Aliases for CATSPERB Gene

Aliases for CATSPERB Gene

  • Cation Channel Sperm Associated Auxiliary Subunit Beta 2 3 5
  • Cation Channel Sperm-Associated Protein Subunit Beta 3 4
  • Catsper Channel Auxiliary Subunit Beta 2 3
  • CatSper-Beta 3 4
  • C14orf161 3 4
  • Cation Channel, Sperm-Associated, Beta 2
  • Cation Channel, Sperm Associated Beta 3
  • Chromosome 14 Open Reading Frame 161 2
  • CatSper(Beta) 3

External Ids for CATSPERB Gene

Previous HGNC Symbols for CATSPERB Gene

  • C14orf161

Previous GeneCards Identifiers for CATSPERB Gene

  • GC14M091117
  • GC14M092047
  • GC14M072223

Summaries for CATSPERB Gene

GeneCards Summary for CATSPERB Gene

CATSPERB (Cation Channel Sperm Associated Auxiliary Subunit Beta) is a Protein Coding gene. Among its related pathways are Fertilization.

UniProtKB/Swiss-Prot Summary for CATSPERB Gene

  • Probably involved in sperm cell hyperactivation via its association with CATSPER1. Sperm cell hyperactivation is needed for sperm motility which is essential late in the preparation of sperm for fertilization.

Additional gene information for CATSPERB Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for CATSPERB Gene

Genomics for CATSPERB Gene

GeneHancer (GH) Regulatory Elements for CATSPERB Gene

Promoters and enhancers for CATSPERB Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH14J091779 Enhancer 0.8 Ensembl ENCODE 506.4 +0.2 177 1.4 TCF7 TEAD1 FOXA2 CEBPB USF1 FOXA1 MITF TOE1 RXRA ATF2 CATSPERB FBLN5 TC2N piR-49097-036
GH14J091732 Promoter 0.3 EPDnew 500.3 +48.6 48618 0.1 CATSPERB TC2N FBLN5 PPP4R3A ENSG00000275154 ENSG00000260711
GH14J092038 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE CraniofacialAtlas 10.1 -259.0 -258994 3.8 EP300 ZBTB40 ZNF217 TCF12 SIN3A NRF1 USF1 POLR2G GTF2E2 PHF8 lnc-ATXN3-4 TRIP11 lnc-CPSF2-5 piR-43843 ATXN3 GOLGA5 TC2N CATSPERB NDUFB1 L13713-079
GH14J091743 Enhancer 1.2 FANTOM5 Ensembl ENCODE 16.4 +35.9 35896 3.2 ZNF217 ZNF639 ZNF10 ZIC2 ATF2 CTBP1 OSR2 ESRRA WT1 FOXA2 TC2N CATSPERB FBLN5 TRIP11 PPP4R3A ATXN3 ENSG00000260711 ENSG00000275154
GH14J091753 Enhancer 1 Ensembl ENCODE 16.9 +25.2 25233 4.9 ZNF217 KLF4 TEAD1 CTBP1 OSR2 FOXA2 CEBPB BRCA1 FOS CEBPG TC2N CATSPERB PPP4R3A ATXN3 ENSG00000260711 ENSG00000275154
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around CATSPERB on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for CATSPERB

Top Transcription factor binding sites by QIAGEN in the CATSPERB gene promoter:
  • aMEF-2
  • C/EBPalpha
  • Chx10
  • E47
  • Evi-1
  • ITF-2
  • MEF-2A
  • Tal-1
  • Tal-1beta
  • TBP

Genomic Locations for CATSPERB Gene

Genomic Locations for CATSPERB Gene
chr14:91,580,696-91,780,707
(GRCh38/hg38)
Size:
200,012 bases
Orientation:
Minus strand
chr14:92,047,040-92,247,051
(GRCh37/hg19)
Size:
200,012 bases
Orientation:
Minus strand

Genomic View for CATSPERB Gene

Genes around CATSPERB on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CATSPERB Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CATSPERB Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CATSPERB Gene

Proteins for CATSPERB Gene

  • Protein details for CATSPERB Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H7T0-CTSRB_HUMAN
    Recommended name:
    Cation channel sperm-associated protein subunit beta
    Protein Accession:
    Q9H7T0
    Secondary Accessions:
    • A0AV51

    Protein attributes for CATSPERB Gene

    Size:
    1116 amino acids
    Molecular mass:
    126924 Da
    Quaternary structure:
    • Component of the CatSper complex.

