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Aliases for CATSPERE Gene

Aliases for CATSPERE Gene

  • Catsper Channel Auxiliary Subunit Epsilon 2 3 5
  • CatSper-Epsilon 3 4
  • CatSperepsilon 3 4
  • C1orf101 3 4
  • Cation Channel Sperm-Associated Protein Subunit Epsilon 3
  • Chromosome 1 Open Reading Frame 101 2
  • Uncharacterized Protein C1orf101 3
  • C10orf101 3

External Ids for CATSPERE Gene

Previous HGNC Symbols for CATSPERE Gene

  • C1orf101

Summaries for CATSPERE Gene

GeneCards Summary for CATSPERE Gene

CATSPERE (Catsper Channel Auxiliary Subunit Epsilon) is a Protein Coding gene. An important paralog of this gene is CATSPERD.

UniProtKB/Swiss-Prot for CATSPERE Gene

  • Auxiliary component of the CatSper complex, a complex involved in sperm cell hyperactivation. Sperm cell hyperactivation is needed for sperm motility which is essential late in the preparation of sperm for fertilization.

Additional gene information for CATSPERE Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CATSPERE Gene

Genomics for CATSPERE Gene

GeneHancer (GH) Regulatory Elements for CATSPERE Gene

Promoters and enhancers for CATSPERE Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01I244449 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 561 -0.8 -764 3.6 HDGF PKNOX1 FOXA2 ARNT ARID4B SIN3A DMAP1 ZNF2 YY1 POLR2B CATSPERE ADSS ENSG00000236031 HNRNPU DESI2 LOC101928068 COX20 LOC105373264
GH01I244460 Promoter/Enhancer 1.9 EPDnew Ensembl ENCODE 565.3 +9.2 9203 2.4 HDGF PKNOX1 SIN3A FEZF1 GLI4 YY1 GLIS2 ZNF143 KLF7 SP3 CATSPERE DESI2 ADSS GC01M244569
GH01I244860 Promoter/Enhancer 2.5 EPDnew Ensembl ENCODE dbSUPER 19.8 +411.5 411470 6.7 CLOCK MLX ZFP64 FEZF1 DMAP1 IRF4 YY1 SLC30A9 ZNF213 ZNF548 HNRNPU ENSG00000273175 DESI2 COX20 LOC101928068 ADSS CATSPERE
GH01I244940 Enhancer 1.1 ENCODE dbSUPER 32.4 +488.9 488873 1.4 PKNOX1 ZNF529 ZFP64 IRF4 ZNF23 ZNF213 ATF7 BCLAF1 IKZF2 RUNX3 HNRNPU LOC101928068 CATSPERE COX20 DESI2 GC01P244944 ENSG00000273175
GH01I244729 Promoter/Enhancer 1.4 FANTOM5 Ensembl ENCODE 23 +278.3 278301 1.6 MAX BMI1 BATF IRF4 POLR2A BCLAF1 IKZF2 RUNX3 EZH2 NR2F1 ENSG00000282317 ENSG00000284188 C1orf100 CATSPERE RPL37P8
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around CATSPERE on UCSC Golden Path with GeneCards custom track

Genomic Locations for CATSPERE Gene

Genomic Locations for CATSPERE Gene
chr1:244,452,100-244,641,177
(GRCh38/hg38)
Size:
189,078 bases
Orientation:
Plus strand
chr1:244,617,679-244,804,479
(GRCh37/hg19)

Genomic View for CATSPERE Gene

Genes around CATSPERE on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CATSPERE Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CATSPERE Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CATSPERE Gene

Proteins for CATSPERE Gene

  • Protein details for CATSPERE Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5SY80-CTSRE_HUMAN
    Recommended name:
    Cation channel sperm-associated protein subunit epsilon
    Protein Accession:
    Q5SY80
    Secondary Accessions:
    • B4DZR4
    • B7Z7X5
    • E9PEA3
    • Q8IYZ6

    Protein attributes for CATSPERE Gene

    Size:
    951 amino acids
    Molecular mass:
    109662 Da
    Quaternary structure:
    • Component of the CatSper complex.
    SequenceCaution:
    • Sequence=BC028392; Type=Frameshift; Positions=418; Evidence={ECO:0000305};

    Alternative splice isoforms for CATSPERE Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CATSPERE Gene

Post-translational modifications for CATSPERE Gene

No Post-translational modifications

No data available for DME Specific Peptides for CATSPERE Gene

Domains & Families for CATSPERE Gene

Gene Families for CATSPERE Gene

Human Protein Atlas (HPA):
  • Predicted membrane proteins

Protein Domains for CATSPERE Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for CATSPERE Gene

Graphical View of Domain Structure for InterPro Entry

Q5SY80

UniProtKB/Swiss-Prot:

CTSRE_HUMAN :
  • Belongs to the CATSPERD family.
Family:
  • Belongs to the CATSPERD family.
genes like me logo Genes that share domains with CATSPERE: view

Function for CATSPERE Gene

Molecular function for CATSPERE Gene

UniProtKB/Swiss-Prot Function:
Auxiliary component of the CatSper complex, a complex involved in sperm cell hyperactivation. Sperm cell hyperactivation is needed for sperm motility which is essential late in the preparation of sperm for fertilization.

