Aliases for CASTOR3 Gene

Aliases for CASTOR3 Gene

  • CASTOR Family Member 3 2 3 5
  • STAG3OS 2 3 4
  • STAG3 Opposite Strand Transcript Protein 3 4
  • GATS, Stromal Antigen 3 Opposite Strand 2 3
  • Stromal Antigen 3 Opposite Strand 2 3
  • Putative Protein CASTOR 3 3 4
  • GATS 3 4
  • Opposite Strand Transcription Unit To STAG3 3
  • Putative Protein GATS 3
  • DKFZp686B07267 2
  • CASTOR3 5

External Ids for CASTOR3 Gene

Previous HGNC Symbols for CASTOR3 Gene

  • GATS

Previous GeneCards Identifiers for CASTOR3 Gene

  • GC07M100204
  • GC07M100223
  • GC07M100216
  • GC07M100255
  • GC07M100202

Summaries for CASTOR3 Gene

GeneCards Summary for CASTOR3 Gene

CASTOR3 (CASTOR Family Member 3) is a Pseudogene. Diseases associated with CASTOR3 include Cerebral Creatine Deficiency Syndrome 2 and Periodic Fever, Familial, Autosomal Dominant. Among its related pathways are Gastric Cancer Network 1. An important paralog of this gene is CASTOR2.

Additional gene information for CASTOR3 Gene

No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for CASTOR3 Gene

Genomics for CASTOR3 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for CASTOR3 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around CASTOR3 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for CASTOR3

Genomic Locations for CASTOR3 Gene

Genomic Locations for CASTOR3 Gene
chr7:100,200,653-100,272,232
(GRCh38/hg38)
Size:
71,580 bases
Orientation:
Minus strand
chr7:99,798,276-99,869,855
(GRCh37/hg19)
Size:
71,580 bases
Orientation:
Minus strand

Genomic View for CASTOR3 Gene

Genes around CASTOR3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CASTOR3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CASTOR3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CASTOR3 Gene

Proteins for CASTOR3 Gene

  • Protein details for CASTOR3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NAP1-CAST3_HUMAN
    Recommended name:
    Putative protein CASTOR 3
    Protein Accession:
    Q8NAP1
    Secondary Accessions:
    • D6W5V0
    • Q68D93
    • Q6P198
    • Q6PII7
    • Q7Z720
    • Q86UK9

    Protein attributes for CASTOR3 Gene

    Size:
    163 amino acids
    Molecular mass:
    17846 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAH33723.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305}; Sequence=AAH53367.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305}; Sequence=AAH65200.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};

neXtProt entry for CASTOR3 Gene

Post-translational modifications for CASTOR3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CASTOR3 Gene

ENSEMBL proteins:

No data available for DME Specific Peptides for CASTOR3 Gene

Domains & Families for CASTOR3 Gene

Gene Families for CASTOR3 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for CASTOR3 Gene

Suggested Antigen Peptide Sequences for CASTOR3 Gene

GenScript: Design optimal peptide antigens:
  • STAG3 opposite strand transcript protein (GATS_HUMAN)
  • cDNA FLJ42699 fis, clone BRAMY3004672 (Q96NI1_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q8NAP1

UniProtKB/Swiss-Prot:

CAST3_HUMAN :
  • Belongs to the GATS family.
Family:
  • Belongs to the GATS family.
genes like me logo Genes that share domains with CASTOR3: view

Function for CASTOR3 Gene

Phenotypes From GWAS Catalog for CASTOR3 Gene

Phenotypes for CASTOR3 Gene

genes like me logo Genes that share phenotypes with CASTOR3: view

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CASTOR3 Gene

Localization for CASTOR3 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CASTOR3 gene
Compartment Confidence
cytosol 4
mitochondrion 3
plasma membrane 2
extracellular 2
nucleus 2
cytoskeleton 1
endoplasmic reticulum 1
peroxisome 0

