Aliases for CATIP Gene

Aliases for CATIP Gene

  • Ciliogenesis Associated TTC17 Interacting Protein 2 3 5
  • Ciliogenesis-Associated TTC17-Interacting Protein 3 4
  • C2orf62 3 4
  • Chromosome 2 Open Reading Frame 62 2

External Ids for CATIP Gene

Previous HGNC Symbols for CATIP Gene

  • C2orf62

Previous GeneCards Identifiers for CATIP Gene

  • GC02P219222

Summaries for CATIP Gene

GeneCards Summary for CATIP Gene

CATIP (Ciliogenesis Associated TTC17 Interacting Protein) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include calmodulin binding. An important paralog of this gene is BAMBI.

UniProtKB/Swiss-Prot Summary for CATIP Gene

  • Plays a role in primary ciliogenesis by modulating actin polymerization.

Additional gene information for CATIP Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for CATIP Gene

Genomics for CATIP Gene

GeneHancer (GH) Regulatory Elements for CATIP Gene

Promoters and enhancers for CATIP Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around CATIP on UCSC Golden Path with GeneCards custom track

Genomic Locations for CATIP Gene

Genomic Locations for CATIP Gene
chr2:218,356,832-218,368,110
(GRCh38/hg38)
Size:
11,279 bases
Orientation:
Plus strand
chr2:219,221,579-219,232,822
(GRCh37/hg19)
Size:
11,244 bases
Orientation:
Plus strand

Genomic View for CATIP Gene

Genes around CATIP on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CATIP Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CATIP Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CATIP Gene

Proteins for CATIP Gene

  • Protein details for CATIP Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q7Z7H3-CATIP_HUMAN
    Recommended name:
    Ciliogenesis-associated TTC17-interacting protein
    Protein Accession:
    Q7Z7H3

    Protein attributes for CATIP Gene

    Size:
    387 amino acids
    Molecular mass:
    43900 Da
    Quaternary structure:
    • Interacts with TTC17.

neXtProt entry for CATIP Gene

Post-translational modifications for CATIP Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CATIP Gene

No data available for DME Specific Peptides for CATIP Gene

Domains & Families for CATIP Gene

Gene Families for CATIP Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for CATIP Gene

ProtoNet:

Graphical View of Domain Structure for InterPro Entry

Q7Z7H3

UniProtKB/Swiss-Prot:

CATIP_HUMAN :
  • Belongs to the CATIP family.
Family:
  • Belongs to the CATIP family.
genes like me logo Genes that share domains with CATIP: view

No data available for Suggested Antigen Peptide Sequences for CATIP Gene

Function for CATIP Gene

Molecular function for CATIP Gene

UniProtKB/Swiss-Prot Function:
Plays a role in primary ciliogenesis by modulating actin polymerization.

Phenotypes From GWAS Catalog for CATIP Gene

Gene Ontology (GO) - Molecular Function for CATIP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 24475127
genes like me logo Genes that share ontologies with CATIP: view

Phenotypes for CATIP Gene

genes like me logo Genes that share phenotypes with CATIP: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CATIP

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for CATIP Gene

Localization for CATIP Gene

Subcellular locations from UniProtKB/Swiss-Prot for CATIP Gene

Nucleus. Cytoplasm. Cell membrane. Cytoplasm, cytoskeleton. Note=Colocalized with TTC17 at F-actin rich zones and at dynamic plasma membrane protrusions.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CATIP gene
Compartment Confidence
plasma membrane 5
cytoskeleton 5
nucleus 5
cytosol 2
peroxisome 0

Gene Ontology (GO) - Cellular Components for CATIP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA,IDA 24475127
GO:0005737 cytoplasm IEA,IDA 24475127
GO:0005856 cytoskeleton IEA --
GO:0005886 plasma membrane IEA,IDA 24475127
GO:0015629 actin cytoskeleton IDA 24475127
genes like me logo Genes that share ontologies with CATIP: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for CATIP Gene

Pathways & Interactions for CATIP Gene

PathCards logo

SuperPathways for CATIP Gene

No Data Available

Gene Ontology (GO) - Biological Process for CATIP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0030030 cell projection organization IEA --
GO:0030041 actin filament polymerization IBA,IMP 24475127
GO:0044782 cilium organization IMP 24475127
genes like me logo Genes that share ontologies with CATIP: view

No data available for Pathways by source and SIGNOR curated interactions for CATIP Gene

