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Aliases for CASTOR1 Gene

Aliases for CASTOR1 Gene

  • Cytosolic Arginine Sensor For MTORC1 Subunit 1 2 3 4 5
  • Cellular Arginine Sensor For MTORC1 Protein 1 3 4
  • GATS Protein Like 3 2 3
  • GATS-Like Protein 3 3 4
  • GATSL3 3 4
  • GATS Protein-Like 3 2

External Ids for CASTOR1 Gene

Previous HGNC Symbols for CASTOR1 Gene

  • GATSL3

Summaries for CASTOR1 Gene

GeneCards Summary for CASTOR1 Gene

CASTOR1 (Cytosolic Arginine Sensor For MTORC1 Subunit 1) is a Protein Coding gene. Among its related pathways are mTOR signaling pathway (KEGG). An important paralog of this gene is CASTOR2.

UniProtKB/Swiss-Prot for CASTOR1 Gene

  • Functions as an intracellular arginine sensor within the amino acid-sensing branch of the TORC1 signaling pathway. As a homodimer or a heterodimer with CASTOR2, binds and inhibits the GATOR subcomplex GATOR2 and thereby mTORC1. Binding of arginine to CASTOR1 allosterically disrupts the interaction of CASTOR1-containing dimers with GATOR2 which can in turn activate mTORC1 and the TORC1 signaling pathway.

Additional gene information for CASTOR1 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CASTOR1 Gene

Genomics for CASTOR1 Gene

GeneHancer (GH) Regulatory Elements for CASTOR1 Gene

Promoters and enhancers for CASTOR1 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH22J030287 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE dbSUPER 619 -0.5 -531 5 HDGF ZFX SP1 CC2D1A CTCF NKRF ZNF121 ZNF687 NCOA3 ZBTB7A CASTOR1 RNF215 CCDC157 DUSP18 ENSG00000248751 TBC1D10A
GH22J030385 Promoter/Enhancer 1.9 EPDnew Ensembl ENCODE 25.9 -97.4 -97449 2.2 HDGF ZFX NKRF ZNF687 CTCF ZBTB7A SP7 SP5 ZNF639 RAD21 RNF215 CASTOR1 ENSG00000249590 TBC1D10A ENSG00000248751 OSM SF3A1 CCDC157 LIF SEC14L3
GH22J030322 Promoter/Enhancer 2.4 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 20.2 -37.3 -37293 8 SP1 ZFX ELF3 ZNF148 NKRF POLR2A ZBTB7A YY1 SP7 TRIM24 TBC1D10A RNF215 CCDC157 CASTOR1 SEC14L3 TUG1 SF3A1 ENSG00000248751 SEC14L2 ENSG00000249590
GH22J030300 Promoter/Enhancer 1.9 FANTOM5 Ensembl ENCODE dbSUPER 20.4 -21.4 -21358 20.9 CC2D1A CBFA2T2 CEBPG ZNF687 ZSCAN21 ZBTB7A SP7 RELA SP1 CREM RNF215 CASTOR1 PES1 MORC2 CCDC157 TUG1 SF3A1 SEC14L3 SEC14L2 MTMR3
GH22J030355 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 17.1 -67.2 -67174 3.2 HDGF SP1 CC2D1A ZFX ELF3 SIX5 NKRF POLR2A CEBPG GTF2F1 CCDC157 SF3A1 RNF215 CASTOR1 SEC14L6 SEC14L3
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around CASTOR1 on UCSC Golden Path with GeneCards custom track

Genomic Locations for CASTOR1 Gene

Genomic Locations for CASTOR1 Gene
chr22:30,285,117-30,289,627
(GRCh38/hg38)
Size:
4,511 bases
Orientation:
Minus strand
chr22:30,681,106-30,685,616
(GRCh37/hg19)
Size:
4,511 bases
Orientation:
Minus strand

Genomic View for CASTOR1 Gene

Genes around CASTOR1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CASTOR1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CASTOR1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CASTOR1 Gene

Proteins for CASTOR1 Gene

  • Protein details for CASTOR1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8WTX7-CAST1_HUMAN
    Recommended name:
    Cytosolic arginine sensor for mTORC1 subunit 1
    Protein Accession:
    Q8WTX7
    Secondary Accessions:
    • O76052
    • Q96ND9
    • Q9UIE8

