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Aliases for CASTOR2 Gene
Aliases for CASTOR2 Gene
External Ids for CASTOR2 Gene
- HGNC: 37073
- Entrez Gene: 729438
- Ensembl: ENSG00000274070
- OMIM: 617033
- UniProtKB: A6NHX0
Previous HGNC Symbols for CASTOR2 Gene
- GATSL1
- GATSL2
Summaries for CASTOR2 Gene
GeneCards Summary for CASTOR2 Gene
CASTOR2 (Cytosolic Arginine Sensor For MTORC1 Subunit 2) is a Protein Coding gene. Diseases associated with CASTOR2 include Spinal Cord Glioma and Spinal Cancer. Among its related pathways are mTOR signaling pathway (KEGG). An important paralog of this gene is CASTOR1.
UniProtKB/Swiss-Prot Summary for CASTOR2 Gene
-
Functions as a negative regulator of the TORC1 signaling pathway through the GATOR complex. As part of homodimers or heterodimers with CASTOR1, directly binds and inhibits the GATOR subcomplex GATOR2 and thereby mTORC1. Does not directly bind arginine, but binding of arginine to CASTOR1 disrupts the interaction of CASTOR2-containing heterodimers with GATOR2 which can in turn activate mTORC1 and the TORC1 signaling pathway.
Additional gene information for CASTOR2 Gene
- HGNC(37073)
- Entrez Gene(729438)
- Ensembl(ENSG00000274070)
- OMIM(617033)
- UniProtKB(A6NHX0)
- Open Targets Platform(ENSG00000274070)
- Search for CASTOR2 at DataMed
- Search for CASTOR2 at HumanCyc
No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for CASTOR2 Gene
Genomics for CASTOR2 Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for CASTOR2 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around CASTOR2 on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for CASTOR2
Genomic Locations for CASTOR2 Gene
Genomic Locations for CASTOR2 Gene
- chr7:74,964,693-75,031,531
- (GRCh38/hg38)
- Size:
- 66,839 bases
- Orientation:
- Plus strand
- chr7:74,379,083-74,438,803
- (GRCh37/hg19)
- Size:
- 59,721 bases
- Orientation:
- Plus strand
Genomic View for CASTOR2 Gene
Genes around CASTOR2 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 7q11.23 by HGNC
- 7q11.23 by Entrez Gene
- 7q11.23 by Ensembl
CASTOR2 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for CASTOR2 Gene
Proteins for CASTOR2 Gene
-
Protein details for CASTOR2 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- A6NHX0-CAST2_HUMAN
- Recommended name:
- Cytosolic arginine sensor for mTORC1 subunit 2
- Protein Accession:
- A6NHX0
- A6NNH0
- B9EJH9
Protein attributes for CASTOR2 Gene
- Size:
- 329 amino acids
- Molecular mass:
- 36056 Da
- Quaternary structure:
-
- Forms homodimers and heterodimers with CASTOR1 (PubMed:26972053). Interacts with the GATOR2 complex which is composed of MIOS, SEC13, SEH1L, WDR24 and WDR59; the interaction is not regulated by arginine (PubMed:26972053).
Post-translational modifications for CASTOR2 Gene
Other Protein References for CASTOR2 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- Novus Biologicals Antibodies for CASTOR2
- Invitrogen Antibodies for CASTOR2 (AFLGC-CASTOR2)
Protein Products
-
OriGene Purified Proteins for CASTOR2
- Search Origene for MassSpec and Protein Over-expression Lysates for CASTOR2
- Origene Custom Protein Services for CASTOR2
- Novus Biologicals proteins for CASTOR2
No data available for DME Specific Peptides for CASTOR2 Gene
Domains & Families for CASTOR2 Gene
Gene Families for CASTOR2 Gene
- Human Protein Atlas (HPA):
-
- Predicted intracellular proteins
Protein Domains for CASTOR2 Gene
- InterPro:
- ProtoNet:
Suggested Antigen Peptide Sequences for CASTOR2 Gene
- GenScript: Design optimal peptide antigens:
-
- GATS-like protein 1 (GATL1_HUMAN)
- GATS-like protein 2 (GATL2_HUMAN)
Graphical View of Domain Structure for InterPro Entry
A6NHX0- Family:
-
- Belongs to the GATS family.
