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Aliases for CATSPER3 Gene
Aliases for CATSPER3 Gene
External Ids for CATSPER3 Gene
- HGNC: 20819
- Entrez Gene: 347732
- Ensembl: ENSG00000152705
- OMIM: 609120
- UniProtKB: Q86XQ3
Previous GeneCards Identifiers for CATSPER3 Gene
- GC05P134334
- GC05P134379
- GC05P134331
- GC05P129491
Summaries for CATSPER3 Gene
GeneCards Summary for CATSPER3 Gene
CATSPER3 (Cation Channel Sperm Associated 3) is a Protein Coding gene. Among its related pathways are Fertilization. Gene Ontology (GO) annotations related to this gene include ion channel activity and calcium activated cation channel activity. An important paralog of this gene is SCN3A.
UniProtKB/Swiss-Prot Summary for CATSPER3 Gene
-
Voltage-gated calcium channel that plays a central role in calcium-dependent physiological responses essential for successful fertilization, such as sperm hyperactivation, acrosome reaction and chemotaxis towards the oocyte.
Additional gene information for CATSPER3 Gene
- Monarch Initiative
- Search for CATSPER3 at DataMed
- Search for CATSPER3 at HumanCyc
No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for CATSPER3 Gene
Genomics for CATSPER3 Gene
GeneHancer (GH) Regulatory Elements for CATSPER3 Gene
Promoters and enhancers for CATSPER3 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around CATSPER3 on UCSC Golden Path with GeneCards custom track
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for CATSPER3
- Top Transcription factor binding sites by QIAGEN in the CATSPER3 gene promoter:
-
- AREB6
- CUTL1
- FOXO4
- GATA-1
- ISGF-3
- Lhx3a
- LHX3b
- Pbx1a
- POU3F2
- RP58
Genomic Locations for CATSPER3 Gene
Genomic Locations for CATSPER3 Gene
- chr5:134,967,906-135,011,707
- (GRCh38/hg38)
- Size:
- 43,802 bases
- Orientation:
- Plus strand
- chr5:134,303,596-134,347,397
- (GRCh37/hg19)
- Size:
- 43,802 bases
- Orientation:
- Plus strand
Genomic View for CATSPER3 Gene
Genes around CATSPER3 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 5q31.1 by HGNC
- 5q31.1 by Entrez Gene
- 5q31.1 by Ensembl
CATSPER3 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for CATSPER3 Gene
Proteins for CATSPER3 Gene
-
Protein details for CATSPER3 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q86XQ3-CTSR3_HUMAN
- Recommended name:
- Cation channel sperm-associated protein 3
- Protein Accession:
- Q86XQ3
- Q86XS6
Protein attributes for CATSPER3 Gene
- Size:
- 398 amino acids
- Molecular mass:
- 46422 Da
- Quaternary structure:
-
- Heterotetramer; possibly composed of CATSPER1, CATSPER2, CATSPER3 and CATSPER4 (Potential). Component of the CatSper complex. Interacts with CATSPER1 (By similarity).
Protein Expression for CATSPER3 Gene
Post-translational modifications for CATSPER3 Gene
Other Protein References for CATSPER3 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- G Biosciences Immunotag™ CATSPER3 Antibody
- Creative Diagnostics Anti-CATSPER3 (aa 299-398) polyclonal antibody
-
Abcam antibodies for CATSPER3
- Invitrogen Antibodies for CATSPER3 (AFLGC-CATSPER3)
Protein Products
-
OriGene Purified Proteins for CATSPER3
- Search Origene for MassSpec and Protein Over-expression Lysates for CATSPER3
- Origene Custom Protein Services for CATSPER3
- antibodies-online: Show 4 available CATSPER3 Proteins ranked by validation data
- Compare Top CATSPER3 Proteins
-
Quality Products:
-
Abcam proteins for CATSPER3
No data available for DME Specific Peptides for CATSPER3 Gene
Domains & Families for CATSPER3 Gene
Gene Families for CATSPER3 Gene
- HGNC:
- IUPHAR :
- Human Protein Atlas (HPA):
-
- Predicted membrane proteins
- Transporters
Protein Domains for CATSPER3 Gene
- InterPro:
- ProtoNet:
Suggested Antigen Peptide Sequences for CATSPER3 Gene
- GenScript: Design optimal peptide antigens:
-
- One-repeat calcium channel-like protein (CTSR3_HUMAN)
Graphical View of Domain Structure for InterPro Entry
Q86XQ3UniProtKB/Swiss-Prot:
CTSR3_HUMAN :- Belongs to the cation channel sperm-associated (TC 1.A.1.19) family.
