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Aliases for CATSPERD Gene

Aliases for CATSPERD Gene

  • Cation Channel Sperm Associated Auxiliary Subunit Delta 2 3 5
  • Transmembrane Protein 146 2 3 4
  • Catsper Channel Auxiliary Subunit Delta 2 3
  • CatSper-Delta 3 4
  • CatSperdelta 3 4
  • TMEM146 3 4
  • Cation Channel Sperm-Associated Protein Subunit Delta 3

External Ids for CATSPERD Gene

Previous HGNC Symbols for CATSPERD Gene

  • TMEM146

Summaries for CATSPERD Gene

GeneCards Summary for CATSPERD Gene

CATSPERD (Cation Channel Sperm Associated Auxiliary Subunit Delta) is a Protein Coding gene. Among its related pathways are Reproduction. An important paralog of this gene is CATSPERE.

UniProtKB/Swiss-Prot for CATSPERD Gene

  • Auxiliary component of the CatSper complex, a complex involved in sperm cell hyperactivation. Sperm cell hyperactivation is needed for sperm motility which is essential late in the preparation of sperm for fertilization. Required for CATSPER1 stability before intraflagellar transport and/or incorporation of the CatSper complex channel into the flagellar membrane.

Additional gene information for CATSPERD Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CATSPERD Gene

Genomics for CATSPERD Gene

GeneHancer (GH) Regulatory Elements for CATSPERD Gene

Promoters and enhancers for CATSPERD Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH19I005717 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 550.8 -1.1 -1146 4.4 CLOCK MLX FEZF1 DMAP1 IRF4 YY1 ZNF213 E2F8 ZNF143 SP3 LONP1 CATSPERD DUS3L ENSG00000267571 SAFB KHSRP KDM4B RANBP3 RPL36 PTPRS
GH19I005826 Enhancer 1.5 Ensembl ENCODE dbSUPER 12.1 +107.7 107737 3.7 MLX FEZF1 DMAP1 YY1 SLC30A9 ZNF213 ZNF143 SP3 MEF2D SSRP1 DUS3L ENSG00000267571 VMAC GPR108 NDUFA11 PTPRS PRR22 SAFB CATSPERD KDM4B
GH19I006055 Enhancer 1.8 FANTOM5 Ensembl ENCODE dbSUPER 9.4 +342.1 342079 13.8 PKNOX1 CLOCK FOXA2 ARNT ARID4B NEUROD1 SIN3A FEZF1 YY1 ZNF766 RFX2 ACSBG2 PRR22 SAFB SNRPEP4 DUS3L SLC25A41 KHSRP CATSPERD DENND1C
GH19I005913 Promoter/Enhancer 1.6 EPDnew Ensembl ENCODE dbSUPER 10.5 +194.9 194917 3.3 KLF1 MAZ RFX1 KLF17 ZIC2 RAD21 OSR2 ZFP69B GLIS2 ZNF692 CAPS ENSG00000267571 FUT3 FUT6 CATSPERD ENSG00000267314 GC19P005968 RANBP3
GH19I005798 Enhancer 1.2 ENCODE dbSUPER 11.8 +79.0 79004 0.9 HDGF SMAD1 ATF1 TCF12 ZNF766 GATA2 RXRA NCOA1 REST MBD2 DUS3L CATSPERD LONP1 FUT6 FUT3 FUT5 NDUFA11 VMAC NRTN
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around CATSPERD on UCSC Golden Path with GeneCards custom track

Genomic Locations for CATSPERD Gene

Genomic Locations for CATSPERD Gene
chr19:5,720,401-5,778,734
(GRCh38/hg38)
Size:
58,334 bases
Orientation:
Plus strand
chr19:5,720,688-5,778,745
(GRCh37/hg19)

Genomic View for CATSPERD Gene

Genes around CATSPERD on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CATSPERD Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CATSPERD Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CATSPERD Gene

Proteins for CATSPERD Gene

  • Protein details for CATSPERD Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q86XM0-CTSRD_HUMAN
    Recommended name:
    Cation channel sperm-associated protein subunit delta
    Protein Accession:
    Q86XM0
    Secondary Accessions:
    • Q6ZRP1

    Protein attributes for CATSPERD Gene

    Size:
    798 amino acids
    Molecular mass:
    90468 Da
    Quaternary structure:
    • Component of the CatSper complex.
    SequenceCaution:
    • Sequence=AAH43005.2; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for CATSPERD Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CATSPERD Gene

Post-translational modifications for CATSPERD Gene

  • Glycosylation at posLast=240240, posLast=472472, and posLast=538538
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for CATSPERD Gene

Domains & Families for CATSPERD Gene

Gene Families for CATSPERD Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted membrane proteins
  • Transporters

Protein Domains for CATSPERD Gene

Suggested Antigen Peptide Sequences for CATSPERD Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q86XM0

UniProtKB/Swiss-Prot:

CTSRD_HUMAN :
  • Belongs to the CATSPERD family.
Family:
  • Belongs to the CATSPERD family.
genes like me logo Genes that share domains with CATSPERD: view

Function for CATSPERD Gene

Molecular function for CATSPERD Gene

UniProtKB/Swiss-Prot Function:
Auxiliary component of the CatSper complex, a complex involved in sperm cell hyperactivation. Sperm cell hyperactivation is needed for sperm motility which is essential late in the preparation of sperm for fertilization. Required for CATSPER1 stability before intraflagellar transport and/or incorporation of the CatSper complex channel into the flagellar membrane.