Function for CASTOR2 Gene
Molecular function for CASTOR2 Gene
- UniProtKB/Swiss-Prot Function:
- Functions as a negative regulator of the TORC1 signaling pathway through the GATOR complex. As part of homodimers or heterodimers with CASTOR1, directly binds and inhibits the GATOR subcomplex GATOR2 and thereby mTORC1. Does not directly bind arginine, but binding of arginine to CASTOR1 disrupts the interaction of CASTOR2-containing heterodimers with GATOR2 which can in turn activate mTORC1 and the TORC1 signaling pathway.
Phenotypes From GWAS Catalog for CASTOR2 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005515 | protein binding | IPI | 26972053 |
| GO:0034618 | NOT arginine binding | IDA | 26972053 |
| GO:0042802 | identical protein binding | IDA | 26972053 |
Phenotypes for CASTOR2 Gene
- GenomeRNAi human phenotypes for CASTOR2:
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for CASTOR2 - Select products 50% OFF >
- * CASTOR2 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for CASTOR2
miRNA for CASTOR2 Gene
- miRTarBase miRNAs that target CASTOR2
-
- hsa-miR-6734-5p (MIRT444691)
- hsa-miR-1226-5p (MIRT444692)
- hsa-miR-6834-5p (MIRT444693)
- hsa-miR-421 (MIRT444694)
- hsa-miR-505-3p (MIRT444695)
- hsa-miR-7159-5p (MIRT444696)
- hsa-miR-4721 (MIRT444697)
- hsa-miR-3616-3p (MIRT444698)
- hsa-miR-676-5p (MIRT444699)
- hsa-miR-3065-5p (MIRT444700)
- hsa-miR-7160-3p (MIRT444701)
- hsa-miR-100-3p (MIRT444702)
- hsa-miR-4642 (MIRT502382)
- hsa-miR-5093 (MIRT502383)
- hsa-miR-4518 (MIRT502384)
- hsa-miR-1266-5p (MIRT502385)
- hsa-miR-3664-3p (MIRT502386)
- hsa-miR-580-5p (MIRT502387)
- hsa-miR-191-5p (MIRT502388)
- hsa-miR-1271-5p (MIRT502389)
- hsa-miR-96-5p (MIRT502390)
- hsa-miR-182-5p (MIRT502391)
- hsa-miR-6749-3p (MIRT616400)
- hsa-miR-6792-3p (MIRT616401)
- hsa-miR-4691-5p (MIRT616402)
- hsa-miR-4755-3p (MIRT616403)
- hsa-miR-1233-3p (MIRT616404)
- hsa-miR-1236-3p (MIRT616405)
- hsa-miR-877-3p (MIRT616406)
- hsa-miR-4258 (MIRT616407)
- hsa-miR-6840-5p (MIRT616408)
- hsa-miR-4673 (MIRT616409)
- hsa-miR-4645-5p (MIRT616410)
- hsa-miR-6715b-5p (MIRT616411)
- hsa-miR-4269 (MIRT616412)
- hsa-miR-4687-5p (MIRT616413)
- hsa-miR-7703 (MIRT623820)
- hsa-miR-6720-5p (MIRT623821)
- hsa-miR-6512-3p (MIRT623822)
- hsa-miR-214-5p (MIRT623823)
- hsa-miR-766-3p (MIRT623824)
- hsa-miR-372-5p (MIRT623825)
- hsa-miR-371a-5p (MIRT623826)
- hsa-miR-616-5p (MIRT623827)
- hsa-miR-373-5p (MIRT623828)
- hsa-miR-371b-5p (MIRT623829)
- hsa-miR-5699-3p (MIRT623830)
- hsa-miR-4421 (MIRT623831)
- hsa-miR-6849-3p (MIRT623832)
- hsa-miR-1273g-3p (MIRT623833)
- hsa-miR-3613-3p (MIRT623834)
- hsa-miR-4523 (MIRT623835)
- hsa-miR-4793-3p (MIRT628190)
- hsa-miR-508-5p (MIRT628191)
- hsa-miR-1303 (MIRT657924)
- hsa-miR-6866-5p (MIRT657925)
- hsa-miR-877-5p (MIRT657926)
- hsa-miR-8059 (MIRT657927)
- hsa-miR-4471 (MIRT657928)
- hsa-miR-7158-5p (MIRT657929)