- Family:
-
- Belongs to the cation channel sperm-associated (TC 1.A.1.19) family.
Function for CATSPER3 Gene
Molecular function for CATSPER3 Gene
- UniProtKB/Swiss-Prot Function:
- Voltage-gated calcium channel that plays a central role in calcium-dependent physiological responses essential for successful fertilization, such as sperm hyperactivation, acrosome reaction and chemotaxis towards the oocyte.
- UniProtKB/Swiss-Prot EnzymeRegulation:
- The CatSper calcium channel is indirectly activated by extracellular progesterone and prostaglandins following the sequence: progesterone > PGF1-alpha = PGE1 > PGA1 > PGE2 >> PGD2 (PubMed:21412338, PubMed:21412339, PubMed:26989199). The CatSper calcium channel is directly inhibited by endocannabinoid 2-arachidonoylglycerol (2AG) (PubMed:26989199). Indirect activation by progesterone takes place via the following mechanism: progesterone binds and activates the acylglycerol lipase ABHD2, which in turn mediates hydrolysis of 2AG inhibitor, relieving inhibition of the CatSper channel (PubMed:26989199). The primary effect of progesterone activation is to shift voltage dependence towards more physiological, negative membrane potentials; it is not mediated by metabotropic receptors and second messengers (PubMed:21412338, PubMed:21412339). Sperm capacitation enhances the effect of progesterone by providing additional negative shift. Also activated by the elevation of intracellular pH (PubMed:21412338, PubMed:21412339).
Phenotypes From GWAS Catalog for CATSPER3 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005216 | ion channel activity | IEA | -- |
| GO:0005244 | voltage-gated ion channel activity | IEA | -- |
| GO:0005245 | voltage-gated calcium channel activity | IEA | -- |
| GO:0005262 | calcium channel activity | IEA | -- |
Phenotypes for CATSPER3 Gene
- MGI mutant phenotypes for CATSPER3:
- inferred from 3 alleles
- GenomeRNAi human phenotypes for CATSPER3:
Animal Models for CATSPER3 Gene
Animal Model Products
-
Taconic Biosciences Mouse Models for CATSPER3
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for CATSPER3 - Select products 50% OFF >
- * CATSPER3 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * CATSPER3 CRISPR applications: KO, Activation, Repression, and more - Browse All
-
OriGene CRISPR knockouts for CATSPER3
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for CATSPER3
- genomics-online: gRNA clones - Search results for available CATSPER3 gene related products
-
Santa Cruz Biotechnology (SCBT) CRISPR for CATSPER3
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for CATSPER3
- Browse OriGene Inhibitory RNA Products For CATSPER3
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CATSPER3
- genomics-online: shRNA clones - Search results for available CATSPER3 gene related products
Clone Products
- Applied Biological Materials (abm): Clones for CATSPER3 - Select products 50% OFF >
- * CATSPER3 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * CATSPER3 tags and reporters available: His, HA, Myc, Flag, GFP, RFP, Luciferase - Browse All
- Sino Biological Human cDNA Clone for CATSPER3
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for CATSPER3
- genomics-online: cdna clones - Search results for available CATSPER3 gene related products
- orf clones - Search results for available CATSPER3 gene related products
Cell Line Products
-
Horizon Cell Lines for CATSPER3
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for CATSPER3 Gene
Localization for CATSPER3 Gene
Subcellular locations from UniProtKB/Swiss-Prot for CATSPER3 Gene
- Cell projection, cilium, flagellum membrane; Multi-pass membrane protein. Note=Specifically located in the principal piece of sperm tail.
