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The protein encoded by this gene is a zinc finger transcription factor. The encoded protein may function as a tumor suppressor, and single nucleotide polymorphisms in this gene are associated with blood pressure variation. Alternative splicing results in multiple transcript variants that encode different protein isoforms. [provided by RefSeq, Jul 2012]
CASZ1 (Castor Zinc Finger 1) is a Protein Coding gene. Diseases associated with CASZ1 include Retroperitoneal Sarcoma and Retroperitoneum Carcinoma.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000981 | DNA-binding transcription factor activity, RNA polymerase II-specific | ISA | -- |
GO:0003676 | nucleic acid binding | IEA | -- |
GO:0003677 | DNA binding | IEA | -- |
GO:0046872 | metal ion binding | IEA | -- |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005634 | nucleus | IEA | -- |
GO:0005654 | nucleoplasm | IDA | -- |
GO:0005829 | cytosol | IDA | -- |
GO:0043231 | intracellular membrane-bounded organelle | IDA | -- |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0006355 | regulation of transcription, DNA-templated | IEA | -- |
GO:0006357 | regulation of transcription by RNA polymerase II | IEA | -- |
GO:0007275 | multicellular organism development | IEA | -- |
GO:0045893 | positive regulation of transcription, DNA-templated | IDA | 27693370 |
This gene was present in the common ancestor of animals.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
chimpanzee (Pan troglodytes) |
Mammalia | CASZ1 33 32 |
|
OneToOne | |
cow (Bos Taurus) |
Mammalia | CASZ1 33 32 |
|
OneToOne | |
dog (Canis familiaris) |
Mammalia | CASZ1 33 32 |
|
OneToOne | |
mouse (Mus musculus) |
Mammalia | Casz1 17 33 32 |
|
||
rat (Rattus norvegicus) |
Mammalia | Casz1 32 |
|
||
platypus (Ornithorhynchus anatinus) |
Mammalia | CASZ1 33 |
|
OneToOne | |
oppossum (Monodelphis domestica) |
Mammalia | CASZ1 33 |
|
OneToOne | |
chicken (Gallus gallus) |
Aves | CASZ1 33 32 |
|
OneToOne | |
lizard (Anolis carolinensis) |
Reptilia | CASZ1 33 |
|
OneToOne | |
tropical clawed frog (Silurana tropicalis) |
Amphibia | casz1 32 |
|
||
zebrafish (Danio rerio) |
Actinopterygii | casz1 33 32 |
|
OneToOne | |
wufc21h10 32 |
|
||||
fruit fly (Drosophila melanogaster) |
Insecta | cas 33 |
|
OneToMany | |
CG7512 33 |
|
OneToMany | |||
sea squirt (Ciona savignyi) |
Ascidiacea | -- 33 |
|
OneToMany | |
CSA.2018 33 |
|
OneToMany |
SNP ID | Clin | Chr 01 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
rs1000005027 | -- | 10,675,696(-) | C/A/T | intron_variant | |
rs1000041809 | -- | 10,645,549(-) | C/T | genic_downstream_transcript_variant, intron_variant | |
rs1000055969 | -- | 10,671,037(-) | G/A | intron_variant | |
rs1000065042 | -- | 10,772,153(-) | G/A | genic_upstream_transcript_variant, intron_variant | |
rs1000065352 | -- | 10,727,503(-) | C/T | genic_upstream_transcript_variant, intron_variant |
Disorder | Aliases | PubMed IDs |
---|---|---|
retroperitoneal sarcoma |
|
|
retroperitoneum carcinoma |
|
|
chromosome 1p36 deletion syndrome |
|
|
dilated cardiomyopathy |
|
|
neuroblastoma 1 |
|
|