- hsa-miR-4680-5p (MIRT657930)
- hsa-miR-6822-5p (MIRT657931)
- hsa-miR-6750-5p (MIRT657932)
- hsa-miR-6873-5p (MIRT657933)
- hsa-miR-3692-3p (MIRT668210)
- hsa-miR-376b-3p (MIRT668211)
- hsa-miR-376a-3p (MIRT668212)
- hsa-miR-3976 (MIRT668213)
- hsa-miR-6856-5p (MIRT668214)
- hsa-miR-6758-5p (MIRT668215)
- hsa-let-7a-5p (MIRT735563)
- hsa-let-7b-5p (MIRT735592)
- hsa-let-7c-5p (MIRT735616)
- hsa-let-7d-5p (MIRT735643)
- hsa-let-7e-5p (MIRT735670)
- hsa-let-7f-5p (MIRT735702)
- hsa-let-7g-5p (MIRT735733)
- hsa-let-7i-5p (MIRT735761)
- hsa-miR-1180-3p (MIRT735871)
- hsa-miR-1249-5p (MIRT736421)
- hsa-miR-125a-3p (MIRT736622)
- hsa-miR-1275 (MIRT736918)
- hsa-miR-138-5p (MIRT737530)
- hsa-miR-2117 (MIRT738973)
- hsa-miR-28-5p (MIRT739479)
- hsa-miR-296-3p (MIRT739513)
- hsa-miR-3139 (MIRT740165)
- hsa-miR-3191-5p (MIRT740996)
- hsa-miR-326 (MIRT741266)
- hsa-miR-330-5p (MIRT741324)
- hsa-miR-3907 (MIRT742815)
- hsa-miR-4270 (MIRT743551)
- hsa-miR-431-3p (MIRT743972)
- hsa-miR-4441 (MIRT744518)
- hsa-miR-4443 (MIRT744580)
- hsa-miR-4447 (MIRT744636)
- hsa-miR-4458 (MIRT744749)
- hsa-miR-4472 (MIRT744962)
- hsa-miR-4487 (MIRT745195)
- hsa-miR-4497 (MIRT745344)
- hsa-miR-4500 (MIRT745469)
- hsa-miR-4525 (MIRT745908)
- hsa-miR-4537 (MIRT746077)
- hsa-miR-4664-3p (MIRT746720)
- hsa-miR-4665-5p (MIRT746756)
- hsa-miR-4685-5p (MIRT746955)
- hsa-miR-4710 (MIRT747393)
- hsa-miR-4723-5p (MIRT747641)
- hsa-miR-5010-5p (MIRT749490)
- hsa-miR-518c-5p (MIRT749900)
- hsa-miR-548q (MIRT750782)
- hsa-miR-5584-5p (MIRT750966)
- hsa-miR-5698 (MIRT751273)
- hsa-miR-6077 (MIRT751694)
- hsa-miR-625-5p (MIRT752583)
- hsa-miR-6515-5p (MIRT753281)
- hsa-miR-6730-5p (MIRT753972)
- hsa-miR-6731-5p (MIRT753991)
- hsa-miR-6732-5p (MIRT754060)
- hsa-miR-6754-5p (MIRT754693)
- hsa-miR-6760-5p (MIRT754914)
- hsa-miR-6764-3p (MIRT755040)
- hsa-miR-6784-5p (MIRT755777)
- hsa-miR-6797-5p (MIRT756181)
- hsa-miR-6799-5p (MIRT756288)
- hsa-miR-6804-5p (MIRT756420)
- hsa-miR-6824-3p (MIRT756932)
- hsa-miR-6825-5p (MIRT756962)
- hsa-miR-6837-5p (MIRT757237)
- hsa-miR-6870-5p (MIRT757974)
- hsa-miR-708-5p (MIRT758808)
- hsa-miR-7111-5p (MIRT759031)
- hsa-miR-7113-5p (MIRT759097)
- hsa-miR-8085 (MIRT760194)
- hsa-miR-9500 (MIRT760875)
- hsa-miR-98-5p (MIRT760932)
- hsa-miR-1827 (MIRT783960)
- hsa-miR-204-3p (MIRT784140)
- hsa-miR-2467-3p (MIRT784313)
- hsa-miR-34b-3p (MIRT784906)
- hsa-miR-3614-5p (MIRT784959)
- hsa-miR-377-5p (MIRT785374)
- hsa-miR-3929 (MIRT785458)
- hsa-miR-4257 (MIRT785539)
- hsa-miR-4419b (MIRT785784)
- hsa-miR-4478 (MIRT785976)
- hsa-miR-4646-5p (MIRT786285)
- hsa-miR-4649-3p (MIRT786292)
- hsa-miR-4722-5p (MIRT786525)
- hsa-miR-4747-5p (MIRT786604)
- hsa-miR-4768-3p (MIRT786666)
- hsa-miR-485-5p (MIRT786876)
- hsa-miR-490-3p (MIRT786896)
- hsa-miR-5196-5p (MIRT787225)
- hsa-miR-6086 (MIRT788005)
- hsa-miR-6500-3p (MIRT788201)
- hsa-miR-665 (MIRT788441)
- hsa-miR-6808-5p (MIRT788864)