    Protein attributes for CASTOR1 Gene

    Size:
    329 amino acids
    Molecular mass:
    36275 Da
    Quaternary structure:
    • Forms homodimers and heterodimers with CASTOR2 (PubMed:26972053, PubMed:27487210). Interacts with the GATOR2 complex which is composed of MIOS, SEC13, SEH1L, WDR24 and WDR59; the interaction is negatively regulated by arginine (PubMed:26972053, PubMed:27487210).
    SequenceCaution:
    • Sequence=AAC23432.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=AAC23433.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=BAB70963.1; Type=Erroneous termination; Positions=310; Note=Translated as Glu.; Evidence={ECO:0000305}; Sequence=EAW59868.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for CASTOR1 Gene

neXtProt entry for CASTOR1 Gene

Post-translational modifications for CASTOR1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CASTOR1 Gene

No data available for DME Specific Peptides for CASTOR1 Gene

Domains & Families for CASTOR1 Gene

Gene Families for CASTOR1 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for CASTOR1 Gene

Suggested Antigen Peptide Sequences for CASTOR1 Gene

GenScript: Design optimal peptide antigens:
  • GATS-like protein 3 (GATL3_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q8WTX7

UniProtKB/Swiss-Prot:

CAST1_HUMAN :
  • Based on x-ray crystallography data, the protein would be constituted of 4 tandem ACT domains instead of the 2 predicted from the sequence.
  • Belongs to the GATS family.
Domain:
  • Based on x-ray crystallography data, the protein would be constituted of 4 tandem ACT domains instead of the 2 predicted from the sequence.
Family:
  • Belongs to the GATS family.
genes like me logo Genes that share domains with CASTOR1: view

Function for CASTOR1 Gene

Molecular function for CASTOR1 Gene

UniProtKB/Swiss-Prot Function:
Functions as an intracellular arginine sensor within the amino acid-sensing branch of the TORC1 signaling pathway. As a homodimer or a heterodimer with CASTOR2, binds and inhibits the GATOR subcomplex GATOR2 and thereby mTORC1. Binding of arginine to CASTOR1 allosterically disrupts the interaction of CASTOR1-containing dimers with GATOR2 which can in turn activate mTORC1 and the TORC1 signaling pathway.

Phenotypes From GWAS Catalog for CASTOR1 Gene

Gene Ontology (GO) - Molecular Function for CASTOR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
GO:0034618 arginine binding IDA 26972053
GO:0042802 identical protein binding IDA,IPI 25416956
genes like me logo Genes that share ontologies with CASTOR1: view
genes like me logo Genes that share phenotypes with CASTOR1: view

Animal Models for CASTOR1 Gene

MGI Knock Outs for CASTOR1:

Animal Model Products

CRISPR Products

Clone Products

  • Applied Biological Materials (abm): Clones for CASTOR1 - Now 50% OFF >
  • * CASTOR1 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
  • * CASTOR1 tags and reporters available: His, HA, Myc, Flag, GFP, RFP, Luciferase - Browse All

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for CASTOR1 Gene

Localization for CASTOR1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CASTOR1 Gene

Cytoplasm, cytosol.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CASTOR1 gene
Compartment Confidence
cytosol 5
nucleus 2
lysosome 1

Gene Ontology (GO) - Cellular Components for CASTOR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005829 cytosol IDA,IBA 26972053
GO:0061700 colocalizes_with GATOR2 complex IDA 26972053
genes like me logo Genes that share ontologies with CASTOR1: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for CASTOR1 Gene

Pathways & Interactions for CASTOR1 Gene

PathCards logo

SuperPathways for CASTOR1 Gene

SuperPathway Contained pathways
1 mTOR signaling pathway (KEGG)
genes like me logo Genes that share pathways with CASTOR1: view

Pathways by source for CASTOR1 Gene

1 KEGG pathway for CASTOR1 Gene

Gene Ontology (GO) - Biological Process for CASTOR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:1902531 regulation of intracellular signal transduction IBA 21873635
GO:1903432 regulation of TORC1 signaling IEA --
GO:1903577 cellular response to L-arginine IMP 26972053
GO:1904262 negative regulation of TORC1 signaling IBA,IMP 26972053
genes like me logo Genes that share ontologies with CASTOR1: view

No data available for SIGNOR curated interactions for CASTOR1 Gene

Drugs & Compounds for CASTOR1 Gene

No Compound Related Data Available

Transcripts for CASTOR1 Gene

mRNA/cDNA for CASTOR1 Gene

(1) REFSEQ mRNAs :
(6) Additional mRNA sequences :
(14) Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Clone Products