| Compartment | Confidence |
|---|---|
| plasma membrane | 5 |
| endoplasmic reticulum | 2 |
| extracellular | 1 |
| cytoskeleton | 1 |
| mitochondrion | 1 |
| nucleus | 1 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0001669 | acrosomal vesicle | IEA | -- |
| GO:0005783 | endoplasmic reticulum | IEA | -- |
| GO:0005886 | plasma membrane | TAS | -- |
| GO:0005929 | cilium | IEA | -- |
| GO:0016020 | membrane | IEA | -- |
No data available for Subcellular locations from the Human Protein Atlas (HPA) for CATSPER3 Gene
Pathways & Interactions for CATSPER3 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Fertilization |
1.00
1.00
|
|
Pathways by source for CATSPER3 Gene
3 Reactome pathways for CATSPER3 Gene
Interacting Proteins for CATSPER3 Gene
GPS-Prot Interaction Network for CATSPER3
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006811 | ion transport | IEA | -- |
| GO:0006814 | sodium ion transport | IEA | -- |
| GO:0006816 | calcium ion transport | IEA | -- |
| GO:0007275 | multicellular organism development | IEA | -- |
| GO:0007283 | spermatogenesis | IEA | -- |
No data available for SIGNOR curated interactions for CATSPER3 Gene
Drugs & Compounds for CATSPER3 Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| Progesterone | Approved, Vet_approved | Pharma | Full agonist, Activator, Agonist, Inhibition, Pore Blocker, inhibitor | Endogenous progesterone receptor agonist | 721 | |
| Calcium | Approved | Nutra | 7884 | |||
| Mibefradil | Investigational, Withdrawn | Pharma | Channel blocker, Antagonist, Pore Blocker, Inhibition, blocker | Calcium channel blocker | 3 | |
| NNC55-0396 | Pharma | Inhibition, Pore Blocker | 0 | |||
| PGE<sub>1</sub> | Pharma | Full agonist, Activator, Agonist | 0 |
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
|---|---|---|---|---|---|---|
| PGF<sub>1alpha</sub> |
|
Full agonist, Activator |
|
Transcripts for CATSPER3 Gene
mRNA/cDNA for CATSPER3 Gene
- 1 REFSEQ mRNAs :
- 8 NCBI additional mRNA sequence :
- 2 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000282611 1355 bps (ENST00000282611.8)
- ENST00000511235 551 bps (ENST00000511235.1)
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for CATSPER3 - Select products 50% OFF >
- * CATSPER3 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * CATSPER3 CRISPR applications: KO, Activation, Repression, and more - Browse All
-
OriGene CRISPR knockouts for CATSPER3
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for CATSPER3
- genomics-online: gRNA clones - Search results for available CATSPER3 gene related products
-
Santa Cruz Biotechnology (SCBT) CRISPR for CATSPER3
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for CATSPER3
- Browse OriGene Inhibitory RNA Products For CATSPER3
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CATSPER3
- genomics-online: shRNA clones - Search results for available CATSPER3 gene related products
Clone Products
- Applied Biological Materials (abm): Clones for CATSPER3 - Select products 50% OFF >
- * CATSPER3 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * CATSPER3 tags and reporters available: His, HA, Myc, Flag, GFP, RFP, Luciferase - Browse All
- Sino Biological Human cDNA Clone for CATSPER3
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for CATSPER3
- genomics-online: cdna clones - Search results for available CATSPER3 gene related products
- orf clones - Search results for available CATSPER3 gene related products
Relevant External Links for CATSPER3 Gene
- GeneLoc Exon Structure for
- CATSPER3
Expression for CATSPER3 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
mRNA differential expression in normal tissues according to GTEx for CATSPER3 Gene
This gene is overexpressed in Testis (x21.6).
This gene is overexpressed in Cerebrospinal fluid (69.0).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for CATSPER3 Gene
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for CATSPER3
SOURCE GeneReport for Unigene cluster for CATSPER3 Gene:
Hs.631804mRNA Expression by UniProt/SwissProt for CATSPER3 Gene:
Q86XQ3-CTSR3_HUMAN
Tissue specificity:
Testis-specific.