- hsa-miR-6828-5p (MIRT788973)
- hsa-miR-6884-5p (MIRT789296)
- hsa-miR-6893-5p (MIRT789359)
- hsa-miR-7160-5p (MIRT789456)
- hsa-miR-7851-3p (MIRT789584)
- hsa-miR-940 (MIRT789992)
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for CASTOR2
- Browse OriGene Inhibitory RNA Products For CASTOR2
Clone Products
- Applied Biological Materials (abm): Clones for CASTOR2 - Select products 50% OFF >
- * CASTOR2 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Sino Biological Human cDNA Clone for CASTOR2
Cell Line Products
-
Horizon Cell Lines for CASTOR2
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CASTOR2 Gene
Localization for CASTOR2 Gene
Subcellular locations from UniProtKB/Swiss-Prot for CASTOR2 Gene
- Cytoplasm, cytosol.
| Compartment | Confidence |
|---|---|
| cytosol | 5 |
| endosome | 1 |
| lysosome | 1 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005737 | cytoplasm | IEA | -- |
| GO:0005829 | cytosol | IBA,IDA | 26972053 |
| GO:0061700 | colocalizes_with GATOR2 complex | IDA | 26972053 |
No data available for Subcellular locations from the Human Protein Atlas (HPA) for CASTOR2 Gene
Pathways & Interactions for CASTOR2 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | mTOR signaling pathway (KEGG) | ||
Pathways by source for CASTOR2 Gene
1 KEGG pathway for CASTOR2 Gene
Interacting Proteins for CASTOR2 Gene
GPS-Prot Interaction Network for CASTOR2
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:1902531 | regulation of intracellular signal transduction | IBA | 21873635 |
| GO:1903577 | cellular response to L-arginine | IBA | 21873635 |
| GO:1904262 | negative regulation of TORC1 signaling | IBA,IMP | 26972053 |
No data available for SIGNOR curated interactions for CASTOR2 Gene
Transcripts for CASTOR2 Gene
mRNA/cDNA for CASTOR2 Gene
- 1 REFSEQ mRNAs :
- 11 NCBI additional mRNA sequence :
- 2 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000616305 8100 nts (view in UCSC)
- ENST00000622472 809 nts (view in UCSC)
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for CASTOR2 - Select products 50% OFF >
- * CASTOR2 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for CASTOR2
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for CASTOR2
- Browse OriGene Inhibitory RNA Products For CASTOR2
Clone Products
- Applied Biological Materials (abm): Clones for CASTOR2 - Select products 50% OFF >
- * CASTOR2 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Sino Biological Human cDNA Clone for CASTOR2
Relevant External Links for CASTOR2 Gene
- GeneLoc Exon Structure for
- CASTOR2
Expression for CASTOR2 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Blood (Hematopoietic System)
- Natural Killer Cells Peripheral Blood
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for CASTOR2
mRNA Expression by UniProt/SwissProt for CASTOR2 Gene:
A6NHX0-CAST2_HUMAN
Tissue specificity:
Widely expressed.
