External Ids for CAT Gene
Previous GeneCards Identifiers for CAT Gene
This gene encodes catalase, a key antioxidant enzyme in the bodies defense against oxidative stress. Catalase is a heme enzyme that is present in the peroxisome of nearly all aerobic cells. Catalase converts the reactive oxygen species hydrogen peroxide to water and oxygen and thereby mitigates the toxic effects of hydrogen peroxide. Oxidative stress is hypothesized to play a role in the development of many chronic or late-onset diseases such as diabetes, asthma, Alzheimer's disease, systemic lupus erythematosus, rheumatoid arthritis, and cancers. Polymorphisms in this gene have been associated with decreases in catalase activity but, to date, acatalasemia is the only disease known to be caused by this gene. [provided by RefSeq, Oct 2009]
GeneCards Summary for CAT Gene
CAT (Catalase) is a Protein Coding gene. Diseases associated with CAT include Acatalasemia and Pneumoconiosis. Among its related pathways are Cellular Senescence (REACTOME) and Metabolism of nucleotides. Gene Ontology (GO) annotations related to this gene include protein homodimerization activity and enzyme binding.
UniProtKB/Swiss-Prot Summary for CAT Gene
Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide. Promotes growth of cells including T-cells, B-cells, myeloid leukemia cells, melanoma cells, mastocytoma cells and normal and transformed fibroblast cells.