its related pathways are Fertilization.

UniProtKB/Swiss-Prot Summary for CATSPERG Gene

  • Probably involved in sperm cell hyperactivation via its association with CATSPER1. Sperm cell hyperactivation is needed for sperm motility which is essential late in the preparation of sperm for fertilization.

Additional gene information for CATSPERG Gene

No data available for CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for CATSPERG Gene

Genomics for CATSPERG Gene

GeneHancer (GH) Regulatory Elements for CATSPERG Gene

Promoters and enhancers for CATSPERG Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH19J038336 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE CraniofacialAtlas 520.8 +0.7 724 2.6 ZBTB40 ZNF217 CTCF SIN3A NRF1 TCF12 USF1 SP1 BCLAF1 RBAK CATSPERG HNRNPL ZNF527 ZFP30 ZNF571 ZNF573 C19orf33 ZNF607 ZNF540 ZNF793
GH19J038337 Enhancer 0.5 ENCODE 500.7 -0.6 -629 0 ZNF335 ZNF18 ZNF416 LARP7 ZNF493 ZNF138 CATSPERG ZFP30 ZNF793 ZNF607 ZNF573 ZNF527 ZNF781 ZNF540 ENSG00000267152 lnc-KCNK6-1
GH19J038335 Enhancer 0.3 ENCODE 500.7 -0.7 -749 0 ZNF493 ZNF138 CATSPERG ZNF793 ZNF607 ZFP30 ZNF527 ZNF781 ZNF540 ENSG00000267152 lnc-KCNK6-1
GH19J038262 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 24.8 -69.9 -69909 6.7 ZNF217 EP300 NRF1 TCF12 USF1 RBAK PHF8 FOS ZFX ZNF639 C19orf33 SPINT2 piR-35524 ZNF527 ZNF571 ZFP30 ZNF875 HNRNPL CATSPERG ZNF607
GH19J038312 Promoter/Enhancer 2.7 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 19.7 -18.2 -18155 9.9 HNRNPK ZNF217 NRF1 TCF12 POLR2G USF1 SP1 PHF8 PHB2 ZNF639 KCNK6 YIF1B C19orf33 ZNF527 ZNF573 ZNF571 CATSPERG ZFP30 SPINT2 ZNF540
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around CATSPERG on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for CATSPERG

Genomic Locations for CATSPERG Gene

Genomic Locations for CATSPERG Gene
chr19:38,335,775-38,370,949
(GRCh38/hg38)
Size:
35,175 bases
Orientation:
Plus strand
chr19:38,826,415-38,861,589
(GRCh37/hg19)
Size:
35,175 bases
Orientation:
Plus strand

Genomic View for CATSPERG Gene

Genes around CATSPERG on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CATSPERG Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CATSPERG Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CATSPERG Gene

Proteins for CATSPERG Gene

  • Protein details for CATSPERG Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6ZRH7-CTSRG_HUMAN
    Recommended name:
    Cation channel sperm-associated protein subunit gamma
    Protein Accession:
    Q6ZRH7
    Secondary Accessions:
    • A6NEG6
    • Q659E1

    Protein attributes for CATSPERG Gene

    Size:
    1159 amino acids
    Molecular mass:
    133032 Da
    Quaternary structure:
    • Component of the CatSper complex.
    SequenceCaution:
    • Sequence=BAC87333.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for CATSPERG Gene

Post-translational modifications for CATSPERG Gene

  • Glycosylation at Asn355 and Asn426
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for CATSPERG Gene

Domains & Families for CATSPERG Gene

Gene Families for CATSPERG Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted membrane proteins
  • Predicted secreted proteins
  • Transporters

Protein Domains for CATSPERG Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for CATSPERG Gene

GenScript: Design optimal peptide antigens:
  • Cation channel sperm-associated protein subunit gamma (CTSRG_HUMAN)
  • C19orf15 protein (Q32MQ2_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q6ZRH7

UniProtKB/Swiss-Prot:

CTSRG_HUMAN :
  • Belongs to the CATSPERG family.
Family:
  • Belongs to the CATSPERG family.
genes like me logo Genes that share domains with CATSPERG: view

Function for CATSPERG Gene

Molecular function for CATSPERG Gene

UniProtKB/Swiss-Prot Function:
Probably involved in sperm cell hyperactivation via its association with CATSPER1. Sperm cell hyperactivation is needed for sperm motility which is essential late in the preparation of sperm for fertilization.

Phenotypes From GWAS Catalog for CATSPERG Gene

genes like me logo Genes that share phenotypes with CATSPERG: view

miRNA for CATSPERG Gene

miRTarBase miRNAs that target CATSPERG

Clone Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CATSPERG Gene

Localization for CATSPERG Gene

Subcellular locations from UniProtKB/Swiss-Prot for CATSPERG Gene

Membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CATSPERG gene
Compartment Confidence
plasma membrane 5

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Nucleoli (2)
  • Nucleoplasm (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for CATSPERG Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
GO:0031514 motile cilium IBA 21873635
GO:0036128 CatSper complex ISS,IEA --
genes like me logo Genes that share ontologies with CATSPERG: view

Pathways & Interactions for CATSPERG Gene

PathCards logo

SuperPathways for CATSPERG Gene

SuperPathway Contained pathways
1 Fertilization
genes like me logo Genes that share pathways with CATSPERG: view

Pathways by source for CATSPERG Gene

3 Reactome pathways for CATSPERG Gene

Interacting Proteins for CATSPERG Gene

;

Gene Ontology (GO) - Biological Process for CATSPERG Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007275 multicellular organism development IEA --
GO:0007283 spermatogenesis IEA --
GO:0030154 cell differentiation IEA --
GO:0032570 response to progesterone TAS --
GO:0035036 sperm-egg recognition TAS --
genes like me logo Genes that share ontologies with CATSPERG: view