Primer Products
-
OriGene qPCR primer pairs for CASTOR2
No data available for mRNA expression in normal human tissues , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for CASTOR2 Gene
Orthologs for CASTOR2 Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | GATSL2 30 |
|
||
| Cow (Bos Taurus) |
Mammalia | GATSL2 30 |
|
||
| Mouse (Mus musculus) |
Mammalia | Gatsl2 30 |
|
||
| Castor2 17 |
|
||||
| Dog (Canis familiaris) |
Mammalia | GATSL2 30 |
|
||
| Rat (Rattus norvegicus) |
Mammalia | Gatsl2 30 |
|
||
| Chicken (Gallus gallus) |
Aves | GATSL2 30 |
|
||
| Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | gatsl1 30 |
|
||
| Zebrafish (Danio rerio) |
Actinopterygii | gatsl2 30 |
|
- Species where no ortholog for CASTOR2 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Baker's yeast (Saccharomyces cerevisiae)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Fruit Fly (Drosophila melanogaster)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Lizard (Anolis carolinensis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Oppossum (Monodelphis domestica)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Platypus (Ornithorhynchus anatinus)
- Rainbow Trout (Oncorhynchus mykiss)
- Rice (Oryza sativa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Vase (Ciona intestinalis)
- Sea Squirt (Ciona savignyi)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Thale Cress (Arabidopsis thaliana)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Wheat (Triticum aestivum)
- Worm (Caenorhabditis elegans)
Evolution for CASTOR2 Gene
- ENSEMBL:
- Gene Tree for CASTOR2 (if available)
- TreeFam:
- Gene Tree for CASTOR2 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for CASTOR2: view image
Paralogs for CASTOR2 Gene
Variants for CASTOR2 Gene
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| dgv11452n54 | CNV | loss | 21841781 |
| dgv3593n106 | CNV | deletion | 24896259 |
| esv1398337 | CNV | insertion | 17803354 |
| esv2658348 | CNV | deletion | 23128226 |
| nsv1032137 | CNV | gain | 25217958 |
| nsv1075033 | CNV | deletion | 25765185 |
| nsv1075972 | CNV | deletion | 25765185 |
| nsv1112935 | CNV | deletion | 24896259 |
| nsv1119128 | CNV | deletion | 24896259 |
| nsv1145144 | CNV | deletion | 24896259 |
| nsv7402 | OTHER | inversion | 18451855 |
| nsv8145 | CNV | gain | 18304495 |
| nsv950552 | CNV | deletion | 24416366 |
| nsv951355 | CNV | deletion | 24416366 |
| nsv970534 | CNV | duplication | 23825009 |
| nsv970537 | CNV | duplication | 23825009 |
| nsv970882 | CNV | duplication | 23825009 |
| nsv981529 | CNV | duplication | 23825009 |
| nsv981530 | CNV | duplication | 23825009 |
| nsv981533 | CNV | duplication | 23825009 |
| nsv981668 | CNV | duplication | 23825009 |
Gene Damage Index Score:
0.20;
4.51% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for CASTOR2 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- CASTOR2
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for CASTOR2 Gene