Gene Ontology (GO) - Cellular Components for CASTOR3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005829 cytosol IBA 21873635
GO:0061700 colocalizes_with GATOR2 complex IBA 21873635
genes like me logo Genes that share ontologies with CASTOR3: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from the Human Protein Atlas (HPA) for CASTOR3 Gene

Pathways & Interactions for CASTOR3 Gene

PathCards logo

SuperPathways for CASTOR3 Gene

SuperPathway Contained pathways
1 Gastric Cancer Network 1
genes like me logo Genes that share pathways with CASTOR3: view

Pathways by source for CASTOR3 Gene

1 BioSystems pathway for CASTOR3 Gene

Interacting Proteins for CASTOR3 Gene

Gene Ontology (GO) - Biological Process for CASTOR3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:1902531 regulation of intracellular signal transduction IBA 21873635
GO:1903577 cellular response to L-arginine IBA 21873635
GO:1904262 negative regulation of TORC1 signaling IBA 21873635
genes like me logo Genes that share ontologies with CASTOR3: view

No data available for SIGNOR curated interactions for CASTOR3 Gene

Drugs & Compounds for CASTOR3 Gene

(1) Additional Compounds for CASTOR3 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with CASTOR3: view

Transcripts for CASTOR3 Gene

mRNA/cDNA for CASTOR3 Gene

1 REFSEQ mRNAs :
23 NCBI additional mRNA sequence :
13 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for CASTOR3 Gene

No ASD Table

Relevant External Links for CASTOR3 Gene

GeneLoc Exon Structure for
CASTOR3

Expression for CASTOR3 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for CASTOR3

Evidence on tissue expression from TISSUES for CASTOR3 Gene

  • Nervous system(5)
  • Eye(4.4)
  • Muscle(2.2)
No Expression Related Data Available

Primer Products

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for CASTOR3 Gene

Orthologs for CASTOR3 Gene

Evolution for CASTOR3 Gene

ENSEMBL:
Gene Tree for CASTOR3 (if available)
TreeFam:
Gene Tree for CASTOR3 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for CASTOR3: view image

No data available for Orthologs for CASTOR3 Gene

Paralogs for CASTOR3 Gene

Paralogs for CASTOR3 Gene

Pseudogenes.org Pseudogenes for CASTOR3 Gene

genes like me logo Genes that share paralogs with CASTOR3: view

Variants for CASTOR3 Gene

Additional dbSNP identifiers (rs#s) for CASTOR3 Gene

Structural Variations from Database of Genomic Variants (DGV) for CASTOR3 Gene

Variant ID Type Subtype PubMed ID
esv26986 CNV gain 19812545
esv2734888 CNV deletion 23290073
esv2734890 CNV deletion 23290073
esv3329662 CNV insertion 20981092
esv3614292 CNV gain 21293372
esv3614293 CNV gain 21293372
esv3614294 CNV gain 21293372
nsv428180 CNV gain 18775914
nsv436898 CNV insertion 17901297
nsv5867 CNV deletion 18451855
nsv8182 CNV gain 18304495
nsv970560 CNV duplication 23825009
nsv981558 CNV duplication 23825009

Variation tolerance for CASTOR3 Gene

Residual Variation Intolerance Score: 39.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.58; 12.57% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CASTOR3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CASTOR3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for CASTOR3 Gene

Disorders for CASTOR3 Gene

MalaCards: The human disease database

(2) MalaCards diseases for CASTOR3 Gene - From: DISEASES

- elite association - COSMIC cancer census association via MalaCards
genes like me logo Genes that share disorders with CASTOR3: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CASTOR3 Gene

Publications for CASTOR3 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 2 3
  3. Downregulation of GATS gene inhibits proliferation, clonogenicity and migration in triple negative breast cancer cells MDA-MB-231 by cell autophagy. (PMID: 31381506) Feng F … Zhang X (Cancer biomarkers : section A of Disease markers 2019) 3
  4. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3
  5. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin EL … Gygi SP (Cell 2015) 3

Products for CASTOR3 Gene

Sources for CASTOR3 Gene