Aliases for CATSPERE Gene

Aliases for CATSPERE Gene

  • Catsper Channel Auxiliary Subunit Epsilon 2 3 5
  • Cation Channel Sperm-Associated Protein Subunit Epsilon 3 4
  • CatSper-Epsilon 3 4
  • CatSperepsilon 3 4
  • C1orf101 3 4
  • Chromosome 1 Open Reading Frame 101 2
  • Uncharacterized Protein C1orf101 3
  • C10orf101 3

External Ids for CATSPERE Gene

Previous HGNC Symbols for CATSPERE Gene

  • C1orf101

Summaries for CATSPERE Gene

GeneCards Summary for CATSPERE Gene

CATSPERE (Catsper Channel Auxiliary Subunit Epsilon) is a Protein Coding gene.

UniProtKB/Swiss-Prot Summary for CATSPERE Gene

  • Auxiliary component of the CatSper complex, a complex involved in sperm cell hyperactivation. Sperm cell hyperactivation is needed for sperm motility which is essential late in the preparation of sperm for fertilization.

Additional gene information for CATSPERE Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for CATSPERE Gene

Genomics for CATSPERE Gene

GeneHancer (GH) Regulatory Elements for CATSPERE Gene

Promoters and enhancers for CATSPERE Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around CATSPERE on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for CATSPERE

Genomic Locations for CATSPERE Gene

Genomic Locations for CATSPERE Gene
189,078 bases
Plus strand
186,801 bases
Plus strand

Genomic View for CATSPERE Gene

Genes around CATSPERE on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CATSPERE Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CATSPERE Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CATSPERE Gene

Proteins for CATSPERE Gene

  • Protein details for CATSPERE Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Cation channel sperm-associated protein subunit epsilon
    Protein Accession:
    Secondary Accessions:
    • B4DZR4
    • B7Z7X5
    • E9PEA3
    • Q8IYZ6

    Protein attributes for CATSPERE Gene

    951 amino acids
    Molecular mass:
    109662 Da
    Quaternary structure:
    • Component of the CatSper complex.
    • Sequence=BC028392; Type=Frameshift; Evidence={ECO:0000305};

    Alternative splice isoforms for CATSPERE Gene


neXtProt entry for CATSPERE Gene

Post-translational modifications for CATSPERE Gene

  • Glycosylation at Asn61, Asn114, Asn472, and Asn535
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for CATSPERE Gene

Domains & Families for CATSPERE Gene

Gene Families for CATSPERE Gene

Human Protein Atlas (HPA):
  • Predicted membrane proteins

Protein Domains for CATSPERE Gene


Suggested Antigen Peptide Sequences for CATSPERE Gene

GenScript: Design optimal peptide antigens:
  • Chromosome 1 open reading frame 101 (B1AQM6_HUMAN)
  • cDNA FLJ58653 (B4DZR4_HUMAN)

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the CATSPERD family.
  • Belongs to the CATSPERD family.
genes like me logo Genes that share domains with CATSPERE: view

Function for CATSPERE Gene

Molecular function for CATSPERE Gene

UniProtKB/Swiss-Prot Function:
Auxiliary component of the CatSper complex, a complex involved in sperm cell hyperactivation. Sperm cell hyperactivation is needed for sperm motility which is essential late in the preparation of sperm for fertilization.

Phenotypes From GWAS Catalog for CATSPERE Gene

Phenotypes for CATSPERE Gene

genes like me logo Genes that share phenotypes with CATSPERE: view

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for CATSPERE Gene

Localization for CATSPERE Gene

Subcellular locations from UniProtKB/Swiss-Prot for CATSPERE Gene

Cell projection, cilium, flagellum membrane; Single-pass type I membrane protein. Note=Specifically located in the principal piece of sperm tail. {ECO:0000269 PubMed:28226241}.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CATSPERE gene
Compartment Confidence
plasma membrane 5
extracellular 0
endoplasmic reticulum 0

Gene Ontology (GO) - Cellular Components for CATSPERE Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005929 cilium IEA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
GO:0031514 motile cilium IEA --
GO:0036128 CatSper complex ISS --
genes like me logo Genes that share ontologies with CATSPERE: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for CATSPERE Gene

Pathways & Interactions for CATSPERE Gene

PathCards logo

SuperPathways for CATSPERE Gene

No Data Available

Interacting Proteins for CATSPERE Gene


Gene Ontology (GO) - Biological Process for CATSPERE Gene


No data available for Pathways by source and SIGNOR curated interactions for CATSPERE Gene

Drugs & Compounds for CATSPERE Gene

No Compound Related Data Available

Transcripts for CATSPERE Gene


7 NCBI additional mRNA sequence :
10 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for CATSPERE Gene

No ASD Table

Relevant External Links for CATSPERE Gene

GeneLoc Exon Structure for

Expression for CATSPERE Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for CATSPERE

No Expression Related Data Available

Primer Products

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for CATSPERE Gene

Orthologs for CATSPERE Gene

This gene was present in the common ancestor of chordates.