Disorders for CASTOR2 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| spinal cord glioma |
|
|
| spinal cancer |
|
|
Search CASTOR2 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for CASTOR2
No data available for UniProtKB/Swiss-Prot and Genatlas for CASTOR2 Gene
Publications for CASTOR2 Gene
- The CASTOR Proteins Are Arginine Sensors for the mTORC1 Pathway. (PMID: 26972053) Chantranupong L … Sabatini DM (Cell 2016) 2 3 4
- The DNA sequence of human chromosome 7. (PMID: 12853948) Hillier LW … Wilson RK (Nature 2003) 3 4
- Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3
- The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin EL … Gygi SP (Cell 2015) 3
- A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein MY … Mann M (Cell 2015) 3
ExternalLinks
Products for CASTOR2 Gene
- Browse OriGene Antibodies
- Custom Antibody Services
- Browse OriGene ELISA Kits
- Custom Assay Services
- OriGene Purified Proteins for CASTOR2
- Search Origene for MassSpec and Protein Over-expression Lysates for CASTOR2
- Origene Custom Protein Services for CASTOR2
- Origene shrna, sirna, and RNAi products in human, mouse, rat for CASTOR2
- Browse OriGene Inhibitory RNA Products For CASTOR2
- OriGene qPCR primer pairs for CASTOR2
- OriGene CRISPR knockouts for CASTOR2
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For CASTOR2
- Sino Biological Human cDNA Clone for CASTOR2
- Browse Sino Biological Recombinant Proteins
- Browse Sino Biological Cell Lysates
- Browse Sino Biological Antibodies
- Browse Sino Biological Assays
- Browse cDNA Clones
- Browse ELISA Kits
- Browse CRO Services
- High-throughput Antibody Production Service
- Protein Production Service
- Epitope Tag Antibodies & Reporter Protein Antibodies
- Lentiviral ORF Clones
- Novus Biologicals Antibodies for CASTOR2
- Novus Biologicals proteins for CASTOR2
- Browse Antibodies
- Browse Peptides and Proteins
- Browse Lysates
- Browse ELISA Kits
- Invitrogen Antibodies for CASTOR2 (AFLGC-CASTOR2)
- VectorBuilder Custom and pre-made DNA vectors for CASTOR2 (ie. gene expression, shRNA knockdown, CRISPR)
- VectorBuilder Viral vectors for CASTOR2 (ie. lentivirus, AAV, adenovirus)
- VectorBuilder CRISPR vectors for CASTOR2 (ie. knockout, knockin, CRISPRa, CRISPRi)
- VectorBuilder Virus packaging for CASTOR2 CRISPR vectors (ie. lentivirus, AAV, adenovirus)
- VectorBuilder Stable cell line generation for CASTOR2
- antibodies-online: Show 8 available GATSL1 Antibodies ranked by validation data
- Compare Top GATSL1 Antibodies
- Quality Products:
- antibodies-online: Search results for available GATSL1 related products ranked by validation data
- antibodies-online: Search results for available GATSL1 related products ranked by validation data
- Horizon Cell Lines for CASTOR2
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for knockout CRISPR/Cas9 clones, lentivirus, and/or AAV products for CASTOR2
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles, and/or promoter clone products for CASTOR2