No data available for SIGNOR curated interactions for CATSPERG Gene

Drugs & Compounds for CATSPERG Gene

No Compound Related Data Available

Transcripts for CATSPERG Gene

mRNA/cDNA for CATSPERG Gene

2 REFSEQ mRNAs :
14 NCBI additional mRNA sequence :
16 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for CATSPERG Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b · 6c ^ 7 ^ 8a · 8b · 8c ^ 9 ^ 10a · 10b ^ 11 ^ 12 ^ 13 ^ 14a · 14b ^ 15 ^ 16a · 16b ^
SP1: - - - - - - - -
SP2: - - - - - - -
SP3: - - - -
SP4: - - - - - -
SP5: - - - - -
SP6:
SP7:
SP8:
SP9: -
SP10:

ExUns: 17 ^ 18 ^ 19a · 19b ^ 20 ^ 21 ^ 22 ^ 23 ^ 24a · 24b ^ 25a · 25b ^ 26 ^ 27 ^ 28 ^ 29a · 29b ^ 30 ^ 31a · 31b
SP1: - - -
SP2: - -
SP3: - - -
SP4:
SP5:
SP6: -
SP7:
SP8:
SP9:
SP10:

Relevant External Links for CATSPERG Gene

GeneLoc Exon Structure for
CATSPERG

Expression for CATSPERG Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for CATSPERG Gene

mRNA differential expression in normal tissues according to GTEx for CATSPERG Gene

This gene is overexpressed in Testis (x25.7).

Protein differential expression in normal tissues from HIPED for CATSPERG Gene

This gene is overexpressed in Spinal cord (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for CATSPERG Gene



Protein tissue co-expression partners for CATSPERG Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for CATSPERG

SOURCE GeneReport for Unigene cluster for CATSPERG Gene:

Hs.324335
genes like me logo Genes that share expression patterns with CATSPERG: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for CATSPERG Gene

Orthologs for CATSPERG Gene

This gene was present in the common ancestor of chordates.

Orthologs for CATSPERG Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CATSPERG 31 30
  • 99.29 (n)
OneToOne
dog
(Canis familiaris)
Mammalia CATSPERG 31 30
  • 81.72 (n)
OneToOne
cow
(Bos Taurus)
Mammalia CATSPERG 31 30
  • 81.2 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Catsperg1 31 30
  • 67.83 (n)
OneToMany
Catsperg2 17 31
  • 55 (a)
rat
(Rattus norvegicus)
Mammalia Catsperg1 30
  • 66.93 (n)
oppossum
(Monodelphis domestica)
Mammalia CATSPERG 31
  • 51 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CATSPERG 31
  • 48 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia -- 31
  • 43 (a)
OneToMany
-- 31
  • 41 (a)
OneToMany
-- 31
  • 41 (a)
OneToMany
Species where no ortholog for CATSPERG was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for CATSPERG Gene

ENSEMBL:
Gene Tree for CATSPERG (if available)
TreeFam:
Gene Tree for CATSPERG (if available)
Aminode:
Evolutionary constrained regions (ECRs) for CATSPERG: view image

Paralogs for CATSPERG Gene

(50) SIMAP similar genes for CATSPERG Gene using alignment to 7 proteins:

  • CTSRG_HUMAN
  • B8ZZI7_HUMAN
  • F8WDD6_HUMAN
  • H9KV36_HUMAN
  • K7EQR6_HUMAN
  • K7EQY4_HUMAN
  • M0QZ16_HUMAN
genes like me logo Genes that share paralogs with CATSPERG: view

No data available for Paralogs for CATSPERG Gene

Variants for CATSPERG Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for CATSPERG Gene

SNP ID Clinical significance and condition Chr 19 pos Variation AA Info Type
rs2286550 - p.Met1137Thr
rs2302182 - p.Leu29Pro
rs3745953 - p.Ser650Arg

Additional dbSNP identifiers (rs#s) for CATSPERG Gene

Structural Variations from Database of Genomic Variants (DGV) for CATSPERG Gene

Variant ID Type Subtype PubMed ID
esv22727 CNV loss 19812545
esv2718532 CNV deletion 23290073
nsv1064275 CNV loss 25217958
nsv1152248 CNV deletion 26484159
nsv470140 CNV gain 18288195
nsv833822 CNV loss 17160897
nsv833823 CNV loss 17160897
nsv953296 CNV deletion 24416366

Variation tolerance for CATSPERG Gene

Residual Variation Intolerance Score: 11.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.74; 66.44% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CATSPERG Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CATSPERG

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CATSPERG Gene

Disorders for CATSPERG Gene

Additional Disease Information for CATSPERG

No disorders were found for CATSPERG Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CATSPERG Gene

Publications for CATSPERG Gene

  1. A novel, single, transmembrane protein CATSPERG is associated with CATSPER1 channel protein. (PMID: 19516020) Wang H … Ren D (Biology of reproduction 2009) 2 3 54
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 54
  3. Genome-wide CRISPR screen identifies HNRNPL as a prostate cancer dependency regulating RNA splicing. (PMID: 28611215) Fei T … Brown M (Proceedings of the National Academy of Sciences of the United States of America 2017) 3 54
  4. Charting the landscape of tandem BRCT domain-mediated protein interactions. (PMID: 22990118) Woods NT … Monteiro AN (Science signaling 2012) 3 54
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. (PMID: 21873635) Gaudet P … Thomas PD (Briefings in bioinformatics 2011) 3 54

Products for CATSPERG Gene

Sources for CATSPERG Gene