Evidence on tissue expression from TISSUES for CATSPER3 Gene
- Nervous system(4)
Primer Products
-
OriGene qPCR primer pairs for CATSPER3
-
OriGene qPCR primer pairs and template standards for CATSPER3
- genomics-online: primer clones - Search results for available CATSPER3 gene related products
Gene Expression Assay Products
No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for CATSPER3 Gene
Orthologs for CATSPER3 Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | CATSPER3 31 30 |
|
OneToOne | |
| dog (Canis familiaris) |
Mammalia | CATSPER3 31 30 |
|
OneToOne | |
| cow (Bos Taurus) |
Mammalia | CATSPER3 31 30 |
|
OneToOne | |
| mouse (Mus musculus) |
Mammalia | Catsper3 17 31 30 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Catsper3 30 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | CATSPER3 31 |
|
OneToOne | |
| lizard (Anolis carolinensis) |
Reptilia | CATSPER3 31 |
|
OneToOne | |
| sea squirt (Ciona savignyi) |
Ascidiacea | -- 31 |
|
OneToOne |
- Species where no ortholog for CATSPER3 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- chicken (Gallus gallus)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- platypus (Ornithorhynchus anatinus)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- tropical clawed frog (Silurana tropicalis)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
- zebrafish (Danio rerio)
Evolution for CATSPER3 Gene
- ENSEMBL:
- Gene Tree for CATSPER3 (if available)
- TreeFam:
- Gene Tree for CATSPER3 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for CATSPER3: view image
Paralogs for CATSPER3 Gene
Paralogs for CATSPER3 Gene
Variants for CATSPER3 Gene
Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for CATSPER3 Gene
| SNP ID | Clinical significance and condition | Chr 05 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs3896260 | - | p.Asn204Lys |
Residual Variation Intolerance Score:
89.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
3.58;
56.12% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for CATSPER3 Gene
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CATSPER3 Gene
Disorders for CATSPER3 Gene
Additional Disease Information for CATSPER3
- Genetic Association Database
- (GAD)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No disorders were found for CATSPER3 Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CATSPER3 Gene
Publications for CATSPER3 Gene
- Identification of human and mouse CatSper3 and CatSper4 genes: characterisation of a common interaction domain and evidence for expression in testis. (PMID: 12932298) Lobley A … Michalovich D (Reproductive biology and endocrinology : RB&E 2003) 2 3 4 23 54
- Cloning of a novel one-repeat calcium channel-like gene. (PMID: 12646162) Arias JM … Perez-Reyes E (Biochemical and biophysical research communications 2003) 2 3 4 54
- Many sequence variants affecting diversity of adult human height. (PMID: 18391951) Gudbjartsson DF … Stefansson K (Nature genetics 2008) 3 41 54
- Expression of CatSper family transcripts in the mouse testis during post-natal development and human ejaculated spermatozoa: relationship to sperm motility. (PMID: 17347248) Li HG … Xiong CL (Molecular human reproduction 2007) 4 23 54
- All four CatSper ion channel proteins are required for male fertility and sperm cell hyperactivated motility. (PMID: 17227845) Qi H … Clapham DE (Proceedings of the National Academy of Sciences of the United States of America 2007) 2 3 54
ExternalLinks
Products for CATSPER3 Gene
- Custom Antibody Services
- Browse OriGene ELISA Kits
- Custom Assay Services
- OriGene Purified Proteins for CATSPER3
- Search Origene for MassSpec and Protein Over-expression Lysates for CATSPER3
- Origene Custom Protein Services for CATSPER3
- Origene shrna, sirna, and RNAi products in human, mouse, rat for CATSPER3
- Browse OriGene Inhibitory RNA Products For CATSPER3
- OriGene qPCR primer pairs for CATSPER3
- OriGene qPCR primer pairs and template standards for CATSPER3
- OriGene CRISPR knockouts for CATSPER3
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For CATSPER3
- Sino Biological Human cDNA Clone for CATSPER3
- Browse Sino Biological Recombinant Proteins
- Browse Sino Biological Cell Lysates
- Browse Sino Biological Antibodies
- Browse Sino Biological Assays
- Browse cDNA Clones
- Browse ELISA Kits
- Browse CRO Services
- High-throughput Antibody Production Service
- Protein Production Service
- Epitope Tag Antibodies & Reporter Protein Antibodies
- Lentiviral ORF Clones
- Novus Biologicals proteins and lysates for CATSPER3
- Browse Antibodies
- Browse Peptides and Proteins