Phenotypes for CATSPERE Gene

GenomeRNAi human phenotypes for CATSPERE:
genes like me logo Genes that share phenotypes with CATSPERE: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for CATSPERE Gene

Localization for CATSPERE Gene

Subcellular locations from UniProtKB/Swiss-Prot for CATSPERE Gene

Cell projection, cilium, flagellum membrane; Single-pass type I membrane protein. Note=Specifically located in the principal piece of sperm tail. {ECO:0000269 PubMed:28226241}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CATSPERE gene
Compartment Confidence
plasma membrane 5
extracellular 1
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for CATSPERE Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
GO:0036128 CatSper complex ISS --
GO:0042995 cell projection IEA --
GO:0097228 sperm principal piece IDA 28226241
genes like me logo Genes that share ontologies with CATSPERE: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for CATSPERE Gene

Pathways & Interactions for CATSPERE Gene

SuperPathways for CATSPERE Gene

No Data Available

Interacting Proteins for CATSPERE Gene

Gene Ontology (GO) - Biological Process for CATSPERE Gene

None

No data available for Pathways by source and SIGNOR curated interactions for CATSPERE Gene

Drugs & Compounds for CATSPERE Gene

No Compound Related Data Available

Transcripts for CATSPERE Gene

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for CATSPERE Gene

No ASD Table

Relevant External Links for CATSPERE Gene

GeneLoc Exon Structure for
CATSPERE
ECgene alternative splicing isoforms for
CATSPERE

Expression for CATSPERE Gene

NURSA nuclear receptor signaling pathways regulating expression of CATSPERE Gene:

CATSPERE
No Expression Related Data Available

Primer Products

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for CATSPERE Gene

Orthologs for CATSPERE Gene

This gene was present in the common ancestor of chordates.

Orthologs for CATSPERE Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia C1H1orf101 33
  • 99.19 (n)
C1orf101 34
  • 98 (a)
OneToOne
dog
(Canis familiaris)
Mammalia C7H1orf101 33
  • 81.68 (n)
C1orf101 34
  • 70 (a)
OneToOne
cow
(Bos Taurus)
Mammalia C16H1orf101 33
  • 80.44 (n)
C1orf101 34
  • 64 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia RGD1565309 33
  • 65.7 (n)
mouse
(Mus musculus)
Mammalia LOC102632386 33
  • 65.37 (n)
Gm16432 34
  • 18 (a)
OneToOne
Catspere2 16
platypus
(Ornithorhynchus anatinus)
Mammalia C1orf101 34
  • 42 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia C1orf101 34
  • 39 (a)
OneToOne
chicken
(Gallus gallus)
Aves C3H1orf101 33
  • 51.84 (n)
C1orf101 34
  • 29 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia C1orf101 34
  • 35 (a)
OneToOne
Species where no ortholog for CATSPERE was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for CATSPERE Gene

ENSEMBL:
Gene Tree for CATSPERE (if available)
TreeFam:
Gene Tree for CATSPERE (if available)

Paralogs for CATSPERE Gene

Paralogs for CATSPERE Gene

genes like me logo Genes that share paralogs with CATSPERE: view

Variants for CATSPERE Gene

Sequence variations from dbSNP and Humsavar for CATSPERE Gene

SNP ID Clin Chr 01 pos Variation AA Info Type
VAR_035494 A breast cancer sample p.Thr653Ile
rs1000016398 -- 244,504,629(+) G/C intron_variant
rs1000101778 -- 244,559,615(+) G/C intron_variant
rs1000104572 -- 244,566,399(+) G/A intron_variant
rs1000104984 -- 244,601,836(+) C/A genic_downstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for CATSPERE Gene

Variant ID Type Subtype PubMed ID
nsv945426 CNV duplication 23825009
nsv818866 CNV gain 17921354
nsv549492 CNV loss 21841781
nsv528017 CNV gain 19592680
nsv516557 CNV gain 19592680
nsv5154 CNV insertion 18451855
nsv1160479 CNV deletion 26073780
nsv1137861 CNV deletion 24896259
nsv1133956 CNV deletion 24896259
nsv1119771 CNV deletion 24896259
nsv1119770 CNV deletion 24896259
esv992950 CNV deletion 20482838
esv3589412 CNV loss 21293372
esv3589411 CNV loss 21293372
esv3589410 CNV loss 21293372
esv3589409 CNV loss 21293372
esv3589408 CNV loss 21293372
esv3007798 CNV deletion 24192839
esv2726673 CNV deletion 23290073
esv2726662 CNV deletion 23290073
esv2726651 CNV deletion 23290073
esv2726640 CNV deletion 23290073
esv2659474 CNV deletion 23128226
esv2639096 CNV deletion 19546169
esv24695 CNV loss 19812545
esv2107521 CNV deletion 18987734
esv1291880 CNV deletion 17803354
esv1134718 CNV deletion 17803354

Variation tolerance for CATSPERE Gene

Residual Variation Intolerance Score: 67% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.59; 44.92% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CATSPERE Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CATSPERE

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CATSPERE Gene

Disorders for CATSPERE Gene

No disorders were found for CATSPERE Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CATSPERE Gene

Publications for CATSPERE Gene

  1. CatSperζ regulates the structural continuity of sperm Ca2+ signaling domains and is required for normal fertility. (PMID: 28226241) Chung JJ … Clapham DE (eLife 2017) 2 3 4 58
  2. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory SG … Prigmore E (Nature 2006) 3 4 58
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  4. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 58
  5. The consensus coding sequences of human breast and colorectal cancers. (PMID: 16959974) Sjöblom T … Velculescu VE (Science (New York, N.Y.) 2006) 4 58

Products for CATSPERE Gene

Sources for CATSPERE Gene

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