    Alternative splice isoforms for CATSPERB Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CATSPERB Gene

Post-translational modifications for CATSPERB Gene

  • Glycosylation at Asn90, Asn100, Asn118, Asn226, and Asn321
  • Modification sites at PhosphoSitePlus

Other Protein References for CATSPERB Gene

No data available for DME Specific Peptides for CATSPERB Gene

Domains & Families for CATSPERB Gene

Gene Families for CATSPERB Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted membrane proteins
  • Transporters

Protein Domains for CATSPERB Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for CATSPERB Gene

GenScript: Design optimal peptide antigens:
  • Cation channel sperm-associated protein subunit beta (CTSRB_HUMAN)
genes like me logo Genes that share domains with CATSPERB: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for CATSPERB Gene

Function for CATSPERB Gene

Molecular function for CATSPERB Gene

UniProtKB/Swiss-Prot Function:
Probably involved in sperm cell hyperactivation via its association with CATSPER1. Sperm cell hyperactivation is needed for sperm motility which is essential late in the preparation of sperm for fertilization.

Phenotypes From GWAS Catalog for CATSPERB Gene

genes like me logo Genes that share phenotypes with CATSPERB: view

Animal Model Products

CRISPR Products

miRNA for CATSPERB Gene

miRTarBase miRNAs that target CATSPERB

Clone Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CATSPERB Gene

Localization for CATSPERB Gene

Subcellular locations from UniProtKB/Swiss-Prot for CATSPERB Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CATSPERB gene
Compartment Confidence
plasma membrane 5
endoplasmic reticulum 0

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for CATSPERB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0005929 cilium IBA 21873635
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
GO:0036128 CatSper complex ISS,IEA --
genes like me logo Genes that share ontologies with CATSPERB: view

Pathways & Interactions for CATSPERB Gene

PathCards logo

SuperPathways for CATSPERB Gene

SuperPathway Contained pathways
1 Fertilization
genes like me logo Genes that share pathways with CATSPERB: view

Pathways by source for CATSPERB Gene

3 Reactome pathways for CATSPERB Gene

Gene Ontology (GO) - Biological Process for CATSPERB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007275 multicellular organism development IEA --
GO:0007283 spermatogenesis IEA --
GO:0030154 cell differentiation IEA --
GO:0032570 response to progesterone TAS --
GO:0035036 sperm-egg recognition TAS --
genes like me logo Genes that share ontologies with CATSPERB: view

No data available for SIGNOR curated interactions for CATSPERB Gene

Drugs & Compounds for CATSPERB Gene

No Compound Related Data Available

Transcripts for CATSPERB Gene

mRNA/cDNA for CATSPERB Gene

1 REFSEQ mRNAs :
11 NCBI additional mRNA sequence :
8 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for CATSPERB Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14a · 14b ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21 ^ 22 ^ 23 ^ 24 ^ 25 ^
SP1:
SP2: -

ExUns: 26 ^ 27a · 27b
SP1:
SP2:

Relevant External Links for CATSPERB Gene

GeneLoc Exon Structure for
CATSPERB

Expression for CATSPERB Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for CATSPERB Gene

mRNA differential expression in normal tissues according to GTEx for CATSPERB Gene

This gene is overexpressed in Pancreas (x17.1), Artery - Aorta (x4.7), and Minor Salivary Gland (x4.4).