Phenotypes From GWAS Catalog for CATSPERD Gene

Gene Ontology (GO) - Molecular Function for CATSPERD Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with CATSPERD: view
genes like me logo Genes that share phenotypes with CATSPERD: view

Animal Models for CATSPERD Gene

MGI Knock Outs for CATSPERD:

Animal Model Products

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for CATSPERD Gene

Localization for CATSPERD Gene

Subcellular locations from UniProtKB/Swiss-Prot for CATSPERD Gene

Cell projection, cilium, flagellum membrane; Single-pass type I membrane protein. Note=Specifically located in the principal piece of sperm tail. {ECO:0000250 UniProtKB:E9Q9F6}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CATSPERD gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for CATSPERD Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0005929 cilium IEA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
GO:0031514 motile cilium IEA --
genes like me logo Genes that share ontologies with CATSPERD: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for CATSPERD Gene

Pathways & Interactions for CATSPERD Gene

SuperPathways for CATSPERD Gene

SuperPathway Contained pathways
1 Reproduction
genes like me logo Genes that share pathways with CATSPERD: view

Pathways by source for CATSPERD Gene

3 Reactome pathways for CATSPERD Gene

Interacting Proteins for CATSPERD Gene

Gene Ontology (GO) - Biological Process for CATSPERD Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007275 multicellular organism development IEA --
GO:0007283 spermatogenesis ISS --
GO:0030154 cell differentiation IEA --
GO:0030317 flagellated sperm motility ISS --
GO:0032570 response to progesterone TAS --
genes like me logo Genes that share ontologies with CATSPERD: view

No data available for SIGNOR curated interactions for CATSPERD Gene

Drugs & Compounds for CATSPERD Gene

No Compound Related Data Available

Transcripts for CATSPERD Gene

mRNA/cDNA for CATSPERD Gene

Unigene Clusters for CATSPERD Gene

Catsper channel auxiliary subunit delta:
Representative Sequences:

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for CATSPERD Gene

No ASD Table

Relevant External Links for CATSPERD Gene

GeneLoc Exon Structure for
CATSPERD
ECgene alternative splicing isoforms for
CATSPERD

Expression for CATSPERD Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CATSPERD Gene

mRNA differential expression in normal tissues according to GTEx for CATSPERD Gene

This gene is overexpressed in Testis (x39.8).

Protein differential expression in normal tissues from HIPED for CATSPERD Gene

This gene is overexpressed in Testis (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for CATSPERD Gene



Protein tissue co-expression partners for CATSPERD Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of CATSPERD Gene:

CATSPERD

SOURCE GeneReport for Unigene cluster for CATSPERD Gene:

Hs.631842
genes like me logo Genes that share expression patterns with CATSPERD: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for CATSPERD Gene

Orthologs for CATSPERD Gene

This gene was present in the common ancestor of chordates.

Orthologs for CATSPERD Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CATSPERD 33
  • 96.12 (n)
dog
(Canis familiaris)
Mammalia CATSPERD 33 34
  • 76.97 (n)
cow
(Bos Taurus)
Mammalia CATSPERD 33 34
  • 74.94 (n)
rat
(Rattus norvegicus)
Mammalia Catsperd 33
  • 62.58 (n)
mouse
(Mus musculus)
Mammalia Catsperd 33 16 34
  • 61.91 (n)
oppossum
(Monodelphis domestica)
Mammalia CATSPERD 34
  • 39 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CATSPERD 34
  • 33 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia -- 34
  • 40 (a)
OneToMany
-- 34
  • 35 (a)
OneToMany
-- 34
  • 34 (a)
OneToMany
Species where no ortholog for CATSPERD was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for CATSPERD Gene

ENSEMBL:
Gene Tree for CATSPERD (if available)
TreeFam:
Gene Tree for CATSPERD (if available)

Paralogs for CATSPERD Gene

Paralogs for CATSPERD Gene

(19) SIMAP similar genes for CATSPERD Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with CATSPERD: view

Variants for CATSPERD Gene

Sequence variations from dbSNP and Humsavar for CATSPERD Gene

SNP ID Clin Chr 19 pos Variation AA Info Type
rs751508398 uncertain-significance, not specified 5,719,892(+) C/G/T upstream_transcript_variant
rs1000019060 -- 5,741,509(+) A/G genic_upstream_transcript_variant, intron_variant
rs1000031550 -- 5,757,858(+) C/T coding_sequence_variant, missense_variant
rs1000084373 -- 5,747,463(+) C/T genic_upstream_transcript_variant, intron_variant
rs1000122652 -- 5,738,829(+) G/C genic_upstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for CATSPERD Gene

Variant ID Type Subtype PubMed ID
dgv1697n106 CNV tandem duplication 24896259
esv1495928 CNV insertion 17803354
esv2718046 CNV deletion 23290073
esv2718047 CNV deletion 23290073
esv2718048 CNV deletion 23290073
esv3555932 CNV deletion 23714750
esv3643537 CNV loss 21293372
esv3643538 CNV loss 21293372
nsv1062851 CNV gain 25217958
nsv1071900 CNV deletion 25765185
nsv1131390 CNV deletion 24896259
nsv1138660 CNV deletion 24896259
nsv1142251 CNV tandem duplication 24896259
nsv470119 CNV loss 18288195
nsv525707 CNV loss 19592680

Variation tolerance for CATSPERD Gene

Residual Variation Intolerance Score: 96.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 8.32; 85.28% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CATSPERD Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CATSPERD

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CATSPERD Gene

Disorders for CATSPERD Gene

Additional Disease Information for CATSPERD

No disorders were found for CATSPERD Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CATSPERD Gene

Publications for CATSPERD Gene

  1. A novel gene required for male fertility and functional CATSPER channel formation in spermatozoa. (PMID: 21224844) Chung JJ … Clapham DE (Nature communications 2011) 2 3 58
  2. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
  3. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T … Vidal M (Cell 2014) 3 58
  4. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 58
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 4 58

Products for CATSPERD Gene

Sources for CATSPERD Gene

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