  • Applied Biological Materials (abm): Clones for CASTOR1 - Now 50% OFF >
  • * CASTOR1 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
  • * CASTOR1 tags and reporters available: His, HA, Myc, Flag, GFP, RFP, Luciferase - Browse All

Alternative Splicing Database (ASD) splice patterns (SP) for CASTOR1 Gene

No ASD Table

Relevant External Links for CASTOR1 Gene

GeneLoc Exon Structure for
CASTOR1
ECgene alternative splicing isoforms for
CASTOR1

Expression for CASTOR1 Gene

NURSA nuclear receptor signaling pathways regulating expression of CASTOR1 Gene:

CASTOR1

mRNA Expression by UniProt/SwissProt for CASTOR1 Gene:

Q8WTX7-CAST1_HUMAN
Tissue specificity: Widely expressed.

Evidence on tissue expression from TISSUES for CASTOR1 Gene

  • Lung(4.1)
  • Nervous system(2.7)

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for CASTOR1 Gene

Orthologs for CASTOR1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CASTOR1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia GATSL3 34
  • 99.7 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia GATSL3 35
  • 94 (a)
OneToOne
cow
(Bos Taurus)
Mammalia GATSL3 35 34
  • 91.49 (n)
OneToOne
dog
(Canis familiaris)
Mammalia GATSL3 35 34
  • 90.27 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Gatsl3 35 34
  • 86.48 (n)
OneToOne
Castor1 17
rat
(Rattus norvegicus)
Mammalia Gatsl3 34
  • 86.18 (n)
oppossum
(Monodelphis domestica)
Mammalia GATSL3 35
  • 86 (a)
OneToOne
chicken
(Gallus gallus)
Aves GATSL3 35 34
  • 77.47 (n)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia gatsl3 34
  • 67.59 (n)
zebrafish
(Danio rerio)
Actinopterygii gatsl3 34
  • 66.97 (n)
Species where no ortholog for CASTOR1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CASTOR1 Gene

ENSEMBL:
Gene Tree for CASTOR1 (if available)
TreeFam:
Gene Tree for CASTOR1 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for CASTOR1: view image

Paralogs for CASTOR1 Gene

Paralogs for CASTOR1 Gene

genes like me logo Genes that share paralogs with CASTOR1: view

Variants for CASTOR1 Gene

Sequence variations from dbSNP and Humsavar for CASTOR1 Gene

SNP ID Clin Chr 22 pos Variation AA Info Type
rs1000389680 -- 30,287,670(-) G/T intron_variant
rs1000404870 -- 30,286,064(-) C/T coding_sequence_variant, missense_variant
rs1000404940 -- 30,287,955(-) G/A intron_variant
rs1001116980 -- 30,290,587(-) T/A upstream_transcript_variant
rs1002474096 -- 30,287,610(-) C/A intron_variant

Structural Variations from Database of Genomic Variants (DGV) for CASTOR1 Gene

Variant ID Type Subtype PubMed ID
esv2676362 CNV deletion 23128226
nsv1062388 CNV gain 25217958
nsv1110864 OTHER inversion 24896259
nsv522605 CNV loss 19592680
nsv588885 CNV loss 21841781
nsv829171 CNV loss 20364138
nsv834174 CNV gain+loss 17160897

Variation tolerance for CASTOR1 Gene

Residual Variation Intolerance Score: 48.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.16; 61.58% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CASTOR1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CASTOR1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CASTOR1 Gene

Disorders for CASTOR1 Gene

Additional Disease Information for CASTOR1

No disorders were found for CASTOR1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CASTOR1 Gene

Publications for CASTOR1 Gene

  1. The CASTOR Proteins Are Arginine Sensors for the mTORC1 Pathway. (PMID: 26972053) Chantranupong L … Sabatini DM (Cell 2016) 2 3 4 58
  2. Mechanism of arginine sensing by CASTOR1 upstream of mTORC1. (PMID: 27487210) Saxton RA … Sabatini DM (Nature 2016) 3 4 58
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  4. A genome annotation-driven approach to cloning the human ORFeome. (PMID: 15461802) Collins JE … Dunham I (Genome biology 2004) 3 4 58
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58

Products for CASTOR1 Gene

Sources for CASTOR1 Gene

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