Protein differential expression in normal tissues from HIPED for CATSPERB Gene

This gene is overexpressed in Plasma (22.3), Ovary (11.4), Adipocyte (10.0), NK cells (7.5), and Prostate (6.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for CATSPERB Gene



Transcriptomic regulation report from SPP (The Signaling Pathways Project) for CATSPERB

SOURCE GeneReport for Unigene cluster for CATSPERB Gene:

Hs.131755
genes like me logo Genes that share expression patterns with CATSPERB: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for CATSPERB Gene

Orthologs for CATSPERB Gene

This gene was present in the common ancestor of chordates.

Orthologs for CATSPERB Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CATSPERB 31 30
  • 99.4 (n)
OneToOne
dog
(Canis familiaris)
Mammalia CATSPERB 31 30
  • 81.38 (n)
OneToOne
cow
(Bos Taurus)
Mammalia CATSPERB 31 30
  • 81.35 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Catsperb 17 31 30
  • 70.02 (n)
rat
(Rattus norvegicus)
Mammalia LOC100910102 30
  • 67.31 (n)
oppossum
(Monodelphis domestica)
Mammalia -- 31
  • 49 (a)
OneToMany
-- 31
  • 45 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia CATSPERB 31
  • 44 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CATSPERB 31
  • 42 (a)
OneToOne
Species where no ortholog for CATSPERB was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for CATSPERB Gene

ENSEMBL:
Gene Tree for CATSPERB (if available)
TreeFam:
Gene Tree for CATSPERB (if available)
Aminode:
Evolutionary constrained regions (ECRs) for CATSPERB: view image

Paralogs for CATSPERB Gene

Pseudogenes.org Pseudogenes for CATSPERB Gene

genes like me logo Genes that share paralogs with CATSPERB: view

No data available for Paralogs for CATSPERB Gene

Variants for CATSPERB Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for CATSPERB Gene

SNP ID Clinical significance and condition Chr 14 pos Variation AA Info Type
rs57706558 - p.Phe318Tyr

Additional dbSNP identifiers (rs#s) for CATSPERB Gene

Structural Variations from Database of Genomic Variants (DGV) for CATSPERB Gene

Variant ID Type Subtype PubMed ID
esv1003307 CNV insertion 20482838
esv1421109 CNV insertion 17803354
esv2430078 CNV insertion 19546169
esv2589440 CNV deletion 19546169
esv3581388 CNV loss 25503493
esv3635327 CNV gain 21293372
nsv1396 CNV insertion 18451855
nsv480161 CNV novel sequence insertion 20440878
nsv480224 CNV novel sequence insertion 20440878
nsv480894 CNV novel sequence insertion 20440878
nsv481336 CNV novel sequence insertion 20440878
nsv974365 CNV duplication 23825009

Variation tolerance for CATSPERB Gene

Residual Variation Intolerance Score: 4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.47; 71.63% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CATSPERB Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CATSPERB

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CATSPERB Gene

Disorders for CATSPERB Gene

Additional Disease Information for CATSPERB

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for CATSPERB Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CATSPERB Gene

Publications for CATSPERB Gene

  1. CatSperbeta, a novel transmembrane protein in the CatSper channel complex. (PMID: 17478420) Liu J … Ren D (The Journal of biological chemistry 2007) 2 3 54
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 54
  3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. (PMID: 21873635) Gaudet P … Thomas PD (Briefings in bioinformatics 2011) 3 54
  4. Expression of conjoined genes: another mechanism for gene regulation in eukaryotes. (PMID: 20967262) Prakash T … Taylor TD (PloS one 2010) 3 54
  5. Genome-wide association study of bone mineral density in premenopausal European-American women and replication in African-American women. (PMID: 20164292) Koller DL … Foroud T (The Journal of clinical endocrinology and metabolism 2010) 3 54

Products for CATSPERB Gene

Sources for CATSPERB Gene