Drugs & Compounds for CATIP Gene

No Compound Related Data Available

Transcripts for CATIP Gene

mRNA/cDNA for CATIP Gene

(2) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(9) Selected AceView cDNA sequences:
(5) Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CATIP

Alternative Splicing Database (ASD) splice patterns (SP) for CATIP Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10
SP1: - - -
SP2: - - -
SP3:
SP4:

Relevant External Links for CATIP Gene

GeneLoc Exon Structure for
CATIP
ECgene alternative splicing isoforms for
CATIP

Expression for CATIP Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CATIP Gene

mRNA differential expression in normal tissues according to GTEx for CATIP Gene

This gene is overexpressed in Testis (x7.5), Whole Blood (x5.7), Kidney - Cortex (x4.8), Fallopian Tube (x4.3), and Thyroid (x4.2).

Protein differential expression in normal tissues from HIPED for CATIP Gene

This gene is overexpressed in Bone marrow stromal cell (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for CATIP Gene



Protein tissue co-expression partners for CATIP Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of CATIP Gene:

CATIP

mRNA Expression by UniProt/SwissProt for CATIP Gene:

Q7Z7H3-CATIP_HUMAN
Tissue specificity: Strongly expressed in round and elongating spermatids, weakly in pachytene spermatocytes. Expressed in Leydig cells (at protein level). Expressed in testis, placenta, prostate and lung, and moderately in ovary and brain.

Evidence on tissue expression from TISSUES for CATIP Gene

  • Nervous system(4.1)
genes like me logo Genes that share expression patterns with CATIP: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and Phenotype-based relationships between genes and organs from Gene ORGANizer for CATIP Gene

Orthologs for CATIP Gene

This gene was present in the common ancestor of chordates.

Orthologs for CATIP Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CATIP 32
  • 99.48 (n)
C2orf62 33
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia CATIP 32
  • 84.96 (n)
C2orf62 33
  • 79 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia LOC690437 32
  • 78.66 (n)
dog
(Canis familiaris)
Mammalia C2orf62 33
  • 72 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Gm216 33
  • 51 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia C2orf62 33
  • 51 (a)
OneToOne
chicken
(Gallus gallus)
Aves CATIP 32
  • 54.44 (n)
C2orf62 33
  • 42 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia C2orf62 33
  • 44 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100495462 32
  • 55.52 (n)
zebrafish
(Danio rerio)
Actinopterygii catip 32
  • 54.12 (n)
C6H2orf62 33
  • 40 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 33
  • 37 (a)
OneToOne
Species where no ortholog for CATIP was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CATIP Gene

ENSEMBL:
Gene Tree for CATIP (if available)
TreeFam:
Gene Tree for CATIP (if available)
Aminode:
Evolutionary constrained regions (ECRs) for CATIP: view image

Paralogs for CATIP Gene

Paralogs for CATIP Gene

genes like me logo Genes that share paralogs with CATIP: view

Variants for CATIP Gene

Sequence variations from dbSNP and Humsavar for CATIP Gene

SNP ID Clin Chr 02 pos Variation AA Info Type
rs1000097055 -- 218,366,957(+) A/G intron_variant
rs1000149248 -- 218,367,349(+) T/C intron_variant
rs1000726209 -- 218,358,816(+) C/T intron_variant
rs1000864296 -- 218,365,105(+) A/C intron_variant
rs1001614594 -- 218,362,556(+) A/G intron_variant

Structural Variations from Database of Genomic Variants (DGV) for CATIP Gene

Variant ID Type Subtype PubMed ID
esv2763102 CNV loss 21179565
nsv519829 CNV loss 19592680

Variation tolerance for CATIP Gene

Residual Variation Intolerance Score: 68.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.02; 37.22% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CATIP Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CATIP

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CATIP Gene

Disorders for CATIP Gene

Additional Disease Information for CATIP

No disorders were found for CATIP Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CATIP Gene

Publications for CATIP Gene

  1. C2orf62 and TTC17 are involved in actin organization and ciliogenesis in zebrafish and human. (PMID: 24475127) Bontems F … Lane L (PloS one 2014) 2 3 4 56
  2. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T … Vidal M (Cell 2014) 3 56
  3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. (PMID: 21873635) Gaudet P … Thomas PD (Briefings in bioinformatics 2011) 3 56
  4. Interactions of pathological hallmark proteins: tubulin polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PMID: 21832049) Oláh J … Ovádi J (The Journal of biological chemistry 2011) 3 56
  5. hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PMID: 17207965) Lamesch P … Vidal M (Genomics 2007) 3 56

Products for CATIP Gene

Sources for CATIP Gene