- Search GeneCopoeia for miRNA 3'UTR Target clone products for CASTOR2
- Search GeneCopoeia for shRNA, lentivirus, and/or AAV clone products for CASTOR2
Sources for CASTOR2 Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) UniProtKB/TrEMBL
- (14) InterPro
- (15) ProtoNet
- (16) Blocks
- (17) MGI
- (18) IUBMB
- (19) KEGG
- (20) MINT
- (21) STRING
- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) ASD
- (28) SAGE
- (29) SOURCE
- (30) HomoloGene
- (31) PanEnsembl
- (32) euGenes
- (33) SGD
- (34) FlyBase
- (35) WormBase
- (36) Pseudogene
- (37) DGV
- (38) dbSNP
- (39) GenAtlas
- (40) HGMD
- (41) GAD
- (42) BGMUT
- (43) HuGE
- (44) Atlas
- (45) GenBank
- (46) HORDE
- (47) HUGE
- (48) IMGT
- (49) Leiden
- (50) miRBase
- (51) DME
- (52) OriGene
- (53) PubMed
- (54) R&D Systems
- (55) TGDB
- (56) Tocris
- (57) Abcam
- (58) Novus Biologicals
- (59) ProSpec
- (60) Sino Biological
- (61) GenScript
- (62) Qiagen
- (63) OCA
- (64) Proteopedia
- (65) MOPED
- (66) neXtProt
- (67) Reactome
- (68) GeneGo (Thomson Reuters)
- (69) DISEASES
- (70) SIMAP
- (71) GenomeRNAi
- (72) LifeMap
- (73) miRTarBase
- (74) MalaCards
- (75) Invitrogen
- (76) BitterDB
- (77) ESI-BIO
- (78) RefSeq
- (79) BioSystems
- (80) MaxQB
- (81) IUPHAR
- (82) BioGPS
- (83) Illumina
- (84) COMPARTMENTS
- (85) HOMER
- (86) PaxDb
- (87) ApexBio
- (88) Addgene
- (89) antibodies-online
- (90) CYP
- (91) NONCODE
- (92) TreeFam
- (93) PathCards
- (94) GeneReviews
- (95) GeneTex
- (96) Taconic Biosciences
- (97) GTEx
- (98) ProteomicsDB
- (99) SCBT
- (100) DGIdb
- (101) ClinicalTrials
- (102) RVIS
- (103) SIGNOR
- (104) diseasecard
- (105) NIH Rare Diseases
- (106) Orphanet
- (107) UMLS
- (108) GTR
- (109) Disease Ontology
- (110) Genetics Home Reference
- (111) MeSH
- (112) MedlinePlus
- (113) CDC
- (114) NINDS
- (115) NCBI Bookshelf
- (116) ClinVar
- (117) Gene Damage Index
- (118) HPO
- (119) UDN
- (120) VISTA
- (121) FANTOM5
- (122) ENCODE
- (123) ProSci
- (124) Horizon
- (125) The Signaling Pathways Project (SPP)
- (126) IID
- (127) VectorBuilder
- (128) SNPedia
- (129) BRCA Exchange
- (130) CIViC
- (131) ProteoGenix
- (132) dbSUPER
- (133) TISSUES
- (134) Gene ORGANizer
- (135) abm
- (136) Human Protein Atlas
- (137) GWAS Catalog
- (138) Monarch Initiative
- (139) DataMed
- (140) HumanCyc
- (141) UCNEbase
- (142) EPDnew
- (143) Applied Biosystems
- (144) GlyConnect
- (145) Aminode
- (146) GeneCopoeia
- (147) GPS-Prot
- (148) RNACentral
- (149) LncRNADisease
- (150) LOVD
- (151) miR2Disease
- (152) DiseaseEnhancer
- (153) Boster Bio
- (154) Biorbyt
- (155) Biocompare
- (156) Mastermind
- (157) CTD^2 Dashboard
- (158) CraniofacialAtlas
- (159) GeneImprint
- (160) Synthego
- (161) ENA
- (162) GtRNAdb
- (163) LncBase
- (164) LncBook
- (165) LNCipedia
- (166) Modomics
- (167) PDBe
- (168) Rfam
- (169) SILVA
- (170) snOPY
- (171) SRPDB
- (172) GENCODE
- (173) TarBase
- (174) Signalway Antibody
- (175) Open Targets Platform
- (176) 5SRRNADB
- (177) snoDB
- (178) MirGeneDB