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CATSPER3 (Cation Channel Sperm Associated 3) is a Protein Coding gene. Among its related pathways are Fertilization. Gene Ontology (GO) annotations related to this gene include ion channel activity and calcium activated cation channel activity. An important paralog of this gene is SCN5A.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005216 | ion channel activity | IEA | -- |
GO:0005244 | voltage-gated ion channel activity | IEA | -- |
GO:0005245 | voltage-gated calcium channel activity | IEA,IBA | 21873635 |
GO:0005262 | calcium channel activity | IEA | -- |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0001669 | acrosomal vesicle | IEA,IBA | 21873635 |
GO:0005783 | endoplasmic reticulum | IEA | -- |
GO:0005886 | plasma membrane | TAS | -- |
GO:0005929 | cilium | IEA | -- |
GO:0016020 | membrane | IEA | -- |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Fertilization |
1.00
1.00
|
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0006811 | ion transport | IEA | -- |
GO:0006814 | sodium ion transport | IEA,IBA | 21873635 |
GO:0006816 | calcium ion transport | IEA | -- |
GO:0007275 | multicellular organism development | IEA | -- |
GO:0007283 | spermatogenesis | IEA | -- |
Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
---|---|---|---|---|---|---|
Progesterone | Approved, Vet_approved | Pharma | Activator, Full agonist, Agonist, Pore Blocker, Inhibition, inhibitor | Endogenous progesterone receptor agonist | 755 | |
Mibefradil | Investigational, Withdrawn | Pharma | Channel blocker, Pore Blocker, Antagonist, Inhibition, blocker | Calcium channel blocker | 3 | |
NNC55-0396 | Pharma | Channel blocker, Pore Blocker, Inhibition | 0 | |||
PGE<sub>1</sub> | Pharma | Activator, Full agonist, Agonist | 0 | |||
PGE<sub>2</sub> | Pharma | Activator, Full agonist, Agonist | 0 |
This gene was present in the common ancestor of chordates.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | CATSPER3 30 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | CATSPER3 30 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | CATSPER3 30 31 |
|
OneToOne | |
Mouse (Mus musculus) |
Mammalia | Catsper3 30 17 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | Catsper3 30 |
|
||
Oppossum (Monodelphis domestica) |
Mammalia | CATSPER3 31 |
|
OneToOne | |
Lizard (Anolis carolinensis) |
Reptilia | CATSPER3 31 |
|
OneToOne | |
Sea Squirt (Ciona savignyi) |
Ascidiacea | -- 31 |
|
OneToOne |
No disorders were found for CATSPER3 Gene.