Orthologs for CATSPERE Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia C1H1orf101 30
  • 99.19 (n)
C1orf101 31
  • 98 (a)
(Canis familiaris)
Mammalia C7H1orf101 30
  • 81.68 (n)
C1orf101 31
  • 70 (a)
(Bos Taurus)
Mammalia C16H1orf101 30
  • 80.44 (n)
C1orf101 31
  • 64 (a)
(Rattus norvegicus)
Mammalia RGD1565309 30
  • 65.7 (n)
(Mus musculus)
Mammalia LOC102632386 30
  • 65.37 (n)
Gm16432 31
  • 18 (a)
Catspere1 17
(Ornithorhynchus anatinus)
Mammalia C1orf101 31
  • 42 (a)
(Monodelphis domestica)
Mammalia C1orf101 31
  • 39 (a)
(Gallus gallus)
Aves C3H1orf101 30
  • 51.84 (n)
C1orf101 31
  • 29 (a)
(Anolis carolinensis)
Reptilia C1orf101 31
  • 35 (a)
Species where no ortholog for CATSPERE was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for CATSPERE Gene

Gene Tree for CATSPERE (if available)
Gene Tree for CATSPERE (if available)

Paralogs for CATSPERE Gene

No data available for Paralogs for CATSPERE Gene

Variants for CATSPERE Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for CATSPERE Gene

SNP ID Clinical significance and condition Chr 01 pos Variation AA Info Type
638071 Uncertain Significance: not provided 244,605,783(+) ACTATGG/A INFRAME_DELETION
VAR_035494 A breast cancer sample p.Thr653Ile
rs11586356 - p.Thr66Lys
rs58602830 - p.Thr56Ser

Additional dbSNP identifiers (rs#s) for CATSPERE Gene

Structural Variations from Database of Genomic Variants (DGV) for CATSPERE Gene

Variant ID Type Subtype PubMed ID
esv1134718 CNV deletion 17803354
esv1291880 CNV deletion 17803354
esv2107521 CNV deletion 18987734
esv24695 CNV loss 19812545
esv2639096 CNV deletion 19546169
esv2659474 CNV deletion 23128226
esv2726640 CNV deletion 23290073
esv2726651 CNV deletion 23290073
esv2726662 CNV deletion 23290073
esv2726673 CNV deletion 23290073
esv3007798 CNV deletion 24192839
esv3589408 CNV loss 21293372
esv3589409 CNV loss 21293372
esv3589410 CNV loss 21293372
esv3589411 CNV loss 21293372
esv3589412 CNV loss 21293372
esv992950 CNV deletion 20482838
nsv1119770 CNV deletion 24896259
nsv1119771 CNV deletion 24896259
nsv1133956 CNV deletion 24896259
nsv1137861 CNV deletion 24896259
nsv1160479 CNV deletion 26073780
nsv5154 CNV insertion 18451855
nsv516557 CNV gain 19592680
nsv528017 CNV gain 19592680
nsv549492 CNV loss 21841781
nsv818866 CNV gain 17921354
nsv945426 CNV duplication 23825009

Variation tolerance for CATSPERE Gene

Residual Variation Intolerance Score: 67% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.59; 44.92% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CATSPERE Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CATSPERE Gene

Disorders for CATSPERE Gene

Additional Disease Information for CATSPERE

No disorders were found for CATSPERE Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CATSPERE Gene

Publications for CATSPERE Gene

  1. CatSperζ regulates the structural continuity of sperm Ca2+ signaling domains and is required for normal fertility. (PMID: 28226241) Chung JJ … Clapham DE (eLife 2017) 2 3 4 54
  2. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory SG … Prigmore E (Nature 2006) 3 4 54
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 54
  4. Delineating WWOX Protein Interactome by Tandem Affinity Purification-Mass Spectrometry: Identification of Top Interactors and Key Metabolic Pathways Involved. (PMID: 30619736) Hussain T … Aldaz CM (Frontiers in oncology 2018) 3 54
  5. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 54

Products for CATSPERE Gene

Sources for CATSPERE Gene