- Browse Lysates
- Browse ELISA Kits
- Abcam antibodies for CATSPER3
- Abcam proteins for CATSPER3
- Find your target
- Browse Primary Antibodies
- Browse Conjugated Primary Antibodies
- Browse Secondary Antibodies
- Browse ELISA Kits
- Browse Matched Antibody Pairs
- Browse Proteins and Peptides
- Search Knockout (KO) Validated Antibodies
- Browse Monoclonal Antibodies
- Browse Recombinant Antibodies
- Taconic Biosciences Mouse Models for CATSPER3
- Find your next knockout model in the Taconic Knockout Repository
- Genetically Engineered Models Available Immediately
- Humanized Mice
- Invitrogen Antibodies for CATSPER3 (AFLGC-CATSPER3)
- antibodies-online: Show 31 available CATSPER3 Antibodies ranked by validation data
- Compare Top CATSPER3 Antibodies
- antibodies-online: Search results for available CATSPER3 related products ranked by validation data
- antibodies-online: Show 4 available CATSPER3 Proteins ranked by validation data
- Compare Top CATSPER3 Proteins
- Quality Products:
- Horizon Cell Lines for CATSPER3
- genomics-online: cdna clones - Search results for available CATSPER3 gene related products
- orf clones - Search results for available CATSPER3 gene related products
- genomics-online: gRNA clones - Search results for available CATSPER3 gene related products
- genomics-online: primer clones - Search results for available CATSPER3 gene related products
- genomics-online: shRNA clones - Search results for available CATSPER3 gene related products
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for CATSPER3
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for CATSPER3
- Search GeneCopoeia for miRNA 3'UTR Target clone products for CATSPER3
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CATSPER3
Sources for CATSPER3 Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) UniProtKB/TrEMBL
- (14) InterPro
- (15) ProtoNet
- (16) Blocks
- (17) MGI
- (18) IUBMB
- (19) KEGG
- (20) MINT
- (21) STRING
- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) ASD
- (28) SAGE
- (29) SOURCE
- (30) HomoloGene
- (31) PanEnsembl
- (32) euGenes
- (33) SGD
- (34) FlyBase
- (35) WormBase
- (36) Pseudogene
- (37) DGV
- (38) dbSNP
- (39) GenAtlas
- (40) HGMD
- (41) GAD
- (42) BGMUT
- (43) HuGE
- (44) Atlas
- (45) GenBank
- (46) H-invDB
- (47) HORDE
- (48) HUGE
- (49) IMGT
- (50) Leiden
- (51) miRBase
- (52) DME
- (53) OriGene
- (54) PubMed
- (55) R&D Systems
- (56) TGDB
- (57) Tocris
- (58) Abcam
- (59) Novus Biologicals
- (60) ProSpec
- (61) Sino Biological
- (62) GenScript
- (63) Qiagen
- (64) OCA
- (65) Proteopedia
- (66) MOPED
- (67) neXtProt
- (68) Reactome
- (69) GeneGo (Thomson Reuters)
- (70) DISEASES
- (71) SIMAP
- (72) GenomeRNAi
- (73) LifeMap
- (74) miRTarBase
- (75) MalaCards
- (76) Invitrogen
- (77) BitterDB
- (78) ESI-BIO
- (79) RefSeq
- (80) BioSystems
- (81) MaxQB
- (82) IUPHAR
- (83) BioGPS
- (84) Illumina
- (85) COMPARTMENTS
- (86) HOMER
- (87) PaxDb
- (88) ApexBio
- (89) Addgene
- (90) antibodies-online
- (91) CYP
- (92) NONCODE
- (93) TreeFam
- (94) PathCards
- (95) GeneReviews
- (96) GeneTex
- (97) Taconic Biosciences
- (98) GTEx
- (99) ProteomicsDB
- (100) SCBT
- (101) DGIdb
- (102) ClinicalTrials
- (103) RVIS
- (104) SIGNOR
- (105) diseasecard
- (106) NIH Rare Diseases
- (107) Orphanet
- (108) UMLS
- (109) GTR
- (110) Disease Ontology
- (111) Genetics Home Reference
- (112) MeSH
- (113) MedlinePlus
- (114) CDC
- (115) NINDS
- (116) NCBI Bookshelf
- (117) ClinVar
- (118) Gene Damage Index
- (119) HPO
- (120) UDN
- (121) VISTA
- (122) FANTOM5
- (123) ENCODE
- (124) ProSci
- (125) Horizon
- (126) The Signaling Pathways Project (SPP)
- (127) IID
- (128) VectorBuilder
- (129) SNPedia
- (130) BRCA Exchange
- (131) CIViC
- (132) ProteoGenix
- (133) dbSUPER
- (134) TISSUES
- (135) Gene ORGANizer
- (136) abm
- (137) Human Protein Atlas
- (138) GWAS Catalog
- (139) Monarch Initiative
- (140) DataMed
- (141) HumanCyc
- (142) genomics-online
- (143) UCNEbase
- (144) EPDnew
- (145) Applied Biosystems
- (146) GlyConnect
- (147) Aminode
- (148) GeneCopoeia
- (149) GPS-Prot
- (150) RNACentral
- (151) LncRNADisease
- (152) LOVD
- (153) miR2Disease
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- (157) Biocompare
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- (159) CTD^2 Dashboard
- (160) CraniofacialAtlas
- (161) GeneImprint
- (162) Synthego
- (163) Bio Basic
- (164) ENA
- (165) GtRNAdb
- (166) LncBase
- (167) LncBook
- (168) LNCipedia
- (169) LncRNAdb
- (170) Modomics
- (171) PDBe
- (172) Rfam
- (173) SILVA
- (174) snOPY
- (175) SRPDB
- (176) GENCODE
- (177) TarBase
- (178) MyBioSource